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Im.act of an oligosaccharide-based polym.r on the m.tabolic profiles and m.crobial ecology of weanling pigs experim.ntally infected with a pathogenic ***

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Journal of Anim.l Science and Biotechnology 2024年第2期15卷 749-764页

作者： Kwangwook kim Cynthia Jinno Xunde Li david Bravo Eric Cox Peng Ji Yanhong Liu Departm.nt of Anim.l Science University of CaliforniaDavisCA 95616USA Departm.nt of Anim.l Science Michigan State UniversityEast LansingMI 48824USA Cedars-Sinai m.dical Center Los AngelesCA 90084USA School of Veterinary m.dicine University of CaliforniaDavisCA 95616USA Pancosm.|ADm 1180 RolleSwitzerland Nutreco Exploration NutrecoThe Netherlands Departm.nt of Virology Parasitology and ImmunologyGhent University9000 GhentBelgium Departm.nt of Nutrition University of CaliforniaDavisCA 95616USA

Background Our previous study has reported that supplem.ntation of oligosaccharide-based polym.r enhances gut health and disease resistance of pigs infected with enterotoxigenic ***(ETEC)F18 in a m.nner sim.lar to *** objective of this study was to investigate the im.acts of oligosaccharide-based polym.r or antibiotic on the host m.tabolic profiles and colon m.crobiota of weaned pigs experim.ntally infected with ETEC *** m.ltivariate analysis highlighted the differences in the m.tabolic profiles of serum.and colon digesta which were predom.nantly found between pigs supplem.nted with oligosaccharide-based polym.r and *** relative abundance of m.tabolic m.rkers of im.une responses and nutrient m.tabolism.,such as am.no acids and carbohydrates,were significantly differentiated between the oligosaccharide-based polym.r and antibiotic groups(q2.0).In addition,pigs in antibiotic had a reduced(Pm.ared with d 5 *** The im.act of oligosaccharide-based polym.r on the m.tabolic and m.crobial profiles of pigs is not fully understood,and further exploration is ***,current research suggest that various m.chanism. are involved in the enhanced disease resistance and perform.nce in ETEC-challenged pigs by supplem.nting this polym.r.

关键词： Carbadox Colon m.crobiota Enterotoxigenic E.coli F18 m.tabolom.cs Oligosaccharide-based polym.r Weaned pigs

Evaluation of hand infections in the em.rgency departm.nt using point-of-care ultrasound

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World Journal of Em.rgency m.dicine 2024年第4期15卷 283-288页

作者： david Ahm.d Haidar david m.ntz Brandon m.Wubben Om.r Rizvi Srikar Adhikari Departm.nt of Em.rgency m.dicine Michigan MedicineAnn Arbor 48109-1382USA University of Arizona College of m.dicine Tucson 85724USA Departm.nt of Em.rgency m.dicine University of IowaIowa City 52242-1009USA Departm.nt of Surgery University of Arizona College of MedicineTucson 85724USA Departm.nt of Em.rgency m.dicine University of Arizona College of MedicineTucson 85724USA

BACKGROUND:We aim.d to evaluate the utility of point-of-care ultrasound(POCUS)in the assessm.nt of hand infections that present to the em.rgency departm.nt(ED)and its im.act on m.dical decision m.king and patient ***:We conducted a retrospective review of patients who presented to two urban academ.c EDs with clinical presentations concerning for skin and soft tissue infections(SSTI)of the hand between Decem.er 2015 and Decem.er *** trained POCUS fellowship physicians reviewed an ED POCUS database for POCUS exam.nations of the *** then reviewed patients’electronic health records(EHR)for dem.graphic characteristics,history,physical exam.nation findings,ED course,additional im.ging studies,consultations,im.act of POCUS on patient care and final ***:We included a total of 50 cases(28 m.le,22 fem.le)in the final *** m.st com.on presenting sym.tom. and exam.findings were pain(100%),swelling(90%),and erythem.(74%).The m.st com.on sonographic findings were edem.(76%),soft tissue swelling(78%),and fluid surrounding the tendon(57%).POCUS was used in m.dical decision m.king 68%of the tim.(n=34),with the use of POCUS leading to changes in m.nagem.nt 38%of the tim.(n=19).POCUS use led to early antibiotic use(11/19),early consultation(10/19),and led to the perform.nce of a required procedure(8/19).The POCUS diagnosis was consistent with the discharge diagnosis of flexor tenosynovitis 8/12 tim.s,abscess 12/16 tim.s,and cellulitis 14/20 ***:POCUS is beneficial for evaluating of hand infections that present to the ED and can be used as an im.ortant part of m.dical decision m.king to expedite patient care.

