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Functional mechanism study of the allelochemical myrigalone A identifies a group of ultrapotent inhibitors of ethylene biosynthesis in plants

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Plant Communications 2024年第6期5卷 246-262页

作者： George Heslop-Harrison Kazumi Nakabayashi Ana Espinosa-Ruiz Francesca Robertson Robert Baines Christopher R.l.Thompson Katrin Hermann david Alabadí gerhard leubner-Metzger Robin s.B.Williams Centre for Biomedical sciences Department of Biological SciencesRoyal Holloway University of LondonEgham TW200EXUK Centre for Plant Molecular sciences Department of Biological SciencesRoyal Holloway University of LondonEgham TW200EXUK Instituto de Biología Molecular y Celular de Plantas(CsIC-UPV) 46022 ValenciaSpain Centre for life’s Origins and Evolution Department of GeneticsEvolution and EnvironmentUniversity College LondonLondonUK syngenta Crop Protection AGSteinSwitzerland

Allelochemicals represent a class of natural products released by plants as root,leaf,and fruit exudates that interfere with the growth and survival of neighboring *** how allelochemicals function to regulate plant responses may provide valuable new approaches to better control plant *** such allelochemical,Myrigalone A(MyA)produced by Myrica gale,inhibits seed germination and seedling growth through an unknown ***,we investigate MyA using the tractable modelDictyostelium discoideum and reveal that its activity depends on the conserved homolog of the plant ethylenesynthesis protein 1-aminocyclopropane-1-carboxylic acid oxidase(ACO).Furthermore,in silico modeling predicts the direct binding of MyA to ACO within the catalytic *** ***,ablation of ACO mimics the MyA-dependent developmental delay,which is partially restored by exogenous ethylene,and MyA reduces ethylene *** Arabidopsis thaliana,MyA treatment delays seed germination,and this effect is rescued by exogenous *** also mimics the effect of established ACO inhibitors on root and hypocotyl extension,blocks ethylenedependent root hair production,and reduces ethylene ***,in silico binding analyses identify a rangeof highlypotentethylene inhibitorsthatblock ethylene-dependent responseand reduce ethyleneproduction in ***,we demonstrate a molecular mechanism by which the allelochemical MyA reduces ethylene biosynthesis and identify a range of ultrapotent inhibitors of ethylene-regulated responses.

关键词： 1-aminocyclopropane-1-carboxylic acid ACC ACC oxidase ACO allelochemicals ethylene synthesis inhibitors structure-activity relationship

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Metallo-β-lactamases:A Major Threat to Human Health

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American Journal of Molecular Biology 2014年第3期4卷 89-104页

作者： Emer K.Phelan Manfredi Miraula Christopher selleck david l.ollis.gerhard s.henk Natasa Mitic Department of Chemistry National University of Ireland-MaynoothMaynoothIreland school of Chemistry and Molecular Biosciences The University of QueenslandBrisbaneAustralia Research school of Chemistry Australian National UniversityCanberraAustralia

Antibiotic resistance is one of the most significant challenges facing global healthcare. since the 1940s, antibiotics have been used to fight infections, initially with penicillin and subsequently with various derivatives including cephalosporins, carbapenams and monobactams. A common characteristic of these antibiotics is the four-memberedβ-lactam ring. Alarmingly, in recent years an increasing number of bacteria have become resistant to these antibiotics. A major strategy employed by these pathogens is to use Zn(II)-dependent enzymes, the metallo-β-lactamases (MBls), which hydrolyse theβ-lactam ring. Clinically useful MBl inhibitors are not yet available. Consequently, MBls remain a major threat to human health. In this review biochemical properties of MBls are discussed, focusing in particular on the interactions between the enzymes and the functionally essential metal ions. The precise role(s) of these metal ions is still debated and may differ between different MBls. However, since they are required for catalysis, their binding site may present an alternative target for inhibitor design.

关键词： Antibiotic Resistance β-lactam Antibiotics Metallo-β-lactamases Reaction Mechanism Metal Ion Binding

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The future of computer-aided sperm analysis

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Asian Journal of Andrology 2015年第4期17卷 545-553页

作者： sharon T Mortimer gerhard van der Horst david Mortimer Oozoa Biomedical West Vancouver BC Canada Department of Medical Biosciences University ofthe Western Cape Bellville South Africa 0ozoaBiomedical West Vancouver BC Canada.

