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Hormones and sport： physiology, pharmacology ＆ forensic science

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Asian journal of Andrology 2008年第3期10卷 348-350页

作者： Prof. david j. Handelsman Prof. Louis j. Gooren Department of Endocrinology VU University Medical Center Amsterdam 1007 MB the Netherlands. (E-mail: ljgooren@truemail.co.th)

Sport is probably the most ubiquitous voluntary human social activity. Defined as the playing of competitive games according to rules, sport forms a microcosm of human society that combines playfulness （＂homo luden... 详细信息

关键词： Hormones Sport physiology

Protein kinase small molecule inhibitors for rheumatoid arthritis: Medicinal chemistry/clinical perspectives

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World journal of Orthopedics 2014年第4期5卷 496-503页

作者： Charles j Malemud david E Blumenthal The Arthritis Research Laboratory Department of Medicine Division of Rheumatic Diseases Case Western Reserve University Cleveland OH 44106-5076 United States Department of Anatomy Case Western Reserve University Cleveland OH 44106-5076 United States School of Medicine Division of Rheumatology Veteran’s Administration Medical Center Cleveland OH 44106 United States

Medicinal chemistry strategies have contributed to the development, experimental study of and clinical trials assessment of the first type of protein kinase small molecule inhibitor to target the janus kinase/Signal Transducers and Activators of Transcription(jAK/STAT) signaling pathway. The orally administered small molecule inhibitor, tofacitinib, is the first drug to target the jAK/STAT pathway for entry into the armamentarium of the medical therapy of rheumatoid arthritis. The introduction of tofacitinib into general rheumatologic practice coupled with increasing understanding that additional cellular signal transduction pathways including the mitogen-activated protein kinase and phosphatidylinositide-3-kinase/Akt/mammalian target of rapa-mycin pathways as well as spleen tyrosine kinase also contribute to immune-mediated inflammatory in rheumatoid arthritis makes it likely that further development of orally administered protein kinase small molecule inhibitors for rheumatoid arthritis will occur in the near future.

关键词： Clinical trials Protein kinase Signal transduction Small molecule inhibitor Rheumatoid arthritis

Control of synthetic gene networks and its applications

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Frontiers of Electrical and Electronic Engineering in China 2017年第2期5卷 124-135页

作者： david j Menn Ri-Qi Su Xiao Wang School of Biological and Health Systems Engineering Arizona State University Tempe AZ 85287 USA

Background： One of the underlying assumptions of synthetic biology is that biological processes can be engineered in a controllable way. Results： Here we discuss this assumption as it relates to synthetic gene regulatory networks （GRNs）. We first cover the theoretical basis of GRN control, then address three major areas in which control has been leveraged： engineering and analysis of network stability, temporal dynamics, and spatial aspects. Conclusion： These areas lay a strong foundation for further expansion of control in synthetic GRNs and pave the way for future work synthesizing these disparate concepts.

关键词： synthetic biology gene regulatory networks modeling GRN control stochasticity

From Slater to Mott physics by epitaxially engineering electronic correlations in oxide interfaces

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npj Computational Materials 2021年第1期7卷 846-851页

作者： Carla Lupo Evan Sheridan Edoardo Fertitta david Dubbink Chris j.Pickard Cedric Weber Theory and Simulation of Condensed Matter King’s College LondonLondonUK Happy Electron Ltd LondonUK Department of Materials Science and Metallurgy University of CambridgeCambridgeUK Advanced Institute for Materials Research Tohoku UniversitySendaiJapan

Using spin-assisted ab initio random structure searches,we explore an exhaustive quantum phase diagram of archetypal interfaced Mott insulators,***-iron and lanthanum-titanium *** particular,we report that the charge transfer induced by the interfacial electronic reconstruction stabilises a high-spin ferrous Fe2+*** provide a pathway to control the strength of correlation in this electronic state by tuning the epitaxial strain,yielding a manifold of quantum electronic phases,***-Hubbard,charge transfer and Slater insulating ***,we report that the electronic correlations are closely related to the structural oxygen octahedral rotations,whose control is able to stabilise the low-spin state of Fe2+at low pressure previously observed only under the extreme high pressure conditions in the Earth’s lower ***,we provide avenues for magnetic switching via THz radiations which have crucial implications for next generation of spintronics technologies.

