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Phase Ⅱ trial of CDK4/6 inhibitor palbociclib in advanced sarcoma based on mRNA expression of CDK4/CDKN2A

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Signal Transduction and Targeted Therapy 2023年第11期8卷 5518-5527页

作者： Javier Martin-Broto Jeronimo Martinez-Garcia david SMoura Andres Redondo Antonio Gutierrez Antonio Lopez-Pousa Javier Martinez-Trufero Isabel Sevilla Roberto Diaz-Beveridge Maria Pilar Solis-Hernandez Amancio carnero Marco Perez david Marcilla Jesus Garcia-Foncillas Pablo Romero Javier Fernandez-Jara Daniel Lopez-Lopez Ivan Arribas Nadia Hindi Health Research Institute-Fundación Jiménez Díaz University Hospital Universidad Autónoma de Madrid(IIS-FJDUAM)28040MadridSpain Medical Oncology Department Fundación Jimenez Diaz University Hospital28040MadridSpain General de Villalba University Hospital 28400MadridSpain Medical Oncology Department University Hospital Virgen de la Arrixaca30120MurciaSpain Department of Medical Oncology Hospital Universitario La Paz-IdiPAZP.Castellana26128046MadridSpain Hematology Department University Hospital Son Espases07120MallorcaSpain Medical Oncology Department Sant Pau Hospital08025BarcelonaSpain Medical Oncology Department University Hospital Miguel Servet50009ZaragozaSpain Investigación Clínica y Traslacional en Cáncer/Instituto de Investigaciones Biomédicas de Malaga(IBIMA)/Hospitales Universitarios Regional y Virgen de la Victoria de Malaga MalagaSpain Medical Oncology Department Hospital Universitari i Politècnic La Fe46026ValenciaSpain Medical Oncology Department Central University Hospital of Asturias33011OviedoSpain Instituto de Biomedicina de Sevilla(IBiS HUVRCSICUS)41013SevillaSpain Pathology Department Virgen del Rocio University Hospital41013SevillaSpain Radiology Department Fundación Jimenez Diaz University Hospital28040MadridSpain Computational Medicine Platform Fundación progreso y salud(FPS)Hospital Virgen del Rocío41013SevilleSpain Bioinformatics in Rare Diseases(BiER).Centro de Investigación Biomédica en Red de Enfermedades Raras(CIBERER) FPSHospital Virgen del RocioSevillaSpain Universitat de València-ERI-CES 46010ValenciaSpain

Cyclin-dependent kinases 4 and 6(CDK4/6)inhibitors demonstrated activity in terms of progression-free survival(PFS)in advanced dedifferentiated liposarcoma(DD-LPS),a sarcoma with CDK4 ***4 overexpression is by far more common than amplification in sarcomas and it might be a rational target for CDK *** investigators of this study found that CDK4 overexpression,while not of CDKN2A,was the most consistent predictive factor for palbociclib efficacy in *** adult-type soft-tissue sarcoma,excluding DD-LPS,or bone sarcoma patients,progressing after at least one systemic line,whose tumors overexpressed CDK4,but not CDKN2A at baseline biopsy,were accrued in this single-arm phase II trial(EudraCT number:2016-004039-19).With the main endpoint of a 6-month PFS rate,40%was considered promising in this *** was administered orally at 125 mg/day for 21 days in 28-day cycles.A total of 214 patients with 236 CDK4/CDKN2A determinations were assessed for prescreening,archival material(141),and screening,baseline biopsy(95).There were 28(29%)with favorable mRNA profiles from 95 screened patients at *** 23 enrolled patients,21 evaluable,the 6-month PFS rate was 29%(95%CI 9–48),and there were 6 patients out of 21 with a PFS longer than 6 *** median PFS and overall survival were 4.2(95%CI 3.6–4.8)and 12(95%CI 8.7–15.4)months,*** research showed a significant correlation between CDK4 mRNA and protein *** was active in a variety of sarcoma subtypes,selected by CDK4/CDKN2A,and deserves further investigation in the sarcoma context.

