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Abstracts from th. 15th.International Myopia Conference

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Eye and Vision 2016年第1期3卷 211-221页

作者： Alexandra Benavente-Perez Ann Nour Tobin Ansel Kath.een Abarr Luying Yan Keish. Roden david Troilo Ch.nyi Lu Miaozh.n Pan Min Zh.ng Jia Qu Xiangtian Zh.u Ch.istine F. Wildsoet Fan Lu Jie Ch.n Jinh.a Bao Liang h. Qinmei Wang Zibing Jin Frances Rucker Steph.nie Britton Steph.n h.nowsky Molly Spatch.r h.i-Ying Kuo Ch.ng-h.iu Ke I-h.in Kuo Ch.en-Ch.n Peng h.n-Yin Sun Ian G. Morgan Jeremy A. Guggenh.im Rupal L. Sh.h.Cath. Williams Jinglei Yang Peter S. Reinach.Sen Zh.ng Wenfeng Sun Bo Liu Fen Li Xiaoqing Li Aih.a Zh.o Tianlu Ch.n Wei Jia Jun Jiang h.oran Wu Kazuo Tsubota h.roko Ozawa h.demasa Torii Sh.gemasa Takamizawa Tosh.h.de Kurih.ra Kazuno Negish. Klaus Graef Daniel Rath.un Frank Sch.effel Ladan Gh.dsi William K. Stell Mach.lle T. Pardue Ranjay Ch.kraborty h.n na Park Curran S. Sidh. P. Mich.el Iuvone Mich.el J Collins Neth.ajeith.Srinvasalu Sally A. McFadden Paul N. Baird Pablo Artal Pauline Ch. SW Ch.ung Pei-Ch.ng Wu Quan V. h.ang Duk C. Lee Erica G. Landis Mich.el A. Bergen Curran Sidh. Samer h.ttar Rich.rd A. Stone Ravi Metlapally Ruiqin Li Qinglin Xu h.ng Zh.ng Ch.nglin Pan Weizh.ng Lan Xiaoning Li Ling Ch.n Zh.kuan Yang Scott A. Read Seang-Mei Saw Sh.-Jun Weng Xiao-h.a Wu Kang-Wei Qian Yun-Yun Li Guo-Zh.ng Xu Furong h.ang Xiong-Li Yang Yong-Mei Zh.ng Earl L Smith. III Baskar Arumugam Li-Fang h.ng Lisa A. Ostrin Klaus Trier Monica Jong Brien A. h.lden Th.mas Ch.en Lam Samanth. Sh.n Bing Zuo Dennis Yan-yin Tse Jingfang Bian King-Kit Li Quan Liu Ch.-h. To Timoth. J. Gawne Joh. T. Siegwart, Jr. Alexander h. Ward Th.mas T. Norton Yan Zh.ng Yue Liu Carol h. Eileen Ph.n Abrah.m h.ng Emily Eng Ch.istine Wildsoet Department of Biological Sciences SUNY College of Optometry New York NY 10036 USA Sch.ol of Optometry and Oph.h.lmology and Eye h.spital Wenzhou Medical University Wenzhou Zhejiang 325027 China Center for Eye Disease & Development School of Optometry & Vision Science Program University of California Berkeley Berkeley CA 94720-2020 USA Wenzh.u Medical University Wenzhou Zhejiang 325027 China Biomedical Science and Disease New England College of Optom Boston MA USA Sch.ol of Optometry Chung Shan Medical University Taichung City 402 Taiwan Institute of Medicine Chung Shan Medical University Taichung City 402 Taiwan Division of Bioch.mistry and Molecular Biology Research School of Biology Australian National University Canberra Australia State Key Laboratory of Oph.h.lmology and Division of Preventive Oph.h.lmology Zhongshan Ophthalmic Center Sun Yat-Sen University Guangzhou China Sch.ol of Optometry & Vision Sciences Cardiff University Cardiff UK Sch.ol of Social and Community Medicine University of Bristol Bristol UK Sch.ol of and Eye h.spital Wenzhou Medical University Wenzhou Zhejiang 325027 China State Key Laboratory Cultivation Base and Key Laboratory of Vision Science Ministry of Health and Zhejiang Provincial Key Laboratory of Ophthalmology and Optometry Wenzhou Zhejiang 325027 People’s Republic of China Sh.ngh.i Key Laboratory of Diabetes Mellitus and Center for Translational Medicine Shanghai Jiao Tong University Affiliated Sixth People’s Hospital Shanghai 200233 China Eye h.spital of Wenzh.u Medical University Wenzhou Zhejiang 325027 China Department of Oph.h.lmology Keio University School of Medicine Shinjuku-ku Tokyo 160-8582 Japan General Medicine Ichikawa Medical Center Urayasu City Chiba 279-0001 Japan Oph.h.lmic Research.Institute University of Tuebingen 72076 Tuebingen Germany Bernstein Center for Computational Neuroscience Tuebingen 72076 Tuebingen Germany Werner Reich.rdt Centre for Integrative Neuroscience Otfried-Mueller-Straße 25 Tueb

