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Tophaceous gout of the middle ear

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Journal of Otology 2019年第4期14卷 155-157页

作者： Stephane Gargula Guillaume Poillon Mary Daval Marc Williams mathieu Veyrat Homa Adle-Biassette Denis Ayache Department of Otolaryngogy Head and Neck SurgeryFoundation Adolphe de Rothschild HospitalParisFrance Department of Neuroradiology Foundation Adolphe de Rothschild HospitalParisFrance Department of Pathology Lariboisiere HospitalParis DiderotParis-Cite-Sorbonne UniversityParisFrance

We present a very rare case of tophaceous gout of the middle ear causing conductive hearing loss,with special emphasis on Computed Tomography presentation.

关键词： Gout Middle ear Hearing loss Conductive hearing loss Computed tomography

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农业跨国公司垄断对我国粮食安全的影响

西北农林科技大学学报（社会科学版） 2016年第3期16卷 84-93页

作者：周伟 Boulanger mathieu 吴先明武汉大学经济与管理学院武汉大学中国产学研合作问题研究中心武汉430072

分析了在华FDI的主要跨国粮商和跨国种业公司的垄断优势,借助粮食贸易依存度指标探讨了我国粮食安全的现状,并在此基础上,研究了农业跨国公司对我国粮食安全的影响。研究发现:跨国粮商通过控制世界大豆主要产区的种植、贸易,控制粮食产... 详细信息

分析了在华FDI的主要跨国粮商和跨国种业公司的垄断优势,借助粮食贸易依存度指标探讨了我国粮食安全的现状,并在此基础上,研究了农业跨国公司对我国粮食安全的影响。研究发现:跨国粮商通过控制世界大豆主要产区的种植、贸易,控制粮食产业链附加值较高的两端——育种和加工,对我国的粮食安全构成了威胁;跨国种业公司在研发和育种领域的高投入和高产出加深了农户对其依赖。因此,建议通过宏观调控提高大豆种植面积和产量,减少对农业跨国公司的依赖;基于种业发展机制创新,鼓励民营企业进入种业育种,培育一批具有国际竞争力的本土种子企业。

关键词：农业跨国公司垄断优势粮食安全

Levetiracetam-Associated Acute Kidney Injury and Drug Reaction with Eosinophilia and Systemic Symptoms (DRESS) Syndrome

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Open Journal of Nephrology 2014年第4期4卷 152-155页

作者： mathieu Leblanc Martin Plaisance Internal Medecine Residency Program Faculté de Médecine et des Sciences de la santé Université de Sherbrooke Sherbrooke Canada Nephrology Division Department of Medicine Centre Hospitalier Universitaire de Sherbrooke Sherbrooke Canada

DRESS syndrome is a severe drug induced reaction. Acute kidney injury (AKI) is sometimes present in the form of an acute interstitial nephritis. We present the case of a 75-year-old man with glioblastoma who developed a DRESS two months after starting levetiracetam and a few days after stopping dexamethasone. His skin and kidneys improved after removing levetiracetam and introducing again corticosteroids. DRESS has been reported more frequently with other antiepileptics, rarely with levetiracetam. Clinicians should add this drug to the list of potential causes of AKI.

关键词： Acute Kidney Injury DRESS Syndrome HSV-1 Levetiracetam

LA STRATIGRAPHIE DU SYSTME SINIEN DANS LA RGION DE LANCHOW, CHIHLI

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地质学报 1924年第1期 73-84页

作者： PAR F.F.mathieu

Dans un recent travail, publie par le "Bulletin of the Geological Society of China" le Professeur A. W. Grabau a propose de conserver dans la nomenclature stratigraphique de la Chine le terme "Systeme Sinien", autrefois cree par Richthofen, mais en limitant son extension aux couches homologues du systeme local de Hu To (Neo-Pr(?)terozoique), tel qu’il fut defini par Bailey Willis.

关键词： La Plus ME SINIEN DANS LA R CHIHLI GION DE LANCHOW LA STRATIGRAPHIE DU SYST DE

Chronological constraints on the Paleoproterozoic Francevillian Group in Gabon

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Geoscience Frontiers 2017年第2期8卷 397-407页

作者： Yusuke Sawaki mathieu Moussavou Tomohiko Sato Kazue Suzuki Cédric Ligna Hisashi Asanuma Shuhei Sakata Hideyuki Obayashi Takafumi Hirata Amboise Edou-Minkoinko Department of Earth and Planetary Sciences Tokyo Institute of Technology2-12-1 O-okayamaMeguro-kuTokyo 152-8551Japan University of Sdences and Technology in Masuku BP:90190025 FrancevilleGabon Earth-Life Science Institute(ELSI) Tokyo Institute of Technology2-12-1 O-okayamaMeguro-kuTokyo 152-8551Japan Department of Chemistry Gakushuin UniversityMejiro 1-5-1Toshima-kuTokyo 171-8588Japan Division of Earth and Planetary Sciences Graduate School of ScienceKyoto UniversityKitashirakawa Oiwake-choSakyo-kuKyoto 606-8502Japan Geochemistry Research Center The University of TokyoHongo 7-3-1Bunkyo-kuTokyo 113-0033Japan