关键词： Slater lanthanum quantum

Keeping an eye on the diabetic foot: The connection between diabetic eye disease and wound healing in the lower extremity

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World journal of Diabetes 2022年第12期13卷 1035-1048页

作者： david j Ramsey james T Kwan Arjun Sharma Department of Ophthalmology Lahey Hospital and Medical CenterBurlingtonMA 01805United States Department of Ophthalmology Tufts University School of MedicineBostonMA 02111United States

Diabetic eye disease is strongly associated with the development of diabetic foot ulcers(DFUs).DFUs are a common and significant complication of diabetes mellitus(DM)that arise from a combination of micro-and macrovascular *** and associated metabolic dysfunction in DM lead to impaired wound healing,immune dysregulation,peripheral vascular disease,and diabetic neuropathy that predisposes the lower extremities to repetitive injury and progressive tissue damage that may ultimately necessitate *** retinopathy(DR)is caused by cumulative damage to the retinal microvasculature from hyperglycemia and other diabetes-associated *** severity of DR is closely associated with the development of DFUs and the need for lower extremity revascularization procedures and/or *** the lower extremity,the eye may also suffer end-organ damage from macrovascular compromise in the form of cranial neuropathies that impair its motility,cause optic neuropathy,or result in partial or complete ***,poor perfusion of the eye can cause ischemic retinopathy leading to the development of proliferative diabetic retinopathy or neovascular glaucoma,both serious,visionthreatening ***,diabetic corneal ulcers and DFUs share many aspects of impaired wound healing resulting from neurovascular,sensory,and immunologic ***,alterations in serum biomarkers,such as hemoglobin A1c,ceruloplasmin,creatinine,low-density lipoprotein,and highdensity lipoprotein,are associated with both DR and *** these parameters can aid in prognosticating long-term outcomes and shed light on shared pathogenic mechanisms that lead to end-organ *** frequent cooccurrence of diabetic eye and foot problems mandate that patients affected by either condition undergo reciprocal comprehensive eye and foot evaluations in addition to optimizing diabetes management.

关键词： Foot ulcer Diabetic Wound healing Diabetes complications Amputation Diabetic retinopathy Corneal ulcer

Ab Initio Molecular Dynamic Simulation on the Elasticity of Mg_3Al_2Si_3O_(12) Pyrope

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journal of Earth Science 2011年第2期22卷 169-175页

作者： Li Li Donald j Weidner john Brodholt Dario Alfe G david Price Mineral Physics Institute Department of Geosciences University of New York at Stony Brook Stony Brook NY 11790 USA Department of Earth Sciences University College London Gower Street London WC1E6BT UK

We calculated thermo-elastic properties of pyrope（Mg3Al2Si3O12） at mantle pressures and temperatures using Ab initio molecular dynamic simulation.A third-order Birch-Murnaghan equation at a reference temperature of 2 000 K fits the calculations with bulk modulus,K0=159.5 GPa,K0＇=4.3,V0=785.89 A3,Grüneisen parameter,γ0=1.15,q=0.80,Anderson Grüneisen parameter δT=3.76 and thermal expansion,α0=2.93×10^-5 K^-*** to room temperature,where V0=750.80 A3,γ0 and α0 become 1.11 and 2.47×10^-5 K^-*** elastic properties of pyrope are found to be nearly isotropic at transition zone conditions.

关键词： AIMD thermo-elasticity pyrope high pressure.

