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Routine invasive strategy and frailty burden in non-ST-segment elevation acute myocardial infarction

Journal of Geriatric Cardiology 2024年第10期21卷 954-961页

作者： Albert Ariza-Solé Juan Andrés Bermeo Francesc Formiga Héctor Bueno Gemma Miñana Oriol Alegre david martí Manuel martínez-Sellés Laura Domínguez-Pérez Pablo Díez-Villanueva JoséA Barrabés Francisco Marín Adolfo Villa Marcelo Sanmartín Cinta Llibre Alessandro Sionís Antoni Carol Sergio García-Blas María JoséMorales Gallardo Jaime Elízaga Iván Gómez-Blázquez Fernando Alfonso Bruno García Del Blanco Julio Núñez Juan Sanchis Cardiology Department Hospital Universitari de BellvitgeL’Hospitalet de LlobregatBarcelonaSpain Internal Medicine Department Hospital Universitari de BellvitgeL’Hospitalet de LlobregatBarcelonaSpain Centro Nacional de Investigaciones Cardiovasculares(CNIC) MadridSpain.Cardiology DepartmentHospital 12 de Octubreand Instituto de Investigación Sanitaria Hospital 12 de Octubre(imas12)MadridCIBERCVMadridSpain.Universidad ComplutenseMadridSpain Cardiology Department Hospital Clínico Universitario de ValenciaINCLIVAUniversidad de ValenciaCIBERCVValenciaSpain Cardiology Department Hospital Central de la DefensaMadridSpain Cardiology Department Hospital Universitario Gregorio MarañónCIBERCVUniversidad ComplutenseUniversidad EuropeaMadridSpain Cardiology Department Hospital Universitario La PrincesaIIS-IPCIBERCVMadridSpain Cardiology Department Hospital Universitari Vall d’HebronCIBERCVBarcelonaSpain Cardiology Department Hospital Virgen de la ArrixacaCIBERCVEl PalmarMurciaSpain Cardiology Department Hospital Universitario del SuresteArganda del ReyMadridSpain Cardiology Department Hospital Ramon y CajalCIBERCVMadridSpain Cardiology Department Hospital Germans Trias i PujolCIBERCVBadalonaBarcelonaSpain Cardiology Department Hospital Sant PauCIBERCVBarcelonaSpain Cardiology Department Hospital Moisés BroggiSant Joan DespíBarcelonaSpain

Objective To assess the prognostic impact of a routine invasive strategy according to the frailty burden in patients with non-ST-segment elevation myocardial infarction(NSTEMI)from the MOSCA-FRAIL clinical *** The MOSCA-FRAIL trial randomized 167 frail patients,defined by a Clinical Frailty Scale(CFS)≥4,with NSTEMI to an invasive or conservative *** primary endpoint was the number of days alive and out of hospital(DAOH)one year after *** this subanalysis,we compared the impact of an invasive strategy on the outcomes between vulnerable(CFS=4,n=43)and frail(CFS>4,n=124)*** Compared to vulnerable patients,frail patients presented lower values of DAOH(289.8 vs.320.6,P=0.146),more read-missions(1.03 vs.0.58,P=0.046)and higher number of days spent at the hospital during the first year(10.8 vs.3.8,P=0.014).The cau-ses of readmission were mostly non-cardiac(56%).Among vulnerable patients,DAOH were similar regardless of strategy(invasive ***:325.7 vs.314.7,P=0.684).Among frailest patients,the invasive group tended to have less DAOH(267.7 vs.311.1,P=0.117).Indeed,patients with CFS>4,invasively managed lived 29 days less than their conservative *** contrast,the-re were no differences in the subgroup with CFS=*** Adult patients with frailty and NSTEMI showed different prognosis according to the degree of frailty.A routine in-vasive strategy does not improve outcomes and might be harmful to the frailest patients.

