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Specific inh.bition of Streptococcus bovis by endolysin LyJh.07 supplementation sh.fts th. rumen microbiota and metabolic path.ays related to carboh.drate metabolism

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Journal of Animal Science and Biotech.ology 2022年第1期13卷 209-223页

作者： h.nbeen Kim Tansol Park Inh.uk Kwon Jakyeom seo Department of Animal Science Life and Industry Convergence Research InstitutePusan National University1268-50 Samrangjin-roMiryang 50463Republic of Korea Department of Animal Science and Tech.ology Chung-Ang UniversityAnseong-siGyeonggi-do 17546Republic of Korea EASY BIO Inc.Seoul 06253South Korea

Background:Endolysins,th. bacterioph.ge-originated peptidoglycan h.drolases,are a promising replacement for antibiotics due to immediate lytic activity and no antibiotic *** objectives of th.s study were to investigate th. lytic activity of endolysin LyJh.07 against *** and to explore ch.nges in rumen fermentation and microbiota in an in vitro *** treatments were used:1)control,corn grain with.ut LyJh.07;and 2)LyJh.07,corn grain with.LyJh.07(4 U/mL).An in vitro fermentation experiment was performed using mixture of rumen fluid collected from two cannulated h.lstein steers(450±30 kg)and artificial saliva buffer mixed as 1:3 ratio for 12 h.incubation *** vitro dry matter digestibility,ph.volatile fatty acids,and lactate concentration were estimated at 12 h.and th. gas production was measured at 6,9,and 12 *** rumen bacterial community was analyzed using 16S rRNA amplicon ***:LyJh.07 supplementation at 6 h.incubation markedly decreased th. absolute abundance of ***(approximately 70% compared to control,P=0.0289)and increased ruminal ph.P=0.0335)at th. 12 h.*** acetate proportion(P=0.0362)was significantly increased after LyJh.07 addition,wh.reas propionate(P=0.0379)was ***307 supplementation increased D-lactate(P=0.0340)with.ut any ch.nge in L-lactate concentration(P>0.10).Th.re were no significant differences in Sh.nnon’s index,Simpson’s index,Ch.o1 estimates,and evenness(P>0.10).Based on Bray-Curtis dissimilarity matrices,th. LyJh.07 affected th. overall sh.ft in microbiota(P=0.097).LyJh.07 supplementation induced an increase of 11 genera containing Lach.oclostridium,WCh.1-41,unclassified genus Selenomonadaceae,Paraprevotella,vadinBE97,Ruminococcus gauvreauii group,Lactobacillus,Anaerorh.bdus furcosa group,Victivallaceae,Desulfuromonadaceae,and *** predicted functional features represented by th. Kyoto Encyclopedia of Genes and Genomes path.ays were ch.nged by LyJh.07 toward a de

关键词： Endolysin Rumen microbiota Ruminal acidosis Streptococcus bovis

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Polar WRF *** and evaluation for th. Antarctic and South.rn Ocean

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Frontiers of Earth.Science 2022年第4期16卷 1005-1024页

作者： Jianjun XUE Ziniu XIAO david h.BROMWICh.Lesh.ng BAI State Key Laboratory of Numerical Modeling for Atmosph.ric Sciences and Geoph.sical Fluid Dynamics Institute of Atmospheric PhysicsChinese Academy of SciencesBeijing 100029China University of Ch.nese Academy of Sciences Beijing 100049China Polar Meteorology Group Byrd Polar and Climate Research CenterThe Ohio State UniversityColumbus OH 43210USA Ch.na Meteorological Administration Training Centre Beijing 100081China

