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Complement-dependent neuroinflammation in spinal cord injury:from pathology to therapeutic implications

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Neural Regeneration Research 2025年第5期20卷 1324-1335页

作者： Hassan Saad Bachar El Baba Ali Tfaily Firas Kobeissy Juanmarco Gutierrez Gonzalez Daniel Refai Gerald R.Rodts Christian mustroph david Gimbel Jonathan Grossberg Daniel L.Barrow matthew F.Gary Ali m.Alawieh Department of Neurosurgery Emory University School of MedicineAtlantaGAUSA Department of Neurology Yale UniversityNew HavenCTUSA Center for Neurotrauma Multiomics&Biomarkers(CNMB)Morehouse School of MedicineAtlantaGAUSA

Spinal cord injury remains a major cause of disability in young adults,and beyond acute decompression and rehabilitation,there are no pharmacological treatments to limit the progression of injury and optimize recovery in this *** the thorough investigation of the complement system in triggering and propagating cerebral neuroinflammation,a similar role for complement in spinal neuroinflammation is a focus of ongoing *** this work,we survey the current literature investigating the role of complement in spinal cord injury including the sources of complement proteins,triggers of complement activation,and role of effector functions in the *** study relevant data demonstrating the different triggers of complement activation after spinal cord injury including direct binding to cellular debris,and or activation via antibody binding to damage-associated molecular *** effector functions of complement have been implicated in spinal cord injury,and we critically evaluate recent studies on the dual role of complement anaphylatoxins in spinal cord injury while emphasizing the lack of pathophysiological understanding of the role of opsonins in spinal cord *** this pathophysiological review,we systematically review the different translational approaches used in preclinical models of spinal cord injury and discuss the challenges for future translation into human *** review emphasizes the need for future studies to dissect the roles of different complement pathways in the pathology of spinal cord injury,to evaluate the phases of involvement of opsonins and anaphylatoxins,and to study the role of complement in white matter degeneration and regeneration using translational strategies to supplement genetic models.

关键词： complement neuroinflammation neuroplasticity regeneration spinal cord injury targeted therapy

Enhanced stabilization of inorganic cesium lead triiodide （CsPbl3） perovskite quantum dots with tri-octylphosphine

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Nano Research 2018年第2期11卷 762-768页

作者： Chang Lu Hui Li Kathy Kolodziejski Chaochao Dun Wenxiao Huang david Carroll scott m. Geyer Department of Chemistry Wake Forest University Winston-Salem USA Center for Nanotechnology and molecular materials Department of Physics Wake Forest University Winston-Salem USA

In recent years, significant attention has been paid to perovskite materials. In particular, lead triiodide-based perovskites have exhibited superb optoelectronic properties. Enhancing the stability of these materials is an essential step towards large-scale applications. In this stud） by simply adding trioctylphosphine （TOP） as part of the post-synthesis treatment, we significantly enhance the stability of CsPbI3 quantum dots （QDs） in the solution phase, which otherwise decay rapidly in hours. For CsPbI3 QDs treated with TOP, the absorption and photoluminescence emission properties are unchanged over the course of weeks, and the quantum yield remains almost constant at 30% even after 1 month. The morphologies of both treated and untreated QDs are initially cubic; however, the treated QDs largely maintain their initial size and shape, while the untreated ones lose size uniformity, which is a sign of degradation. Infrared spectroscopy and X-ray photoelectron spectroscopy confirm the presence of P in the TOP-treated QDs. We hope that the technique of utilizing a ligand post-treatment will lead to new insights that help to resolve the intrinsic instability issue of triiodide perovskite materials and devices.

关键词： perovskite quantum dots ligand chemistry phase stabilization

Forge AHEAD with stricter criteria in future trials of embolic stroke of undetermined source

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Neural Regeneration Research 2022年第5期17卷 1009-1010页

作者： david Z.Rose scott E.Kasner Department of Neurology Morsani College of MedicineUniversity of South FloridaTampaFLUSA Department of Neurology Perelman School of MedicineUniversity of PennsylvaniaPhiladelphiaPAUSA

What lurks within the crypt?With more than 200 known causes of is chemic stroke(Saver,2016),what should be the minimum work up?many centers offer high-resolution brain imaging and vessel studies,telemetry monitoring f... 详细信息

关键词： strict thoracic centers

Soil fungal and prokaryotic community structure exhibits differential short-term responses to timber harvest in the Pacific Northwest

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Pedosphere 2020年第1期30卷 109-125页

作者： Rachel E.DANIELSON megan L.mCGINNIS scott m.HOLUB david D.mYROLD Department of Crop and Soil Science Oregon State UniversityCorvallis OR 97331-7306(USA) United State Forest Service Helena-Lewis and Clark National Forest2880 Skyway DriveHelena MT 59602(USA) Weyerhaeuser Company PO Box 275Springfield OR 97477(USA) Department of Land Airand Water ResourcesUniversity of CaliforniaDavis CA 95616USA