关键词： routine invasive infarction

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Forecast of the Luminescent Phenomena of Silicon Rich Oxide Films off Stoichiometry by Means of the Global Reaction Model

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Journal of Modern Physics 2015年第11期6卷 1679-1694页

作者： Néstor david Espinosa-Torres José álvaro david Hernández de la Luz José Francisco Javier Flores-Gracia José Alberto Luna-López Javier martínez-Juárez Gregorio Flores-Carrasco IC-CIDS Benemérita Universidad Autónoma de Puebla Puebla México Ex Graduate Research Trainee at Plasma Processing Laboratory Chemical Engineering Department McGill University Montreal Canada Department of Materials Science and Engineering and Chemical Engineering University Carlos III of Madrid and IAAB Madrid Spain

The Global Reaction Model describes a set of chemical reactions that can potentially occur during the process of obtaining silicon rich oxide (SRO) films, regardless of the technique used to grow such films which are an outside stoichiometry material. Particularly, chemical reactions that occur during the process of growing of SRO films by LPCVD technique are highlighted in this model. We suggest and evaluate either some types of molecules or resulting nanostructures and we predict theoretically, by applying the density functional theory, the contribution that they may have to the phenomenon of luminescence which is measured in SRO films. Also, we have calculated the opto-electronic properties of SRO films. The suggested model provides enough information required to identify the molecular structures resulting from the presence of defects in SRO films and also those corresponding to charged structures. It is also possible to detect the molecular structures which are modified due to the effect of heat treatment, and identify the presence of different oxidation states inclusive the formation of siloxanes.

关键词： Global Reactions Model Silicon Rich-Oxide Defects LPCVD Luminescence

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Magnetic resonance imaging findings of spontaneous pyomyoma in a premenopausal woman managed with myomectomy:A case report

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World Journal of Radiology 2023年第3期15卷 83-88页

作者： david martínez Gustavo E Sanchez Jhonatan Gómez Luis J Sonda Luis D Suárez Carlos S López Juan J Vega Daniel A Cepeda Department of Radiology Hospital Christus MuguerzaPuebla 72501PueblaMexico Department of Radiology Hospital Regional Dr.Juan Graham CasasùsVillahermosa 86126TabascoMexico Department of Radiology Hospital de Especialidades 5 de MayoPuebla 72550PueblaMexico

BACKGROUND Acute fibroid complications are ***,failure to recognize and treat acute complications expeditiously when they occur can lead to catastrophic,even deadly,*** is a rare but potentially fatal condition resulting from infarction and infection of a fibroid through bacterial seeding and direct,hematogenous,or lymphatic *** though the diagnosis is established through clinical and laboratory findings,imaging is an important complementary method to support the suspected *** SUMMARY Herein,we report a case of a pyomyoma in a nulliparous woman previously diagnosed with uterine leiomyomatosis according to ultrasound *** patient had previously attended the emergency room due to hypogastric pain unresponsive to *** a week of persistent pain,she developed sepsis without any identifiable *** resonance imaging revealed findings compatible with uterine myomatosis with red degeneration,and a possible diagnosis of a pyomyoma was made according to the imaging findings along with the patient’s clinical *** decided to perform myomectomy(which is an infrequently performed surgical treatment due to the procedure’s intrinsic implic-ations)due to the patient’s desire to preserve *** results revealed a uterine leiomyoma with coagulative and liquefactive necrosis,while the tissue culture showed gram-negative cocci bacteria,which were successfully treated using antibiotic *** patient’s health status improved after several *** The main diagnostic tools to evaluate pyomyomas are the clinical and laboratory findings as well as tissue ***,magnetic resonance imaging can help to corroborate these findings as well as to better characterize myomas with its different complications.

关键词： Diffusion-weighted images Apparent diffusion coefficient Leiomyoma Sepsis Magnetic resonance imaging Case report

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Robust transcriptional indicators of immune cell death revealed by spatiotemporal transcriptome analyses

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Molecular Plant 2022年第6期15卷 1059-1075页

作者： Jose Salguero-Linares Irene Serrano Nerea Ruiz-Solani marta Salas-Gómez Ujjal Jyoti Phukan Victor Manuel González martíBernardo-Faura Marc Valls david Rengel Nuria S.Coll Centre for Research in Agricultural Genomics(CRAG) CSIC-IRTA-UAB-UBCampus UABBellaterra08193 BarcelonaSpain LIPM Universitéde ToulouseINRACNRS84195 Castanet-TolosanFrance INRAE GeT-PlaGeGenotoul31326 Castanet-TolosanFrance Department of Genetics Universitat de Barcelona08028 BarcelonaSpain Consejo Superior de Investigaciones Científicas(CSIC) BarcelonaSpain Department of Plant Molecular Biology and Physiology.Albrechtvon Haller Institute for Plant Sciences niversity of GottingenJulia-Lermontowa-Weg3.37077 GottingenGrmany Institut de Phammacologie et de Biologie Structurale IPBS Universite deToulouse CNRSUPSBP 64182205 route de Nartxonne310077 Toulouse Cedex 04France