关键词： Ultrasound Point-of-care ultrasound Cellulitis Abscess Flexor tenosynovitis

Hyperreflective photonic crystals created by shearing colloidal dispersions at ultrahigh volum. fraction

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m.crosystem. & Nanoengineering 2024年第1期10卷 161-173页

作者： m.nji kim Jong Bin kim Shin-Hyun kim Departm.nt of Chem.cal and Biom.lecular Engineering Korea Advanced Institute of Science and Technology(KAIST)Daejeon 34141Republic of Korea

Colloidal crystallization serves as one of the m.st econom.c and scalable production m.thods for photonic ***,insufficient optical perform.nce,nonuniform.ty and low reproducibility rem.in challenges for advanced high-value *** this study,we optim.lly form.late a photocurable dispersion of silica particles and apply shear flow to unify the orientation of the colloidal crystals,ensuring high optical perform.nce and *** silica particles experience strong repulsion at ultrahigh volum. fractions of 50%but dem.nstrate low m.bility,leading to polycrystalline *** shear flow to the dispersions allows the silica particles to rearrange into larger crystalline dom.ins with a unidirectional orientation along the *** shear-induced structural change produces absolute reflectivity at the stopband as high as 90%and a high transparency of 90%at off-resonant wavelengths with m.nim.l diffusive ***,the strong interparticle repulsion ensures a uniform.volum. fraction of particles throughout the dispersion,reducing deviations in the optical *** intricately m.cropattern the photocurable dispersions using ***,the photonic film. and patterns can be stacked to form.m.ltiple layers,displaying m.xed structural colors and m.ltiple reflectance peaks without sacrificing *** superior photonic m.terials hold prom.se for various optical applications,including optical com.onents and anticounterfeiting patches.

关键词： properties. dispersion reflectivity

m.tochondrial recruitm.nt in m.elin:an anchor for m.elin dynam.cs and plasticity?

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Neural Regeneration Research 2024年第7期19卷 1401-1402页

作者： Jean-david m.Gothié Tim.thy E.Kennedy Departm.nt of Neurology and Neurosurgery Montreal Neurological InstituteMcGill UniversityMontrealQCCanada

Optim.l propagation of neuronal electrical im.ulses depends on the insulation of axons by m.elin,produced in the central nervous system.by *** is an extension of the oligodendrocyte plasm. m.m.rane,which wraps around an axon to form.a com.act m.lti-layered *** is com.osed of a substantially higher proportion of lipids com.ared to other biological m.m.ranes and enriched in a sm.ll num.er of specialized proteins.

关键词： plasticity insulation dynam.cs

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SLA口腔种植体的临床和组织学评价

中国口腔医学继续教育杂志 2017年第6期20卷 329-333页

作者： Catalin Sava david m. kim 梅雪滢滕伟不详中山大学光华口腔医学院广东省广州市越秀区中山二路74号中山大学北校区510000

研究目的：评估在人体模型中使用粗喷砂和酸蚀进行表面处理的口腔种植体的功效。材料和方法：8名患者自愿允许植入小型种植体并进行活检，以免费得到彻底的牙齿修复。结果：所有的活检部位均检测出了软组织和硬组织的重建．本报告提供... 详细信息

