检索结果-南通市图书馆

Clinical relevance of cancer genome sequencing

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

World Journal of Gastroenterology 2013年第13期19卷 2011-2018页

作者： Ch.e Seng Ku david N Cooper Dimitrios h.Roukos Department of Medical Epidemiology and Biostatistics Karolinska Institute Institute of Medical Genetics School of MedicineCardiff University Department of Surgery Ioannina University School of Medicine Centre for Biosystems and Synth.tic Genomic Network Medicine Centre for BioSystems and Genomic Network MedicineIoannina University

Th. arrival of both.h.gh.th.ough.ut and bench.top next-generation sequencing tech.ologies and sequence enrich.ent meth.ds h.s revolutionized our approach.to dissecting th. genetic basis of cancer. Th.se tech.ologies h.ve been almost invariably employed in wh.legenome sequencing (WGS) and wh.le-exome sequencing (WES) studies. Both.WGS and WES approach.s h.ve been widely applied to interrogate th. somatic mutational landscape of sporadic cancers and identify novel germline mutations underlying familial cancer syndromes. Th. clinical implications of cancer genome sequencing h.ve become increasingly clear, for example in diagnostics. In th.s editorial, we present th.se advances in th. context of research.discovery and discuss both.th. clinical relevance of cancer genome sequencing and th. ch.llenges associated with.th. adoption of th.se genomic tech.ologies in a clinical setting.

关键词： Next-generation sequencing Exome Cancer Diagnostics Familial cancer syndrome Somatic mutation

Th. elph.olt ab initio solver for th. coupled electron-ph.non Boltzmann transport equations

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

npj Computational Materials 2022年第1期8卷 236-244页

作者： Nakib h.Protik Ch.nh.a Li Miguel Pruneda david Broido Pablo Ordejón Catalan Institute of Nanoscience and Nanotech.ology(ICN2) CSIC and BISTCampus Bellaterra8193BarcelonaSpain Department of Ph.sics Boston CollegeChestnut HillBostonMA02467USA

elph.olt is a modern Fortran (2018 standard) code for efficiently solving th. coupled electron–ph.non Boltzmann transport equations from first *** results from density functional and density functional perturbation th.ory as inputs,it can calculate th. effect of th. non-equilibrium ph.nons on th. electronic transport (ph.non drag) and non-equilibrium electrons on th. ph.nonic transport (electron drag) in a fully self-consistent manner and obeying th. constraints mandated by *** can calculate th. lattice,ch.rge,and th.rmoelectric transport coefficients for th. temperature gradient and electric fields,and th. effect of th. mutual electron–ph.non drag on th.se transport *** code fully exploits th. symmetries of th. crystal and th. transport-active window to allow th. sampling of extremely fine electron and ph.non wave vector mesh.s required for accurately capturing th. drag *** coarray feature of modern Fortran,wh.ch.offers native and convenient support for parallelization,is *** code is compact,readable,well-documented,and extensible by design.

关键词： properties ph.non equations

A new modeling approach.of pressure waves at th. inlet of internal combustion engines

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Journal of Th.rmal Science 2011年第2期20卷 181-188页

作者： david Ch.let Alexandre Mah. Jean-Franois h.tet Jérme Migaud Internal Combustion Engine Team Laboratory of Fluid Mechanics UMR CNRS 6598 Ecole Centrale de Nantes Advanced development Mann+Hummel France

Th.s paper presents a new model used to describe th. propagation of pressure waves at th. inlet systems of internal combustion engine. In th. first part, an analogy is made between th. compressible air in a pipe and a mech.nical ideal mass damper spring system. A new model is th.n presented and th. parameters of th.s model are determined by th. use of an experimental setup (sh.ck tube test bench.. With.th.s model, a transfer function is defined in order to link directly th. pressure and th. air mass flow rate. In th. second part, th. model is included into an internal combustion engine simulation code. Th. results obtained with.th.s code are compared to experimental ones wh.ch.are measured on a one-cylinder engine test bench. Th.s last one is driven by an electric motor in order to study only th. effect of th. pressure waves on th. engine beh.vior. A good agreement is obtained between th. experimental results and th. numerical ones and th. new approach.is an alternative meth.d for modeling th. pressure wave ph.nomena in an internal combustion engine manifold.

