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Impact o. cancer diagno.is o. life expectancy by area-level so.io.co.o.ic gro.ps in New So.th Wales, Australia: a po.ulatio.-based study

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Cancer Bio.o.y & Medicine 2024年第8期21卷 692-702页

作者： md Mijanur Rahman Michael david david Go.dsbury Karen Canfell Ko. Ko. Paramita Dasgupta Peter Baade Xue Qin Yu The Daffo.il Centre The University of SydneyA Joint Venture with Cancer Council NSWSydneyNSW 1340Australia Scho.l o. Medicine and Dentistry Griffith UniversityGold CoastQLD 4222Australia Cancer Co.ncil Queensland BrisbaneQLD 4006Australia

o.jective: Impro.ement in cancer survival o.er recent decades has no. been acco.panied by a narro.ing o. so.io.co.o.ic disparities. This study aimed to.quantify the lo.s o. life expectancy(Lo.E) resulting fro. a cancer diagno.is and examine disparities in Lo.E based o. area-level so.io.co.o.ic status(SES).Metho.s: Data were co.lected fo. all peo.le between 50 and 89 years o. age who.were diagno.ed with cancer, registered in the NSW Cancer Registry between 2001 and 2019, and underwent mo.tality fo.lo.-up evaluatio.s until December 2020. Flexible parametric survival mo.els were fitted to.estimate the Lo.E by gender and area-level SES fo. 12 co.mo. ***: o. 422,680 peo.le with cancer, 24% and 18% lived in the mo.t and least disadvantaged areas, respectively. Patients fro. the mo.t disadvantaged areas had a significantly greater average Lo.E than patients fro. the least disadvantaged areas fo. cancers with high survival rates, including pro.tate [2.9 years(95% CI: 2.5±3.2 years) vs. 1.6 years(95% CI: 1.3±1.9 years)] and breast cancer [1.6 years(95% CI: 1.4±1.8 years) vs. 1.2 years(95% CI: 1.0±1.4 years)]. The highest average Lo.E o.curred in males residing in the mo.t disadvantaged areas with pancreatic [16.5 years(95% CI: 16.1±16.8 years) vs. 16.2 years(95% CI: 15.7±16.7 years)] and liver cancer [15.5 years(95% CI: 15.0±16.0 years) vs. 14.7 years(95% CI: 14.0±15.5 years)]. Females residing in the least disadvantaged areas with thyro.d cancer [0.9 years(95% CI: 0.4±1.4 years) vs. 0.6 years(95% CI: 0.2±1.0 years)] o. melano.a [0.9 years(95% CI: 0.8±1.1 years) vs. 0.7 years(95% CI: 0.5±0.8 years)] had the lo.est average ***: Patients fro. the mo.t disadvantaged areas had the highest Lo.E with SES-based differences greatest fo. patients diagno.ed with cancer at an early stage o. cancers with higher survival rates, suggesting the need to.prio.itise early detectio. and reduce treatment-related barriers and survivo.ship challenges to.impro.e life expec

关键词： Cancer diagno.is life expectancy lo.s o. life expectancy area-level so.io.co.o.ic status flexible parametric mo.el

老年择期关节置换术患者术后谵妄的认知和功能预测因子及其后遗症

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麻醉与镇痛 2013年第6期9卷 13-22页

作者： Christo.her J. Janko.ski, md Max R. Trenerry, PhD david J. Co.k, md Sho.ie L. Buenvenida, m'q Susanna R. Stevens, MS Darrell R. Schro.der, MS david o. warner, md 张文奇(译) 刘晓(译) 郭曲练(校) Departments o. Anesthesio.o.y Psychology and Biostatistics and Department o. Anesthesio.o.y Anesthesiology Clinical Research Unit Mayo Clinic Rochester Minnesota 不详

背景术后谵妄（po.to.erativedelirium，Po.）在老年患者中很常见，且与不良预后相关。在行择期手术的患者中，Po.的认知和功能性后遗症尚且未知。我们试图研究：①在老年手术患者中，敏感性神经认知测试的较低评分能否作为Po.的独立风... 详细信息

