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Recent advances towards single biomolecule level understanding of protein adsorption phenomena unique to nanoscale polymer surfaces with chemical variations

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Nano Research 2020年第5期13卷 1295-1317页

作者： david h.cho Tian Xie Johnson Truong Andrew C.Stoner Jong-in hahm Department of Chemistry Georgetown University37th&O Sts.NW.WashingtonDC 20057USA

Protein adsorption onto polymer surfaces is a very complex and ubiquitous phenomenon whose integrated process impacts essential applications in our daily lives such as food packaging materials,health devices,diagnostic tools,and medical ***,novel polymer materials with greater chemical intricacy and reduced dimensionality are used for various applications involving adsorbed proteins on their ***,the nature of protein-surface interactions to consider is becoming much more complicated than before.A large body of literature exists for protein ***,most of these investigations have focused on collectively measured,ensemble-averaged protein behaviors that occur on macroscale and chemically unvarying polymer surfaces instead of direct measurements at the single protein or sub-protein *** addition,interrogations of protein-polymer adsorption boundaries in these studies were typically carried out by indirect methods,whose insights may not be suitably applied for explaining individual protein adsorption processes occurring onto nanostructured,chemically varying polymer ***,an important gap in our knowledge still exists that needs to be systematically addressed via direct measurement means at the single protein and sub-protein *** efforts will require multifaceted experimental and theoretical approaches that can probe multilength scales of protein adsorption,while encompassing both single proteins and their collective ensemble behaviors at the length scale spanning from the nanoscopic all the way to the macroscopic *** this review,key research achievements in nanoscale protein adsorption to date will be ***,protein adsorption studies involving polymer surfaces with their defining feature dimensions and associated chemical partitions comparable to the size of individual proteins will be discussed in *** this regard,recent works bridging the crucial knowledge gap in protein adso

关键词： nanoscale protein adsorption nanoscale protein assembly protein self-assembly on polymer protein nanopatterning protein-nanosurface interaction

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Iron-promoted zirconia-alumina supported Ni catalyst for highly efficient and cost-effective hydrogen production via dry reforming of methane

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Journal of Environmental Sciences 2025年第2期148卷 274-282页

作者： Ahmed S.Al-Fatesh Naitik Patel Vijay Kumar Srivastava Ahmed I.Osman david W.Rooney Anis h.Fakeeha Ahmed E.Abasaeed Mohammed F.Alotibi Rawesh Kumar Chemical Engineering Department College of EngineeringKing Saud UniversityP.O.Box 800Riyadh 11421Saudi Arabia Department of Chemistry Indus UniversityAhmedabadGujarat 382115India School of Chemistry and Chemical Engineering Queen’s University BelfastBelfast BT95AGNorthern IrelandUK Institute of Refining and Petrochemicals Technologies King Abdulaziz City for Science and Technology(KACST)P.O.Box 6086Riyadh 11442Kingdom of Saudi Arabia

Developing cost-effective and high-performance catalyst systems for dry reforming of methane(DRM)is crucial for producing hydrogen(h_(2))***,we investigate using iron(Fe)as a promoter and major alumina support in Ni-based catalysts to improve their DRM *** addition of iron as a promotor was found to add reducible iron species along with reducible NiO species,enhance the basicity and induce the deposition of oxidizable *** incorporating 1 wt.%Fe into a 5Ni/10ZrAl catalyst,a higher CO_(2) interaction and formation of reducible"NiO-species having strong interaction with support"was observed,which led to an∼80%h_(2) yield in 420 min of Time on Stream(TOS).Further increasing the Fe content to 2 wt.%led to the formation of additional reducible iron oxide species and a noticeable rise in h_(2) yield up to 84%.Despite the severe weight loss on Fe-promoted catalysts,high h_(2) yield was maintained due to the proper balance between the rate of Ch_(4) decomposition and the rate of carbon deposit ***,incorporating 3 wt.%Fe into the 5Ni/10ZrAl catalyst resulted in the highest CO_(2) interaction,wide presence of reducible NiO-species,minimumgraphitic deposit and an 87%h_(2) *** findings suggest that ironpromoted zirconia-alumina-supported Ni catalysts can be a cheap and excellent catalytic system for h_(2) production via DRM.

