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作者：孟同（david Matacate Sitoe）中国石油大学(北京)

学位级别：硕士

The topic of global warming is one of the most pressing worldwide concerns,and with each passing day,the problem grows more complicated with numerous variables,due to the increase in demand for its primary causal element（energy）.In fact,it is a troublesome network,however,to limit carbon dioxide（CO）with more than 50%of emissions in the atmosphere,we must equalize the main factors of this dilemma.A kind of sustainability in the oil and gas sector is the use of carbon dioxide flooding,as a stimulation method for extracting oil from *** is an important variable to address while dealing with global warming dilemma,once it gives two alternative solutions:carbon dioxide sequestration and consequently decreasing emissions as well as,assisting on energy production as Enhanced Oil Recovery（EOR）*** Lavoisier’s law nothing is lost,nothing is wasted,and everything is transformed,we transform the emitted CO into CO–EOR flooding *** study stems from the approach of CO–EOR flooding equation,in terms of classifying the potential evaluation for the prospective implementation of the CO-flooding technologies,as well as,assisting on the mitigation of global warming *** from active fields were analyzed using machine learning principles based on PCA（Principal Component Analysis）and k-means clustering *** total12 primary parameters（reservoir temperature,reservoir depth,reservoir pressure,reservoir thickness,reservoir dip,permeability,porosity,wettability,heterogeneity,API gravity,oil viscosity,and oil saturation）,were categorized and *** the application of CO flooding,the minimum miscibility pressure（MMP）and reservoir temperature stands out since are fundamental requirements of miscibility,a condition where two fluids can be mixed in all proportions,and there is no interface between ***’s established from this study that over 210 projects are using the COflooding method,and the USA bears 81%of ***,a screening crit

关键词： Machine learning miscibility carbon dioxide principal component analysis

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Post-translational O-GlcNAcylation is essential for nuclear pore integrity and maintenance of the pore selectivity filter

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Journal of Molecular Cell Biology 2016年第1期8卷 2-16页

作者： Yanping Zhu Ta-Wei Liu Zarina Madden Scott A.Yuzwa Kelsey Murray Samy Cecioni Natasha Zachara david J.Vocadlo Department of Chemistry Simon Fraser UniversityBurnabyBritish Columbia V5A 1S6Canada Department of Molecular Biology and Biochemistry Simon Fraser UniversityBurnabyBritish Columbia V5A 1S6Canada Department of Biological Chemistry Johns Hopkins University Medical SchoolBaltimoreMD 21205USA

O-glycosylation of the nuclear pore complex(NPC)by O-linked N-acetylglucosamine(O-GlcNAc)is conserved within *** nucleoporins(Nups)comprising the NPC are constitutively O-GlcNAcylated,but the functional role of this modification remains *** loss ofO-GlcNAc,induced by either inhibition ofO-GlcNAc transferase(OGT)or deletion of the gene encoding OGT,leads to decreased cellular levels of a number of natively O-GlcNAcylated *** of O-GlcNAc enables increased ubiquitination of these Nups and their increased proteasomal *** decreased half-life of these deglycosylated Nups manifests in their gradual loss from the NPC and a downstream malfunction of the nuclear pore selective permeability barrier in both dividing and post-mitotic *** findings define a critical role of O-GlcNAc modification of the NPC in maintaining its composition and the function of the selectivity *** results implicate NPC glycosylation as a regulator of NPC function and reveal the role of conserved glycosylation of the NPC among metazoans.

关键词： post-translational modiﬁcation O-GlcNAcylation nuclear pore complex protein stability ubiquitination nucleoporin glycosylation

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OLD V Live long and prosper

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城市漫步（全国英文版） 2015年第5期 44-45页

作者： david W.Kay 不详

Eeryone is banging on about how China is getting old these ***'s all'ageing population1 this,'grey tide1 that and,quite frankly,it's getting kind of old(see what I did there?).Part of me can't help thinking that all this ageing society talk is just another stickfor the Western media to beat China with-China is quickly turning into a nation of pyjama-clad zombies who will wreck the economy before you can say"fancy a Weather's Original"!

