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Efficacy and safety of tenofovir in chronic hepatitis B: Australian real world experience

World Journal of Hepatology 2017年第1期9卷 48-56页

作者： Grace C Lovett Tin Nguyen david M iser Jacinta A Holmes Robert Chen Barbara Demediuk Gideon Shaw Sally J Bell Paul V Desmond Alexander J Thompson Department of Gastroenterology St Vincent’s Hospital Melbourne Faculty of Medicine University of Melbourne

AIMTo evaluate the long-term treatment outcomes of tenofovir therapy in patients in a real world Australian tertiary care setting. METHODSWe performed a retrospective analysis of treatment outcomes among treatment-naïve and treatment-experienced patients receiving a minimum 3 mo tenofovir therapy through St Vincent’s Hospital Melbourne, Australia. We included patients receiving tenofovir [tenofovir disoproxil fumarate (TDF)] monotherapy, as well as patients treated with TDF in combination with a second antiviral agent. Patients were excluded if they demonstrated human immune-deficiency virus/hepatitis C virus/hepatitis delta virus coinfection or were less than 18 years of age. We considered virological and biochemical response, as well as safety outcomes. Virological response was determined by measurement of hepatitis B virus (HBV) DNA using sensitive assays; biochemical response was determined via serum liver function tests; histological response was determined from liver biopsy and fibroscan; safety analysis focused on glomerular renal function and bone mineral density. The primary efficacy endpoint was complete virological suppression over time, defined by HBV DNA RESULTSNinety-two patients were identified who fulfilled the enrolment criteria. Median follow-up was 26 mo (range 3-114). Mean age was 46 (24-78) years, 64 (70%) were male and 77 (84%) were of Asian origin. 55 (60%) patients were treatment-naïve and 62 patients (67%) were HBeAg-negative. Complete virological suppression was achieved by 45/65 (71%) patients at 12 mo, 37/46 (80%) at 24 mo and 25/28 (89%) at 36 mo. Partial virological response (HBV DNA 20-2000 IU/mL) was achieved by 89/92 (96.7%) of patients. Multivariate analysis showed a significant relationship between virological suppression at end of follow-up and baseline HBV DNA level (OR = 0.897, 95%CI: 0.833-0.967, P = 0.0046) and HBeAg positive status (OR = 0.373, 95%CI: 0.183-0.762, P = 0.0069). There was no difference in respon

关键词： Tenofovir Hepatitis B virus Australia Real-life Virological suppression Chronic hepatitis B

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Human immunodeficiency virus infection and the liver

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World Journal of Hepatology 2012年第3期4卷 91-98页

作者： Megan Crane david iser Sharon R Lewin Department of Medicine Monash University Centre for Virology Burnet Institute Department of Gastroenterology St Vincent's Hospital Australia Infectious Disease Unit

Liver disease in human immunodeficiency virus(HIV)-infected individuals encompasses the spectrum from abnormal liver function tests,liver decompensation,with and without evidence of cirrhosis on biopsy,to non-alcoholic liver disease and its more severe form,non-alcoholic steatohepatitis and hepatocellular *** can infect multiple cells in the liver,leading to enhanced intrahepatic apoptosis,activation and *** can also alter gastro-intestinal tract permeability,leading to increased levels of circulating lipopolysaccharide that may have an impact on liver *** review focuses on recent changes in the epidemiology,pathogenesis and clinical presentation of liver disease in HIV-infected patients,in the absence of co-infection with hepatitis B virus or hepatitis C virus,with a specific focus on issues relevant to low and middle income countries.

关键词： Human immunodeficiency virus Liver dis-ease Low-middle income settings

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Synergistic effect of cobalt and niobium in Co_(3)-Nb-O_(x)on performance of selective catalytic reduction of NO with NH_(3)

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Rare Metals 2022年第1期41卷 166-178页

作者： Bo-Lin Zhang Li-Feng Deng Bo Liu Chun-Yun Luo Michael Liebau Shen-Gen Zhang Roger Glaser Institute for Advanced Materials and Technology University of Science and Technology BeijingBeijing 100083China Shunde Graduate School University of Science and Technology BeijingFoshan 528399China Jiangsu Longkingcotech Co. Ltd.Yancheng 224000China Institute of Chemical Technology Universita¨t LeipzigLeipzig 04103Germany e-mail:roger.glaeser

Combining the redox properties of Co and the acid properties of Nb in a Co_(3)-Nb-O_(x)catalyst is shown to provide superior performance in the selective catalytic reduction of NO with NH_(3)(NH_(3)-SCR).Co_(3)O_(4)shows average activity,however,it exhibits a poor N_(2)***_(2)O_(5)is not active for NH_(3)-***,the mixed Co_(3)-Nb-O_(x) catalyst shows higher NO conversion and N_(2)selectivity than the single Co_(3)O_(4)and Nb_(2)O_(5)catalysts at 100–300℃.The results of temperature programmed reduction by H_(2)and X-ray photoelectron(XP)spectra indicate that the addition of Nb changes the chemical states of Co and decreases the concentration of Co^(3+) and Oa,adjusting the activity for catalytic oxidation to a moderate *** suppresses the formation of undesired N_(2)O from the over-oxidation of NH_(3).Incorporation of Co and Nb into one solid synergistically couples their redox behavior and surface acidity,ensuring the high catalytic activity and N2 selectivity in NH3-SCR.

