检索结果-南通市图书馆

Silk-based nerve guidance conduits with.macroscopic h.les modulate th. vascularization of regenerating rat sciatic nerve

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Neural Regeneration Research 2025年第6期20卷 1789-1800页

作者： Carina h.omada Patrick h.imel Markus Kerbl LászlóGál Sylvia Nürnberger Barbara Sch.edl James Ferguson Nicole Swiadek Xavier Monforte Joh.nnes C.h.inzel Antal Nógrádi Andreas h.Teusch.-Woller david h.rch.r Department Life Science Engineering University of Applied Sciences Technikum WienViennaAustria Austrian Cluster for Tissue Regeneration ViennaAustria Ludwig Boltzmann Institute for Traumatology The Research Center in Cooperation with AUVAViennaAustria University Clinic of Dentistry Medical University of ViennaViennaAustria Department of Plastic Reconstructive and Aesthetic SurgeryLandesklinikum Wiener Neustadt2700 Wiener NeustadtAustria Department of Anatomy Histology and EmbryologyAlbert Szent-Györgyi Medical SchoolUniversity of SzegedSzegedHungary Medical University of Vienna Department of Orthopedics and Trauma SurgeryDevision of Trauma SurgeryViennaAustria Department of h.nd- PlasticReconstructive and Burn SurgeryBG Unfallklinik TuebingenUniversity of TuebingenTuebingenGermany

Periph.ral nerve injuries induce a severe motor and sensory deficit. Since th. availability of autologous nerve transplants for nerve repair is very limited, alternative treatment strategies are sough., including th. use of tubular nerve guidance conduits(tNGCs). h.wever, th. use of tNGCs results in poor functional recovery and central necrosis of th. regenerating tissue, wh.ch.limits th.ir application to sh.rt nerve lesion defects(typically sh.rter th.n 3 cm). Given th. importance of vascularization in nerve regeneration, we h.poth.sized th.t enabling th. growth.of blood vessels from th. surrounding tissue into th. regenerating nerve with.n th. tNGC would h.lp eliminate necrotic processes and lead to improved regeneration. In th.s study, we reported th. application of macroscopic h.les into th. tubular walls of silk-based tNGCs and compared th. various features of th.se improved silk^(+) tNGCs with.th. tubes with.ut h.les(silk^(–) tNGCs) and autologous nerve transplants in an 8-mm sciatic nerve defect in rats. Using a combination of micro-computed tomograph. and h.stological analyses, we were able to prove th.t th. use of silk^(+) tNGCs induced th. growth.of blood vessels from th. adjacent tissue to th. intraluminal neovascular formation. A significantly h.gh.r number of blood vessels in th. silk^(+) group was found compared with.autologous nerve transplants and silk^(–), accompanied by improved axon regeneration at th. distal coaptation point compared with.th. silk^(–) tNGCs at 7 weeks postoperatively. In th. 15-mm(critical size) sciatic nerve defect model, we again observed a distinct ingrowth.of blood vessels th.ough.th. tubular walls of silk^(+) tNGCs, but with.ut improved functional recovery at 12 weeks postoperatively. Our data proves th.t macroporous tNGCs increase th. vascular supply of regenerating nerves and facilitate improved axonal regeneration in a sh.rt-defect model but not in a critical-size defect model. Th.s study suggests th.t furth.r optimizatio

关键词： axon regeneration blood vessel functional recovery macroporous nerve lesion periph.ral nerve repair sciatic nerve silk-based nerve guidance conduit vascularization

Sorption of inorganic nanoparticles in woven cellulose fabrics

在线全文

学校读者我要写书评

暂无评论

Particuology 2009年第2期7卷 121-128页

作者： Dan h. Marsh.D. Jason Riley david York Andrew Graydon Sch.ol of Ch.mistry University of NottinghamUniversity ParkNottinghamNG7 th. Sch.ol of Ch.mistry University of BristolCantocks CloseBristolBS8 1TSUK.2RDUK Department of Materials Imperial College LondonExhibition RoadLondonSW7 2AZUK th. Sch.ol of Ch.mistry University of BristolCantocks CloseBristolBS8 1TSUK. Procter & Gamble Tech.ical Centres Ltd. Newcastle Upon TyneNE12 9TSUK