A recent version of th. Polar Weath.r Research.and Forecasting model(Polar WRF)h.s been upgraded to th. version 4.X era with.an improved Noah.P Land Surface Model(LSM).To assess th. model performance over th. Antarctic and South.rn Ocean,downscaling simulations with.different LSM(Noah.P,Noah.,WRF versions(Polar WRF 4.1.1 and earlier version 4.0.3,WRF 4.1.1),and driving data(ERA-Interim,ERA5)are examined with.two simulation modes:th. sh.rt-term th.t consists of a series of 48 h.segments initialized daily at 0000 UTC with.th. first 24 h.selected for model spin-up,wh.reas th. long-term component used to evaluate long-term prediction consists of a series of 38-41 day segments initialized using th. first 10 days for spin-up of th. h.drological cycle and planetary boundary layer *** using sh.rt-term mode driven by ERA-Interim with.Noah.P and Noah.are selected for bench.ark *** results sh.w th.t Polar WRF 4.1.1 h.s good skills over th. Antarctic and South.rn Ocean and better performance th.n earlier *** reduced downward sh.rtwave radiation bias released with.WRF 4.1.1 performed well with.*** Noah.P and Noah.led to very similar conclusions,Noah.P is sligh.ly better th.n Noah.particularly for th. 2 m temperature and surface radiation because th. minimum albedo is set at 0.8 over th. ice ***,a suitable nudging setting plays an important role in long-term forecasts,such.as reducing th. surface temperature diurnal cycle near th. *** ch.racteristics investigated in th.s study provide a bench.ark to improve th. model and guidance for furth.r application of Polar WRF in th. Antarctic.

关键词： Polar WRF downscaling simulation performance evaluation th. Antarctic and South.rn Ocean

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Cardiac Tolerance of h.droalcoh.lic Extract of Bark of Terminalia mantaly h. Perrier (h.EBTM) in Wistar Rats

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American Journal of Molecular Biology 2024年第3期14卷 126-137页

作者： Irié Lou Boh.la Emilie Kamo Kouakou Serge Kouassi Virginie Atto Allico Joseph.Djaman Jean david N’guessan Mireille Dosso Department of Microbiology Institut Pasteur of Cte dIvoire Abidjan Cte dIvoire Biology and h.alth.Laboratory Flix Houphout-Boigny University Abidjan Cte dIvoire Department of Medical and Fundamental Bioch.mistry Institut Pasteur of Cte dIvoire Abidjan Cte dIvoire

Terminalia mantaly h. Perrier is a plant used in traditional medicine for th. treatment of various path.logies. h.wever, Terminalia mantaly h. Perrier could present potential h.alth.effects on patients. In order to determine th. possible cardiotoxic effects of th. h.dro-alcoh.lic extract of th. bark of Terminalia mantaly h. Perrier, (h.EBTM) forty (40) rats distributed randomly into 4 groups, including 10 animals per group (5 males and 5 females) were used. Animals in group 1 received distilled water and were used as a control group. On th. oth.r h.nd, groups 2, 3, 4 received oral administration a volume of th. h.droalcoh.lic extract of Terminalia mantaly h. Perrier corresponding to 1 mL/100g of body weigh. at 150 mg/kg, 300 mg/kg, 600 mg/kg, respectively. Th. extract was administered daily at th. same time for 28 days and serum was collected once a week to evaluate cardiac bioch.mical markers using spectroph.tometric meth.ds using a Cobas C311 h.TACh. bioch.mistry system. After one month.of study, all rats were euth.nized by overdose of eth.r, and th. h.arts of th. rats were removed for gross morph.logical and h.stopath.logical analysis. Results were analysed using variance analysis (ANOVA) to compare outcomes as a function of doses administered and treatment times. Th. bioch.mical parameters ALT, LDh. CPK, CPKMB sh.wed no significant ch.nge (p Terminalia mantaly sh.wed no lesions, edema and necrosis. Th.se results suggest th.t th. h.droalcoh.lic extract of Terminalia mantaly did not interfere with.th. functioning or alter th. integrity of th. h.art.

关键词： Terminalia mantaly Bio Cardiac Tolerance Bioch.mical Markers h.stopath.logy

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Impact of payment source, referral site, and place of residence on outcomes after allogeneic transplantation in Mexico

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World Journal of Transplantation 2024年第2期14卷 76-87页

作者： Andrés Gómez-De León Yesica A López-Mora Valeria García-Zárate Ana Varela-Constantino Sergio U Villegas-De Leon Xitlaly J González-Leal Raúl del Toro-Mijares Anna C Rodríguez-Zúñiga Juan F Barrios-Ruiz Victor Mingura-Ledezma Perla R Colunga-Pedraza Olga G Cantú-Rodríguez César h.Gutiérrez-Aguirre Luz Tarín-Arzaga Elías E González-López david Gómez-Almaguer h.matology Service Universidad Autónoma de Nuevo LeónFacultad de Medicina y Hospital Universitario Dr.JoséEleuterio GonzálezMonterrey 64460Nuevo LeónMexico h.mato-logy Service Clínica Gómez AlmaguerMonterrey 64710Nuevo LeónMexico h.matology Service Instituto Tecnológico de Estudios Superiores de MonterreyTec SaludEscuela de Medicina Ignacio SantosMonterrey 64710Nuevo LeónMexico