关键词： turning ageing getting

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Quality Control of Selected Antimalarials Sold in the Illicit Market: An Investigation Conducted in Porto-Novo City (Republic of Benin)

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Advances in Bioscience and Biotechnology 2015年第10期6卷 637-644页

作者： Farid Baba-Moussa Jacob Bonou Hélène Ahouandjinou Tamègnon Victorien Dougnon Lisette Kpavode Nawal Raimi Aurore Ogouyemi-Hounto Idrissou Abdoulaye Fatiou Toukourou Frédéric Loko Dorothée kindé-Gazard Flore Gangbo Lamine Baba-Moussa National laboratory Control of Quality of Medicines and Edible Medical Ministry of Health Cotonou Benin Laboratory of Microbiology and Food Technology Faculty of Sciences and Techniques University of Abomey-Calavi Institute of Applied Biomedical Sciences Champ de Foire Cotonou Benin Research Laboratory in Applied Biology Polytechnic School of Abomey-Calavi University of Abomey-Calavi Cotonou Benin Parasitology and Mycology Laboratory Faculty of Health Sciences University of Abomey-Calavi Cotonou Benin Biochemistry Laboratory Faculty of Health Sciences CNHU-HKM Cotonou Benin Cytogenetics and Human Biology Laboratory ISBA-Champ de Foire Cotonou Benin Laboratory of Biology and Molecular Typing in Microbiology Faculty of Sciences and Techniques University of Abomey-Calavi Cotonou Benin

Malaria is a parasitic disease caused by the bite of female Anopheles mosquito and particularly affects the tropical areas of the world. According to national statistics it is the leading cause of consultations and hospitalizations. Nowadays, despite the surveillance systems for efficient malaria control and access to generic drugs, Benin is witnessing an increased development of illicit drug markets with a large part of the population going towards such markets. However, this is not without adverse impact on the health of individuals, as well as, the economic status of the country. Therefore, the situation needs to be seriously considered by policy makers at various levels, health professionals but also the entire international community in order to thwart this *** the aforementioned situation, the current study was undertaken aiming to perform a quality control of selected antimalarial drugs of the illegal market in Porto-Novo city. Therefore, 40 antimalarial batches were randomly collected in the illicit drug market and submitted to analytical tests such as: macroscopic examination (a visual and critical examination);mass uniformity test;disintegration test;identification test and active ingredients’ content measurement. At the end of the study, the percentages of non-compliance is 97.5%, 5%, 15% and 27.5%, respectively for the content uniformity tests, disintegration, identification and assay. Over-all, 42.5% of noncompliance was recorded. The findings of this study prove that street vended drugs offer no guarantee of good quality and pose a threat to the health of populations. Also, the rate of non-compliance denotes a flaw in the security of the drug distribution system.

关键词： Antimalarial Counterfeit Medicine Quality Control Illicit Market

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Scientific evidence is just the starting point: A generalizable process for developing sports injury prevention interventions

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Journal of Sport and Health Science 2016年第3期5卷 334-341页

作者： Alex Donaldson david G.Lloyd Belinda J.Gabbe Jill Cook Warren Young Peta White Caroline F.Finch Australian Centre for Research into Injury in Sport and its Prevention (ACRISP) Federation University Australia Centre for Musculoskeletal Research Griffith Health Institute Griffith University Department of Epidemiology and Preventive Medicine Monash University La Trobe Sport and Exercise Medicine Research Centre La Trobe University School of Health Sciences Federation University Australia