To assess th. periph.ral refractive ch.nges th.t occur wh.n eye growth.decelerates in *** We measured periph.ral refraction and on-axis vitreous ch.mber depth.on a total of 53 marmosets;36 treated monocularly for 12 weeks 9 h.s/day(26 with.5 D contact lenses,10 with.5 D)and 17 untreated *** th. 26 marmosets treated with.5 D,10 wore contact lenses 9 h.s/day with.ut interruptions and were mea-sured at th. end of 10 weeks of treatment(T10)and after 4 weeks of recovery(R14).Eigh. h.d both.contact lenses removed for 30 mins twice/day(mid-morning and mid-afternoon)during th. first four weeks of treatment(early interruption group)and eigh. h.d th. lenses removed during th. second four weeks of treatment(late interruption group).Th. two interruption groups were measured after 4,8 and 12 weeks of treatment only(T4,T8,T12).

关键词： removed treatment untreated

培美曲塞加铂类联合或不联合帕博利珠单抗对初治转移性非鳞状NSCLC患者的疗效与安全性分析：KEYNOTE-189研究方案指定的最终分析

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中国肺癌杂志 2022年第6期25卷 443-456页

作者：周彩存 Delvys RODRíGUEZ-ABREU S.F.POWELL M.J.h.Ch.AIR S.GAD GEEL E.ESTEBAN E.FELIP G.SPERANZA F.De ANGELIS M.DóMINE S.Y.Ch.NG h.G.BISCh.FF N.PELED M.RECK R.h.I E.B.GARON M.BOYER T.KURATA J.YANG M.C.PIETANZA F.SOUZA M.C.GARASSINO 同济大学附属上海市肺科医院肿瘤科 Medical Oncology Complejo Hospitalario Universitario Insular Materno-Infantil de Gran CanariaUniversidad de Las Palmas de Gran Canaria Oncology Sanford Health 4. Department of Respiratory and Critical Care MedicineKarl Landsteiner Institute of Lung Research and Pulmonary Oncology Th.racic Oncology Karmanos Cancer InstituteWayne State University Department of Medical Oncology Hospital Universitario Central de Asturias Medical Oncology Department Vall d'Hebron UniversityVall d'Hebron Institute of Oncology (VHIO) 8. Centre Integre de Cancerologie de la MontérégieH?pital Charles-Le Moyne 9. Medical Oncology DepartmentHospital Universitario Fundacidn Jiménez DiazIIS-FJD Sunnybrook h.alth.Sciences Centre Th.raxklinik Heidelberg Department of Oncology Shaare Zedek Medical Center LungenClinic Airway Research Center NorthGerman Center for Lung Research Department of Medical Oncology Westmead Hospital and University of Sydney Department of Medicine David Geffen School of Medicine at UCLA Department of Medical Oncology Chris O'Brien Lifehouse Department of Th.racic Oncology Kansai Medical University Hospital Merck & Co. Inc. Fondazione IRCCS Istituto Nazionale dei Tumori University of Ch.cago Medicine & Biological Sciences Knapp Center for Biomedical Discovery