关键词： Co-Nb Selective catalytic reduction Lowtemperature Acid property Redox behavior

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Obesity in people with diabetes in COVID-19 times: Important considerations and precautions to be taken

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World Journal of Clinical Cases 2021年第20期9卷 5358-5371页

作者： Adriano Alberti Fabiana Schuelter-Trevisol Betine Pinto Moehlecke iser Eliane Traebert Viviane Freiberger Leticia Ventura Gislaine Tezza Rezin Bruna Becker da Silva Fabiana Meneghetti Dallacosta Leoberto Grigollo Paula Dias Gracielle Fin Josiane Aparecida De Jesus Fabiane Pertille Carina Rossoni Ben Hur Soares Rudy JoséNodari Júnior Clarissa Martinelli Comim Research Group in Neurodevelopment of Childhood and Adolescence Laboratory of Experimental NeurosciencePostgraduate Program in Health SciencesUniversity of South Santa Catarina(Unisul)Palhoça88137-270Santa CatarinaBrazil Brazil Clinical Research Center Postgraduate Program in Health SciencesUniversity of Southern Santa Catarina at TubarãoTubarão88704-900Santa CatarinaBrazil Postgraduate Programme in Health Sciences University of Southern Santa CatarinaPalhoça88137-270Santa CatarinaBrazil Postgraduate Program in Biosciences and Health University of the West of Santa CatarinaJoaçaba89600-000Santa CatarinaBrazil Department of Physical Education University of the West of Santa CatarinaJoaçaba89600-000Santa CatarinaBrazil Environmental Health Institute of the Faculty of Medicine of the University of Lisbon Lisboa1649-029Portugal Health Science University of Passo FundoPasso Fundo99052-900Rio Grande do SulBrazil Research department Salus DermatoglifiaLuzerna89609-000Santa CatarinaBrazil

At the end of 2019,a new disease with pandemic potential appeared in *** was a novel coronavirus called coronavirus disease 2019(COVID-19).Later,in the first quarter of 2020,the World Health Organization declared the outbreak of this disease a *** people,people with comorbidities,and health care professionals are more vulnerable to *** has been growing exponentially worldwide,affecting several age *** is a morbidity that is associated with genetic,epigenetic,environment factors and/or interaction between *** is associated with the development of several diseases including diabetes mellitus,mainly type *** affects a significant portion of the global *** and diabetes are among the main risk factors for the development of severe symptoms of COVID-19,and individuals with these conditions constitute a risk *** on a literature review on obesity in people with diabetes in the framework of the COVID-19 pandemic,this study presents updated important considerations and care to be taken with this population.

关键词： Obesity Diabetes COVID-19 Population World Disease

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Synthesis and Radiation Dosimetry of [68Ga]-Ga-Lys1, Lys3-DOTA-Bombesin (1,14) Antagonist for PET-Imaging, as a Potential Theragnostic Tracer in Oncology

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Journal of Encapsulation and Adsorption Sciences 2020年第2期10卷 29-41页

作者： Juan C. Manrique-Arias Quetzali Pitalua-Cortes Roberto Pedrero-Piedras Géiser Rodríguez-Mena Tessy López Cristian Cabezas-Ortiz Osvaldo García-Pérez Departamento de Medicina Nuclear Ciclotrón y Radiofarmacia Instituto Nacional de Cancerología México City México Cancer Center Cyclotron Department Doctors Hospital Monterrey México Departamento de Atención a la Salud Universidad Autónoma Metropolitana-Xochimilco México City México

This Bombesin (BBN), a tetradecapeptide analog of human gastrin-releasing peptide (GRP) with a high binding affinity for GRP receptors (GRPR), is over- expressed in early stages of androgen-dependent prostate carcinomas, but not in advanced stages. Therefore, there is a need to develop effective tracers for the accurate and specific detection of this disease. The objective of this study was to evaluate Lys1, Lys3-DOTA-BBN (1,14) analog with the radiolabeled positron emitter [68Ga]-Ga-BBN for receptor imaging with PET, and to determine its biodistribution and radiation dosimetry using whole-body (WB) PET scans in healthy volunteers. The highest uptake was in the pancreas, followed by urinary bladder. The critical organ was pancreas with a mean absorbed dose of 206 ± 0.7, 210 ± 0.7, 120 ± 0.9, 390.23 ± 0.6 μGy/MBq and the effective doses were estimated as 73.2 ± 0.6, 49.8 ± 0.3 μGy/MBq (women and men, respectively).