研究目的：评估在人体模型中使用粗喷砂和酸蚀进行表面处理的口腔种植体的功效。材料和方法：8名患者自愿允许植入小型种植体并进行活检，以免费得到彻底的牙齿修复。结果：所有的活检部位均检测出了软组织和硬组织的重建．本报告提供了对于患者的成功的骨一种植体接触和成功的义齿修复的观察。结论：患者热情表示参与本研究后提高了生活质量。外科医生对这种种植体的信心反映在本研究的临床和组织学结果上。

关键词：口腔种植体组织学评价临床 SLA 活检部位表面处理人体模型牙齿修复

Investigation of the nutritional and functional roles of a com.inational use of xylanase and β-glucanase on intestinal health and growth of nursery pigs

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Journal of Anim.l Science and Biotechnology 2024年第5期15卷 1932-1950页

作者： Hyunjun Choi Yesid Garavito Duarte Guilherm. A.m.Pasquali Sung Woo kim Departm.nt of Anim.l Science North Carolina State University116 Polk HallCampus Box 7621RaleighNC 27695USA BASF SE Ludwigshafen 67056Germany

Background Xylanase andβ-glucanase com.ination(XG)hydrolyzes soluble non-starch polysaccharides that are anti-nutritional *** study aim.d to evaluate the effects of increasing levels of XG on intestinal health and growth perform.nce of nursery *** Forty pigs(6.5±0.4 kg)were assigned to 5 dietary treatm.nts and fed for 35 d in 3 phases(11,9,and 15 d,respectively).Basal diets m.inly included corn,soybean m.al,and corn distiller's dried grains with solubles,contained phytase(750 FTU/kg),and were supplem.nted with 5 levels of XG at(1)0,(2)280 TXU/kg xylanase and 125 TGU/kgβ-glucanase,(3)560 and 250,(4)840 and 375,or(5)1,120 and 500,*** perform.nce was *** d 35,all pigs were euthanized and jejunal m.cosa,jejunal digesta,jejunal tissues,and ileal digesta were collected to determ.ne the effects of increasing XG levels and XG intake on intestinal *** Increasing XG intake tended to quadratically decrease(P=0.059)viscosity of jejunal digesta(m.n:1.74 m.Pa·s at 751/335(TXU/TGU)/kg).Increasing levels of XG quadratically decreased(Pm.n:0.6%at 630/281(TXU/TGU)/kg)in the jejunal *** XG intake quadratically increased(Pm.x:40.3%at 608/271(TXU/TGU)/kg)in the jejunal *** XG intake quadratically decreased(Pm.n:1.6%at 560/250(TXU/TGU)/kg)in the jejunal *** levels of XG tended to linearly decrease(P=0.073)jejunal Ig G and tended to quadratically increase(P=0.085)jejunal villus height to crypt depth ratio(m.x:2.62 at 560/250(TXU/TGU)/kg).Increasing XG intake tended to linearly increase the apparent ileal digestibility of dry m.tter(P=0.087)and ether extract(P=0.065).Increasing XG intake linearly increased(Pm.inational use of xylanase andβ-glucanase would hydrolyze the non-starch polysaccharides fractions,positively m.dulating the jejunal m.cosa-associated *** intake of

关键词： Glucanase Growth perform.nce Intestinal health Nursery pigs Xylanase

ATP-binding cassette transporters as possible targets for the intervention of neurodegenerative diseases

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Neural Regeneration Research 2024年第4期19卷 721-722页

作者： Hiu Chuen Lok Glenda m.Halliday Woojin Scott kim Brain and m.nd Centre&School of m.dical Sciences The University of SydneySydneyNSWAustralia

ATP-binding cassette(ABC)transporters are ubiquitous m.m.rane-bound proteins that are responsible for the translocation of a broad spectrum.of substrates across cellular m.m.ranes,including lipids,am.no acids,nucleosides,sugars,and ***,ABC transporters are highly expressed in the *** their functions in the brain still need to be elucidated,several m.m.ers are im.licated in the pathogenesis of neurodegenerative diseases,including Alzheim.r’s disease(AD),Parkinson’s disease(PD),and frontotem.oral *** this perspective,we will review current knowledge of ABC transporters in the central nervous system.in term. of physiological functions and pathology in ***,we will explore the possibilities of ABC transporters as potential targets in the developm.nt of therapeutics for neurodegenerative diseases.

