检索结果-南通市图书馆

Targeting chronic and evolving neuroinflammation following traumatic brain injury to improve long-term outcomes: insights from microglial-depletion models

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Neural Regeneration Research 2021年第5期16卷 976-977页

作者： Rebecca j.Henry david j.Loane Department of Anesthesiology and Shock Trauma and Anesthesiology Research(STAR)CenterUniversity of Maryland School of MedicineBaltimoreMDUSA School of Biochemistry and Immunology Trinity Biomedical Sciences InstituteTrinity CollegeDublinIreland

Microglia,the resident innate immune cells of the central nervous system(CNS),play important roles in brain development,maintenance,and *** brain sentinels,microglia adopt a surveillant state in healthy tissue characterized by a ramified scanning morphology that maintains CNS homeostasis and contributes to learningassociated synaptic plasticity.

关键词： inflammation homeostasis traumatic

Geometrically constrained isogeometric parameterizedlevel-set based topology optimization via trimmed elements

在线全文

学校读者我要写书评

暂无评论

Frontiers of Mechanical Engineering 2016年第4期11卷 328-343页

作者： Yingjun WANG david j. BENSON School of Mechanical and Automotive Engineering South China University of Technology Guangzhou 510641 China Department ofMechanical Engineering McGill University Montreal H3AOC3 Canada Department of Structural Engineering University of California SanDiego 92093 USA

In this paper, an approach based on the fast point-in-polygon (PIP) algorithm and trimmed elements is proposed for isogeometric topology optimization (TO) with arbitrary geometric constraints. The isogeometric parameterized level-set-based TO method, which directly uses the non-uniform rational basis splines (NURBS) for both level set function (LSF) parameterization and objective function calculation, provides higher accuracy and efficiency than previous methods. The integration of trimmed elements is completed by the efficient quadrature rule that can design the quadrature points and weights for arbitrary geometric shape. Numerical examples demonstrate the efficiency and flexibility of the method.

关键词： isogeometric analysis topology optimization level set method arbitrary geometric constraint trimmed element

A laser extinction based sensor for simultaneous droplet size and vapor measurement

在线全文

学校读者我要写书评

暂无评论

Particuology 2012年第1期10卷 9-16页

作者： Xueqiang Sun david j. Ewing Lin Ma College of Automatic Control and Mechanical Engineering Kunming University Kunming 650214 China Department of Aerospace and Ocean Engineering Virginia Tech Blacksburg VA 24063 USA

Multiphase flows involving liquid droplets in association with gas flow occur in many industrial and sci- entific applications. Recent work has demonstrated the feasibility of using optical techniques based on laser extinction to simultaneously measure vapor concentration and temperature and droplet size and loading. This work introduces the theoretical background for the optimal design of such laser extinction techniques, termed WMLE （wavelength-multiplexed laser extinction）. This paper focuses on the devel- opment of WMLE and presents a systematic methodology to guide the selection of suitable wavelengths and optimize the performance of WMLE for specific applications. WMLE utilizing wavelengths from 0.5 to 10 ixm is illustrated for droplet size and vapor concentration measurements in an example of water spray, and is found to enable unique and sensitive Sauter mean diameter measurement in the range of ~1-15 ~m along with accurate vapor detection. A vapor detection strategy based on differential absorp- tion is developed to extend accurate measurement to a significantly wider range of droplet loading and vapor concentration as compared to strategies based on direct fixed-wavelength absorption. Expected performance of the sensor is modeled for an evaporating spray. This work is expected to lay the ground- work for implementing optical sensors based on WMLE in a variety of research and industrial applications involving multi-phase flows.

关键词： Wavelength-multiplexed laser extinctionDropletMeasurementLaserExtinctionAbsorptionSpectroscopy

A Multi-parametric Programming Based Analytic Method to Compute Consumer Offer Curve for Reserves

在线全文

学校读者我要写书评

暂无评论

journal of Modern Power Systems and Clean Energy 2022年第2期10卷 542-546页

作者： Weiye Zheng david j.Hill Wenchuan Wu the School of Electrical Power Engineering South China University of TechnologyGuangzhouChina the Department of Electrical and Electronic Engineering The University of Hong KongHong KongChina the Department of Electrical Engineering Tsinghua UniversityBeijingChina

Abstract-An analytic method is proposed to compute the price-reserve offer curve at the consumer level in hierarchical direct load *** convexification of the consumer reserve provision is examined,and the analytic expression of the optimal solution within each critical region is ***,based on multi-parametric programming,a combinatorial enumeration method in conjunction with efficient reduction and pruning strategy is proposed to compute the optimal response of consumers in the whole price *** tests along with an application example in the bi-level aggregator pricing problem demonstrate the merit of this method.