The Francevillian Group in Gabonese Republic was recently established as a typical sedimentary sequence for the ***,its age is rather poorly constrained,mainly based on Rb-Sr and Nd-Sm *** study reports new zircon data obtained from Chaillu massif and N＇goutou complex,which constrain the protolith age of the basement orthogneisses and the igneous age of an intrusive granite,*** zircons from the orthogneisses are blue and exhibit oscillatory zoning in cathode-luminescence *** with lower common lead abundances tend to be distributed close to the concordia *** age clusters around 2860 Ma and 2910 Ma are found in zircons plotted on the concordia *** on the Th/U ratios of zircons,these ages correspond to the protolith ages of the orthogneisses,and the zircons are not metamorphic in *** and granites were collected from the N＇goutou complex that intrudes into the FA and FB units of the Francevillian *** granitoids exhibit chemical composition of A-type granite *** of zircons separated from the granite are non-luminous,and the remaining half exhibit obscure internal textures under cathode-luminescence *** zircon grains contain significant amounts of common lead;the lead isotopic variability is probably attributed to the mixing of two components in the *** zircon radiogenic ^（207）Pb/^（206）Pb ratio is 0.13707 ± *** to a ^（207）Pb/^（206）Pb age of 2191 ± 13 *** constrains the minimum depositional age of the FA and FB ***,the FB unit consists of manganese-rich carbonate rocks and organic carbon-rich black shales with macroscopic *** on our age constraints,these organisms appeared in the study area just after the last Paleoproterozoic Snowball Earth event,in concert with global scale oxidation event encompassing the Snowball Earth.

关键词： Gabon Francevillian Group Paleoproterozoic N'goutou complex Zircon MC-ICP-MS

Almitrine for COVID-19 critically ill patients – a vascular therapy for a pulmonary vascular disease: Three case reports

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World Journal of Clinical Cases 2021年第14期9卷 3385-3393页

作者： Pierre Huette Osama Abou Arab Vincent Jounieaux mathieu Guilbart Mohamed Belhout Guillaume Haye HervéDupont Christophe Beyls Yazine Mahjoub Department of Anaesthesia and Critical Care Amiens Hospital UniversityAmiens 80000France Department of Respiratory Medicine Amiens Hospital UniversityAmiens 80000France Department of Pharmacy Amiens Hospital UniversityAmiens 80000France

BACKGROUND Several reports with clinical,histological and imaging data have observed the involvement of lung vascular function to explain the severe hypoxemia in coronavirus disease 2019(COVID-19)*** has been hypothesized that an increased pulmonary blood flow associated with an impairment of hypoxic pulmonary vasoconstriction is responsible for an intrapulmonary ***-19 may lead to refractory hypoxemia(PaO_(2)/FiO_(2) ratio below 100 mmHg)despite mechanical ventilation and prone *** hypothesized that the use of a pulmonary vasoconstrictor may help decrease the shunt and thus enhance *** SUMMARY We report our experience with three patients with refractory hypoxemia treated with almitrine to enhance *** dose almitrine(Vectarion®;Servier,Suresnes,France)was started at an infusion rate of 4μg×kg/min on a central *** PaO_(2)/FiO_(2) ratio and total respiratory system compliance during almitrine infusion were *** the three patients,the PaO_(2)/FiO_(2) ratio time-course showed a dramatic increase whereas total respiratory system compliance was *** three patients were discharged from the intensive care *** intensive care unit length of stay for patient 1,patient 2 and patient 3 was 30 d,32 d and 31 d,*** from mechanical ventilation was performed 13 d,18 d and 15 d after almitrine infusion for patient 1,2 and 3,*** found no deleterious effects on the right ventricular function,which was similar to previous studies on almitrine *** Almitrine may be effective and safe to enhance oxygenation in coronavirus disease 2019 *** controlled studies are required.

关键词： COVID-19 Treatment Acute vascular distress syndrome Almitrine Intensive care unit Safety Case report

Cystatin C Peptide Effects on B16F10 Melanoma Cells

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CellBio 2021年第1期10卷 1-9页

作者： mathieu Hill James L. Cox AT Still University Department of Biochemistry West Jefferson Kirksville Missouri USA

Background: Metastasis is a major problem for effective therapy of cancer. Small cysteine protease inhibitors, cystatins have been shown to be anti-metastatic for a number of different cancers. We have identified a small peptide of cystatin which exhibits anti-cancer properties for B16 melanoma cells in vitro. Methods: B16 melanoma cells were measured for growth, proliferation, migration, and apoptosis in the presence and absence of cystatin peptide. Results: The cystatin peptide reduced melanoma cell growth, proliferation, migration, and increased apoptosis in melanoma cells in culture. Conclusion: Cystatin peptide exhibits anti-cancer effects on highly metastatic B16 melanoma cells in culture.