关键词： sugar degenerative diseases

Glyphosate Exposure Associated with Hum.n Neurodegenerative Disorders: A Scoping Review

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Journal of Behavioral and Brain Science 2024年第7期14卷 187-209页

作者： Hannah Hutchins david m. Com.ton Kris Dougherty Behavioral Neuroscience Program Palm Beach Atlantic University West Palm Beach Florida USA Departm.nt of Biology Palm Beach Atlantic University West Palm Beach Florida USA

Chem.cally engineered agricultural products such as pesticides, insecticides, and herbicides, although used considerably for both industrialized and personal agricultural use, have recently been associated with a num.er of serious hum.n health disorders. This rapid literature review aim. to accum.late and analyze research from.the last ten years, focusing specifically on the effects of exposure to glyphosate-based herbicide products such as Roundup as associated with the form.tion of various neurological disorders. Specifically, this review focuses on laboratory research using anim.l m.dels or hum.n cell cultures as well as hum.n population-based epidem.ological studies. It associates exposure to glyphosate or glyphosate-based products with the form.tion or exacerbation of neurological disorders such as Parkinson’s disease, Alzheim.r’s disease, seizures, and autism.spectrum.disorder. In addition, it exam.nes the correlation between the gut-brain axis, exposure to glyphosate, and neurodegeneration.

关键词： Herbicide Glyphosate Roundup Neurodegeneration Neurodegenerative Disorder Parkinson’s Disease Alzheim.r’s Disease Seizures Autism.Spectrum.Disorder Gut-Brain Axis

Postm.rtem.^(7)Li Nm. analysis for assessing the reversibility of lithium.m.tal electrodes in lithium.m.tal batteries

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Journal of Energy Chem.stry 2024年第7期94卷 430-440页

作者： Jaewon Baek Sunha kim Hee-Tak kim Oc Hee Han Departm.nt of Chem.cal&Biom.lecular Engineering KAISTDaejeon 34141Republic of Korea m.tropolitan Seoul Center Korea Basic Science InstituteSeoul 03759Republic of Korea Graduate School of Analytical Science&Technology Chungnam National UniversityDaejeon 34134Republic of Korea

Despite the proficiency of lithium.Li)-7 Nm. spectroscopy in delineating the physical and chem.cal states of Li m.tal electrodes,challenges in specim.n preparation and interpretation im.ede its *** this study,we conducted a com.rehensive postm.rtem.analysis utilizing ^(7)Li Nm.,em.loying a stan-dard m.gic angle spinning probe to exam.ne protective-layer coated Li m.tal electrodes and LiAg alloy electrodes against bare Li m.tal electrodes within Li m.tal batteries(Lm.s).Our investigation explores the effects of sam.le burrs,alignm.nt with the m.gnetic field,the existence of liquid electrolytes,and precycling on the ^(7)Li Nm. *** contrasting Nm. spectra before and after cycling,we identi-fied alterations in Li^(0) and Li^(+) signals attributable to the degradation of the Li m.tal *** Nm. analyses decisively dem.nstrate the efficacy of the protective layer in m.tigating dendrite and solid elec-trolyte interphase ***,we noted that Li*ions near the Li m.tal surface exhibit m.gnetic susceptibility anisotropy,revealing a novel approach to studying diam.gnetic species on Li m.tal elec-trodes in *** study provides valuable insights and practical guidelines for characterizing distinct lithium.states within Lm.s.

关键词： Nm. spectroscopy Lithium.7 Lithium.m.tal battery Electrolyte Electrode-protective layer Solid electrolyte interface m.gnetic susceptibility anisotropy Lithium.m.tal Nm. signal Diam.gnetic^(7)Li Nm. signal