Recognition of a pathogen by the plant immune system often triggers a form of regulated cell death traditionally known as the hypersensitive response(HR).This type of cell death occurs precisely at the site of pathogen recognition,and it is restricted to a few *** research has shed light on how plant immune receptors are mechanistically ***,two central key questions remain largely unresolved:how does cell death zonation take place,and what are the mechanisms that underpin this phenomenon?Consequently,bona fide transcriptional indicators of HR are lacking,which prevents deeper insight into its mechanisms before cell death becomes macroscopic and precludes early or live *** this study,to identify the transcriptional indicators of HR we used the paradigmatic Arabidopsis thaliana–Pseudomonas syringae pathosystem and performed a spatiotemporally resolved gene expression analysis that compared infected cells that will undergo HR upon pathogen recognition with bystander cells that will stay alive and activate *** data revealed unique and time-dependent differences in the repertoire of differentially expressed genes,expression profiles,and biological processes derived from tissue undergoing HR and that of its ***,we generated a pipeline based on concatenated pairwise comparisons between time,zone,and treatment that enabled us to define 13 robust transcriptional HR *** these genes,the promoter of an uncharacterized AAA-ATPase was used to obtain a fluorescent reporter transgenic line that displays a strong spatiotemporally resolved signal specifically in cells that will later undergo pathogen-triggered cell *** valuable set of genes can be used to define cells that are destined to die upon infection with HR-triggering bacteria,opening new avenues for specific and/or high-throughput techniques to study HR processes at a single-cell level.

关键词： Arabidopsis thaliana cell death indicator effector-triggered immunity hypersensitive response pattern-triggered immunity plant immunity Pseudomonas syringae

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Risk of gastrointestinal cancer in a symptomatic cohort after a complete colonoscopy:Role of faecal immunochemical test

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World Journal of Gastroenterology 2020年第1期26卷 70-85页

作者： Noel Pin-Vieito María J Iglesias david Remedios Lorena Rodríguez-Alonso Francisco Rodriguez-Moranta VictoriaÁlvarez-Sánchez Fernando Fernández-Bañares Jaume Boadas Eva martínez-Bauer Rafael Campo Luis Bujanda Ángel Ferrandez Virginia Piñol Daniel Rodríguez-Alcalde Jordi Guardiola Joaquín Cubiella Gastroenterology Department Complexo Hospitalario Universitario de OurenseCentro de Investigación Biomédica en Red de Enfermedades Hepáticas y Digestivas(CIBERehd)Ourense 32005Spain Department of Gastroenterology and Hepatology University Hospital of Bellvitge-IDIBELLL'Hospitalet de LlobregatBarcelona 08907Spain.Ciber de Epidemiología y Salud Pública(CIBERESP)Spain Gastroenterology Department Complejo Hospitalario de PontevedraPontevedra 36001Spain Gastroenterology Department Hospital Universitari Mútua de TerrassaCIBERehdTerrassa 08221Spain Gastroenterology Department Consorci Sanitari de TerrassaTerrassa 08221Spain Gastroenterology Department Hospital de SabadellCorporacióSanitària Donostia Hospital Biodonostia InstituteUniversity of the Basque Country UPV/EHUCIBERehdSan Sebastian 20010Spain Servicio de Aparato Digestivo Hospital Clínico UniversitarioIIS AragónUniversity of ZaragozaCIBERehdZaragoza 50009Spain Gastroenterology Department Hospital Dr.Josep TruetaGirona 17007Spain Digestive Disease Section Hospital Universitario de MóstolesMadrid 28935Spain