关键词： Dry reforming of methane Coke resistant hydrogen production Cheap catalyst Fe-promoted catalyst

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Making bridges between preclinical and clinical insights into age-related cognitive decline

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Neural Regeneration Research 2025年第8期20卷 2321-2322页

作者： david VC Brito Clévio Nóbrega Algarve Biomedical Center-Research Institute(ABC-RI) Campus GambelasFaroPortugal Algarve Biomedical Center-(ABC) Campus GambelasFaroPortugal Faculty of Medicine and Biomedical Sciences(FMCB) University of AlgarveGambelas CampusFaroPortugal

With people living longer,the societal impact of age-related cognitive decline is becoming more pronounced(Crimmins,2015).Thus,it is increasingly important to comprehend the cognitive shifts linked to aging-whether th... 详细信息

关键词： bridges becoming insight

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Strong resistance toβ-cyfluthrin in a strain of the beetle Alphitobius diaperinus:a de novo transcriptome analysis

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Insect Science 2025年第1期32卷 209-226页

作者： Gwenola Gouesbet david Renault Stéphane APDerocles hervéColinet CNRS ECOBIO(EcosystèmesBiodiversitéÉvolution)—UMR 6553University of RennesRennesFrance Institut Universitaire de France 1 rue DescartesCEDEX 05ParisFrance

The lesser mealworm,Alphitobius diaperinus,is an invasive tenebrionid beetle and a vector of *** to the emergence of insecticide resistance and consequent outbreaks that generate significant phytosanitary and energy costs for poultry farmers,it has become a major insect pest *** better understand the molecular mechanisms behind this resistance,we studied a strain of *** from a poultry house in Brittany that was found to be highly resistant to theβ-*** strain survivedβ-cyfluthrin exposures corresponding to more than 100 times the recommended *** used a comparative de novo RNA-Seq approach to explore genes expression in resistant versus sensitive *** de novo transcriptomic analyses showed that responses toβ-cyfluthrin likely involved a whole set of resistance *** related to detoxification,metabolic resistance,cuticular hydrocarbon biosynthesis and proteolysis were found to be constitutively overexpressed in the resistant compared to the sensitive ***-up enzymatic assays confirmed that the resistant strain exhibited high basal activities for detoxification enzymes such as cytochrome P450 monooxygenase and *** in-depth analysis of differentially expressed genes suggests the involvement of complex regulation of signaling *** knowledge of these resistance mechanisms is essential for the establishment of effective pest control.

关键词： Alphitobius diaperinus de novo transcriptome insecticide resistance P450 xenobiotic metabolism

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Women in visual neural regeneration research

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Neural Regeneration Research 2025年第2期20卷 489-490页

作者： Tonia S.Rex david J.Calkins Vanderbilt Eye Institute Vanderbilt University Medical CenterNashvilleTNUSA

The year 2024 marks the 60^(th)anniversary of Title IX and 25 years since the New York Times revealed bias against female faculty members at the Massachusetts Institute of *** take an opportunity here to examine the state of gender bias in a relatively new yet already prominent field,neural regeneration in the visual system,for which there is a well-defined context useful for this *** National Eye Institute(NEI)provided the first round of research funding for its Audacious Goals Initiative(AGI)on visual neural regeneration in 2013 and the last round in ***,we focus on this *** sources included PubMed,the National Science Foundation(NSF),the NEI,the Blue Ridge Institute for Medical Research and data from the major professional organization for eye and vision research,the Association for Research in Vision and Ophthalmology(ARVO).

关键词： neural visual Times

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Why is China Promoting Economic Globalization?A Leadership Theory of Globalization

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China & World Economy 2025年第1期33卷 1-35页

作者： Meixin Guo david Daokui Li Kun Lang Academic Center for Chinese Economic Practice and Thinking School of Social ScienceTsinghua UniversityChina School of Marxism Tsinghua UniversityChina

This article proposes a leadership theory of globalization to explain how economic globalization occurs and evolves,and why China wants to take a leading role in *** theory posits that an economy equipped with advanced industrial technology,a substantial domestic market,and robust institutional capacity is more likely to take the lead in driving economic *** advantages in high-tech industries position an economy favorably within the global value chains,maximizing its benefits from economic globalization.A large domestic market can entice other countries to agree to open their markets *** capacity enables governments to deter opposition to globalization from those disadvantaged by economic *** paper presents studies of historical cases of economic globalization and provides a three-stage model of *** argues that China has been gaining on three fronts in recent decades and is therefore willing to promote economic globalization.