Computer-aided sperm analysis （CAsA） technology was developed in the late 1980s for analyzing sperm movement characteristics or kinematics and has been highly successful in enabling this field of research. CAsA has also been used with great success for measuring semen characteristics such as sperm concentration and proportions of progressive motility in many animal species, including wide application in domesticated animal production laboratories and reproductive toxicology. However, attempts to use CAsA for human clinical semen analysis have largely met with poor success due to the inherent difficulties presented by many human semen samples caused by sperm clumping and heavy background debris that, until now, have precluded accurate digital image analysis. The authors review the improved capabilities of two modern CAsA platforms （Hamilton Thorne CAsA-II and Microptic sCA6） and consider their current and future applications with particular reference to directing our focus towards using this technology to assess functional rather than simple descriptive characteristics of spermatozoa. specific requirements for validating CAsA technology as a semi-automated system for human semen analysis are also provided, with particular reference to the accuracy and uncertainty of measurement expected of a robust medical laboratory test for implementation in clinical laboratories operating according to modern accreditation standards.

关键词： HIsTORICAl INTRODUCTION

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Unusual metallo-β-lactamases may constitute a new subgroup in this family of enzymes

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American Journal of Molecular Biology 2014年第1期4卷 11-15页

作者： Chun-Feng D.Hou Emer K.Phelan Manfredi Miraula david l.ollis.gerhard s.henk Natasa Mitic Research school of Chemistry Australian National UniversityCanberraAustralia Department of Chemistry National University of Ireland-MaynoothMaynoothIreland school of Chemistry and Molecular Biosciences The University of QueenslandBrisbaneAustralia

Metallo-β-lactamases (MBls) are a family of Zn2+-dependent enzymes that have contributed strongly to the emergence and spread of antibiotic resistance. Novel members as well as variants of existing members of this family are discovered continuously, compounding their threat to global health care. MBls are divided into three subgroups, i.e. B1, B2 and B3. The recent discovery of an unusual MBl from serratia proteamaculans (sPR-1) suggests the presence of an additional subgroup, i.e. B4. A database search reveals that sPR-1 has only one homologue from Cronobacter sakazakii, *** two MBls have a unique active site and may employ a mechanism distinct from other MBls, but reminiscent of some organophosphate-degrading hydrolases.

关键词： Antibiotic Resistance β-lactam Antibiotics Metallo-β-lactamases sequence Homology serratia proteamaculans Cronobacter sakazakii

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Broad spectrum antibiotic-degrading metallo-β-lactamases are phylogenetically diverse

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Protein & Cell 2020年第8期11卷 613-617页

作者： Marcelo Monteiro Pedroso david W.Waite Okke Melse liam Wilson Natasa Mitic Ross P.McGeary Iris Antes luke W.Guddat Philip Hugenholtz gerhard s.henk school of Chemistry and Molecular Biosciences The University of QueenslandSt.LuciaQLDBrisbane 4072Australia Australian Centre for Ecogenomics The University of QueenslandSt.LuciaQLDBrisbane 4072Australia Center for Integrated Protein science Munich at the TUM school of life sciences Technische Universit(a)t München85354 FreisingGermany Department of Chemistry Maynooth UniversityMaynoothCo.KildareIreland

Dear Editor, Antibiotic resistance has emerged as a major threat to global health;multi-drug resistant bacteria already kill more patients in the United states each year than HIV/AIDs, Parkinson's disease, emphysema and homicide combined (laxminarayan et al., 2013).Among the most effective bacterial resistance mechanisms are β-lactamases, a family of enzymes that are divided into four distinct *** A, C and D (serine-β-lactamases, sBls) use a catalytic site serine residue to initiate inactivation of the antibiotic, while Class B (metallo-β-lactamases, MBls) relies on a Zn2+-activated hydroxide (Walsh et al., 2005;Bush and Jacoby,2010;Mitic et al., 2014;lisa et al., 2017).Clinically relevant inhibitors of Class C and D sBls are available and in use (e.g., clavulanic acid (CA), Drawz et al., 2010), but for MBls the search for such inhibitors has remained challenging (McGeary et al., 2017).

关键词： hydroxide metallo spectrum

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高宽比效应对厚壁复合材料固化过程的影响:Ⅰ.数值模拟(英文)

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材料工程 2009年第S2期37卷 368-377,382页

作者：吴旺青 Florian Klunker david Christian Berg 朱丹 gerhard Ziegmann 蒋炳炎聚合物材料与塑料工程研究所教育部现代复杂装备与极端制造重点实验室

纤维增强聚合物基复合材料(FRP)面临制造厚度为10mm以上的零件的技术挑战。这是因为零件体积与表面积比的增大以及纤维与树脂的较低的热导率,使得树脂固化过程中产生的大量的热量无法及时散去。随着零件的厚度增加,树脂温度会因为反应... 详细信息