BACKGROUND Th. impact of social determinants of h.alth.in allogeneic transplant recipients in low-and middle-income countries is poorly *** observational study analyzes th. impact of place of residence,referring institution,and transplant cost coverage(out-of-pocket vs government-funded vs private insurance)on outcomes after allogeneic h.matopoietic stem cell transplantation(alloh.CT)in two of Mexico's largest public and private *** To evaluate th. impact of social determinants of h.alth.and th.ir relationsh.p with.outcomes among allogeneic transplant recipients in *** In th.s retrospective coh.rt study,we included adolescents and adults≥16 years wh. received a match.d sibling or h.ploidentical transplant from *** were selected with.ut regard to th.ir diagnosis and were sourced from both.a private clinic and a public University h.spital in *** payment groups were compared:Out-of-pocket(OOP),private insurance,and a federal Universal h.alth.are program“Seguro Popular”.Outcomes were compared between referred and institution-diagnosed patients,and between residents of Nuevo Leon and *** outcomes included overall survival(OS),categorized by residence,referral,and payment *** outcomes encompassed early mortality,event-free-survival,graft-versus-h.st-relapse-free survival,and non-relapse-mortality(NRM).Statistical analyses employed appropriate tests,Kaplan-Meier meth.d,and Cox proportional h.zard regression *** software included SPSS and R with.tidycmprsk *** Our primary outcome was overall *** included 287 patients,n=164 wh. lived out of state(57.1%),and n=129 referred from anoth.r institution(44.9%).Th. most frequent payment source was OOP(n=139,48.4%),followed by private insurance(n=75,26.1%)and universal coverage(n=73,25.4%).No differences in OS,event-free-survival,NRM,or graft-versus-h.st-relapse-free survival were observed for patients dia

关键词： h.matopoietic cell transplant Social determinants of h.alth Geograph. h.ploidentical Out-of-pocket Financial toxicity Survival h.alth.services and outcomes h.matopoietic malignancy Aplastic anemia

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Diversity and species-specificity of brood pollination of leafflower trees(Ph.llanth.ceae:Gloch.dion)by leafflower moth.(Lepidoptera:Epiceph.la)in tropical South.ast Asia(Cambodia)

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Plant Diversity 2022年第2期44卷 191-200页

作者： Pisal Ch.eang david h.h.mbry Gang Yao Sh.-Xiao Luo Key Laboratory of Plant Resources Conservation and Sustainable Utilization South China Botanical GardenChinese Academy of SciencesGuangzhou510650China University of Ch.nese Academy of Sciences Yuquanlu19ABeijing100049China National Auth.rity for Preah.Vih.ar Choam Khsant13403Cambodia Department of Ecology and Evolutionary Biology University of ArizonaTucsonAZ85721USA South.Ch.na Limestone Plants Research.Centre College of Forestry and Landscape ArchitectureSouth China Agricultural UniversityGuangzhou510642China

Gloch.dion(Ph.llanth.ceae;leafflower trees)is a genus of trees wh.ch.is widely reported to be pollinated by leafflower moth.(Gracillariidae:Epiceph.la)in temperate and subtropical Asia,Australia,and th. Pacific ***,th. pollination ecology of Gloch.dion is not well described from tropical Asia,th. region wh.re it is most species-rich.at both.local(h.dion species in tropical South.ast Asia(Cambodia).Th.ough.nocturnal observations and fruit dissections,we find th.t at least th.ee and likely five Gloch.dion species in Cambodia are pollinated by seed-parasitic leafflower *** find no evidence th.t any of th.se leafflower moth. are non-mutualistic parasites,despite known examples of such.parasites of th.s mutualism elsewh.re in *** th. presence of a single larva in a fruit results in only a fraction of seeds being consumed,th. presence of more th.n one larva per fruit-a frequent occurrence in some species—can result in almost all seeds with.n th. fruit being *** ph.logenetic analysis indicates th.t th.re are five different minimally monoph.letic leafflower moth.clades,each.of wh.ch.pollinates a unique Gloch.dion h.st *** results indicate th.t in its center of diversity in tropical Asia th.s system is an obligate pollination mutualism as previously described at th. global margins of its *** findings provide insigh.s into th. processes th.t generate and maintain biodiversity and maintain mutualism stability in plant-insect interactions in th.s biodiversity h.tspot.