BACKGROUND Faecal immunochemical test(FIT)has been recommended to assess symptomatic patients for colorectal cancer(CRC)***,some conditions could theoretically favour blood originating in proximal areas of the gastrointestinal tract passing through the colon unmetabolized.A positive FIT result could be related to other gastrointestinal cancers(GIC).AIM To assess the risk of GIC detection and related death in FIT-positive symptomatic patients(threshold 10μg Hb/g faeces)without *** Post hoc cohort analysis performed within two prospective diagnostic test studies evaluating the diagnostic accuracy of different FIT analytical systems for CRC and significant colonic lesion *** patients with gastrointestinal symptoms referred consecutively for colonoscopy from primary and secondary healthcare,underwent a quantitative FIT before undergoing a complete *** without CRC were divided into two groups(positive and negative FIT)using the threshold of 10μg Hb/g of faeces and data from follow-up were retrieved from electronic medical records of the public hospitals involved in the *** determined the cumulative risk of GIC,CRC and upper *** rate(HR)was calculated adjusted by age,sex and presence of significant colonic *** We included 2709 patients without CRC and a complete baseline colonoscopy,730(26.9%)with FIT≥10μgr Hb/*** a mean time of 45.5±20.0 mo,a GIC was detected in 57(2.1%)patients:An upper GIC in 35(1.3%)and a CRC in 14(0.5%).Thirty-six patients(1.3%)died due to GIC:22(0.8%)due to an upper GIC and 9(0.3%)due to ***-positive subjects showed a higher CRC risk(HR 3.8,95%CI:1.2-11.9)with no differences in GIC(HR 1.5,95%CI:0.8-2.7)or upper GIC risk(HR 1.0,95%CI:0.5-2.2).Patients with a positive FIT had only an increased risk of CRC-related death(HR 10.8,95%CI:2.1-57.1)and GIC-related death(HR 2.2,95%CI:1.1-4.3),with no differences in upper GIC-related death(HR 1.4,95%CI:0.6-3.3).An

关键词： Colonoscopy Colorectal cancer Faecal immunochemical test Gastric cancer Gastroesophageal cancer Gastrointestinal cancer Symptoms

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Unilateral rNurr1-V5 transgene expression in nigral dopaminergic neurons mitigates bilateral neuropathology and behavioral deficits in parkinsonian rats withα-synucleinopathy

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Neural Regeneration Research 2024年第9期19卷 2057-2067页

作者： Bismark Gatica-Garcia Michael J.Bannon Irma Alicia martínez-Dávila Luis O.Soto-Rojas david Reyes-Corona Lourdes Escobedo Minerva Maldonado-Berny ME Gutierrez-Castillo Armando J.Espadas-Alvarez Manuel A.Fernandez-Parrilla Juan U.Mascotte-Cruz CP Rodríguez-Oviedo Irais E.Valenzuela-Arzeta Claudia Luna-Herrera Francisco E.Lopez-Salas Jaime Santoyo-Salazar Daniel martinez-Fong Departamento de Fisiología Biofísica y NeurocienciasCentro de Investigación y de Estudios AvanzadosCiudad de MéxicoMéxico Department of Pharmacology Wayne State University School of MedicineDetroitMIUSA Laboratorio de Patogénesis Molecular Carrera Médico CirujanoFacultad de Estudios Superiores IztacalaUniversidad Nacional Autónoma de MéxicoTlalnepantla de BazMéxico Red de Medicina para la Educación y Desarrollo y la Investigación Científica de Iztacala(Red MEDICI) Carrera Médico CirujanoFacultad de Estudios Superiores IztacalaUniversidad Nacional Autónoma de MéxicoTlalnepantla de BazMéxico Nanoparticle Therapy Institute AguascalientesMéxico Departamento de Biociencias e Ingeniería Centro Interdisciplinario de Investigaciones y Estudios sobre Medio Ambiente y DesarrolloInstituto Politécnico NacionalCiudad de MéxicoMéxico Escuela Nacional de Medicina y Homeopatía Instituto Politécnico NacionalCiudad de MéxicoMéxico Departamento de Fisiología Escuela Nacional de Ciencias BiológicasInstituto Politécnico NacionalCiudad de MéxicoMéxico Departamento de Biología Molecular y Biotecnología Instituto de Investigaciones BiomédicasUniversidad Nacional Autónoma de MéxicoCiudad de MéxicoMéxico Departamento de Física Centro de Investigación y de Estudios AvanzadosCiudad de MéxicoMéxico Programa de Nanociencias y Nanotecnología Centro de Investigación y de Estudios AvanzadosCiudad de MéxicoMéxico