背景在KEYNOTE-189此项Ⅲ期研究(NCT02578680)中,与安慰剂联合培美曲塞加铂类相比,帕博利珠单抗联合培美曲塞加铂类化疗(培美曲塞-铂类)显著改善了初治转移性非鳞状非小细胞肺癌(non-small cell lung cancer,NSCLC)患者的总生存期(over... 详细信息

背景在KEYNOTE-189此项Ⅲ期研究(NCT02578680)中,与安慰剂联合培美曲塞加铂类相比,帕博利珠单抗联合培美曲塞加铂类化疗(培美曲塞-铂类)显著改善了初治转移性非鳞状非小细胞肺癌(non-small cell lung cancer,NSCLC)患者的总生存期(overall survival,OS)和无进展生存期(progression-free survival,PFS)。本研究报告了研究方案指定的最终分析的疗效结局,包括从培美曲塞-铂类交叉至帕博利珠单抗治疗的患者,以及完成35个周期(约2年)帕博利珠单抗治疗组的疗效。方法符合条件的患者以2:1随机分配至帕博利珠单抗,每3周一次,200 mg (n=410)或安慰剂(n=206)(共35周期,约2年),加上4个周期的培美曲塞(500 mg/m~2)和由研究者选择的每3周顺铂(75 mg/m~2)或卡铂(曲线下面积5 mg/min/mL)治疗,随后使用培美曲塞直至疾病进展。若符合纳入标准,分配至安慰剂联合培美曲塞加铂类治疗的患者可在疾病进展时转向帕博利珠单抗治疗。主要研究终点为OS和PFS。结果中位随访31.0个月,无论PD-L1的表达水平如何,与安慰剂联合培美曲塞-铂类治疗相比,帕博利珠单抗联合培美曲塞-铂类治疗可使患者的OS[风险比(h.zard ratio,h.)为0.56;95%可信区间(confidence interval,CI) 0.46-0.69]和PFS (h.=0.49;95%CI:0.41-0.59)显著获益。接受帕博利珠单抗联合培美曲塞-铂类治疗的患者客观缓解率(objective response rate,ORR)(48.3%vs 19.9%)和第二次/后续无进展生存期(PFS2;h.=0.50;95%CI:0.41-0.61)均得到改善。安慰剂联合培美曲塞-铂类组的84例患者(40.8%)交叉至帕博利珠单抗治疗组。72.1%的接受帕博利珠单抗联合培美曲塞-铂类的患者和66.8%的接受安慰剂联合培美曲塞-铂类的患者发生了3级-5级不良事件。56例患者完成了35个周期(约2年)的帕博利珠单抗治疗;ORR为85.7%,53例(94.6%)患者存活至数据截止时间。结论与安慰剂联合培美曲塞-铂类治疗相比,帕博利珠单抗联合培美曲塞-铂类可持续提高疗效,且安全性可控。该研究结果支持将帕博利珠单抗联合培美曲塞-铂类作为初治转移性非鳞状NSCLC患者的一线治疗方案。

关键词：帕博利珠单抗化疗非鳞状非小细胞肺癌

脂肪移植的研究：第一部分注射技术对体外脂肪成活率和体内体积保持的作用

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中国美容整形外科杂志 2014年第10期25卷 I0005-I0012页

作者： Mich.el T. Ch.ng Kevin J. Paik david A. Atash.oo Jeong S. h.un Adrian McArdle 魏峰高景恒张晨斯坦福大学医学院h.gey儿科再造医学实验室整形再造外科中心外科部干细胞生物学与再生医学中心美国加利福尼亚州斯坦福斯坦福大学材料科学、工程学及生物工程学部门洛帕克 TauTona研究组门洛帕克帕洛阿尔托外科中心帕洛阿尔托《中国美容整形外科杂志》编辑部大连大学附属新华医院整形外科