Background: The 2 most cited sports injury prevention research frameworks incorporate intervention development, yet little guidance is available in the sports science literature on how to undertake this complex process. This paper presents a generalizable process for developing implementable sports injury prevention interventions, including a case study applying the process to develop a lower limb injury prevention exercise training program(Footy First) for community Australian ***: The intervention development process is underpinned by 2 complementary premises:(1) that evidence-based practice integrates the best available scientific evidence with practitioner expertise and end user values and(2) that research evidence alone is insufficient to develop implementable ***: The generalizable 6-step intervention development process involves(1) compiling research evidence, clinical experience, and knowledge of the implementation context;(2) consulting with experts;(3) engaging with end users;(4) testing the intervention;(5) using theory; and(6)obtaining feedback from early implementers. Following each step, intervention content and presentation should be revised to ensure that the final intervention includes evidence-informed content that is likely to be adopted, properly implemented, and sustained over time by the targeted intervention deliverers. For Footy First, this process involved establishing a multidisciplinary intervention development group, conducting 2targeted literature reviews, undertaking an online expert consensus process, conducting focus groups with program end users, testing the program multiple times in different contexts, and obtaining feedback from early implementers of the ***: This systematic yet pragmatic and iterative intervention development process is potentially applicable to any injury prevention topic across all sports settings and levels. It will guide researchers wishing to undertake interventio

关键词： Australian football Implementation Intervention development Lower limb injuries Research-to-practice Sports injury prevention Translation

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Selective serotonin reuptake inhibitors in the treatment of premature ejaculation

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Chinese Medical Journal 2007年第11期120卷 1000-1006页

作者： WANG Wei-fu CHANG Le Suks Minhas david J Ralph Department of Urology People＇s Hospital of Hainan Province Haikou 570311 China Department of Gynaecology People＇s Hospital of Hainan Province Haikou 570311China St Peter＇s Department of Andrology Institute of Urology Middlesex Hospital UCL London UK W1T 3AA

Objective To review and assess the update studies regarding selective serotonin reuptake inhibitors （SSRIs） in the treatment of premature ejaculation （PE） and then provide practical recommendations and possible mechanisms concerning state of the art knowledge for the use of SSRIs in alleviating PE. Data sources Using the Medline, 48 articles published from January 1st, 1996 to August 1st, 2006 concerning the use of SSRIs and their possible mechanisms in alleviating PE were found and reviewed. Study selection PE, rapid ejaculation, early ejaculation and SSRIs were employed as the keywords, and relevant articles about the use of SSRIs and their possible mechanisms in the treatment of PE were selected. Results Many kinds of SSRIs, such as fluoxetine, sertraline, paroxetine and citalopram, have widely been employed to treat PE. However, their effects are moderate and there is no a universal agreement about the kind, dose, protocol and duration. Dapoxetine, as the first prescription treatment of PE, may change this bottle-neck situation. SSRIs are suggested to be used in young men with lifelong PE, and acquired PE when etiological factors are removed but PE still exists. Phosphodiesterase 5 inhibitors （PDE5-ls） are suggested to be employed alone or combined with SSRIs when SSRIs fail to treat PE or sexual dysfunction associated with SSRIs occurs. The protocol of taking drugs on demand based on taking them daily for a suitable period is proposed to be chosen firstly. The possible mechanisms include increasing serotonergic neurotransmission and activating 5-hydroxytryptamine 2C （5-HT2c） receptors, then switching the ejaculatory threshold to a higher level, decreasing the penile sensitivity and their own effect of antidepression. Conclusion The efficacies of the current SSRIs are moderate in the treatment of PE and they have not been approved by the FDA, therefore new SSRI like dapoxetine needs to be further evaluated.

关键词： premature ejaculation selective serotonin reuptake inhibitions

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Gauge Invariance of Gravitodynamical Potentials in the Jefimenko’s Generalized Theory of Gravitation

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Journal of Modern Physics 2016年第13期7卷 1617-1626页

作者： Augusto Espinoza Andrew Chubykalo david Perez Carlos Unidad Académica de Física Universidad Autónoma de Zacatecas Zacatecas México

In the Jefimenko’s generalized theory of gravitation, it is proposed the existence of certain potentials to help us to calculate the gravitational and cogravitational fields, such potentials are also presumed non-invariant under certain gauge transformations. In return, we propose that there is a way to perform the calculation of certain potentials that can be derived without using some kind of gauge transformation, and to achieve this we apply the Helmholtz’s theorem. This procedure leads to the conclusion that both gravitational and cogravitational fields propagate simultaneously in a delayed and in an instant manner. On the other hand, it is also concluded that these potentials thus obtained can be real physical quantities, unlike potentials obtained by Jefimenko, which are only used as a mathematical tool for calculating gravitational and cogravitational fields.