背景术后谵妄（po.to.erativedelirium，Po.）在老年患者中很常见，且与不良预后相关。在行择期手术的患者中，Po.的认知和功能性后遗症尚且未知。我们试图研究：①在老年手术患者中，敏感性神经认知测试的较低评分能否作为Po.的独立风险因子；@Po.能否预测手术3个月后的认知和功能下降。方法我们对年龄I〉65岁的全髋关节或全膝关节置换术患者进行了一项前瞻性队列研究。参与者接受术前的神经认知和功能测试。使用混乱评估法诊断Po.。出现Po.的患者组与对照组在手术后3个月接受重复的神经认知和功能测试。结果418例患者符合入选标准，有42例出现Po.。各组之间在基础细微精神状态检查评分、酗酒、抑郁和语言智力等方面没有差别。Po.的独立预测因子包括年龄、精神疾病史、功能状态的下降和语言记忆的下降。对于所有测试，Po.患者组和匹配的对照组之／＇^-J在术前和术后3个月的变化相似。结论术前神经认知和功能状态的轻微下降可以预测Po.。然而在出现Po.的小群体中，没有手术后3个月出现认知和功能下降的证据。Po.与术前认知功能的降低有关，但在择期手术的老年患者中，可能不存在手术后3个月有害的认知或功能后遗症。

关键词：独立预测因子全膝关节置换术老年患者神经认知择期手术术后谵妄后遗症精神状态检查

The link between intracellular calcium signaling and exo.o.al PD-L1 in cancer pro.ressio. and immuno.herapy

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Genes & Diseases 2024年第1期11卷 321-334页

作者： md Rakibul Alam md Mizanur Rahman Zhiguo.Li Department o. To.ico.o.y and Cancer Bio.o.y College of MedicineUniversity of KentuckyLexingtonKY 40506USA Department o. Medicine(Nephro.o.y) Faculty of Medicine and DentistryUniversity of AlbertaEdmontonAlberta T6E2H7Canada

Exo.o.es are small membrane vesicles co.taining micro.NA,RNA,DNA fragments,and pro.eins that are transferred fro. do.o. cells to.recipient *** cells release exo.so.es to.repro.ram the facto.s asso.iated with the tumo. micro.nviro.ment(TME)causing tu-mo. metastasis and immune *** evidence revealed that cancer cell-derived exo.o.es carry immune inhibito.y mo.ecule pro.ram death ligand 1(PD-L1)that binds with re-cepto. pro.ram death pro.ein 1(PD-1)and pro.o.e tumo. pro.ressio. by escaping immune ***,so.e FDA-appro.ed mo.o.lo.al antibo.ies are clinicallyused fo. cancer treatment by blo.king PD-1/PD-L1 *** no.able treatment o.tco.es,so.e pa-tients sho. po.r drug *** PD-L1 plays a vital ro.e in lo.ering the treatment respo.se,sho.ing resistance to.PD-1/PD-L1 blo.kage therapy thro.gh recapitulating the ef-fect o. cell surface *** enhance therapeutic respo.se,inhibitio. o. exo.o.al PD-L1 is *** signaling is the central regulato. o. tumo.igenesis and can regulate exo.o.e bio.enesis and secretio. by mo.ulating Rab GTPase family and membrane fusio. ***-mune checkpo.nts are also.co.nected with calcium signaling and calcium channel blo.kers like amlo.ipine,nifedipine,lercanidipine,diltiazem,and verapamil were also.repo.ted to.suppress cellular PD-L1 ***,to.enhance the PD-1/PD-L1 blo.kage therapy respo.se,the reductio. o. exo.o.al PD-L1 secretio. fro. cancer cells is in o.r therapeutic *** this review,we pro.o.ed a therapeutic strategy by targeting calcium signaling to.inhibit the expressio. o. PD-L1-co.taining exo.o.e levels that co.ld reduce the anti-PD-1/PD-L1 therapy resistance and increase the patient's drug respo.se rate.

关键词： Calcium signaling CD8^(+)T cells Exo.o.al PD-L1 Exo.o.es bio.enesis Immuno.uppressio. Immuno.herapy

Synergistic enhancement o. pho.o.atalytic and antimicro.ial efficacy o. nitro.en and erbium co.do.ed Zno.nano.articles

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Jo.rnal o. Rare Earths 2024年第5期42卷 859-868,I0002页

作者： Sudipta Mo.dal Mo.iruzzaman Jamal Sikder Ashikuzzaman Ayo. md Jannatul Ferdo.s Anik md Muktadir Billah Department o. Materials and Metallurgical Engineering Bangladesh University of Engineering and TechnologyDhaka1000Bangladesh Scho.l o. Materials Engineering Purdue UniversityWest LafayetteIN47907USA Department o. Materials Science and Engineering University of CaliforniaBerkeleyCA94720USA Department o. Materials Science and Engineering Northwestern UniversityEvanstonI28USA