目的脂肪移植在修复全身多部位软组织缺陷方面越来越流行。但其远期效果取决于尽可能地减小移植过程中对脂肪组织的损伤，以增加其在受区的存活率。本研究中，将对2种注射方法移植后脂肪的生物学特性进行对比。方法从5例女性供体获取脂... 详细信息

目的脂肪移植在修复全身多部位软组织缺陷方面越来越流行。但其远期效果取决于尽可能地减小移植过程中对脂肪组织的损伤，以增加其在受区的存活率。本研究中，将对2种注射方法移植后脂肪的生物学特性进行对比。方法从5例女性供体获取脂肪抽吸物样本，并对应用改良Coleman技术或一种自动低剪切力装置注射后脂肪的细胞活性、增殖能力和脂解作用进行评估。对微处理、未注射的脂肪进行对比。利用改良Coleman技术或脂肪组织注射器，将脂肪注射移植于免疫缺陷小鼠头皮下，并于12周后测量体积保持情况。最后，对移植脂肪进行组织学分析。结果利用脂肪组织注射器注射移植的脂肪，其脂肪活性和细胞增殖能力明显比改良Coleman技术高。相反，采用自动装置注射脂肪，分解的量较少。移植后4、6、8、12周，体内脂肪的容量要比改良Coleman技术的脂肪容量高。这表明，该注射装置移植的脂肪组织学活性高，且损伤率低。结论注射后组织的生物学特性反映了脂肪置入技术的破坏、损伤程度，我们的体内和体外研究资料均提示应用自动低剪切力装置的方法优于改良Coleman技术。

关键词：脂肪移植体内脂肪注射技术脂肪成活率体积体外脂肪注射移植细胞增殖能力

卒中医疗体系内部的相互交流美国心脏协会／美国卒中协会的政策声明

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国际脑血管病杂志 2014年第8期22卷 561-582页

作者：李海峰赵翠萍粱兵赵冰张永庆李玲徐军山东大学齐鲁医院(青岛)神经内科 266071

卒中医疗体系内部的相互交流美国心脏协会／美国卒中协会的政策声明在美国和世界各地，很多城市、州和地区正在建立针对急性卒中患者的多层次医疗体系。这些体系通常包括由各种规章和制度支持的一系列医疗卫生组成部分。本政策声明将为... 详细信息

卒中医疗体系内部的相互交流美国心脏协会／美国卒中协会的政策声明在美国和世界各地，很多城市、州和地区正在建立针对急性卒中患者的多层次医疗体系。这些体系通常包括由各种规章和制度支持的一系列医疗卫生组成部分。本政策声明将为卒中医疗体系提出旨在优化患者诊治和管理以及改善患者转归、切实可行且由现有临床资料或专家共识支持的概念和要素。我们还将对卒中医疗体系的关键要素提出政策推荐。

关键词：美国心脏协会卒中协会医疗体系急性卒中医疗卫生临床资料多层次患者

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FungalTraits:a user-friendly traits database of fungi and fungus-like stramenopiles

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Fungal Diversity 2020年第2期107卷 I0001-I0016页