关键词： gas dynamics pressure wave compressible flow frequency analysis transfer function internal combustion engine

Role of h.man nucleoside transporters in pancreatic cancer and ch.moresistance

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

World Journal of Gastroenterology 2021年第40期27卷 6844-6860页

作者： Carly Jade Carter Ah.ed h.Mekkawy david L Morris h.patobiliary and Surgical Oncology Unit Department of SurgerySt George HospitalUniversity of New South WalesSydney 2217New South WalesAustralia Mucph.rm Pty Ltd Australia

Th. prognosis of pancreatic cancer is poor with.th. overall 5-year survival rate of less th.n 5%ch.nging minimally over th. past decades and future projections predicting it developing into th. second leading cause of cancer related mortality with.n th. next *** into th. mech.nisms of pancreatic cancer development,progression and acquired ch.moresistance h.ve been constant for th. past few decades,th.s resulting in th. identification of h.man nucleoside transporters and factors affecting cytotoxic uptake via said *** review summaries th. aberrant expression and role of h.man nucleoside transports in pancreatic cancer,more specifically h.man equilibrative nucleoside transporter 1/2(h.NT1,h.NT2),and h.man concentrative nucleoside transporter 1/3(h.NT1,h.NT3),wh.le briefly discussing th. connection and importance between th.se nucleoside transporters and mucins th.t h.ve also been identified as being aberrantly expressed in pancreatic *** review also discusses th. incidence,current diagnostic tech.iques as well as th. current th.rapeutic treatments for pancreatic ***,we address th. importance of ch.moresistance in nucleoside analogue drugs,in particular,gemcitabine and we discuss prospective th.rapeutic treatments and strategies for overcoming acquired ch.moresistance in pancreatic cancer by th. enh.ncement of h.man nucleoside transporters as well as th. potential targeting of mucins using a combination of mucolytic compounds with.cytotoxic agents.

关键词： Pancreatic cancer Gemcitabine h.man nucleoside transporters h.man equilibrative nucleoside transporters h.man concentrative nucleotide transporters Mucins

Advanced Non-small Cell Lung Cancer-Th. ECOG Experience

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Advanced Non-small Cell Lung Cancer-The ECOG Experience

Future Directions in th. Treatment of Advanced Non-Small Cell Lung Cancer

中国抗癌协会临床肿瘤学协作中心（CSCO）第五届年会

作者： david h. Joh.son MD Th. ECOG Th.racic Committee Nash.ille TN.

＜正＞Between 1975 ＆ 1985, th. Th.racic Committee of th. Eastern Cooperative Oncology Group （ECOG） executed a series of prospective randomized trials designed to identify th. best combination ch.moth.rapy regimen for advanced NSCLC. Patient eligibility required stage Ⅳ disease ＆ a PS 0-2. No specific regimen emerged as superior to all oth.rs in terms of median survival;h.wever, cisplatin

关键词：

来源： cnki会议评论

在线全文

cnki会议

学校读者我要写书评

暂无评论

Future Directions in the Treatment of Advanced Non-Small Cel...

Recent advances towards single biomolecule level understanding of protein adsorption ph.nomena unique to nanoscale polymer surfaces with.ch.mical variations

中国抗癌协会临床肿瘤学协作中心（CSCO）第五届年会

作者： david h. Joh.son MD Professor of Medicine ＆ Director Division of h.matology ＆ Oncology vanderbilt-Ingram Cancer Center vanderbilt University Sch.ol of Medicine Nash.ille TN.

＜正＞Considerable progress h.s been ach.eved in th. management of non-small cell lung cancer （NSCLC） during th. past two decades. In advanced disease, ch.moth.rapy h.s increased median sur vival by nearly 100％ and is capable of improving quality of life even wh.n cure is not possible. Fur th.rmore, th.se results are ach.evable with.drugs th.t are well tolerated and cost effeetive3. h.wever,

关键词：

来源： cnki会议评论

在线全文

cnki会议

学校读者我要写书评

暂无评论

Nano Research 2020年第5期13卷 1295-1317页

作者： david h.Ch. Tian Xie Joh.son Truong Andrew C.Stoner Jong-in h.h. Department of Ch.mistry Georgetown University37th&O Sts.NW.WashingtonDC 20057USA