Using the chemical co.precipitatio. appro.ch,a series o. nitro.en(N) and erbium(Er) co.do.ed Zno.nano.articles(NPs) was effectively synthesized to.enhance the pho.o.atalytic and antibacterial *** characterizatio. techniques,including X-ray diffractio.(XRD),X-ray pho.o.lectro. spectro.sco.y(XPS),scanning electro. micro.co.y(SEM),UV-vis,and pho.o.uminescence(PL) spectro.co.y,were carried o.t to.validate the evaluated pho.o.atalytic and antibacterial *** analysis co.firms the pure wurtzite Zno.phase witho.t the presence o. any seco.dary *** analysis co.firms the succe ssful inco.po.atio. o. nitro.en and erbium into.the Zno.*** o.tical bandgap o. Zno.calculated fro. UV-vis spectro.co.y sho.s a redshift after Er-N co.do.ing,with the lo.est bandgap o. 3.215 eV calculated fo. Zn_(0.97)Er_(0.03)N_(0.01)o.(0.99) *** images demo.strate the fo.matio. o. nano.o.s after N-Er co.do.ing,fo.lo.ed by gradually increase d ro. diameter and length after N-Er ***,the pho.o.atalytic activities o. Zno.samples we re measured by their ability to.facilitate the pho.o.egradatio. o. Rho.amine B under UV *** with 1 mo.% N do.ing exhibits 88% pho.o.egradatio. o. RhB under UV light within 360 min,and the pho.o.egradatio. and antibacterial activity are greatly impro.ed with Er *** fact,3 mo.% Er-1 mo.% N do.ed Zno.NPs demo.strate the highest pho.o.atalytic activity,with appro.imately 96% degradatio. after 360 min,as well as superio. antibacterial activity against Staphylo.o.cus aureus(Gram-po.itive bacteria) and Pseudo.o.as aerugino.a(Gram-negative bacteria) with the highest zo.e o. inhibitio.(Zo.) o. 16 nm,due to.nano.o. fo.matio.,increased reactive o.ygen species(Ro.),and decreased electro.-ho.e reco.binatio.,as validated by SEM,XPS,and PL spectro.co.y.

关键词： Chemical co.precipitatio. Co.do.ing Bandgap Pho.o.atalysis Rare earths Antimicro.ial

Dynamic Hand Gesture-Based Perso. Identificatio. Using Leap Mo.io. and Machine Learning Appro.ches

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Co.puters, Materials & Co.tinua 2024年第4期79卷 1205-1222页

作者： Jungpil Shin md.AlMehedi Hasan md.Maniruzzaman Taiki Watanabe Issei Jo.ume Scho.l o. Co.puter Science and Engineering The University of AizuAizuwakamatsuFukushima965-8580Japan Department o. Co.puter Science&Engineering Rajshahi University of Engineering&TechnologyRajshahi6204Bangladesh

Perso. identificatio. is o.e o. the mo.t vital tasks fo. netwo.k security. Peo.le are mo.e co.cerned abo.t theirsecurity due to.traditio.al passwo.ds beco.ing weaker o. leaking in vario.s attacks. In recent decades, fingerprintsand faces have been widely used fo. perso. identificatio., which has the risk o. info.matio. leakage as a resulto. repro.ucing fingers o. faces by taking a snapsho.. Recently, peo.le have fo.used o. creating an identifiablepattern, which will no. be repro.ucible falsely by capturing psycho.o.ical and behavio.al info.matio. o. a perso.using visio. and senso.-based techniques. In existing studies, mo.t o. the researchers used very co.plex patternsin this directio., which need special training and attentio. to.remember the patterns and failed to.capturethe psycho.o.ical and behavio.al info.matio. o. a perso. pro.erly. To.o.erco.e these pro.lems, this researchdevised a no.el dynamic hand gesture-based perso. identificatio. system using a Leap Mo.io. senso.. Thisstudy develo.ed two.hand gesture-based pattern datasets fo. perfo.ming the experiments, which co.tained mo.ethan 500 samples, co.lected fro. 25 subjects. Vario.s static and dynamic features were extracted fro. the handgeo.etry. Rando.fo.est was used to.measure feature impo.tance using the Gini Index. Finally, the suppo.t vecto.machinewas implemented fo. perso. identificatio. and evaluate its perfo.mance using identificatio. accuracy. Theexperimental results sho.ed that the pro.o.ed system pro.uced an identificatio. accuracy o. 99.8% fo. arbitraryhand gesture-based patterns and 99.6% fo. the same dynamic hand gesture-based patterns. This result indicatedthat the pro.o.ed system can be used fo. perso. identificatio. in the field o. security.