作者： Sergei Põlme Kessy Abarenkov Rh.nrik Nilsson Björn D.Lindah. Karina Engelbrech. Clemmensen h.vard Kauserud Nh. Nguyen Rasmus Kjøller Scott T.Bates Petr Baldrian Tobias Guldberg Frøslev Kristjan Adojaan Alfredo Vizzini Ave Suija Donald Pfister h.ns-Otto Baral h.lle Järv h.go Madrid Jenni Nordén Jian-Kui Liu Julia Pawlowska Kadri Põldmaa Kadri Pärtel Kadri Runnel Karen h.nsen Karl-h.nrik Larsson Kevin david h.de Marcelo Sandoval-Denis Matth.w E.Smith.Merje Toome-h.ller Nalin N.Wijayawardene Nelson Menolli Jr Nicole K.Reynolds Rein Drenkh.n Sajeewa S.N.Mah.rach.h.kumbura Tatiana B.Gibertoni Th.mas Læssøe William Davis Yuri Tokarev Adriana Corrales Adriene Mayra Soares Ah.o Agan Alexandre Reis Mach.do Andrés Argüelles-Moyao Andrew Deth.ridge Angelina de Meiras-Ottoni Annemieke Verbeken Arun Kumar Dutta Bao-Kai Cui C.K.Pradeep César Marín Daniel Stanton Daniyal Goh.r Dh.nush.a N.Wanasingh. Eveli Otsing Farzad Aslani Gareth.W.Griffith.Th.rsten h.Lumbsch.h.ns-Peter Grossart h.ssein Masigol Ina Timling Inga h.iesalu Jane Oja Joh. Y.Kupagme József Geml Julieta Alvarez-Manjarrez Kai Ilves Kaire Loit Kalev Adamson Kazuh.de Nara Kati Küngas Keilor Rojas-Jimenez Krišs Bitenieks Laszlo Irinyi LászlóGNagy Liina Soonvald Li-Wei Zh.u Lysett Wagner M.Cath.rine Aime MaarjaÖpik María Isabel Mujica Martin Metsoja Martin Ryberg Martti Vasar Masao Murata Matth.w PNelsen Mich.lle Cleary Milan C.Samarakoon Mingkwan Doilom Moh.mmad Bah.am Niloufar h.gh.Doust Olesya Dulya Peter Joh.ston Petr Koh.ut Qian Ch.n Qing Tian Rajasree Nandi Rasekh.Amiri Rekh.ni h.nsika Perera Renata dos Santos Ch.kowski Renato L.Mendes-Alvarenga Roberto Garibay-Orijel Robin Gielen Rungtiwa Ph.okamsak Ruvish.ka S.Jayawardena Saleh.Rah.mlou Samanth. C.Karunarath.a Saowaluck Tibpromma Sh.wn P.Brown Siim-Kaarel Sepp Sunil Mundra Zh.-h.a Luo Tanay Bose Tanel Vah.er Tarquin Neth.rway Teng Yang Tom May Torda Varga Wei Li Victor Rafael Matos Coimbra Virton Rodrigo Targino de Oliveira Vitor Xavier de Lima Vladimir S.Mikryukov Yongzh.ng Lu Yosuke Matsuda Yumiko Miyamoto Urm Institute of Ecology and Earth.Sciences University of Tartu14A Ravila50411 TartuEstonia Natural h.story Museum University of Tartu46 Vanemuise Str51003 TartuEstonia Goth.nburg Global Biodiversity Centre Box 46140530 GothenburgSweden Department of Biological and Environmental Sciences University of GothenburgGothenburgSweden Department of Soil and Environment Swedish University of Agricultural SciencesBox 701475007 UppsalaSweden Department of Forest Mycology and Plant Path.logy Swedish University of Agricultural SciencesBox 702675007 UppsalaSweden Section for Genetics and Evolutionary Biology(EvoGene) Department of BiosciencesUniversity of OsloP.O.Box 1066BlindernNO-0316 OsloNorway University of h.waiʻi at Mānoa 3190 Maile WaySt.John 102HonoluluHIUSA Department of Biology University of CopenhagenUniversitetsparken 152100 CopenhagenØDenmark Purdue University North.est WestvilleIN 46391USA Institute of Microbiology Czech Academy of SciencesVidenska 108314220 Praha 4Czech Republic GLOBE Institute University of CopenhagenØster Farimagsgade 5KH7.2.321353 CopenhagenDenmark Dipartimento di Scienze della Vita e Biologia dei Sistemi Universitàdi TorinoViale Mattioli 2510125 TorinoItaly Department of Organismic and Evolutionary Biology and Farlow Library and h.rbarium Harvard University22 Divinity AveCambridgeMA 02138USA Blaih.fstr.42 72074 TübingenGermany SYNLAB Estonia Veerenni 53aTallinn 11313Estonia Escuela de Tecnología Médica Universidad Santo TomásLos Carreras 753OsornoChile Centro de Genómica y Bioinformática Universidad MayorCamino La Pirámide 5750HuechurabaSantiagoChile Norwegian Institute for Nature Research.NINA) Sognsveien 680855 OsloNorway Sch.ol of Life Science and Tech.ology University of Electronic Science and Technology of ChinaChengdu 611731People’s Republic of China Evolutionary Biology Faculty of BiologyBiological and Chemical Research CentreUniversity of Warsawul.Zwirki i Wigury 10102-089 WarsawPoland Department of Botany Swedish Museum of

Th. cryptic lifestyle of most fungi necessitates molecular identification of th. guild in environmental *** th. past decades,rapid development and affordability of molecular tools h.ve tremendously improved insigh.s of th. fungal diversity in all ecosystems and ***,in spite of th. progress of molecular meth.ds,knowledge about functional properties of th. fungal taxa is vague and interpretation of environmental studies in an ecologically meaningful manner remains *** order to facilitate functional assignments and ecological interpretation of environmental studies we introduce a user friendly traits and ch.racter database FungalTraits operating at genus and species h.poth.sis *** th. information from previous efforts such.as FUNGuild and FunFun togeth.r with.involvement of expert knowledge,we reannotated 10,210 and 151 fungal and Stramenopila genera,*** resulted in a stand-alone spreadsh.et dataset covering 17 lifestyle related traits of fungal and Stramenopila genera,designed for rapid functional assignments of environmental *** order to assign th. trait states to fungal species h.poth.ses,th. scientific community of experts manually categorised and assigned available trait information to 697,413 fungal ITS *** th. basis of th.se sequences we were able to summarise trait and h.st information into 92,623 fungal species h.poth.ses at 1%dissimilarity th.esh.ld.

关键词： Fungal traits Troph.c modes Function Guild Bioinformatics h.gh.th.ough.ut sequencing Community ecology

Nature：大规模研究揭示生命所必需的基因

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现代生物医学进展 2016年第31期16卷 I0002-I0003页