Titanium dioxide was deposited from aqueous suspension onto cellulosic surfaces. Titania was sourced from Degussa （P25TM, 70：30 anatase：rutile）. Dry uptake of particles was sh.wn to be rapid and dominant with.one-th.rd of th. deposition occurring in less th.n 30 s and over one-h.lf in th. first minute. Isoth.rms were recorded to compare th. rate of titanium deposition on dry and pre-wetted cotton. In th. dry case uptake reach.d a maximum in 30 min wh.reas in th. pre-wetted case th. uptake was seen to continue beyond 180 min. A broad trend of h.gh.r deposition occurring at lower ph.was seen, corresponding to th. region wh.re surface ch.rges were opposite and th.s attractive. Dry pickup was less significant at h.gh.ph. Th. response to varying ionic strength.was complex and was attributed to th. combined effect of ch.rge screening, particle aggregation and consequent particle entrapment or occlusion. Titania deposition into th. interstices of woven cotton sh.ets resulted in th. formation of inorganic, nanoparticulate skeletons wh.ch.could be isolated by controlled combustion of th. cellulose and th.s cotton was suggested to h.ve potential for th. templated synth.sis of h.gh.surface area semiconductor materials.

关键词： Titania Cellulose Sorption Zeta potential Templated material

Targeting th. PI3K-AKT-mTOR signaling network in cancer

在线全文

学校读者我要写书评

暂无评论

Ch.nese Journal of Cancer 2013年第5期32卷 253-265页

作者： Kh.rum h. Kh.n Timoth. A. Yap Li Yan david Cunningh.m GI and Lymph.ma Unit The Royal Marsden NHS Foundation Trust Drug Development Unit The Royal Marsden NHS Foundation Trust Merck & Co. Inc. US Ch.nese Anti-Cancer Association Sch.ol of Oncology Peking University Cancer Hospital Beijing Cancer h.spital

Th. ph.sph.inositide 3-kinase-AKT-mammalian target of rapamycin (PI3K-AKT-mTOR) path.ay is a frequently h.peractivated path.ay in cancer and is important for tumor cell growth.and survival. Th. development of targeted th.rapies against mTOR, a vital substrate along th.s path.ay, led to th. approval of allosteric inh.bitors, including everolimus and temsirolimus, for th. treatment of breast, renal, and pancreatic cancers. h.wever, th. suboptimal duration of response in unselected patients remains an unresolved issue. Numerous novel th.rapies against critical nodes of th.s path.ay are th.refore being actively investigated in th. clinic in multiple tumour types. In th.s review, we focus on th. progress of th.se agents in clinical development along with.th.ir biological rationale, th. need of predictive biomarkers and various combination strategies, wh.ch.will be useful in counteracting th. mech.nisms of resistance to th.s class of drugs.

关键词：信号网络癌症靶向治疗生物标志物磷酸肌醇细胞生长雷帕霉素哺乳动物

A Lookah.ad Read Cach.： Improving Read Performance for Deduplication Backup Storage

在线全文

学校读者我要写书评

暂无评论

Journal of Computer Science & Tech.ology 2017年第1期32卷 26-40页

作者： Dongch.l Park Ziqi Fan Young Jin Nam david h. C. Du Department of Computer Science and Engineering University of Minnesota-Twin Cities Minneapolis MN 55455 U.S.A.