Two-Factor Cancelable Biometrics Authenticator

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journal of Computer Science & Technology 2007年第1期22卷 54-59页

作者：彭颖涵 Andrew T. B. j david N. C. L Faculty of Information Science and Technology Multimedia University dalan Ayev Keroh Lama 75450 Melaka Malaysia

Biometrics-based authentication system offers advantages of providing high reliability and accuracy. However the contemporary authentication system is impuissance to compromise. If a biometrics data is compromised, it cannot be replaced and rendered unusable. In this paper, a cancelable biometrics-based authenticator is proposed to solve this irrevocability issue. The proposed approach is a two-factor authentication system, which requires both of the random data and facial feature in order to access the system. In this system, tokenized pseudo-random data is coupled with momentbased facial feature via inner product algorithm. The output of the product is then discretized to generate a set of private binary code, coined as 2factor-Hashing code, which is acted as verification key. If this biometrics-based verification key is compromised, a new one can be issued by replacing a different set of random number via token replacement. Then, the compromised one is rendered completely useless. This feature offers an extra protection layer against biometrics fabrication since the verification code is replaceable. Experimental results demonstrate that the proposed system provides zero Equal Error Rate in which there is a clear separation in between the genuine and the imposter distribution populations.

关键词： cancelable biometrics face recognition Geometric moments,pseudo Zernike moment

Antiplane Wave Scattering from a Cylindrical Void in a Pre-Stressed Incompressible Neo-Hookean Material

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Communications in Computational Physics 2012年第2期11卷 367-382页

作者： William j.Parnell I.david Abrahams School of Mathematics Alan Turing BuildingUniversity of ManchesterManchesterM139PLUK

An isolated cylindrical void is located inside an incompressible nonlinearelasticmediumwhose constitutive behaviour is governed by a neo-Hookean strain energy ***-plane hydrostatic pressure is applied in the far-field so that the void changes its radius and an inhomogeneous region of deformation arises in the vicinity of the *** consider scattering from the void in the deformed configuration due to an incident field(of small amplitude)generated by a horizontally polarized shear(SH)line source,a distance r0(R0)away from the centre of the void in the deformed(undeformed)*** show that the scattering coefficients of this scattered field are unaffected by the pre-stress(initial deformation).In particular,they depend not on the deformed void radius a or distance r0,but instead on the original void size A and original distance R0.

关键词： Pre-stress incompressible neo-Hookean rubber incremental SH waves scattering line source

Rapid improvement in post-infectious gastroparesis symptoms with mirtazapine

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World journal of Gastroenterology 2014年第21期20卷 6671-6674页

作者： Shinjini Kundu Shari Rogal Abdulkader Alam david j Levinthal Medical Scientist Training Program University of Pittsburgh School of MedicinePittsburghPA 15261United States Division of Gastroenterology Hepatologyand NutritionDepartment of MedicineUniversity of Pittsburgh Medical CenterPittsburghPA 15213United States Department of Psychiatry Stony Brook University HospitalStony BrookNY 11794United States

We report the case of a 34-year-old woman with severe post-infectious gastroparesis who was transferred from an outside medical facility for a second opinion regarding management. This patient had no prior history of gastrointestinal symptoms. However, in the aftermath of a viral illness, she developed two months of intractable nausea, vomiting, and oral intake intolerance that resulted in numerous hospitalizations for dehydration and electrolyte disturbances. A solid-phase gastric emptying scan had confirmed delayed emptying, confirming gastroparesis. Unfortunately, conventional pro-kinetic agents and numerous anti-emetic drugs provided little or no relief of the patient’s symptoms. At our institution, the patient experienced a cessation of vomiting, reported a significant reduction in nausea, and tolerated oral intake shortly after taking mirtazapine. Based on mirtazapine’s primary action as a serotonin (5-HT) 1a receptor agonist, we infer that this receptor system mediated the clinical improvement through a combination of peripheral and central neural mechanisms. This report highlights the potential utility of 5-HT1a agonists in the management of nausea and vomiting. We conclude that mirtazapine may be effective in treating symptoms associated with non-diabetic gastroparesis that are refractory to conventional therapies.

关键词： Nausea Vomiting Gastroparesis Symptoms Mirtazapine Anti-emetics