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Targeting chronic and evolving neuroinflammation following traumatic brain injury to improve long-term outcomes: insights from microglial-depletion models

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Neural Regeneration Research 2021年第5期16卷 976-977页

作者： Rebecca j.Henry david j.Loane Department of Anesthesiology and Shock Trauma and Anesthesiology Research(STAR)CenterUniversity of Maryland School of MedicineBaltimoreMDUSA School of Biochemistry and Immunology Trinity Biomedical Sciences InstituteTrinity CollegeDublinIreland

Microglia,the resident innate immune cells of the central nervous system(CNS),play important roles in brain development,maintenance,and *** brain sentinels,microglia adopt a surveillant state in healthy tissue characterized by a ramified scanning morphology that maintains CNS homeostasis and contributes to learningassociated synaptic plasticity.

关键词： inflammation homeostasis traumatic

A laser extinction based sensor for simultaneous droplet size and vapor measurement

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Particuology 2012年第1期10卷 9-16页

作者： Xueqiang Sun david j. Ewing Lin Ma College of Automatic Control and Mechanical Engineering Kunming University Kunming 650214 China Department of Aerospace and Ocean Engineering Virginia Tech Blacksburg VA 24063 USA

Multiphase flows involving liquid droplets in association with gas flow occur in many industrial and sci- entific applications. Recent work has demonstrated the feasibility of using optical techniques based on laser extinction to simultaneously measure vapor concentration and temperature and droplet size and loading. This work introduces the theoretical background for the optimal design of such laser extinction techniques, termed WMLE （wavelength-multiplexed laser extinction）. This paper focuses on the devel- opment of WMLE and presents a systematic methodology to guide the selection of suitable wavelengths and optimize the performance of WMLE for specific applications. WMLE utilizing wavelengths from 0.5 to 10 ixm is illustrated for droplet size and vapor concentration measurements in an example of water spray, and is found to enable unique and sensitive Sauter mean diameter measurement in the range of ~1-15 ~m along with accurate vapor detection. A vapor detection strategy based on differential absorp- tion is developed to extend accurate measurement to a significantly wider range of droplet loading and vapor concentration as compared to strategies based on direct fixed-wavelength absorption. Expected performance of the sensor is modeled for an evaporating spray. This work is expected to lay the ground- work for implementing optical sensors based on WMLE in a variety of research and industrial applications involving multi-phase flows.

关键词： Wavelength-multiplexed laser extinctionDropletMeasurementLaserExtinctionAbsorptionSpectroscopy

A Multi-parametric Programming Based Analytic Method to Compute Consumer Offer Curve for Reserves

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journal of Modern Power Systems and Clean Energy 2022年第2期10卷 542-546页

作者： Weiye Zheng david j.Hill Wenchuan Wu the School of Electrical Power Engineering South China University of TechnologyGuangzhouChina the Department of Electrical and Electronic Engineering The University of Hong KongHong KongChina the Department of Electrical Engineering Tsinghua UniversityBeijingChina

Abstract-An analytic method is proposed to compute the price-reserve offer curve at the consumer level in hierarchical direct load *** convexification of the consumer reserve provision is examined,and the analytic expression of the optimal solution within each critical region is ***,based on multi-parametric programming,a combinatorial enumeration method in conjunction with efficient reduction and pruning strategy is proposed to compute the optimal response of consumers in the whole price *** tests along with an application example in the bi-level aggregator pricing problem demonstrate the merit of this method.

关键词： Direct load control multi-parametric programming price-reserve offer curve analytic solution

Analysis of a Casimir-driven parametric amplifier with resilience to Casimir pull-in for MEMS single-point magnetic gradiometry

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Microsystems & Nanoengineering 2021年第5期7卷 183-193页

作者： josh javor Zhancheng Yao Matthias Imboden david K.Campbell david j.Bishop Department of Mechanical Engineering Boston UniversityBostonMA 02215USA Division of Materials Science and Engineering Boston UniversityBostonMA 02215USA K-MEMS St.BlaiseSwitzerland Department of Electrical Engineering Boston UniversityBostonMA 02215USA Department of Physics Boston UniversityBostonMA 02215USA Department of Biomedical Engineering Boston UniversityBostonMA 02215USA