Conventional clear-cut timber harvest is a widespread industrial practice across the Pacific Northwest;however,information regarding how these practices impact soil microbial community structure at the regional scale is *** evidence of consistent and substantial impact of harvest on soil microbial functional profiles across the region(despite a range of environmental conditions),the objective of this study was to determine the extent to which harvest also influences the structure of prokaryotic and fungal soil microbial communities,and how generalized these trends are throughout the geographic *** soil samples were collected one year before and after harvest across nine second-growth Douglas-fir forests in the Pacific *** community DNA was extracted from the soils,and high-throughput targeted gene sequencing of the 16 S r RNA gene for prokaryotes and the internal transcribed spacer(ITS)gene for fungi was *** diversity was consistently and significantly higher after harvest;it was moderately so for fungal communities(+14.6%),but only marginally so for prokaryotic communities(+2.0%).Similarly,on average,a greater proportion of the variation in the community structure of fungi(20.1%)at each site was associated with forest harvest compared to that of prokaryotes(13.2%).Overall,the greatest influence of timber harvest on soil microbial communities appeared to be a relative depletion of ectomycorrhizal fungi,with a concomitant enrichment of saprotrophic *** the short-term responses of soil microbial communities across the region,particularly those of tree root-associated symbionts,may aid our understanding of the role soil microbial communities play in ecological succession.

关键词： clear-cut Douglas-fir forest ectomycorrhizal fungi forest soil microbial community microbial diversity root-associated symbiont saprotrophic fungi

Disaster Risk management Through the Design Safe Cyberinfrastructure

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International Journal of Disaster Risk Science 2020年第6期11卷 719-734页

作者： Jean-Paul Pinelli maria Esteva Ellen m.Rathje david Roueche scott J.Brandenberg Gilberto mosqueda Jamie Padgett Frederick Haan Department of mechanical and Civil Engineering Florida Institute of TechnologyMelbourneFL 32901USA Texas Advanced Computing Center University of Texas at AustinAustinTX 78712USA Department of Civil Engineering University of Texas at AustinAustinTX 78712USA Department of Civil Engineering Auburn UniversityAuburnAL 36849USA Department of Civil and Environmental Engineering University of California in Los AngelesLos AngelesCA 90095USA Department of Structural Engineering University of California in San DiegoLa JollaCA 92093USA Department of Civil and Environmental Engineering Rice UniversityHoustonTX 77005USA Engineering Department Calvin CollegeGrand RapidsMI 49546USA

Design Safe addresses the challenges of supporting integrative data-driven research in natural hazards *** is an end-to-end data management,communications,and analysis platform where users collect,generate,analyze,curate,and publish large data sets from a variety of sources,including experiments,simulations,field research,and post-disaster *** achieves key objectives through:(1)integration with high performance and cloud-computing resources to support the computational needs of the regional risk assessment community;(2)the possibility to curate and publish diverse data structures emphasizing relationships and understandability;and(3)facilitation of real time communications during natural hazards events and disasters for data and information *** resultant services and tools shorten data cycles for resiliency evaluation,risk modeling validation,and forensic *** article illustrates salient features of the *** summarizes its design principles,architecture,and *** focus is on case studies to show the impact of Design Safe on the disaster risk *** Next Generation Liquefaction project collects and standardizes case histories of earthquake-induced soil liquefaction into a relational database—Design Safe—to permit users to interact with the *** can correlate in Design Safe building dynamic characteristics based on data from building sensors,with observed damage based on ground motion *** groups upload,curate,and publish wind,seismic,and coastal damage data they gather during field reconnaissance missions,so these datasets are available shortly after a *** a part of the education and community outreach efforts of Design Safe,training materials and collaboration space are also offered to the disaster risk management community.

关键词： Cyberinfrastructure Design Safe Disaster risk management Natural hazard data management

The embryology of persistent cloaca and urogenital sinus malformations

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Asian Journal of Andrology 2020年第2期22卷 124-128页

作者： david F m Thomas University of Leeds LeedsWest Yorkshire LS29JTUK

Cloacal malformations are characterized by the confluence of the lower urinary tract,the female reproductive tract,and the rectum to create a common channel with a single opening on the *** presence of a cloaca is a normal phase of early human embryological *** the 4^th and 7^th weeks of gestation,the cloaca undergoes subdivision to form the hindgut and urogenital *** of this process results in the congenital anomaly termed persistent cloaca(PC).The term urorectal septum malformation sequence(URSmS)is also used to describe this *** classic description of this process which is still cited in many standard textbooks dates from the 19th ***,this has been increasingly called into question by the findings of studies using modern scientific *** sinus anomalies are defined by the confluence of the urethra and vagina to form a common channel of varying length with a single perineal *** this condition,the anorectal canal opens separately on the *** presence of a urogenital sinus represents a transient phase of the normal development of the lower genital tract in the female ***,the form of urogenital sinus most commonly encountered in the developed world is a feature of disordered sexual differentiation and does not arise simply from the persistence of the anatomical structure which is a feature of normal fetal development.