关键词： CDKN2A sarcoma CDK4

Trends in Global and Mexico Research in Wildfires: A Bibliometric Perspective

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Open Journal of Forestry 2023年第2期13卷 182-199页

作者： Daniel Alejandro Cadena Zamudio Betsabé Ruiz Guerra José Luis Arispe Vázquez José German Flores Garnica Leslie carnero Avilés Rocío Toledo Aguilar david Heriberto Noriega Cantú Adriana Antonio Bautista Juan Mayo Hernandez david Castillo Quiroz Norma Tolama Nava Roger Guevara Hernández Instituto Nacional de Investigaciones Forestales Agrícolas y Pecuarias Iguala de la Independencia Guerrero México Instituto de Ecología A.C Xalapa Veracruz México Instituto Nacional de Investigaciones Forestales Agrícolas y Pecuarias Tepatitlán Guadalajara México Instituto Nacional de Investigaciones Forestales Agrícolas y Pecuarias Delicias Chihuahua México Universidad Autónoma Agraria Antonio Narro Saltillo Coahuila México Instituto Nacional de Investigaciones Forestales Agrícolas y Pecuarias Saltillo Coahuila México

In the last two decades, unprecedented changes have taken place in the frequency and severity of wildfires;in different regions of the world, some fires were even classified as megafires. Although there are studies about the diverse effects of fire, which have made significant theoretical contributions, a comprehensive review of the changes in fire research is required to understand worldwide patterns, particularly in those countries where fire activity is on the rise, such is the case of Mexico. The objective of this study was to analyze the trends in the research on wildfires published in Mexico and worldwide over a 40-year timescale. For this purpose, the Web of Science database, bibliometric tools, and the keywords TI = Forest fire* OR TI = Wildfire* were used to extract as many articles as possible related to fires from 1980 to 2020, without being restricted to those studies whose title included any of the variants of the keywords. There were 8458 publications about fires in the vegetation cover, with a notable increase in the frequency of studies in the previous decade;52% of the studies were concentrated in five countries and 20% of the articles focused on the study of different aspects of the soil. Mexico ranks thirteenth in volume of scientific production and studies in the country have focused mainly on the description of the quantitative relationship between the size of the affected area and the number of occurrences in the landscape, meanwhile, studies on fires and the consequences on the biotic interactions have been little explored.

关键词： Global Warming Fire Regime Forest Ecosystems Biotic Interactions Anthropogenic Activities

The Beneficial Effect of Trichoderma spp. in Seed Treatment of Four Maize (Zea mays L.) Genotypes

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American Journal of Plant Sciences 2023年第6期14卷 625-637页

作者： José Luis Arispe-Vázquez Abiel Sánchez-Arizpe Daniel Alejandro Cadena-Zamudio Ma. Elizabeth Galindo-Cepeda david Heriberto Noriega-Cantú Oscar Guadalupe Barrón-Bravo Leslie carnero-Avilés Juan Mayo-Hernández Susana Elizabeth Ramírez-Sánchez Adriana Antonio-Bautista Instituto Nacional de Investigaciones Forestales Agrícolas y Pecuarias Iguala de la Independencia Guerrero México Departamento de Parasitología Universidad Autónoma Agraria Antonio Narro Saltillo México Instituto Nacional de Investigaciones Forestales Agrícolas y Pecuarias Altamira México Instituto Nacional de Investigaciones Forestales Agrícolas y Pecuarias Delicias México Instituto Nacional de Investigaciones Forestales Agrícolas y Pecuarias Tepatitlán de Morelos Jalisco México Departamento de Fitomejoramiento Universidad Autónoma Agraria Antonio Narro Saltillo México

Maize is the main crop for Mexicans;however, it is affected by species of fungi causing ear rot. This research aimed to evaluate the effect of T. asperellum T11, T. harzianum T1 4 y T. longibrachiatum T1 40 on some agronomic variables of four maize genotypes. The seeds of the genotypes H-515, Zapata 7, and H-507 were treated with a suspension of Trichoderma spp. to 1 × 108 spores mL-1, using a control (untreated seed), and Benomyl as chemical control. The planting was in Morelos, in a completely random block design with a factorial arrangement. The ear rot was natural. Data were obtained at the end of the crop cycle and processed in SAS 9.4®. H-515 genotype had the greatest effect on the treatment of maize seeds with Trichoderma spp. (5.562 kg);T. asperellum T11 was the strain that stood out with a mean yield of 50 ears in an area of 16 m2 of 4.904 kg, and control of 4.448 kg. Our results are an economic option for farmers to contemplate the use of Trichoderma and obtain its benefits.

关键词： