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Treating amyotrophic lateral sclerosis with allogeneic Schwann cell-derived exosomal vesicles: a case report

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Neural Regeneration Research 2025年第4期20卷 1207-1216页

作者： pascal j.Goldschmidt-Clermont Aisha Khan George j.msheleishvili patricia Graham Adriana Brooks Risset Silvera Alexander j.p.Goldschmidt Damien D.pearse W.Dalton Dietrich Allan D.Levi j.mes D.Guest Miller School of Medicine University of MiamiMiamiFLUSA Stem Cell Institute Miller School of MedicineUniversity of MiamiMiamiFLUSA The Miami proj.ct to Cure paralysis Miller School of MedicineUniversity of MiamiMiamiFLUSA Alzady International LLC MiamiFLUSA Neurological Surgery Miller School of MedicineUniversity of MiamiMiamiFLUSA

Schwann cells are essential for the maintenance and function of motor neurons,axonal networks,and the neuromuscular *** amyotrophic lateral sclerosis,where motor neuron function is progressively lost,Schwann cell function may also be ***,important signaling and potential trophic activities of Schwann cell-derived exosomal vesicles have been *** case report describes the treatment of a patient with advanced amyotrophic lateral sclerosis using serial intravenous infusions of allogeneic Schwann cell-derived exosomal vesicles,marking,to our knowledge,the first instance of such *** 81-year-old male patient presented with a 1.5-year history of rapidly progressive amyotrophic lateral *** initial diagnosis,the patient underwent a combination of generic riluzole,sodium phenylbutyrate for the treatment of amyotrophic lateral sclerosis,and *** patient volunteered to participate in an FDA-approved single-patient expanded access treatment and received weekly intravenous infusions of allogeneic Schwann cell-derived exosomal vesicles to potentially restore impaired Schwann cell and motor neuron *** confirmed that cultured Schwann cells obtained from the amyotrophic lateral sclerosis patient via sural nerve biopsy appeared impaired(senescent)and that exposure of the patient’s Schwann cells to allogeneic Schwann cell-derived exosomal vesicles,cultured expanded from a cadaver donor improved their growth capacity in *** a period of observation lasting 10 weeks,during which amyotrophic lateral sclerosis Functional Rating Scale-Revised and pulmonary function were regularly monitored,the patient received weekly consecutive infusions of 1.54×1012(×2),and then consecutive infusions of 7.5×1012(×6)allogeneic Schwann cell-derived exosomal vesicles diluted in 40 mL of Dulbecco’s phosphate-buffered *** of the infusions were associated with adverse events such as infusion reactions(allergic or otherwise)or

关键词： allogeneic amyotrophic lateral sclerosis exosomes infusion neuromuscular j.nction Schwann cell

problems, potentials and future of industrial crystallization

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Frontiers of Chemical Science and Engineering 2013年第1期7卷 1-8页

作者： j. Ulrich p. Frohberg Center for Engineering Science Thermal Process Engineering Martin Luther University Halle-Wittenberg D-06099 Halle (Saale) Germany

This review discusses important research developments and arising challenges in the field of industrial crystallization with an emphasis on recent problems. The most relevant areas of research have been identified. These are the prediction of phase diagrams; the prediction of effects of impurities and additives; the design of fluid dynamics; the process control with process analytical technologies （pAT） tools; the polymorph and solvate screening; the stabilization of non-stable phases; and the product design. The potential of industrial crystallization in various areas is outlined and discussed with particular reference to the product quality, process design, and control. On this basis, possible future directions for research and development have been pointed out to highlight the importance of crystallization as an outstanding technique for separation, purification as well as for product design.

关键词： industrial crystallization potentials and future product design

Factors Affecting Distribution of Vegetation Types on Abandoned Cropland in the Hilly-Gullied Loess plateau Region of China

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pedosphere 2008年第1期18卷 24-33页

作者： j.AO j.-Ying j. TZANOpOULOS p. XOFIS j. MITCHLEY Institute of Soil and Water Conservation Northwest Sci-Technology University of Agriculture and Forestry Yangling Shaanxi 712100 (China) Centre for Agro-Environmental Research Department of Agriculture The University of Reading Barley Gate PO Box237 Reading RG6 6.4 R (UK) Imperial College London Department of Agricultural Sciences Wye Campus Wye Ashford Kent TN25 5AH (UK) nstitute of Soil and Water Conservation Chinese Academy of Sciences and Ministry of Water Resources Yangling Shaanxi 712100 (China)