Parkinsonism by unilateral,intranigralβ-sitosterolβ-D-glucoside administration in rats is distinguished in that theα-synuclein insult begins unilaterally but spreads bilaterally and increases in severity over time,thus replicating several clinical features of Parkinson’s disease,a typicalα-*** Nurr1 repressesα-synuclein,we evaluated whether unilateral transfected of rNurr1-V5 transgene via neurotensin-polyplex to the substantia nigra on day 30 after unilateralβ-sitosterolβ-D-glucoside lesion could affect bilateral neuropathology and sensorimotor deficits on day 30 *** study found that rNurr1-V5 expression but not that of the green fluorescent protein(the negative control)reducedβ-sitosterolβ-D-glucoside-induced ***,a bilateral increase in tyrosine hydroxylase-positive cells and arborization occurred in the substantia nigra and increased tyrosine hydroxylase-positive ramifications in the *** addition,tyrosine hydroxylase-positive cells displayed less senescence markerβ-galactosidase and more neuron-cytoskeleton markerβIII-tubulin and brain-derived neurotrophic factor.A significant decrease in activated microglia(positive to ionized calcium-binding adaptor molecule 1)and neurotoxic astrocytes(positive to glial fibrillary acidic protein and complement component 3)and increased neurotrophic astrocytes(positive to glial fibrillary acidic protein and S100 calcium-binding protein A10)also occurred in the substantia *** effects followed the bilateral reduction inα-synuclein aggregates in the nigrostriatal system,improving sensorimotor *** results show that unilateral rNurr1-V5 transgene expression in nigral dopaminergic neurons mitigates bilateral neurodegeneration(senescence and loss of neuron-cytoskeleton and tyrosine hydroxylase-positive cells),neuroinflammation(activated microglia,neurotoxic astrocytes),α-synuclein aggregation,and sensorimotor *** neurotrophic astrocytes and

关键词： A1 astrocytes A2 astrocytes gene therapy microglia motor deficits nanoparticles neurodegeneration neuroinflammation senescence α-synuclein aggregates

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Cerebral dopamine neurotrophic factor transfection in dopamine neurons using neurotensin-polyplex nanoparticles reverses 6-hydroxydopamine-induced nigrostriatal neurodegeneration

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Neural Regeneration Research 2022年第4期17卷 854-866页

作者： Manuel A.Fernandez-Parrilla david Reyes-Corona Yazmin M.Flores-martinez Rasajna Nadella Michael J.Bannon Lourdes Escobedo Minerva Maldonado-Berny Jaime Santoyo-Salazar Luis O.Soto-Rojas Claudia Luna-Herrera Jose Ayala-Davila Juan A.Gonzalez-Barrios Gonzalo Flores Maria E.Gutierrez-Castillo Armando JEspadas-Alvarez Irma A.martínez-Dávila Porfirio Nava Daniel martinez-Fong Departamento de Fisiología Biofísica y NeurocienciasCentro de Investigación y de Estudios AvanzadosCiudad de MéxicoMéxico Programa Institucional de Biomedicina Molecular Escuela Nacional de Medicina y HomeopatíaInstituto Politécnico NacionalCiudad de MéxicoMéxico Department of Biosciences IIIT-SrikakulamRajiv Gandhi University of Knowledge Technologies(RGUKT)Andhra PradeshIndia Department of Pharmacology Wayne State University School of MedicineDetroitMIUSA Departamento de Física Centro de Investigación y de Estudios AvanzadosCiudad de MéxicoMéxico Facultad de Estudios Superiores Iztacala Universidad Nacional Autónoma de MéxicoTlalnepantla de BazEdo.de MéxicoMéxico Departamento de Fisiología Escuela Nacional de Ciencias BiológicasCiudad de MéxicoMéxico Laboratorio de Medicina Genómica Hospital Regional“1°de Octubre”ISSSTECiudad de MéxicoMéxico Laboratorio de Neuropsiquiatría Instituto de FisiologíaBenemérita Universidad Autónoma de PueblaPueblaPueblaMéxico Departamento de Biociencias e Ingeniería Centro Interdisciplinario de Investigaciones y Estudios sobre Medio Ambiente y DesarrolloInstituto Politécnico NacionalCiudad de MéxicoMéxico Programa de Nanociencias y nanotecnología Centro de Investigación y de Estudios AvanzadosCiudad de MéxicoMéxico