关键词： Gravitational Potentials Cogravitation Helmholtz’s Theorem

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三氟甲磺酸镱催化合成噁唑啉环取代酚(胺)及相关化合物

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化学研究与应用 2007年第5期19卷 535-538页

作者：费学宁 david J. Berg 天津城建学院天津300384 University of Victoria CanadaV8W 3V6

Phenolic Oxazoline is a kind of important *** this paper,Phenolic Oxazolines and its relative compounds were synthesized by a reaction of cyanophenols with aminoalcohol or diamine under the catalyzing of Yb(OSO2CF3)*** influence factors of this reaction were studied,such as the position of substituting groups,the type of cyclization and the kinds of solvent *** structures of thesis compounds were confimed by 1H NMR、13C NMR、Ms and *** a result,a method for the synthesis of Phenolic Oxazolines with a preliminary discussion was reported.

关键词：噁唑啉镧系催化剂三氟甲磺酸镱合成

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大别碰撞造山带的壳内低速体和壳幔界面的断错构造

大别碰撞造山带的壳内低速体和壳幔界面的断错构造

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地壳深部压力状态与地质作用学术研讨会

作者：刘启元 Rainer kind 陈九辉李顺成郭彪 Kurt Wylegalla 中国地震局地质研究所 GeoForschungZentrum Potsdam Telegrafenberg 14473 PotsdamGERMANY GeoForschungZentrum Potsdam Telegrafenberg 14473 Potsdam GERMANY

自20世纪80年代后期以来,由于超高压变质岩,特别是柯石英和微金刚石包裹体的发现,大别造山带超高压变质岩的形成及折返机理成为国内外地学界关注和研究的热点。虽然在大别山造山带研究方面取得了许多重要进展,但人们对大别碰撞造山带壳...

自20世纪80年代后期以来,由于超高压变质岩,特别是柯石英和微金刚石包裹体的发现,大别造山带超高压变质岩的形成及折返机理成为国内外地学界关注和研究的热点。虽然在大别山造山带研究方面取得了许多重要进展,但人们对大别碰撞造山带壳幔结构及其动力学过程的认识仍有待统一和深化。其主要原因在于,已有地震测深研究主要局限于地壳的深度范围,有关大别造山带下方上地幔速度结构研究仅有根据地震层析成像得到的低分辨率的探测结果。获取在岩石圈范围内大别山及其两侧的华北板块与扬子板块接触变形关系的高分辨率证据对进一步统一认识具有极其重要的意义。

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自豪感的概念、功能及其影响因素

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心理科学 2009年第6期32卷 1398-1400页

作者：张向葵冯晓杭 david Matsumoto 东北师范大学心理学系长春130024 东北师范大学儿童发展研究中心长春130024 San Francisco State University USA

自豪感是近年来备受关注的一种自我意识情绪,通常在目标达成或任务成功完成时,由自我评价或他人评价基础上产生。自豪感与羞愧、内疚、尴尬等自我意识情绪既有区别又有联系。社会比较、抚养环境、文化价值观是自豪感产生的主要影响因素... 详细信息

自豪感是近年来备受关注的一种自我意识情绪,通常在目标达成或任务成功完成时,由自我评价或他人评价基础上产生。自豪感与羞愧、内疚、尴尬等自我意识情绪既有区别又有联系。社会比较、抚养环境、文化价值观是自豪感产生的主要影响因素。自豪感产生的心理机制有待进一步探索。

关键词：自豪感自我意识情绪基本情绪

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