A study was conducted in the forest-steppe region of the Loess plateau to provide insight into the factors affecting the process of vegetation establishment,and to provide recommendations for the selection of indigenous species in order to speed up the succession process and to allow the establishment of vegetation more resistant to soil *** distinctive vegetation types were identified,and their distribution was affected not only by the time since abandonment but also by other environmental factors,mainly soil water and total p in the upper soil *** of the vegetation types,dominated by Artemisia scoparia,formed the early successional stage after abandonment while the other three types formed later successional stages with their distribution determined by the soil water content and total *** can be concluded that the selection of appropriate species for introduction to accelerate succession should be determined by the local conditions and especially the total p concentration and soil water content.

关键词： abandoned cropland Loess plateau soil erosion vegetation variation

A statistical study of the interdependence of solar wind parameters

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Chinese j.urnal of Astronomy and Astrophysics 2009年第4期9卷 485-493页

作者： Shollykutty j.hn p. j. Kurian Department of physics St Joseph’s CollegeAlappuzha.Kerala-688012 India physics Research Centre St.Berchmans’ CollegeChanganacherry Kerala-686101 India

Correlation analysis of solar wind parameters, namely solar wind velocity, proton density, proton temperature and mean interplanetary magnetic field （IMF） from the ACE spacecraft data near Earth, was done. To our best knowledge, this study is a novel one since we consider here only the parameters inside the solar wind, including the mean IMF and, hence, the solar wind is a self consistent system. We have proposed a Multiple Linear Regression （MLR） model for the prediction of the response variable （solar wind velocity） using the parameters proton density, proton temperature and mean IMF measured as daily averages. About 60% of the observed value can be predicted using this model. It is shown that, in general, the correlation between solar wind parameters is significant. A deviation from the prediction at the solar maximum is interpreted. These results are verified by a graphical method.

关键词： solar wind-statistical model-correlation-solar wind parameters

Simplified seismic performance assessment and implications for seismic design

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Earthquake Engineering and Engineering Vibration 2014年第S1期13卷 95-122页

作者： Timothy j.Sullivan david p.Welch Gian Michele Calvi University of pavia Department of Civil Engineering & ArchitecturePavia 27100Italy European Centre for Training and Research in Earthquake Engineering Pavia 27100Italy UME School ROSE ProgrammeIUSS Pavia phD candidate IUSS pavia professor

The last decade or so has seen the development of refined performance-based earthquake engineering(pBEE) approaches that now provide a framework for estimation of a range of important decision variables,such as repair costs,repair time and number of casualties. This paper reviews current tools for pBEE,including the pACT software,and examines the possibility of extending the innovative displacement-based assessment approach as a simplified structural analysis option for performance assessment. Details of the displacement-based s+eismic assessment method are reviewed and a simple means of quickly assessing multiple hazard levels is proposed. Furthermore,proposals for a simple definition of collapse fragility and relations between equivalent single-degree-of-freedom characteristics and multi-degree-of-freedom story drift and floor acceleration demands are discussed,highlighting needs for future research. To illustrate the potential of the methodology,performance measures obtained from the simplified method are compared with those computed using the results of incremental dynamic analyses within the pEER performance-based earthquake engineering framework,applied to a benchmark building. The comparison illustrates that the simplified method could be a very effective conceptual seismic design tool. The advantages and disadvantages of the simplified approach are discussed and potential implications of advanced seismic performance assessments for conceptual seismic design are highlighted through examination of different case study scenarios including different structural configurations.

关键词： performance-based earthquake engineering displacement-based assessment seismic assessment

The SARD variety of multi-fractality of ventricular epicardial mapping during ischemia

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Chinese Science Bulletin 2006年第7期51卷 809-814页

作者： CHEN Ying Martyn p. Nash NING Xinbao WANG Yelin david j. p.terson WANG j.n State Key Laboratory of Modern Acoustics Institute for Biomedical Electronical Engineering Nanjing University Nanjing 210093 China Engineering Science and Bioengineering Institute University of Auckland Private Bag 92019 NZ Laboratory of physiology University of Oxford Parks Road Oxford OX13PT UK

We have analyzed cardiac ische- mia-reperfusion in an animal model using epicardial electropotential mapping. We investigated the rela- tionship between ischemia and variability of multi- fractality in epicardial electrograms. We present a new parameter called the singularity spectrum area reference dispersion (SARD) that clearly demon- strates the change in multifractility with the extent of myocardiaischemia. By contrasting the 3D ventricular epicardial SARD map with the activation map, we conclude that myocardial ischemia significantly in- fluences the variety of multifractality of ventricular epicardium electrograms and the SARD parameter is useful in correlating multifractality of epicardial elec- trograms with location of ischemia closely.