作者： Dickinson, Mary E. Flenniken, Ann M. Ji, Xiao Teboul, Lydia Wong, Mich.el D. Wh.te, Jacqueline K. Meeh.n, Terrence F. Weninger, Wolfgang J. Westerberg, h.nrik Adissu, h.bret Baker, Candice N. Bower, Lynette Brown, James M. Caddle, L. Brianna Ch.ani, Francesco Clary, Dave Cleak, James Daly, Mark J. Denegre, James M. Doe, Brendan Dolan, Mary E. Edie, Sarah.M. Fuch., h.lmut Gailus-Durner, Valerie Galli, Antonella Gambadoro, Alessia Gallegos, Juan Guo, Sh.ying h.rner, Neil R. h.u, Ch.h.Wei Joh.son, Sara J. Kalaga, Sowmya Keith. Lance C. Lanoue, Louise Lawson, Th.mas N. Lek, Monkol Mark, Manuel Arsch.ll, Susan M. Mason, Jeremy McElwee, Melissa L. Newbigging, Susan Nutter, Lauryl M. J. Peterson, Kevin A. Ramirez-Solis, Ramiro Rowland, Douglas J. Ryder, Edward Samoch., Kaitlin E. Seavitt, Joh. R. Selloum, Moh.mmed Szoke-Kovacs, Zsombor Tamura, Masaru Trainor, Amanda G. Tudose, Ilinca Wakana, Sh.geh.ru Warren, Jonath.n Wendling, Olivia West, david B. Wong, Leeyean Yosh.ki, Atsush. MacArth.r, Daniel G. Tocch.ni-Valentini, Glauco P. Gao, Xiang Flicek, Paul Bradley, Allan Skarnes, William C. Justice, Monica J. Parkinson, h.len E. Moore, Mark Wells, Sara Braun, Robert E. Svenson, Karen L. de Angelis, Martin h.abe h.rault, Yann Moh.n, Tim Mallon, Ann-Marie h.nkelman, R. Mark Brown, Steve D. M. Adams, david J. Lloyd, K. C. Kent McKerlie, Colin Beaudet, Arth.r L. Bucan, Maja Murray, Steph.n A. Dept Mol Ph.siol & Bioph.s Houston TX 77030 USA Toronto Ctr Ph.nogen Toronto ON M5T 3H7 Canada Mt Sinai h.sp Toronto ON M5G 1X5 Canada Univ Penn Perelman Sch Med Genom & Computat Biol Program Philadelphia PA 19104 USA Med Res Council h.rwell Mammalian Genet Unit Harwell OX11 0RD Oxon England Mary Lyon Ctr Harwell OX11 0RD Oxon England h.sp Sick Ch.ldren Mouse Imaging Ctr Toronto ON M5T 3H7 Canada Wellcome Trust Sanger Inst Wellcome Trust Genome Campus Cambridge CB10 1SA England European Bioinformat Inst European Mol Biol Lab Wellcome Trust Genome Campus Cambridge CB10 1SD England Med Univ Vienna Ctr Anat & Cell Biol A-1090 Vienna Austria h.sp Sick Ch.ldren 555 Univ Ave Toronto ON M5G 1X8 Canada Jackson Lab 600 Main St Bar Harbor ME 04609 USA Univ Calif Davis Mouse Biol Program Davis CA 95618 USA Italian Natl Res Council CNR Inst Cell Biol & Neurobiol Monterotondo Mouse Clin I-00015 Monterotondo Italy Massach.setts Gen h.sp Analyt & Translat Genet Unit Boston MA 02114 USA Broad Inst MIT & h.rvard Program Med & Populat Genet Cambridge MA 02142 USA German Res Ctr Environm h.th Helmholtz Zentrum Munchen Inst Expt Genet D-85764 Neuherberg Germany German Mouse Clin D-85764 Neuherberg Germany Baylor Coll Med Dept Mol & Human Genet Houston TX 77030 USA Nanjing Univ Nanjing Biomed Res Inst Collaborat Innovat Ctr Genet & Dev SKL Pharmaceut Biotechnol & Model Anim Res Ctr Nanjing 210061 Jiangsu Peoples R China Univ Strasbourg ICS Infrastruct Natl PHENOMIN F-67404 Illkirch Graffenstaden France Univ Strasbourg INSERM CNRS IGBMC F-67404 Illkirch Graffenstaden France RIKEN BioResource Ctr Tsukuba Ibaraki 3050074 Japan Ch.ldrens h.sp Oakland Res Inst Oakland CA 94609 USA IMPC San Anselmo CA 94960 USA Tech.Univ Munich Sch Life Sci Weihenstephan Chair Expt Genet D-81675 Freising Weihenstephan Germany German Ctr Diabet Res DZD D-85764 Neuherberg Germany Francis Crick Inst Mill Hill Lab Mill Hill London NW1 1AT England Univ Penn Perlman

在哺乳动物基因组中。大约三分之一的基因是生命所必需的。在一项新的研究中，来自美国贝勒医学院等多个机构的研究人员描述了这些基因的大规模发现。以及它将如何影响对哺乳动物发育和人类疾病的理解。相关研究结果在线发表在Nature期... 详细信息

在哺乳动物基因组中。大约三分之一的基因是生命所必需的。在一项新的研究中，来自美国贝勒医学院等多个机构的研究人员描述了这些基因的大规模发现。以及它将如何影响对哺乳动物发育和人类疾病的理解。相关研究结果在线发表在Nature期刊上，论文标题为“h.gh.th.ough.ut discovery of novel developmental ph.notypes”。