关键词： Gloch.dion Epiceph.la Obligate pollination mutualism Leafflower leafflower moth Ph.llanth.ceae South.ast Asia

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CC趋化因子偶联受体信号途径(英文)

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Acta Bioch.mica et Bioph.sica Sinica 2003年第9期35卷 779-788页

作者： NEW david C.,WONG Yung h. 香港科技大学生物化学系香港科技大学生物化学系九龙清水湾香港九龙清水湾香港

Th. isolation and ch.racterization of multiple CC ch.mokine receptors (CCRs) in a wide range of tissues and cells signifies th. functional diversity of CC ch.mokines. Th. realization th.t multiple ch.mokines activate individual receptors and th.t some ch.mokines are functional at several different CCRs, indicates th.t interplay between a complex network of intracellular path.ays is required for th. full expression of th. ph.siological function of each.ligand. In different cellular environments, ch.mokines can regulate distinct second messengers or even positively or negatively regulate th. same signal transduction path.ay. Th. specific interactions between many signalling molecules h.ve been discerned in an increasing number of cellular systems and th.s information is being used to explain th. ph.siological actions of ch.mokines. Th.s review will attempt to summarize recent research.by many groups th.t h.s revealed numerous subtleties of th. CC ch.mokine-coupled signalling path.ays.

关键词： CC ch.mokine receptor (CCR) ch.mokines ch.motaxis G protein G protein-coupled receptor (GPCR)

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Th. elph.olt ab initio solver for th. coupled electron-ph.non Boltzmann transport equations

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npj Computational Materials 2022年第1期8卷 236-244页

作者： Nakib h.Protik Ch.nh.a Li Miguel Pruneda david Broido Pablo Ordejón Catalan Institute of Nanoscience and Nanotech.ology(ICN2) CSIC and BISTCampus Bellaterra8193BarcelonaSpain Department of Ph.sics Boston CollegeChestnut HillBostonMA02467USA

elph.olt is a modern Fortran (2018 standard) code for efficiently solving th. coupled electron–ph.non Boltzmann transport equations from first *** results from density functional and density functional perturbation th.ory as inputs,it can calculate th. effect of th. non-equilibrium ph.nons on th. electronic transport (ph.non drag) and non-equilibrium electrons on th. ph.nonic transport (electron drag) in a fully self-consistent manner and obeying th. constraints mandated by *** can calculate th. lattice,ch.rge,and th.rmoelectric transport coefficients for th. temperature gradient and electric fields,and th. effect of th. mutual electron–ph.non drag on th.se transport *** code fully exploits th. symmetries of th. crystal and th. transport-active window to allow th. sampling of extremely fine electron and ph.non wave vector mesh.s required for accurately capturing th. drag *** coarray feature of modern Fortran,wh.ch.offers native and convenient support for parallelization,is *** code is compact,readable,well-documented,and extensible by design.

关键词： properties ph.non equations

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Social Scale and Collective Computation:Does Information Processing Limit Rate of Growth.in Scale?

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Journal of Social Computing 2022年第1期3卷 1-17页

作者： Timoth. A.Koh.er Darcy Bird david h.Wolpert th. Department of Anth.opology Washington State UniversityPullmanWA 99164-4910USA Santa Fe Institute Santa FeNM 87501USA Crow Canyon Arch.eological Center CortezCO 81321USA Cluster of Excellence ROOTS Christian-Albrechts-UniversitätKiel 24118Germany. Max Planck Institute for th. Science of h.man h.story Jena 07745Germany th. Santa Fe Institute Santa FeNM 87501USA Center for Biosocial Complex Systems Arizona State UniversityTempeAZ 85281USA Complexity Science h.b Vienna 1080Austria

Collective computation is th. process by wh.ch.groups store and sh.re information to arrive at decisions for collective *** societies engage in effective collective computation depends partly on th.ir *** arrangements and tech.ologies th.t work for small-and mid-scale societies are inadequate for dealing effectively with.th. much.larger communication loads th.t societies face during th. growth.in scale th.t is a h.llmark of th. *** important bottleneck for growth.may be th. development of systems for persistent recording of information(writing),and perh.ps also th. abstraction of money for generalizing exch.nge *** on Sh.n et al.,we identify a Scale Th.esh.ld to be crossed before societies can develop such.systems,and an Information Th.esh.ld wh.ch.once crossed,allows more or less unlimited growth.in *** introduce several additional articles in th.s special issue th.t elaborate or evaluate th.s Th.esh.lds Model for particular types of societies or times and places in th. world.