关键词： Perso. identificatio. leap mo.io. hand gesture rando. fo.est suppo.t vecto. machine

Rando. fractal-based co.putatio.al design o. an ice-ray (IR) lattice shell structure

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Fro.tiers o. Architectural Research 2024年第2期13卷 406-424页

作者： Iasef md Rian Department o. Architecture Xi'an Jiaotong-Liverpool UniversitySuzhou 215123China

Chinese ice-ray (IR) lattices, kno.n fo. their intricate and visually fascinating rando. patterns as deco.ative elements in traditio.al 18th-century Chinese windo. design, exhibit underlying stiffness as latticed windo. fences. Such unique patterns represent a new mo.pho.o.y within the family o. sto.hastic lattices. Ho.ever, the latent structural po.ential within the rando. patterns o. ice-ray lattices remains largely unexplo.ed, particularly in the co.text o. lattice shell design. This study systematically studies the geo.etric qualities o. ice-ray lattice patterns and develo.s an algo.ithm to.mo.el these patterns fo. ice-ray lattice shell design. Subsequently, it assesses the structural feasibility and effectiveness o. these lattice shells in co.pariso. to.co.ventio.al gridshells. The practicality o. co.structing rando. lattice shells using digital fabricatio. to.ls is also.explo.ed. Emplo.ing fractal geo.etry as a fo.ndatio.al framewo.k, this research no. o.ly o.fers insights into.the po.ential o. ice-ray lattices fo. inno.ative lattice shell design but also.intro.uces a new structural mo.pho.o.y to.the field, expanding the po.sibilities o. inco.po.ating sto.hastic patterns in lattice shell design. Ultimately, it o.ens up new o.po.tunities fo. inno.ative lattice shell designs, emphasizing the po.ential o. sto.hastic patterns in structural applicatio.s.

关键词： Ice-ray pattern Fractals Rando. Lattice shells Co.putatio.al design Digital fabricatio.

Seaso.al influence o. freshwater discharge o. spatio.tempo.al variatio.s in primary pro.uctivity, sea surface temperature, and eupho.ic zo.e depth in the no.thern Bay o. Bengal

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Acta o.eano.o.ica Sinica 2024年第6期43卷 1-14页

作者： Hafez Ahmad Felix Jo.e md.Simul Bhuyan md.Nazrul Islam Padmanava Dash Geo.ystems Research Institute/Department o. Geo.ciences Mississippi State UniversityStarkville 39759USA Department o. o.eano.raphy University of ChittagongChittagong 4331Bangladesh Department o. Marine&Earth Sciences Florida Gulf Coast UniversityFort Myers 33965USA Bangladesh o.eano.raphic Research Institute Cox’s Bazar 4730Bangladesh Faculty o. Marine Sciences&Fisheries Institute of Marine SciencesUniversity of ChittagongChittagong 4331Bangladesh Department o. Geo.raphy and Enviro.ment Jahangirnagar UniversityDhaka 1342Bangladesh Department o. Geo.ciences Mississippi State UniversityStarkville 39759USA

o.ean pro.uctivity is the fo.ndatio. o. marine fo.d web,which co.tinuo.sly remo.es atmo.pheric carbo. dio.ide and suppo.ts life at sea and o. ***-tempo.al variability o. net primary pro.uctivity(NPP),sea surface temperature(SST),sea surface salinity(SSS),mixed layer depth(MLD),and eupho.ic zo.e depth(EZD) in the no.thern B ay o. Bengal(Bo.) during three mo.so.n seaso.s were examined in this study based o. remo.e sensing data fo. the perio. 2005 to.*** co.pare the NPP distributio. between the co.stal zo.es and o.en Bo.,the study area was divided into.five zo.es(Z1-Z5).Results suggest that mo.t pro.uctive zo.es Z2 and Zl are lo.ated at the head bay area and are directly influenced by freshwater discharge to.ether with riverine sediment and nutrient *** Z1-Z5,the NPP ranges fro. 5 315.38 mg/(m^(2)·d) to.346.7 mg/(m^(2)·d)(carbo.,since then the same).The highest mo.thly average NPP o. 5 315.38 mg/(m^(2)·d) in February and 5 039.36 mg/(m^(2)·d) in June were o.served fro. Z2,while the lo.est mo.thly average o. 346.72 mg/(m^(2)·d) was o.served in March fro. Z4,which is an o.eanic *** values vary fro. 6-154 m fo. the study area,and it has an inverse co.relatio. with NPP *** is deeper during the summer seaso. and shallo.er during the wintertime,with a co.respo.ding increase in *** the year,mo.thly SST sho.s slight fluctuatio. fo. the entire study area,and statistical analysis sho.s a significant co.relatio. amo.g NPP,and EZD,o.erall po.itive between NPP and MLD,whereas no.significant co.relatio. amo.g SSS,and SST fo. the no.thern ***-term trends in SST and pro.uctivity were significantly po.sitive in head bay zo.es but negatively pro.uctive in the o.en *** findings in this study o. the distributio. o. NPP,SST,SSS,MLD,and EZD and their seaso.al variability in five different zo.es o. Bo. can be used to.further impro.e the management o. marine reso.rces and o.erall enviro.mental co.ditio. in respo.se to.clim

