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Th. ROBOT FARM

中国科技翻译 1999年第2期12卷 62-64页

作者： david h.Freedman

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Ｒｏｂｏｔｈｕｓｂａｎｄｒｙ①ｉｓｔｈｅｂｒａｉｎｃｈｉｌｄ②ｏｆＤａｖｉｄＪｅｆｅｒｓｏｎａｎｄＣｈｕｃｋＴａｙｌｏｒｏｆＵＣＬＡ③．Ｎｅｉｔｈｅｒｏｎｅｏｆｔｈｅｍｈａｄｗｏｒｋｅｄｗｉｔｈｒｏｂｏｔｓｕｎｔｉｌｔｈｅｙｅａｒｂｅｆｏｒｅｌａｓｔ...

关键词：群机器人杰斐逊指令组合繁衍双亲生物体夹钳程序交配再生

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Investigating th. specificity of endoth.lin-traps as a potential th.rapeutic tool for endoth.lin-1 related disorders

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World Journal of Diabetes 2022年第6期13卷 434-441页

作者： Arjun Jain Kristof Bozovicar Vidh. Meh.otra Tomaz Bratkovic Martin h.johnson Ira Jh. ET-Traps Limited Cambridge CB30JEUnited Kingdom Department of Ph.siology Development and NeuroscienceUniversity of CambridgeCambridge CB23DYUnited Kingdom Accelerate Cambridge Judge Business SchoolUniversity of CambridgeCambridge CB21AGUnited Kingdom Department of Ph.rmaceutical Biology Faculty of PharmacyUniversity of LjubljanaSlovenia 1000Slovenia

BACKGROUND Endoth.lin(ET)-traps are Fc-fusion proteins with.a design based on th. ph.siological receptors of *** work h.s sh.wn th.t use of th. selected ET-traps potently and significantly reduces different markers of diabetes path.logy back to normal,non-disease *** To demonstrate th. selected ET-traps potently and significantly bind to *** We performed ph.ge display experiments to test different constructs of ET-traps,and conducted bio-layer interferometry binding assays to verify th.t th. selected ET-traps bind specifically to ET-1 and display binding affinity in th. double-digit picomolar range(an average of 73.8 rM,n=6).RESULTS Th.se experiments h.ve confirmed our ch.ice of th. final ET-traps and provided proof-of-concept for th. potential use of constructs as effective biologics for diseases associated with.path.logically elevated *** Th.re is increased need for such.th.rapeutics as th.y could h.lp save millions of lives around th. world.

关键词： Endoth.lin-1 Endoth.lin-traps Diabetes h.art failure Ch.onic kidney disease Novel th.rapeutic

Radiograph.cal evaluation of ulcerative colitis

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Gastroenterology Report 2014年第3期2卷 169-177页

作者： Parakkal Deepak david h.Bruining Division of Gastroenterology and h.patology Mayo Clinic College of MedicineRochester MNUSA

Radiograph.cal modalities h.ve become important diagnostic tools in cases of ulcerative colitis(UC).Imaging can be used non-invasively to determine th. extent of involvement,severity of disease and to detect disease-related complications and extra-intestinal inflammatory bowel disease(IBD)*** abdominal X-rays and barium enemas still retain th.ir relevance in specific clinical settings,th. use of computed tomograph. enterograph.(CTE)or magnetic resonance enterograph.(MRE)are now used as first-line investigations to exclude active small bowel disease in IBD patients and can be utilized to detect active colonic ***,CT colonograph. and MR colonograph. are emerging tech.iques with.potential applications in ***,leukocyte scintigraph. and positron emission tomograph. are novel abdominal imaging modalities currently being explored for IBD *** pleth.ra of radiological imaging options h.s become a vital component of UC assessments.

关键词： ulcerative colitis inflammatory bowel disease radiograph.cal evaluation

Abnormal psych.logy : an integrative approach./ 3rd ed.

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Recurrent cyclops lesion after primary anterior cruciate ligament reconstruction using bone tendon bone allograft:A case report

2002年

作者： Barlow david h.

来源：畅想之星图书光盘版（南... 评论

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畅想之星图书光盘版（南通市图书馆镜像）

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World Journal of Orth.pedics 2023年第11期14卷 836-842页

作者： Grayson Kelmer Andrea h.johnson Justin J Turcotte Daniel E Redziniak Orth.pedic Research Anne Arundel Medical CenterAnnapolisMD 21401United States Medical Sch.ol Campbell University School of Osteopathic MedicineLillingtonNC 27546United States Orth.pedic Surgery Anne Arundel Medical CenterAnnapolisMD 21401United States

BACKGROUND Cyclops lesions are a known complication of anterior cruciate ligament(ACL)reconstruction,with.symptomatic cyclops syndrome occurring in up to 11%of *** cyclops lesions h.ve been rarely documented;th.s case study documents th. successful treatment of a recurrent cyclops *** SUMMARY A 28-year-old female presented following a non-contact injury to th. righ. *** and clinical exam revealed an ACL tear,and arth.oscopic reconstruction was *** years later a cyclops lesion was discovered and removed via arth.oscopic *** month. postoperatively,th. patient presented with.pain,stiffness,and difficulty ach.eving terminal extension.A smaller recurrent cyclops lesion was diagnosed,and a repeat synovectomy was *** patient recovered *** To th. best of our knowledge,th.s is th. first documented case of recurrent cyclops lesion after bone-patellar tendon-bone allograft ACL reconstruction presenting as cyclops syndrome.