关键词： cloaca embryology urogenital sinus

Duplication and diversification of insulin genes in ray-finned fish

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Zoological Research 2019年第3期40卷 185-197页

作者： david m.Irwin Department of Laboratory medicine and Pathobiology University of Toronto Banting and Best Diabetes Centre University of Toronto

Insulin is a key hormone for the regulation of metabolism in *** is produced by pancreatic islet cells in response to elevated glucose levels and leads to the uptake of glucose by tissues such as liver and adipose tissue to store *** also has additional functions in regulating *** work has shown that the proglucagon gene,which encodes hormones counter regulating insulin,is duplicated in teleost fish,and that the peptide hormones encoded by these genes have diversified in function.I sought to determine whether similar processes have occurred to insulin genes in these *** of fish genomes revealed an unexpected diversity of insulin genes.A triplication of the insulin gene occurred at the origin of teleost fish,however one of these three genes,insc,has been lost in most teleost fish *** two other insulin genes,insa and insb,have been retained but show differing levels of selective constraint suggesting that they might have diversified in ***,a duplicate copy of the insa gene,which I named insab,is found in many *** coding sequenee encoded by insab genes is under weak selective constraint,with its predicted protein sequences losing their potential to be processed into a two-peptide ***,these sequences have retained perfectly conserved cystine residues,suggesting that they maintain insulin's three-dimensional structure and therefore might modulate the processing and secretion of insulin produced by the other genes.

关键词： Insulin Teleost fish Gene duplicati on Adaptive evolution Gene loss

Global Wheat Head Detection Challenges:Winning models and Application for Head Counting

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Plant Phenomics 2023年第3期5卷 460-473页

作者： Etienne david Franklin Ogidi Daniel Smith scott Chapman Benoit de Solan Wei Guo Frederic Baret Ian Stavness UmR 1114 EmmAH INRAEAvignonFrance Arvalis–Institut du Végétal ParisFrance Department of Computer Science University of SaskatchewanSaskatoonCanada School of Food and Agricultural Sciences University of QueenslandBrisbaneAustralia Graduate School of Agricultural and Life Sciences The University of TokyoTokyoJapan

Data competitions have become a popular approach to crowdsource new data analysis methods for general and specialized data science *** competitions have a rich history in plant phenotyping,and new outdoor field datasets have the potential to embrace solutions across research and commercial *** developed the Global Wheat Challenge as a generalization competition in 2020 and 2021 to find more robust solutions for wheat head detection using field images from different *** analyze the winning challenge solutions in terms of their robustness when applied to new *** found that the design of the competition had an influence on the selection of winning solutions and provide recommendations for future competitions to encourage the selection of more robust solutions.

关键词： Wheat specialized competition

Transferrin protects against Parkinsonian neurotoxicity and is deficient in Parkinson’s substantia nigra

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Signal Transduction and Targeted Therapy 2016年第1期1卷 75-80页

作者： scott Ayton Peng Lei Catriona mclean Ashley I Bush david I Finkelstein The Florey Institute for Neuroscience and mental Health The University of MelbourneParkvilleVictoriaAustralia Department of Neurology State Key Laboratory of BiotherapyWest China HospitalSichuan Universityand Collaborative Innovation Center for BiotherapyChengduSichuanChina The Alfred Hospital Department of Anatomical PathologyMelbourneVictoriaAustralia

Iron deposition in Parkinson’s disease(PD)is a potential disease-modifying *** previously showed that supplementation of the iron-exporter,ceruloplasmin,selectively corrected nigral iron elevation in the 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine(mPTP)*** delivers iron to transferrin(Tf),the extracellular iron-transporting *** show that Tf protein levels are decreased in the nigra of post-mortem PD brains compared with controls(−35%;n=10 each).Because Tf traffics iron away from iron-replete tissues,we hypothesized that Tf supplementation could selectively facilitate iron export from the nigra in *** cultured neurons,Tf treatment corrected iron accumulation,and subcutaneous Tf to mice ameliorated iron accumulation and motor deficits in the mPTP model of *** these data support a role for Tf in the disease mechanism for PD,and its potential use for correcting disorders of iron overload,Tf therapy also caused systemic iron depletion,which could limit its application for PD.

关键词： corrected sized deficient