关键词： chlo.o.hyll a sea surface temperature eupho.ic zo.e depth primary pro.uctivity Ganges-Brahmaputra o.ean co.o. Bay o. Bengal mo.so.n

Po.ential ro.e o. tubulin glutamylatio. in neuro.egenerative diseases

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Neural Regeneratio. Research 2024年第6期19卷 1191-1192页

作者： Abdullah md.Sheikh Shatera Tabassum Department o. Labo.ato.y Medicine Shimane University Faculty of MedicineShimaneJapan

The differentiatio. o. neuro.al stem cells into.mature neuro.s is a co.plex pro.ess that invo.ves bo.h structural and functio.al *** cells undergo.differentiatio.,there are no.able functio.al changes,including the expressio. o. vario.s transcriptio. facto.s,cyto.ines,and ***,structural changes o.cur as the cells develo. vario.s pro.esses fro. the cell bo.y and establish synaptic co.tacts with o.her cells.

关键词： diseases degenerative cyto.ines

Surface Mo.pho.o.y and Thermo.Electrical Energy Analysis o. Po.yaniline (PANI) Inco.po.ated Co.to. Fabric

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Energy Engineering 2024年第1期121卷 1-12页

作者： md.Sho.an Parvez md.Mustafizur Rahman Mahendran Samykano.Mo.ammad Yeakub Ali Auto.o.ive Engineering Research Gro.p Faculty of Mechanical and Automotive Engineering TechnologyUniversiti Malaysia Pahang Al-Sultan AbdullahPekanMalaysia Department o. Textile Engineering Khulna University of Engineering&Technology(KUET)KhulnaBangladesh Centre fo. Research in Advanced Fluid and Pro.esses(CARIFF) Universiti Malaysia Pahang Al-Sultan AbdullahLebuhraya Tun RazakGambangMalaysia Mechanical Engineering Pro.ramme Area Faculty of EngineeringUniversiti Teknologi BruneiBruneiDarussalam

With the expo.ential develo.ment in wearable electro.ics,a significant paradigm shift is o.served fro. rigid electro.ics to.flexible wearable ***(PANI)is co.sidered as a do.inant material in this secto.,as it is endo.ed with the o.tical pro.erties o. bo.h metal and ***,its widespread applicatio. go. delineated because o. its irregular rigid fo.m,level o. co.ductivity,and precise cho.ce o. *** PANI in textile materials can generate pro.ising functio.ality fo. wearable *** research wo.k emplo.ed a straightfo.ward in-situ chemical o.idative po.ymerizatio. to.synthesize PANI o. Co.to. fabric surfaces with varying do.ant(HCl)***-treatment using Nao. is implemented to.impro.e the co.ductivity o. the fabric surface by increasing the mo.o.er *** research explo.es the mo.pho.o.ical and structural analysis emplo.ing SEM,FTIR and *** surface resistivity was measured using a digital multimeter,and thermal stability is measured using *** successful po.ymerizatio.,a ho.o.eno.s co.ting layer is *** is revealed that the simple pre-treatment technique significantly reduces the surface resistivity o. Co.to. fabric to.1.27 kΩ/cm with increasing acid co.centratio. and thermal *** electro.thermal energy can also.reach up to.38.2°C within 50 s with a deplo.ed vo.tage o. 15 *** mo.ified fabric is anticipated to.be used in thermal regulatio.,supercapacito.,senso.,UV shielding,antimicro.ial and o.her pro.pective functio.al applicatio.s.

关键词： Po.yaniline co.to. in-situ po.ymerizatio. SEM TGA heating fabric