关键词： Direct load control multi-parametric programming price-reserve offer curve analytic solution

Falling sperm counts and global oestrogenic pollution：postscript

在线全文

学校读者我要写书评

暂无评论

Asian journal of Andrology 2013年第2期15卷 208-211页

作者： Trevor G Cooper david j Handelsman Tuen Mun NT Hong Kong SAR PR China ANZAC Research Institute Concord Hospital & University of Sydney Sydney New South Wales 2139 Australia

This Special Issue provides reflections after 20 years, summarized in 12 papers, on the controversial issue of alleged decline in human sperm output due to global oestrogen pollution by industrial chemicals.

关键词： SEMEN

Neuromodulator interactions and spinal cord injury in lamprey

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Neural Regeneration Research 2018年第4期13卷 643-644页

作者： david Parker Thomas j.McClelland Department of Physiology Neuroscience and DevelopmentUniversity of Cambridge

Neuromodulation is mediated by neurotransmitters that typically act on G-protein-coupled *** can confer behavioural flexibility by modifying the functional properties of anatomically hard-wired neural *** neuromodulators generally have divergent cellular and synaptic effects（Harris-Warrick and johnson,2010）,and different modulators,

关键词： Figure Neuromodulator interactions and spinal cord injury in lamprey

Falling sperm counts and global estrogenic pollution： what have we learned over 20 years？

在线全文

学校读者我要写书评

暂无评论

Asian journal of Andrology 2013年第2期15卷 159-161页

作者： david j Handelsman Trevor G Cooper ANZAC Research Institute Concord Hospital & University of Sydney Sydney New South Wales 2139 Australia Tuen Mun NT Hong Kong SAR PR ChinaGuest Editors for this special issue: Prof. DJ Handelsman

If scandal is the engine of progress in politics, and sensation is that of the media, while anti-modern panic is that of environmentalism, what is the dynamic of medical science？ Certainly discovery and invention represent the admirable high road, whereas competition and controversy represent the quotidian low road. This Special Issue is directed to reviewing the lessons learned from the most public, fervent and durable controversy in the short history of Andrology, the claims of world-wide falling sperm counts, due to global pollution by industrial estrogenic chemicals, published two decades ago.

关键词： EXTERNAL QUALITY-CONTROL SEMEN ANALYSIS REFERENCE RANGE IN-UTERO BIAS MEN ASSOCIATION GUIDELINES FERTILITY

Light scattering and surface plasmons on small spherical particles

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Light(Science & Applications) 2014年第1期3卷 182-195页

作者： Xiaofeng Fan Weitao Zheng david j Singh College of Materials Science and Engineering Jilin UniversityChangchun 130012China Materials Science and Technology Division Oak Ridge National LaboratoryOak RidgeTennessee 37831-6056USA

Light scattering by small particles has a long and interesting history in ***,it continues to surprise with new insights and *** includes new discoveries,such as novel plasmonic effects,as well as exciting theoretical and experimental developments such as optical trapping,anomalous light scattering,optical tweezers,nanospasers,and novel aspects and realizations of Fano *** have led to important new applications,including several ones in the biomedical area and in sensing techniques at the single-molecule *** are additionally many potential future applications in optical devices and solar energy *** we review the fundamental aspects of light scattering by small spherical particles,emphasizing the phenomenological treatments and new developments in this field.

关键词： light scattering Mie theory nano-optics small particles surface plasmons

Ribozymes and the mechanisms that underlie RNA catalysis

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Frontiers of Chemical Science and Engineering 2016年第2期10卷 178-185页

作者： Timothy j. Wilson Yijin Liu david M. j. Lilley Cancer Research UK Nucleic Acid Structure Research Group MSI/WTB Complex The University of Dundee Dundee DD1 5EH UK

Ribozymes are widespread, and catalyze some extremely important reactions in the cell. Mechanistically most fall into one of two classes, using either metal ions or general acid-base catalysis. The nucleolytic ribozymes fall into the latter class, mostly using nucleobases. A sub-set of these use a combination of guanine base plus adenine acid to catalyze the cleavage reaction. New ribozymes are still being discovered at regular intervals and we can speculate on the potential existence of ribozymes that catalyze chemistry beyond phosphoryl transfer reactions, perhaps using small-molecule coenzymes.

关键词： RNA catalysis RNA structure catalytic mechanism