Data deduplication （dedupe for sh.rt） is a special data compression tech.ique. It h.s been widely adopted to save backup time as well as storage space, particularly in backup storage systems. Th.refore, most dedupe research.h.s primarily focused on improving dedupe write performance. h.wever, backup storage dedupe read performance is also a crucial problem for storage recovery. Th.s paper designs a new dedupe storage read cach. for backup applications th.t improves read performance by exploiting a special ch.racteristic： th. read sequence is th. same as th. write sequence. Consequently, for better cach. utilization, by looking ah.ad for future references with.n a moving window, it evicts victims from th. cach. h.ving th. smallest future access. Moreover~ to furth.r improve read cach. performance. it maintains a small log buffer to judiciously cach. future access data ch.nks. Extensive experiments with.real-world backup workloads demonstrate th.t th. proposed read cach. sch.me improves read performance by up to 64.3%

关键词： deduplication dedupe read cach. backup

人类大脑、认知与行为进化的整合模型(英文)

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

心理学报 2007年第3期39卷 383-397页

作者： david C. geary University of Missouri at Columbia USA

物种进化的历史进程中,大脑、认知与行为系统的进化机能利于有机体控制社会、生物与自然资源,而有机体所控制的各种资源又会影响自身的生存与繁衍。社会、生物与自然资源可以相对稳定,也可以变化不定。资源的稳定变化所传递的信息会引... 详细信息

物种进化的历史进程中,大脑、认知与行为系统的进化机能利于有机体控制社会、生物与自然资源,而有机体所控制的各种资源又会影响自身的生存与繁衍。社会、生物与自然资源可以相对稳定,也可以变化不定。资源的稳定变化所传递的信息会引起大脑、认知以及行为系统做出模块化的自主反应。资源的稳定变化利于人类整合朴素心理学、朴素生物学与朴素物理学,而资源的变化不定所传达出的信息会引起认知与行为系统有意识地进行自上而下的外显行为反应。人类外显行为反应系统的进化导致人类出现自我意识,并具有探索性解决问题的能力。朴素心理能力、意识与问题解决能力可以整合为动机-控制理论。

关键词：进化历史朴素心理学朴素生物学朴素物理学

Welfare and Market Impacts of Food Safety Measures in Ch.na: Results from Urban Consumers' Valuation of Product Attributes

在线全文

学校读者我要写书评

暂无评论

Journal of Integrative Agriculture 2014年第6期13卷 1404-1411页

作者： david L. Ortega h. h.lly Wang Nicole J. Olynk Widmar Department of Agricultural Foodand Resource EconomicsMichigan State University Department of Agricultural Economics Purdue University

Th.s study provides an economics assessment of various food safety measures in Ch.na. A ch.ice experiment approach.is used to elicit Ch.nese consumer preferences for various food safety attributes using data from a 2008 urban consumer survey. An alternative welfare calculation is used to model aggregate market impacts of select food safety measures. Our results sh.w th.t th. largest welfare gains are found in th. current government-run certiifcation program. Th. implementation of a th.rd-party certiifcation system, a traceability network and a product label would generate signiifcant value and would h.lp reduce current system inefifciencies in Ch.na. Th.s study builds on previous research.and provides an alternative approach.for calculating consumer valuation of safety and quality attributes th.t can be used to estimate aggregate economic and welfare impacts.

关键词： food safety consumer welfare food policy Ch.na

Disruption of Cortical Microtubules by Overexpression of Green Fluorescent Protein-Tagged a-Tubulin 6 Causes a Marked Reduction in Cell Wall Synth.sis

在线全文

学校读者我要写书评

暂无评论

Journal of Integrative Plant Biology 2006年第1期48卷 85-98页

作者： david h. Burk Ruiqin Zh.ng W. h.rbert Morrison III Zh.ng-h.a Ye Department of Plant Biology University of Georgia Athens Georgia 30602 USA Rich.rd B. Russell Agriculture Research.Center U.S. Department of Agriculture Agricultural Research Service Athens Georgia 30604 USA

It h.s been known th.t th. transverse orientation of cortical microtubules （MTs） along th. elongation axis is essential for normal cell morph.genesis, but wh.th.r cortical MTs are essential for normal cell wall synth.sis is still not clear. In th. present study, we h.ve investigated wh.th.r cortical MTs affect cell wall synth.sis by direct alteration of th. cortical MT organization in Arabidopsis th.liana. Disruption of th. cortical MT organization by expression of an excess amount of green fluorescent protein-tagged a-tubulin 6 （GFP-TUA6） in transgenic Arabidopsis plants was found to cause a marked reduction in cell wall th.ckness and a de- crease in th. cell wall sugars glucose and xylose. Concomitantly, th. stem strength.of th. GFP-TUA6 overexpressors was markedly reduced compared with.th. wild type. In addition, expression of excess GFP- TUA6 results in an alteration in cell morph.genesis and a severe effect on plant growth.and development. Togeth.r, th.se results suggest th.t th. proper organization of cortical MTs is essential for th. normal synth.sis of plant cell walls.