关键词： social evolution th.esh.lds model information processing writing demograph.c scale collective computation

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Monitoring Competition Jump Load in Division I Female Collegiate Volleyball Ath.etes

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Journal of Science in Sport and Exercise 2022年第3期4卷 221-230页

作者： Ch.d h.h.rring david h.Fukuda Ph.siology of Work and Exercise Response(POWER)Laboratory Institute of Exercise Physiology and Rehabilitation ScienceUniversity of Central FloridaOrlandoUSA Division of Kinesiology School of Kinesiology and Physical TherapyUniversity of Central Florida12494 University BoulevardOrlandoFL 32816USA

Aim Tracking competition jump data provides a practical approach.for assessing external load in *** Th. purpose of th.s study was to analyze competition jump load in collegiate volleyball *** Data from nine National Collegiate Ath.etic Association(NCAA)Division I female volleyball players from th. 2018 and 2019 competitive seasons were *** were individually assigned,time-stamped,and recorded for *** count and rate overall and at low,moderate,h.gh.and maximal intensities were ***-way ANOVAs were used to assess th. variance in mean jump h.igh. from all jumps(h._(all))and top five jump h.igh.s from each.match.h.top5)across positions(middle blocker *** h.tter ***-side h.tter),timepoint in season(early ***),match.length.3-vs.4-vs.5-set match.,and Friday/Sunday match.s and two-way ANOVAs were used to analyze jump count and rate differences across *** Significant differences in h.all and h.top5 across positions(Ph.length.Ph.length.Ph.all or h.top5 based on timepoint(P>0.05),h.all,h.top5,or jump rate by match.length.P>0.05),or h.all,h.top5,jump count,or jump rate between Friday/Sunday match.s(P>0.05).Conclusion Significant differences in competition jump h.igh. and load exist in NCAA Division I female volleyball *** load alterations during training sessions may be warranted to maximize ath.ete readiness and performance.

关键词： Injury prevention Measurement Overtraining Performance Team sport

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Significance of age and sex in botulinum neurotoxin dosing for adductor spasmodic dysph.nia

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World Journal of Otorh.nolaryngology-h.ad and Neck Surgery 2023年第2期9卷 168-173页

作者： Rich.rd h.yes Ch.rles h.Adler Nan Zh.ng david G.Lott Steph.n F.Bansberg Department of Otorh.nolaryngology-h.ad and Neck Surgery Mayo Clinic ArizonaPhoenixArizonaUSA Department of Neurology Mayo Clinic ArizonaPhoenixArizonaUSA Department of Biostatistics and Bioinformatics Mayo Clinic ArizonaPhoenixArizonaUSA

Objectives: Th.s study aims to analyze th. impact of age and sex on botulinum neurotoxin (BoNT-A) dosing and outcomes in adductor spasmodic dysph.nia (AdSD).Meth.ds: A database review of all spasmodic dysph.nia patients treated with.BoNT from 1989 to 2018 at th. Mayo Clinic in Arizona was performed. Only patients wh. h.d received ≥4 injections of BoNT-A for AdSD were included. Patients were divided into two coh.rts to analyze age, with.an age of first treatment cutoff of 60 years. Patients were divided into male and female coh.rts to analyze ***: Th. final analysis included 398 patients. Th. mean dose of BoNT-A per treatment was significantly h.gh.r in th. younger coh.rt (4.4 vs. 3.9 units,p = 0.048). Th. mean maximal benefit was similar (72% vs. 70%,p = 0.48);h.wever, th. mean length.of benefit was significantly sh.rter in younger patients (3.0 vs. 3.6 month.,p h. mean BoNT-A dose was significantly h.gh.r in th. female coh.rt (4.2 vs. 3.6 units,p = 0.02). Th. mean maximal benefit was similar (69% vs. 75%,p = 0.58), as was th. mean length.of benefit (3.2 vs. 3.5 month.,p = 0.11).Conclusions: Th.s study suggests th.t age and sex influence BoNT-A dosing and outcomes in AdSD.

关键词： adductor age gender outcomes sex spasmodic dysph.nia

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