关键词： Radiation Dosimetry Biodistribution PET Imaging Radiopharmaceutical Lys1 Lys3-DOTA-BBN (1 14) Bombesin Analogs

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虚构与想象文学人类学疆界

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丛书名：国际美学前沿丛书

2003年

作者：（德）沃尔夫冈·伊瑟尔（Wolfgang iser）陈定家汪正龙等译

本书反映了虚构是一种越界行为。虚构化行为包括三个各有其独立性的行为，即：选择、融合以及自解。

ISBN: (数字)7206041108

ISBN: (纸本)7206041108

本书反映了虚构是一种越界行为。虚构化行为包括三个各有其独立性的行为，即：选择、融合以及自解。

关键词：美学研究

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失败的艺术:贝克特戏剧中被中断的笑

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戏剧（中央戏剧学院学报） 2022年第3期203卷 54-89页

作者： [德]沃尔夫冈·伊瑟尔李言实(译) 刘雅(校) 不详太原理工大学外国语学院美国纽约州立大学石溪分校英语系

在贝克特戏剧的演出中,观众会突然爆发出大笑,但是又会突然戛然而止。这是一种被中断的笑。这种突然爆发又突然中止的笑表现了文学作品和人类行为的相互影响。通过讨论喜剧与笑之间的关系,本文认为喜剧是由两种对立的因素之中一方的崩... 详细信息

在贝克特戏剧的演出中,观众会突然爆发出大笑,但是又会突然戛然而止。这是一种被中断的笑。这种突然爆发又突然中止的笑表现了文学作品和人类行为的相互影响。通过讨论喜剧与笑之间的关系,本文认为喜剧是由两种对立的因素之中一方的崩塌造成的,其结果就是笑。笑是身体对危机处境的回应,起到缓解紧张,摆脱困境的作用。本文以《等待戈多》和《终局》为例,分析了戏剧结构与观众的艺术体验之间的关系。在观看贝克特戏剧时,观众将自己投射进剧中,因此观众自己既是被表现事物的生产者同时又是接收者,这样一个去中心化的主体,以不断创造和否定意义的过程,使得自我与艺术本身一样成为一种体验。

关键词：贝克特戏剧中断的笑失败喜剧艺术体验

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从噬菌体显示程序中筛选抗响尾蛇毒素的组合抗体的特异性和结合亲和性

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蛇志 2002年第4期14卷 13-18页

作者： JIANXIN MENG TED R.JOHN IVANI.KA iser 尹惠琼(译) 范泉水(校) 成都军区联勤部军事医学研究所云南昆明650032 Wyoming大学分子生物系

我们用 Pharmacia公司的重组噬菌体抗体系统的组合方法制出一种对响尾蛇毒素特异的、具有高亲和力的单克隆单链抗体可变区 (sc Fv)。筛选出一个高亲和力的克隆 ,编号为 A1 0 G,对其 DNA进行了测序。A1 0 G蛋白显示出高的反应特异性 ,只... 详细信息

我们用 Pharmacia公司的重组噬菌体抗体系统的组合方法制出一种对响尾蛇毒素特异的、具有高亲和力的单克隆单链抗体可变区 (sc Fv)。筛选出一个高亲和力的克隆 ,编号为 A1 0 G,对其 DNA进行了测序。A1 0 G蛋白显示出高的反应特异性 ,只与响尾蛇神经毒素、concolor毒素和 Mojave毒素有密切的关系。用第二组磷脂酶 A2 s (PLA2 s)筛选 ,与 1 1种显示出交叉反应。第一组磷脂酶 A2 s (PLA2 s)在 ELISA中有交叉反应。编码A1 0 G的基因被亚克隆到一个表达载体 ,结果表达非融合蛋白 ,标记为 A1 0 GPE,复性、纯化至表面均一性。A1 0 G与完整响尾蛇毒素和响尾蛇毒素基本亚单位的解离常数分别为 7× 1 0 - 1 0 M和 6.8× 1 0 - 9M。当 A1 0 GPE与响尾蛇毒素基本亚单位或响尾蛇全毒素以摩尔比 5 :1预先孵育 ,则没有抑制磷脂酶活性现象。然而 ,表达蛋白可以在小鼠中部分中和响尾蛇毒素同系物

关键词：噬菌体显示程序筛选抗响尾蛇毒素组合抗体结合亲和性

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