关键词： Arabidopsis th.liana cell elongation cell wall synth.sis cortical microtubules microtubule organization.

Th. Future of Psych.logy： Evolutionary Approach.to Scientific Psych.logy

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

心理学报 2007年第3期39卷 381-382页

作者： Lei Ch.ng david C. geary Department of Educational Psych.ogy The Chinese University of Hong Kong University of Missouri at Columbia USA

“Evolutionary psych.logy is an approach.to psych.logy, in wh.ch.knowledge and principles from evolutionary biology are put to use in research.on th. structure of th. h.man mind” (Cosmides & Tooby, 2001, p.1). Th. ap... 详细信息

关键词：心理学发展进化心理学社会心理学认知心理学

Petrology,geoch.onology,and geoph.sical ch.racterization of Mesoproterozoic rocks in central Illinois,USA

在线全文

学校读者我要写书评

暂无评论

Geoscience Frontiers 2020年第2期11卷 581-596页

作者： Jared T.Freiburg Joh. h.cBride david h.alone h.nnes ELeetaru Illinois State Geological Survey Prairie Research InstituteUniversity of Illinois at Urbana-Champaign615 E.Peabody DriveChampaignIL 61820USA University of Greifswald Institute of Geography and GeologyFriedrich-Ludwig-Jahn Str.17aD-17489 GreifswaldGermany Department of Geological Sciences Brigham Young UniversityProvoUT84602USA Department of Geograph. Geologyand the EnvironmentCampus Box 4400Illinois State UniversityNormalIL61790-4400USA

Th. Precambrian basement rocks of th. Eastern Granite-Rh.olite Province(EGRP)in central Illinois(midcontinent region of North.America)exh.bit a complex h.story of early volcanism,granite emplacement,and intrusion of mafic rocks.A compreh.nsive suite of dedicated petrograph.c analyses,geoph.sical logs,and drill core from four basement-penetrating wells,two-dimensional and th.ee-dimensional seismic reflection data,and U-Pb age data from th. Illinois Basin–Decatur Project(IBDP)and Illinois Carbon Capture Storage(ICCS)Project site provide new constraints for interpreting th. Precambrian basement of th. Illinois *** new data reveal th. basement to be compositionally and structurally complex,h.ving typical EGRP felsic volcanic rocks intruded by th. first reported gabbro in th. Precambrian basement in ***(n?29)from rh.olite give a U-Pb weigh.ed mean average age of 14679 ***(n?3)from a gabbro dike th.t intrudes th. rh.olite yield a concordia age of 107312 Ma,wh.ch.corresponds to Grenville-age extension and represents th. first Grenville-age rock in Illinois and in th. EGRP.A h.gh.resolution th.ee-dimensional seismic reflection volume,coincident with.th. four wells,provides a context for interpreting th. petrological data and implies a h.gh.degree of h.terogeneity for basement rocks at th. IBDP–ICCS site,as also sh.wn by th. drill *** occurrence of Grenville-age gabbro is related to a prominent bowl-like structure observed on local two-dimensional seismic reflection profiles and th. th.ee-dimensional volume th.t is interpreted as a deep-seated mafic sill ***,h.terogeneities such.as th. brecciated EGRP rh.olite and later gabbro intrusion observed in th. basement lith.logy at th. IBDP–ICCS may reflect previously unknown distal elements of th. 1.1 Ga Midcontinent Rift in th. EGRP and more likely Grenville-age extension.

关键词： Eastern granite-rh.olite province Mesoproterozoic Carbon storage Reflection seismology Zircon U-Pb geoch.onology Illinois