关键词： economic globalization institutional advantage leadership market advantage technological advantage

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Transforming osteosarcoma care:from historical milestones to precision medicine advances

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Science Bulletin 2025年第3期70卷 290-294页

作者： Jichuan Wang david S.Geller Luyang Sun Xiaodong Tang Musculoskleletal Tumor Center Beijing Key Laboratory for Musculoskeletal TumorsPeking University People’s HospitalBeijing 100041China Department of Orthopedic Surgery Montefiore Medical CenterAlbert Einstein College of MedicineBronx 10471USA Department of Biochemistry and Molecular Biology School of Basic Medical SciencesPeking University Health Science CenterBeijing 100191China

Osteosarcoma(OS),one of the earliest recognized cancers in humans,is a rare yet significant malignant bone tumor,diagnosed in 2-6 cases per million annually[1].It predominantly affects adolescents and young adults,with a second peak in incidence occurring around age *** osteosarcoma typically arises in areas of rapid bone growth,such as the knee and shoulder,and often presents persistent bone pain and progressive *** osteosarcoma often has a classic radiographic appearance,diagnosis is ultimately confirmed histologically.

关键词： osteosarcoma diagnosis annually

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Seasonal Fruit Quality Profile of Three Orange Varieties in Teso Subregion—Eastern Uganda

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Agricultural Sciences 2025年第1期16卷 146-160页

作者： Samuel Edgar Tinyiro Moses Matovu Norah Akaba david Bamwirire Julian Achieng Yusuf Mukasa Onesmus Semalulu Angella Kisakye Doreen Nampamya Patricia Driciru Taeson Park cho Ilho John Adriko National Agricultural Research Organisation-National Agricultural Research Laboratories Kampala Uganda National Agricultural Research Organisation-National Livestock Resources Research Institute Kampala Uganda Korea Partnership for Innovation of Agriculture (KOPIA)-Uganda Centre Kampala Uganda National Agricultural Research Organisation-National Forestry Resources Research Institute Kampala Uganda

Teso subregion in Eastern Uganda is a leading production hub for citrus in Uganda. however, information on fruit quality profile of the three major varieties (hamlin, Valencia and Washington navel) grown in this region was limited and/or unreported, partly resulting in their limited use for industrial processing. The current study sought to understand the seasonal quality profile of these varieties during the wet and dry seasons for the years 2019, 2022 and 2023. The study was conducted with farmers in the districts of Kumi, Ngora, Soroti and Kalaki. Mature green oranges were periodically harvested and analysed for physical and chemical properties. The results showed that the quality of oranges varied depending on the season at harvest and the variety with significant differences (p ≤ 0.05). Mean weight per fruit was highest in wet season Washington navel (277.5 g) and lowest in dry season hamlin (149.3 g). Similarly, fruit size varied in the wet season where Washington navel (81.2 mm) had the biggest fruits while dry season hamlin were smallest (66.6 mm). Dry season Washington navel had had the thickest peel (7.9 mm). Valencia from the wet season had the highest juice content (36.9%) compared to Washington navel (26.5%) from the dry season with the lowest. Titratable acidity was higher in the dry season Valencia (0.9%) compared to the wet season Washington navel and hamlin (0.3%). Similarly, Total soluble solids (TSS) was higher in the dry season (Washington navel, 10.1 ˚Brix) in contrast to the wet season (hamlin and Valencia, 7.7 ˚Brix). Valencia had the lowest ph (3.1) however, ph did not vary significantly between season for each variety except for hamlin. Vitamin C content was higher during the dry season led by Valencia (57.6 mg/100g) and hamlin (57.4 mg/100g). Sugar to acid ratio was highest during the wet season (Washington navel, 41.5) and lowest in the dry season (Valencia, 17.1). Overall, dry season fruits and more especially Valencia showed versatility

关键词： Citrus Quality Kyoga Plains Valencia hamlin Washington Navel Physical Chemical