Overexpression of neurotrophic factors in nigral dopamine neurons is a promising approach to reverse neurodegeneration of the nigrostriatal dopamine system,a hallmark in Parkinson's *** human cerebral dopamine neurotrophic factor(h CDNF)has recently emerged as a strong candidate for Parkinson's disease *** study shows that h CDNF expression in dopamine neurons using the neurotensinpolyplex nanoparticle system reverses 6-hydroxydopamine-induced morphological,biochemical,and behavioral *** independent electron microscopy techniques showed that the neurotensin-polyplex nanoparticles containing the h CDNF gene,ranging in size from 20 to 150 nm,enabled the expression of a secretable h CDNF in *** injection in the substantia nigra compacta on day 21 after the 6-hydroxydopamine lesion resulted in detectable h CDNF in dopamine neurons,whose levels remained constant throughout the study in the substantia nigra compacta and *** with the lesioned group,tyrosine hydroxylase-positive(TH^(+))nigral cell population and TH+fiber density rose in the substantia nigra compacta and striatum after h CDNF *** increase inβIII-tubulin and growth-associated protein 43 phospho-S41(GAP43 p)followed TH^(+)cell recovery,as well as dopamine and its catabolite *** reversal(80%)of drugactivated circling behavior and full recovery of spontaneous motor and non-motor behavior were ***-derived neurotrophic factor recovery in dopamine neurons that also occurred suggests its participation in the neurotrophic *** findings support the potential of nanoparticle-mediated h CDNF gene delivery to develop a disease-modifying treatment against Parkinson's *** Institutional Animal Care and Use Committee of Centro de Investigación y de Estudios Avanzados approved our experimental procedures for animal use(authorization No.162-15)on June 9,2019.

关键词： axonal growth brain-derived neurotrophic factor gene delivery nanoparticles neuritogenesis neuronal cytoskeleton neuroregeneration neurorestoration neurotrophic therapy Parkinson's disease reinnervation substantia nigra

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Evaluation of Prediction Algorithms in the Student Dropout Problem

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Journal of Computer and Communications 2020年第3期8卷 20-27页

作者： Luis Earving Lee Salvador Ibarra martínez José Antonio Castán Rocha Jesús david Terán Villanueva Julio Laria Menchaca Mayra Guadalupe Trevino Berrones Emilio Castán Rocha Faculty of Engineering Autonomous University of TamaulipasTampicoTamaulipasMexico Tec NM/Madero Institute of Technology Madero CityTamaulipasMexico.

University dropout is a growing problem which, in recent years, is using computer techniques to assist in the detection process. The paper presents the evaluation of some prediction algorithms to detect a student with a high possibility of scholar desertion. The approach uses real data from past scholar periods to create a dataset with different information of the students (i.e., personal, economic, and academic records). The algorithms selected in the experimental phase were: J48 decision tree, K-near neighbors, and support vector machine. We use two similarity metrics to split the dataset with cases with at least 80% of similarity to evaluate each case. We use the data from 2010 to 2016 with real students’ information to predict if there exists the possibility of a real academic dropout in one test for a period. The results show that the J48 algorithm reaches a better performance in both experiments. Besides, the tree generated for each student is taken as a path of attention, reaching around 88% of effectiveness. Finally, the conclusions argue the contributions of the paper and propose a future line of research.

关键词： Student Dropout Prediction Algorithms J48 K-Near Neighbors Support Vector Machine

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Attenuation of UV-C Solar Radiation as a Function of Altitude(0≤z≤100 km):Rayleigh Diffusion and Photo Dissociation of O_(2) Influence

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Atmospheric and Climate Sciences 2017年第4期7卷 540-553页

作者： Jose Luis Pinedo-Vega Carlos Rios-martínez david Jacobo Navarro-Solis J.Ignacio Davila-Rangel Fernando Mireles-Garcia Sonia Azucena Saucedo-Anaya Eduardo Manzanares-Acuna Valentin Badillo-Almaraz Department:UAEN Universidad Autonoma de ZacatecasZacatecasMexico