关键词： Anterior cruciate ligament Cyclops lesion Cyclops syndrome Knee arth.oscopy Anterior cruciate ligament reconstruction Case report

1st UMN-CAS Bilateral Seminar on PM_(2.5) science,h.alth.effects and control tech.ology Xi'an,Ch.na,May 27-28,2014

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Particuology 2014年第5期12卷 227-229页

作者： Cao, Junji Pui, david Y. h. Kueh., Th.mas T. Tie, Xuexi Ramach.ndran, G. Zh., Tong Wang, Jing Tao, Wenquan Ch.nese Acad Sci Inst Earth Environm Xian Peoples R China Univ Minnesota Minneapolis MN 55455 USA Peking Univ Beijing 100871 Peoples R China ETh CH-8093 Zurich Switzerland Empa CH-8600 Dubendorf Switzerland Xi An Jiao Tong Univ Xian 710049 Peoples R China

Th. First UMN-CAS Bilateral Seminar was successfully con- cluded with.all th. goals met. Th. meeting in Xi＇an was informative, stimulating and enjoyable, th.nks to th. local h.st, Prof. Junji Cao, and h.s capable staff. Th. Bilateral Seminar was organized by Prof. david Y.h. Pui of th. University of Minnesota and Prof. Junji Cao of th. Institute of Earth.Environment, Ch.nese Academy of Sci- ences. It was attended by approximately 100 delegates from th. University of Minnesota （UMN）, th. Center for Filtration Research.（CFR）, th. Ch.nese Academy of Sciences （CAS） and oth.r famous Ch.nese universities. We are grateful for th. opening remarks given by UMN President Eric h.i Li on beh.lf of President Kaler and CAS Vice President Jing- Ch.nli Bai.

关键词： PM UMN-CAS Bilateral Seminar on PM science,h.alth.effects and control tech.ology Xi’an,Ch.na,May 27-28,2014 CAS

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Neutropenia in colorectal cancer treated with.oxaliplatin-based h.perth.rmic intraperitoneal ch.moth.rapy: An observational coh.rt study

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World Journal of Gastrointestinal Oncology 2020年第5期12卷 549-558页

作者： Peter h.Cash.n Lana Gh.nipour Malin Enblad david L Morris Department of Surgical Sciences Section of SurgeryUppsala UniversityAkademiska SjukhusetUppsala 75185Sweden Department of Surgery University of New South WalesSydney 2217New South WalesAustralia

BACKGROUND Th. implications of neutropenia after cytoreductive surgery and h.perth.rmic intraperitoneal ch.moth.rapy(h.PEC)treatment h.ve never been *** To evaluate th. occurrence of neutropenia and its effect on th. risk of increased Clavien-Dindo morbidity as well as its effect on overall or disease-free *** All patients with.colorectal peritoneal metastases(1996-2015)completing cytoreductive surgery and oxaliplatin-based h.PEC treatment from a biinstitutional database(Uppsala and Sydney)were included in th. ***-Dindo grade 3-4 morbidity differences between th. neutropenia group vs nonneutropenia group were calculated and Kaplan-Meier curves with.log rank test were *** and multivariable Cox regression models for diseasefree survival were *** Two h.ndred and forty-six patients were identified–32 postoperative any-grade neutropenia patients and 214 non-neutropenia *** neutropenia group h.d more combination oxaliplatin+irinotecan treatment th.n th. nonneutropenia group(66%vs 13%,P=0.0001).Th. neutropenia group was not associated with.increased Clavien-Dindo grade 3-4 *** overall survival was 53 mo vs 37 mo for th. neutropenia and non-neutropenia group,P=*** disease-free survival was 16 mo vs 11 mo,respectively,P=*** was an independent prognostic factor for disease-free survival with.h.zard ratio:0.58,95%confidence interval:0.36-0.95,P=*** 13%of patients developed neutropenia wh.ch.was not associated with.increased Clavien-Dindo grade 3-4 *** was an independent positive prognostic factor for disease-free survival and was associated with.more intense h.PEC *** is in direct contrast to th. current paradigm of decreasing th. treatment intensity.

关键词： Colorectal cancer Peritoneal metastases Cytoreductive surgery h.perth.rmic intraperitoneal ch.moth.rapy Oxaliplatin Neutropenia

Saluenolide A,A Novel Eremoph.lanolide from Senecio saluenensis

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Ch.nese Ch.mical Letters 2002年第4期13卷 333-334页

作者： Yu Zh.O Peng WANG Simon PARSONS david W.h. RANKIN DepartmentofNaturalDrugResearch CollegeofPharmaceuticalSciencesZhejiangUniversityHangzhou310031

From Senecio saluenensis, a novel eremoph.lanolide Saluenolide A was isolated. Its structure was elucidated by 2D-NMR tech.ique and X-ray diffraction.

关键词： Sesquiterpene eremoph.lanolide Senecio X-ray cytotoxicity.

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Modeling grammatical evolution by automaton

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Science Ch.na(Information Sciences) 2011年第12期54卷 2564-2573页

作者： Colin G.johnson Sch.ol of Computing University of Kent

Twelve years h.ve passed since th. advent of grammatical evolution (GE) in 1998, but such.issues as vast search.space, genotypic readability, and th. inh.rent relationsh.p among grammatical concepts, production rules and derivations h.ve remained untouch.d in almost all existing GE research.s. Model-based approach.is an attractive meth.d to ach.eve different objectives of software engineering. In th.s paper, we make th. first attempt to model syntactically usable information of GE using an automaton, coming up with.a novel solution called model-based grammatical evolution (MGE) to th.se problems. In MGE, th. search.space is reduced dramatically th.ough.th. use of concepts from building blocks, but th. functionality and expressiveness are still th. same as th.t of classical GE. Besides, complex evolutionary process can visually be analyzed in th. context of transition diagrams.

关键词： genetic programming grammatical evolution finite state automaton model