The Casimir force,a quantum mechanical effect,has been observed in several microelectromechanical system(MEMS)*** to its extreme sensitivity to the separation of two objects,the Casimir force has been proposed as an excellent avenue for quantum *** application,however,is challenging due to attractive forces leading to stiction and device failure,called Casimir *** this work,we design and simulate a Casimir-driven metrology platform,where a time-delay-based parametric amplification technique is developed to achieve a steady-state and avoid *** apply the design to the detection of weak,low-frequency,gradient magnetic fields similar to those emanating from ionic currents in the heart and *** parameters are selected from recent experimental platforms developed for Casimir metrology and magnetic gradiometry,both on MEMS *** a MEMS offers many advantages to such an application,the detected signal must typically be at the resonant frequency of the device,with diminished sensitivity in the low frequency regime of biomagnetic *** a Casimir-driven parametric amplifier,we report a 10,000-fold improvement in the best-case resolution of MEMS single-point gradiometers,with a maximum sensitivity of 6 Hz/(pT/cm)at 1 *** development of the proposed design has the potential to revolutionize metrology and may specifically enable the unshielded monitoring of biomagnetic fields in ambient conditions.

关键词： parametric Casimir apply

Harnessing artificial intelligence for identifying conflicts of interest in research

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World journal of Methodology 2025年第1期15卷 6-8页

作者： Abdulqadir j Nashwan Department of Nursing&Midwifery Research Hamad Medical CorporationDoha 3050Qatar

This editorial explores the transformative potential of artificial intelligence(AI)in identifying conflicts of interest(COIs)within academic and scientific *** harnessing advanced data analysis,pattern recognition,and natural language processing techniques,AI offers innovative solutions for enhancing transparency and integrity in *** editorial discusses how AI can automatically detect COIs,integrate data from various sources,and streamline reporting processes,thereby maintaining the credibility of scientific findings.

关键词： Artificial intelligence Conflicts of interest Transparency Research integrity Natural language processing

Falling sperm counts and global oestrogenic pollution：postscript

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Asian journal of Andrology 2013年第2期15卷 208-211页

作者： Trevor G Cooper david j Handelsman Tuen Mun NT Hong Kong SAR PR China ANZAC Research Institute Concord Hospital & University of Sydney Sydney New South Wales 2139 Australia

This Special Issue provides reflections after 20 years, summarized in 12 papers, on the controversial issue of alleged decline in human sperm output due to global oestrogen pollution by industrial chemicals.

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Neuromodulator interactions and spinal cord injury in lamprey

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Neural Regeneration Research 2018年第4期13卷 643-644页

作者： david Parker Thomas j.McClelland Department of Physiology Neuroscience and DevelopmentUniversity of Cambridge

Neuromodulation is mediated by neurotransmitters that typically act on G-protein-coupled *** can confer behavioural flexibility by modifying the functional properties of anatomically hard-wired neural *** neuromodulators generally have divergent cellular and synaptic effects（Harris-Warrick and johnson,2010）,and different modulators,

关键词： Figure Neuromodulator interactions and spinal cord injury in lamprey

Falling sperm counts and global estrogenic pollution： what have we learned over 20 years？

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Asian journal of Andrology 2013年第2期15卷 159-161页

作者： david j Handelsman Trevor G Cooper ANZAC Research Institute Concord Hospital & University of Sydney Sydney New South Wales 2139 Australia Tuen Mun NT Hong Kong SAR PR ChinaGuest Editors for this special issue: Prof. DJ Handelsman

If scandal is the engine of progress in politics, and sensation is that of the media, while anti-modern panic is that of environmentalism, what is the dynamic of medical science？ Certainly discovery and invention represent the admirable high road, whereas competition and controversy represent the quotidian low road. This Special Issue is directed to reviewing the lessons learned from the most public, fervent and durable controversy in the short history of Andrology, the claims of world-wide falling sperm counts, due to global pollution by industrial estrogenic chemicals, published two decades ago.

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Neuroprotection by resveratrol-glucuronide and quercetin-glucuronide via binding to polyphenol-and glycosaminoglycan-binding sites in the laminin receptor

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Neural Regeneration Research 2025年第3期20卷 819-820页

作者： Rayudu Gopalakrishna jennifer Aguilar Emily Lee William j.Mack Department of Integrative Anatomical Sciences Keck School of MedicineUniversity of Southern CaliforniaLos AngelesCAUSA Department of Neurological Surgery Keck School of MedicineUniversity of Southern CaliforniaLos AngelesCAUSA

The dietary polyphenolic compounds resveratrol and quercetin prevent neurodegenerative diseases in experimental models;however, they reach the brain only in nanomolar concentrations in the glucuronidated and sulfated ... 详细信息

关键词： resveratrol molar dated