关键词：局部缺血 SARD 非线性基因定位室性心外膜

Relative toxicity of three wheat herbicides to two species of Coccinellidae

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Insect Science 2010年第5期17卷 434-438页

作者： j. p. Michaud German Vargas Department of Entomology Kansas State University Hays Kansas USA

On the High plains of the USA, herbicides specific for broad-leaf weeds are regularly applied to winter wheat in the early spring, sometimes late enough to coincide with the colonization of fields by cereal aphids and their natural enemies. We tested the toxicity of three such herbicides, Ally （Dupont）, Rave （Syngenta） and 2,4-D ester （generic）, to neonate larvae of two coccinellid species important in cereal aphid biocontrol, Coleomegilla maculata DeGeer and Hippodamia convergens Gurrin-Mrneville. Topical treatment of larvae with 2,4-D resulted in 25% and 60% mortality in the two species, respectively, with surviving C. maculata larvae experiencing a 5% increase in developmental time. No significant effects were noted for the other two materials, save for a 2.5% increase in developmental time for C. maculata larvae exposed to Rave. No material caused significant mortality in either species when larvae were fed on prey （Schizaphis graminum Rondani） treated with herbicide 24 h earlier, although 2,4-D reduced developmental time slightly in C. maculata. When herbicide applications are delayed enough in spring to coincide with aphid activity in wheat, farmers can reduce the risk of disrupting biological control by selecting an alternative to 2,4-D.

关键词： 2,4-D Coleomegilla maculata dicamba Hippodamia convergens Schizaphis graminum thifensulfuron methyl

Solving the Dyson-Schwinger equation around its first singularities in the Borel plane

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Frontiers of physics 2016年第6期11卷 25-30页

作者： Clavier, pierre j. Bellon, Marc p. Sorbonne Universites UPMC Univ Paris 06 UMR 7589 LPTHE Paris France (GRID:grid.5805.8) (ISNI:***) CNRS UMR 7589 LPTHE Paris France (GRID:grid.4444.0) (ISNI:0000 0001 2112 9282)

The Dyson-Schwinger equation of the massless Wess-Zumino model is written as an equation over the anomalous dimension of the theory. Its asymptotic behavior is derived and the procedure to compute the perturbations of this asymptotic behavior is detailed. This procedure uses ill-defined obj.cts. To solve this, the Dyson-Schwinger equation is rewritten for the Borel plane. It is shown that the ill- defined procedure in the physical plane can be applied in the Borel plane. Other results obtained in the Borel plane are stated and the proof for one result is described.

关键词： Dyson-Schwinger equation Wess-Zumino model Borel transform

Chinese life cycle impact assessment factors

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j.urnal of Environmental Sciences 2001年第2期13卷 205-209页

作者： Yang, j.-X. Nielsen, p.H. Research Cntr. for Eco-Envtl. Sci. Chinese Academy of Sciences Beijing 100085 China

The methodological basis and procedures for determination of Chinese normalization references and weighting factors according to the EDIp-method is described. According to Chinese industrial development intensity and population density, China was divided into three regions and the normalization references for each region were calculated on the basis of an inventory of all of the region's environmental emissions in 1990. The normalization reference was determined as the total environmental impact potential for the area in question in 1990(Ep(j.90) divided by the population. The weighting factor was determined as the normalization reference (ER(j.90) divided by society's target contribution in the year 2000 based on Chinese political reduction plans, ER(j.T2000. This paper presents and discuss results obtained for eight different environmental impact categories relevant for China: global warming, stratospheric ozone depletion, acidification, nutrient enrichment, photochemical ozone formation and generation of bulk waste, hazardous waste and slag and ashes.

关键词： Environmental impact Global warming Life cycle Ozone Sustainable development