纤维增强聚合物基复合材料(FRP)面临制造厚度为10mm以上的零件的技术挑战。这是因为零件体积与表面积比的增大以及纤维与树脂的较低的热导率,使得树脂固化过程中产生的大量的热量无法及时散去。随着零件的厚度增加,树脂温度会因为反应热的增加而超过其降解温度。因而,本文着眼于厚壁复合材料零件的高宽比效应对单组分树脂系统RTM6在制造商推荐的固化周期(MRCC)下的最大成型厚度及其固化模式的影响。RTM6是特别为航空业树脂传递塑模(RTM)工艺开发的树脂系统。首先通过差示扫描量热仪(DsC)和参数拟合确定RTM6的固化动力学参数,然后采用有限元法进行模拟分析零件最大成型厚度和固化前沿的扩展过程并与文献结果相比较。结果表明,高宽比对厚壁复合材料零件的最大成型厚度和固化前沿扩展模式均有显著影响。零件最大成型厚度与文献结果的吻合度误差范围为1～7%。相同零件厚度下,随着高宽比的增加,会产生胶凝顺序"由外至内"和"由内至外"两种截然相反的固化前沿扩展模式。通过用户自定义固化周期(UDCC),可以实现将固化前沿扩展模式"由外至内"优化为"由内至外"。综上所述,纤维增强厚壁复合材料零件设计制造过程中,零件的高宽比是一个必须考虑的重要因素。

关键词：厚壁复合材料固化动力学高宽比纤维加强聚合物基复合材料树脂传递模塑

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水平定向钻进期间土颗粒的运移

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非开挖技术 2017年第2期 59-62页

作者： henk.M.G. Kruse Mike Woning david s. Nugroho 陈维鹏

当生产管安装在建好的钻孔中，水平定向钻进（HDD）的成功在很大程度上依赖于回拖操作的成功，损坏管线的费用和回拖操作期间与之后额外措施的费用相当高。钻孔的稳定性与钻孔外土颗粒的运移对装有管线的钻孔的建立很重要。如果钻孔中... 详细信息

当生产管安装在建好的钻孔中，水平定向钻进（HDD）的成功在很大程度上依赖于回拖操作的成功，损坏管线的费用和回拖操作期间与之后额外措施的费用相当高。钻孔的稳定性与钻孔外土颗粒的运移对装有管线的钻孔的建立很重要。如果钻孔中某些部分充满土颗粒，回拖操作期间出现问题的风险可以很大。虽然我们从无数的水平定向钻进工程中得到许多经验，但是为降低潜在的回拖风险，更好地了解土颗粒运移过程是有必要的。当前使用的钻进液携岩能力的设计公式只考虑了钻进液的动切应力。由于最近研究表明钻进液流动过程中的剪切作用和由于土颗粒相互作用引起的聚集会影响钻进液的携岩能力，两参数采用剪切元来研究。不幸的是，一些剪切元测试失败了，所以聚集作用的影响无法研究，但是剪切作用对钻进液携岩能力的影响表现得非常明显。我们有必要对钻进液中土颗粒聚集作用的影响作进一步研究从而得到一个新的设计公式。该公式包含了除实际动切应力之外的多个参数，用以描述水平定向钻进期间土颗粒的运移。

关键词： HDD 运移钻进液

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Fungal diversity notes 1–110:taxonomic and phylogenetic contributions to fungal species

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Fungal Diversity 2015年第3期72卷 1-197页