关键词： Cystatin Peptide Melanoma Metastasis

Matched or nonmatched interventions based on the transtheoretical model to promote physical activity.A meta-analysis of randomized controlled trials

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Journal of Sport and Health Science 2018年第1期7卷 50-57页

作者： Ahmed Jerome Romain Catherine Bortolon mathieu Gourlan Marion Carayol Emmanuelle Decker Olivier Lareyre Grégory Ninot Julie Boiché Paquito Bernard EA4556 Laboratory Epsylon-Dynamics of Human Abilities and Health Behaviours University of Montpellier Montpellier 34000 France Challenge for the Change of Behaviour (CCB) Group Montpellier 34000 France University of Montreal Hospital Research Centre Montreal Quebec H2X OA9 Canada Unit of Adult Psychiatry La colombiere University Hospital of Montpellier Montpellier 34295 France Prevention Department of institut Regional du Cancer de Montpellier Epidaure Montpellier 34298 France Research Centre of the University Hospital of Quebec Quebec GIR 2J6 Canada Cancer Research Centre University of LavaL Quebec G1R 3S3 Canada School of Psychology University of Laval Quebec G1C OA6 Canada

Purpose: The aim of this study was to examine whether the efficacy of transtheoretical model(TTM)-based interventions on physical activity(PA)varied according to the following criteria:(1) interventions targeted the actual stages of change(SOCs) or did not;(2) participants were selected according to their SOC or were not; and(3) its theoretical constructs(decisional balance, temptation, self-efficacy, processes of change).Methods: Thirty-three randomized controlled trials assessing TTM-based interventions promoting PA in adults were systematically ***: The between-group heterogeneity statistic(Qb) did not reveal any differential efficacy either in interventions targeting the actual SOC compared with those that did not(Qb = 1.48, p = 0.22) or in interventions selecting participants according to their SOC compared with those that did not(Qb = 0.01, p = 0.91). TTM-based interventions enhanced PA behavior whether they targeted the actual SOC(Cohen's d = 0.36; 95%confidence interval(CI): 0.22–0.49) or not(d = 0.23; 95%CI: 0.09–0.38) and whether they selected their participants according to their SOC(d = 0.33; 95%CI: 0.13–0.53) or not(d = 0.32; 95%CI: 0.19–0.44). The moderators of the efficacy of TTM-based interventions were the number of theoretical constructs used to tailor the intervention(Qb = 8.82, p = 0.003), the use of self-efficacy(Qb = 6.09, p = 0.01), and the processes of change(Qb = 3.51, p = 0.06).Conclusion: TTM-based interventions significantly improved PA behavior, and their efficacy was not moderated by SOC but by the TTM theoretical constructs.

关键词： Exercise Interventions Meta-regression Moderators Processes of change Stages of change Theory-based

Relationship of preoperative androgen levels and metabolic syndrome with quality of life and erectile function in patients who are to undergo radical prostatectomy

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Asian Journal of Andrology 2021年第5期23卷 520-526页

作者： Yann Neuzillet Jean-Francois Dreyfus Jean-Pierre Raynaud mathieu Rouanne Marc Schneider Morgan Roupret Sarah Drouin Marc Galiano Xavier Cathelineau Thierry Lebret Henry Botto Department of Urology Hopital FochUVSQ-Paris-Saclay UniversitySuresnes 92150France Department of Clinical Research and Innovation Hopital FochUVSQ-Paris-Saclay UniversitySuresnes 92150France Sorbonne University Paris 75013France Department of Urology Hfipital Louis PasteurColmar 68000France Department of Urology Hopital Pitie-SalpetriereAssistance Publique-Hopitaux de ParisSorbonne UniversityParis 75013France Department of Urology Institut Mutualiste MontsourisParis-Descartes UniversityParis 75014France

This study aims to investigate whether clinical and biological preoperative characteristics of patients who were to undergo radical prostatectomy were associated with impairment in patient-reported quality of life(QoL)and erectile dysfunction immediately before *** evaluated patient-reported outcomes among 1019 patients(out of 1343)of the AndroCan study,willing to score the Aging Male Symptom(AMS)and the International Index of Erectile Function 5-item(IIEF-5)*** linear regression and robust multiple regression were used to ascertain the relationship between demographic,clinical,and hormonal parameters and global AMS or IIEF-5 *** a result,most patients(85.1%)of the Androcan cohort agreed to complete *** higher IIEF-5 global scores were found in non-Caucasian and obese patients,with larger waist circumference,metabolic syndrome,diabetes mellitus,cardiovascular disease,hypertension,high blood sugar,concomitant medications,and hypogonadism,while the AMS global score was significantly higher in patients with larger waist circumference,metabolic syndrome,high blood pressure,raised glycemia,and concomitant *** IIEF-5 global score was correlated to age,dehydroepiandrosterone(DHEA),fat mass percentage,and androstenediol(D5).The AMS global score was significantly correlated to DHEA,D5,and DHEA ***,the multivariate models showed that QoL and erectile function were significantly affected,before surgery,by symptoms and signs that are usually considered as pertaining to the metabolic syndrome,while sexual hormones are essentially correlated to erectile dysfunction.

关键词： erectile function metabolic syndrome quality of life radical prostatectomy testosterone