In this paper, we present an analysis of attenuation for UV-C radiation () as a function of the altitude z () by calculating the interaction ratio between the UV-C radiation and the molecular species susceptible of interact with UV-C radiation. The Rayleigh scattering spectral cross sections were calculated, the UV-C spectral cross sections of the species susceptible of interact with UV-C radiation and the UV extraterrestrial (ETR) solar spectrum were standardized with wavelength steps of 1 nm, and The International Standard Atmosphere model (ISO 1972) was adapted to calculate the molecular density. These data were utilized to calculate the photodissociation and Rayleigh scattering ratios as a function of the altitude and to determine to what measure the photodissociation and the Rayleigh diffusion were determinants of the attenuation of UV-C radiation. It became clear that the photo dissociation of O2 is the primordial mechanism of attenuation for the UV-C radiation, but the Rayleigh diffusion appears like a mechanism that encreases the photon flux, raising the performance of the O2 photodissociation. The attenuation capacities of N2O, CO2 and water vapor (H2O) over the UV-C radiation are all similar, although smaller (less than 0.6%), and this is due to their low concentration. The O3, has the theoretical greater attenuation capacity, but it is found in mid-range altitudes? (), where the residual UV-C photons has almost vanished by O2 photo dissociation or Rayleigh diffusion, so the real effect over the UV-C attenuation is minimum.

关键词： UV-C Radiation Rayleigh Scattering O_(2) Photodissociation

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The Administration of Ocoxin Increases the Quality of Life of Patients with Advanced Epithelial or Metastatic Ovarian Cancer Undergoing Neoadjuvant Chemotherapy

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Journal of Cancer Therapy 2022年第9期13卷 561-584页

作者： Karen López Miguel Daniel Ricardo martínez Ávila Lliset Álvarez Pérez Gisselle martínez Rabasa Alejandro Linchenat Lambert Roberto Esperón Noa Lisandra Heredia Manzano Margarita De Quesada Amigó Rafael I. Reyes Velázquez Danay Corrales Otero Ramon Ropero Toirac Idelmis Curbelo Heredia Mircea Betancourt Cabeza Tania A. Agrelo ramos Rosa María Muñoz Reyes Juan Jesús Lence Anta Rosalía Fuentes Sosa Karelia Silvera Candó Kirenia Silva Rodríguez Zaida Lastre Sosa Mayte Robaina García Eduardo Sanz david Marquez Department of Medical Oncology INOR La Habana Cuba Department of Gynaeco-Oncology INOR La Habana Cuba Department of Anatomical Pathology INOR La Habana Cuba Department of Imaging INOR La Habana Cuba Clinical Research Section INOR La Habana Cuba Department of Onco-Psychology INOR La Habana Cuba Clinical Laboratory Department INOR La Habana Cuba Clinical Trials Pharmacy Department INOR La Habana Cuba Department of Biostatistics CENCEC La Habana Cuba Scientific Department CATALYSIS Madrid Spain

Background: 70% of ovarian cancer cases are diagnosed at an advanced stage (III or IV) of the disease and, in turn, with a high prevalence of peritoneal carcinosis and ascites, which leads to progressive malnutrition in patients, with the consequent deterioration of their general condition. There is a very important relationship between nutritional status, quality of life, survival, and the ability to tolerate multidisciplinary treatment of peritoneal carcinosis. Methods: A phase II, open-label, single-center, non-randomised clinical trial was conducted that included 36 patients with advanced disease who were administered the nutritional supplement Ocoxin, 30 ml twice a day, beginning one week before chemotherapy (CT) based on carboplatin/paclitaxel, of which they receive three cycles with neoadjuvant intent. Ocoxin treatment was continued during chemotherapy and for three weeks after completion of the last cycle, as well as during any periods for which this treatment was discontinued due to toxicity. The effect of Ocoxin on the quality of life was assessed through the QLQ C30 and QLQ OV28 questionnaires from the start of treatment until the end of the follow-up period. In addition, the Karnofsky Index and nutritional parameters were assessed. Results: There were no significant differences between adverse events versus baseline values, except in leukocytes, lymphocytes, neutrophils, ALT, and AST. There was no deterioration of the QoL scales, except for those related to the effects of chemotherapy and alopecia. Conclusions: Ocoxin as an adjuvant to chemotherapy appears to improve better tolerance to chemotherapy, showed a good safety profile, and improved quality of life. For further information on Ocoxin neoadjuvant therapy benefits, a phase III clinical trial will be needed.

关键词： Chemotherapy Radiotherapy Ovarian Cancer Oncology Quality of Life Ad-juvant Therapy Supportive Care

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