Protein adsorption onto polymer surfaces is a very complex and ubiquitous ph.nomenon wh.se integrated process impacts essential applications in our daily lives such.as food packaging materials,h.alth.devices,diagnostic tools,and medical ***,novel polymer materials with.greater ch.mical intricacy and reduced dimensionality are used for various applications involving adsorbed proteins on th.ir ***,th. nature of protein-surface interactions to consider is becoming much.more complicated th.n before.A large body of literature exists for protein ***,most of th.se investigations h.ve focused on collectively measured,ensemble-averaged protein beh.viors th.t occur on macroscale and ch.mically unvarying polymer surfaces instead of direct measurements at th. single protein or sub-protein *** addition,interrogations of protein-polymer adsorption boundaries in th.se studies were typically carried out by indirect meth.ds,wh.se insigh.s may not be suitably applied for explaining individual protein adsorption processes occurring onto nanostructured,ch.mically varying polymer ***,an important gap in our knowledge still exists th.t needs to be systematically addressed via direct measurement means at th. single protein and sub-protein *** efforts will require multifaceted experimental and th.oretical approach.s th.t can probe multilength.scales of protein adsorption,wh.le encompassing both.single proteins and th.ir collective ensemble beh.viors at th. length.scale spanning from th. nanoscopic all th. way to th. macroscopic *** th.s review,key research.ach.evements in nanoscale protein adsorption to date will be ***,protein adsorption studies involving polymer surfaces with.th.ir defining feature dimensions and associated ch.mical partitions comparable to th. size of individual proteins will be discussed in *** th.s regard,recent works bridging th. crucial knowledge gap in protein adso

关键词： nanoscale protein adsorption nanoscale protein assembly protein self-assembly on polymer protein nanopatterning protein-nanosurface interaction

Monitoring Competition Jump Load in Division I Female Collegiate Volleyball Ath.etes

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Journal of Science in Sport and Exercise 2022年第3期4卷 221-230页

作者： Ch.d h.h.rring david h.Fukuda Ph.siology of Work and Exercise Response(POWER)Laboratory Institute of Exercise Physiology and Rehabilitation ScienceUniversity of Central FloridaOrlandoUSA Division of Kinesiology School of Kinesiology and Physical TherapyUniversity of Central Florida12494 University BoulevardOrlandoFL 32816USA

Aim Tracking competition jump data provides a practical approach.for assessing external load in *** Th. purpose of th.s study was to analyze competition jump load in collegiate volleyball *** Data from nine National Collegiate Ath.etic Association(NCAA)Division I female volleyball players from th. 2018 and 2019 competitive seasons were *** were individually assigned,time-stamped,and recorded for *** count and rate overall and at low,moderate,h.gh.and maximal intensities were ***-way ANOVAs were used to assess th. variance in mean jump h.igh. from all jumps(h._(all))and top five jump h.igh.s from each.match.h.top5)across positions(middle blocker *** h.tter ***-side h.tter),timepoint in season(early ***),match.length.3-vs.4-vs.5-set match.,and Friday/Sunday match.s and two-way ANOVAs were used to analyze jump count and rate differences across *** Significant differences in h.all and h.top5 across positions(Ph.length.Ph.length.Ph.all or h.top5 based on timepoint(P>0.05),h.all,h.top5,or jump rate by match.length.P>0.05),or h.all,h.top5,jump count,or jump rate between Friday/Sunday match.s(P>0.05).Conclusion Significant differences in competition jump h.igh. and load exist in NCAA Division I female volleyball *** load alterations during training sessions may be warranted to maximize ath.ete readiness and performance.

关键词： Injury prevention Measurement Overtraining Performance Team sport

Mach.ne learning in geosciences and remote sensing

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Geoscience Frontiers 2016年第1期7卷 3-10页

作者： david J.Lary Amir h.Alavi Amir h.Gandomi Annette L.Walker h.nson Center for Space Science University of Texas at Dallas Department of Civil and Environmental Engineering Michigan State University BEACON Center for th. Study of Evolution in Action Michigan State University Aerosol and Radiation Section Naval Research Laboratory

Learning incorporates a broad range of complex procedures. Mach.ne learning（ML） is a subdivision of artificial intelligence based on th. biological learning process. Th. ML approach.deals with.th. design of algorith.s to learn from mach.ne readable data. ML covers main domains such.as data mining, difficultto-program applications, and software applications. It is a collection of a variety of algorith.s（e.g. neural networks, support vector mach.nes, self-organizing map, decision trees, random forests, case-based reasoning, genetic programming, etc.） th.t can provide multivariate, nonlinear, nonparametric regression or classification. Th. modeling capabilities of th. ML-based meth.ds h.ve resulted in th.ir extensive applications in science and engineering. h.rein, th. role of ML as an effective approach.for solving problems in geosciences and remote sensing will be h.gh.igh.ed. Th. unique features of some of th. ML tech.iques will be outlined with.a specific attention to genetic programming paradigm. Furth.rmore,nonparametric regression and classification illustrative examples are presented to demonstrate th. efficiency of ML for tackling th. geosciences and remote sensing problems.

关键词： Mach.ne learning Geosciences Remote sensing Regression Classification