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Silk-based nerve guidance conduits with macroscopic holes modulate the vascularization of regenerating rat sciatic nerve

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Neural Regeneration Research 2025年第6期20卷 1789-1800页

作者： Carina hromada Patrick heimel Markus Kerbl LászlóGál Sylvia Nürnberger Barbara Schaedl James Ferguson Nicole Swiadek Xavier Monforte Johannes C.heinzel Antal Nógrádi Andreas h.Teuschl-Woller david hercher Department Life Science Engineering University of Applied Sciences Technikum WienViennaAustria Austrian Cluster for Tissue Regeneration ViennaAustria Ludwig Boltzmann Institute for Traumatology The Research Center in Cooperation with AUVAViennaAustria University Clinic of Dentistry Medical University of ViennaViennaAustria Department of Plastic Reconstructive and Aesthetic SurgeryLandesklinikum Wiener Neustadt2700 Wiener NeustadtAustria Department of Anatomy Histology and EmbryologyAlbert Szent-Györgyi Medical SchoolUniversity of SzegedSzegedHungary Medical University of Vienna Department of Orthopedics and Trauma SurgeryDevision of Trauma SurgeryViennaAustria Department of hand- PlasticReconstructive and Burn SurgeryBG Unfallklinik TuebingenUniversity of TuebingenTuebingenGermany

Peripheral nerve injuries induce a severe motor and sensory deficit. Since the availability of autologous nerve transplants for nerve repair is very limited, alternative treatment strategies are sought, including the use of tubular nerve guidance conduits(tNGCs). however, the use of tNGCs results in poor functional recovery and central necrosis of the regenerating tissue, which limits their application to short nerve lesion defects(typically shorter than 3 cm). Given the importance of vascularization in nerve regeneration, we hypothesized that enabling the growth of blood vessels from the surrounding tissue into the regenerating nerve within the tNGC would help eliminate necrotic processes and lead to improved regeneration. In this study, we reported the application of macroscopic holes into the tubular walls of silk-based tNGCs and compared the various features of these improved silk^(+) tNGCs with the tubes without holes(silk^(–) tNGCs) and autologous nerve transplants in an 8-mm sciatic nerve defect in rats. Using a combination of micro-computed tomography and histological analyses, we were able to prove that the use of silk^(+) tNGCs induced the growth of blood vessels from the adjacent tissue to the intraluminal neovascular formation. A significantly higher number of blood vessels in the silk^(+) group was found compared with autologous nerve transplants and silk^(–), accompanied by improved axon regeneration at the distal coaptation point compared with the silk^(–) tNGCs at 7 weeks postoperatively. In the 15-mm(critical size) sciatic nerve defect model, we again observed a distinct ingrowth of blood vessels through the tubular walls of silk^(+) tNGCs, but without improved functional recovery at 12 weeks postoperatively. Our data proves that macroporous tNGCs increase the vascular supply of regenerating nerves and facilitate improved axonal regeneration in a short-defect model but not in a critical-size defect model. This study suggests that further optimizatio

关键词： axon regeneration blood vessel functional recovery macroporous nerve lesion peripheral nerve repair sciatic nerve silk-based nerve guidance conduit vascularization

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Large Banks and Systemic Risk:Insights from a Mean-Field Game Model

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Journal of Systems Science & Complexity 2025年第01期 460-494页

作者： ChANG Yuanyuan FIROOZI Dena BENATIA david Department of Decision Sciences HEC Montréal Department of Applied Economics HEC Montréal

This paper presents a dynamic game framework to analyze the role of large banks in interbank markets. By extending existing models, a large bank is incorporated as a dynamic decision-maker interacting with multiple small banks. Using the mean-field game methodology and convex analysis, best-response trading strategies are derived, leading to an approximate equilibrium for the interbank market. The influence of the large bank is investigated on the market stability by examining individual default probabilities and systemic risk, through the use of Monte Carlo simulations. The proposed findings reveal that, when the size of the major bank is not excessively large, it can positively contribute to market stability. however, there is also the potential for negative spillover effects in the event of default, leading to an increase in systemic risk. The magnitude of this impact is further influenced by the size and trading rate of the major bank. Overall, this study provides valuable insights into the management of systemic risk in interbank markets.

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