作者： Jian Kui liu Kevin D.Hyde E.B.Gareth Jones Hiran A.Ariyawansa Darbhe J.Bhat saranyaphat Boonmee sajeewa s.N.Maharachchikumbura Eric H.C.McKenzie Rungtiwa Phookamsak Chayanard Phukhamsakda Belle Damodara shenoy Mohamed A,Abdel-Wahab Bart Buyck Jie Chen K.W.Thilini Chethana Chonticha singtripop Dong Qin Dai Yu Cheng Dai Dinushani ADaranagama Asha J.Dissanayake Mingkwan Doilom Melvina J.D’souza Xin lei Fan Ishani DGoonasekara Kazuyuki Hirayama sinang Hongsanan subashini C.Jayasiri Ruvishika s.Jayawardena samantha C.Karunarathna Wen Jing li Ausana Mapook Chada Norphanphoun Ka lai Pang Rekhani H.Perera Derek Peršoh Umpava Pinruan Indunil Csenanayake sayanh somrithipol satinee suetrong Kazuaki Tanaka Kasun M.Thambugala Qing Tian saowaluck Tibpromma Danushka Udayanga Nalin N.Wijayawardene Dhanuska Wanasinghe Komsit Wisitrassameewong Xiang Yu Zeng Faten AAbdel-Aziz slavomir Adamčík Ali H.Bahkali Nattawut Boonyuen Timur Bulgakov Philippe Callac Putarak Chomnunti Katrin Greiner Akira Hashimoto Valerie Hofstetter Ji Chuan Kang david lewis Xing Hong li Xing Zhong liu Zuo Yi liu Misato Matsumura Peter E.Mortimer gerhard Rambold Emile Randrianjohany Genki sato Veera sri-Indrasutdhi Cheng Ming Tian Annemieke Verbeken Wolfgang von Brackel Yong Wang Ting Chi Wen Jian Chu Xu Ji Ye Yan Rui lin Zhao Erio Camporesi Guizhou Key laboratory of Agricultural Biotechnology Guizhou Academy of Agricultural SciencesGuiyang 550006GuizhouChina Key laboratory for Plant Diversity and Biogeography of East Asia Kunming Institute of BotanyChinese Academy of ScienceKunming 650201YunnanChina Institute of Excellence in Fungal Research and school of science Mae Fah Luang UniversityChiang Rai 57100Thailand Department of Botany and Microbiology King Saudi UniversityRiyadhSaudi Arabia Manaaki Whenua landcare Research Private Bag 92170AucklandNew Zealand Formerly Department of Botany Goa UniversityGoaIndia No.128/1–J Azad Housing SocietyCurcaGoa VelhaIndia Muséum national d’histoire naturelle Dépt.Systématique etévolutionUMR 720575005 ParisFrance Institute of Microbiology&Beijing Key laboratory for Forest Pest Control Beijing Forestry UniversityPO Box 61Beijing 100083China Institute of Plant and Environment Protection Beijing Academy of Agriculture and Forestry SciencesNo.9 of Shu Guang Hua Yuan Zhong LuHaidian DistrictBeijing 10097China The Key laboratory for silviculture and Conservation of Ministry of Education Beijing Forestry UniversityBeijing 100083China Mycology University of BayreuthUniversitätsstraße 3095440 BayreuthGermany The United Graduate school of Agricultural sciences Iwate University18-8 Ueda 3 chomeMorioka 020-8550Japan Apple Experiment station Aomori Prefectural Agriculture and Forestry Research Center24 FukutamiBotandairaKuroishiAomori 036-0332Japan Department of Plant Protection Agroscope Changins-Wadenswil Research Station ACWRte de Duiller1260 NyonSwitzerland Department of Botany and Microbiology College of ScienceKing Saud UniversityP.O.Box:2455Riyadh 1145Saudi Arabia Department of Botany Faculty of ScienceSohag UniversitySohagEgypt Institute of Botany Slovak Academy of SciencesDúbravskácesta 984523 BratislavaSlovakia Hirosaki University Bleakwood262 CR 3062NewtonTexas 75966USA Faculty of Agriculture and life sciences Hirosaki University3 Bunkyo-choHirosakiAomori

This paper is a compilation of notes on 110 fungal taxa,including one new family,10 new genera,and 76 new species,representing a wide taxonomic and geographic *** new family,Paradictyoarthriniaceae is introduced based on its distinct lineage in Dothideomycetes and its unique *** family is sister to Biatriosporaceae and *** new genera are Allophaeosphaeria(Phaeosphaeriaceae),Amphibambusa(Amphisphaeriaceae),Brunneomycosphaerella(Capnodiales genera incertae cedis),Chaetocapnodium(Capnodiaceae),Flammeascoma(Anteagloniaceae),Multiseptospora(Pleosporales genera incertae cedis),Neogaeumannomyces(Magnaporthaceae),Palmiascoma(Bambusicolaceae),Paralecia(squamarinaceae)and sarimanas(Melanommataceae).The newly described species are the Ascomycota Aliquandostipite manochii,Allophaeosphaeria dactylidis,***,Alternaria cesenica,Amphibambusa bambusicola,Amphisphaeria sorbi,Annulohypoxylon thailandicum,Atrotorquata spartii,Brunneomycosphaerella laburni,Byssosphaeria musae,Camarosporium aborescentis,***,***,Chaetocapnodium siamensis,Chaetothyrium agathis,Colletotrichum sedi,Conicomyces pseudotransvaalensis,Cytospora berberidis,***,Diaporthe thunbergiicola,Diatrype palmicola,Dictyosporium aquaticum,***,***,Didymella cirsii,Dinemasporium nelloi,Flammeascoma bambusae,Kalmusia italica,***,Keissleriella sparticola,lauriomyces synnematicus,leptosphaeria ebuli,lophiostoma pseudodictyosporium,***,lophiotrema eburnoides,Montagnula graminicola,Multiseptospora thailandica,Myrothecium macrosporum,Natantispora unipolaris,Neogaeumannomyces bambusicola,Neosetophoma clematidis,***,Oxydothis atypica,Palmiascoma gregariascomum,Paraconiothyrium nelloi,***,Paradictyoarthrinium tectonicola,Paralecia pratorum,Paraphaeosphaeria spartii,Pestalotiopsis digitalis,***,***,Phaeoisaria pseudoclematidis,Phragmocapnias philippinensis,Pseudocamarosporium cotinae,Pseudocercospora tam

关键词： Ascomycota Basidiomycota Global Taxonomy Initiative Phylogeny Taxonomy

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