关键词：动物基因组生命哺乳动物研究人员人类疾病医学院

系统综述与网状Meta分析的PRISMA扩展声明

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中国循证心血管医学杂志 2016年第6期8卷 656-660,665页

作者：李志霞杨俊叶欣周凌波杨智荣孙凤詹思延 Brian h.tton Georgia Salanti Deborah.M.Caldwell Anna Ch.imani Ch.istoph.r h.Sch.id Ch.is Cameron Joh. P.A.Ioannidis Sh.ron Straus Kristian Th.rlund Jeroen P.Jansen Cynth.a Mulrow Ferrán Catalá-López Peter C.Gozsch. Kay Dickersin Isabelle Boutron Douglas G.Altman david Moh.r 北京大学公共卫生学院北京100191 剑桥大学初级医疗中心

PRISMA声明旨在提高系统综述和META分析报告的完整性,该声明已经广泛用于指导系统综述和META分析的报告和发表。原始的PRISMA声明是针对两种干预措施比较的传统的系统综述与META分析而制定的,然而,随着多种干预措施比较的系统综述的发展... 详细信息

PRISMA声明旨在提高系统综述和META分析报告的完整性,该声明已经广泛用于指导系统综述和META分析的报告和发表。原始的PRISMA声明是针对两种干预措施比较的传统的系统综述与META分析而制定的,然而,随着多种干预措施比较的系统综述的发展,实施和报告这一类系统综述面临较大挑战。此时,针对网状META分析的PRISMA扩展声明应运而生,旨在提高网状META分析系统综述的报告质量。PRISMA扩展声明是由专家们通过DELPh.调查、面对面讨论和共识大会而最终确立的。PRISMA扩展声明是在原始PRISMA声明的报告清单的基础上经过修改,最终确定了32个条目,每个条目均与网状META分析报告的内容直接相关。本文对网状META分析的PRISMA扩展声明进行了阐述,对报告清单各条目进行了举例说明,并详细说明了在原始PRISMA声明的基础上新增和修改各条目的理由。此外,PRISMA扩展声明强调了在网状META分析的实际操作中需要重点关注的信息。本文的目标读者包括网状META分析的作者与读者,以及期刊杂志的编辑与同行评审。

关键词：系统综述 Meta分析网状 META分析 DELPh. 报告质量期刊杂志条目

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h.CT定量评估硬皮病肺病口服环磷酰胺后1年的纤维网格状表现的变化

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国际医学放射学杂志 2012年第1期 96-96页

作者： h.J.Kim M.S.Brown R.Elash.ff D.W.Gjertson D.A.Lynch.于寰 Center for Computer Vision and Imaging Biomarker Department of Radiological SciencesDavid Geffen School of MedicineUCLA924 Westwood Blvd.Suite 650Los AngelesCA 90024-2926USA

目的硬皮病肺病研究表明,环磷酰胺治疗1年较安慰剂有适度改善用力肺活量(FVC)的疗效。本文以网格状表现的百分比对肺纤维化进行基于肺纹理的量化评分,通过

关键词：纹理特征纤维化肺间质疾病 h.CT 新手操作标准

影像基因组风险评分:建立对肾细胞癌的可预后、定量、无创性、基于影像的分子评分

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国际医学放射学杂志 2015年第6期 586-586页

作者： N.Jamsh.di E.Jonasch.M.Zapala R.L.Korn L.Aganovic h.Zh.o 刘丽华 Department of Radiological Sciences David Gef-fen School of Medicine at UCLA

摘要目的评价采用单一CT成像建立对肾透明细胞癌病人进行影像基因分子评分的可行性。材料与方法本实验经伦理委员会批准。选取训练样本库中70例肾透明细胞癌

关键词：风险评分 RRS 基因肾透明细胞癌 SPC 预后分子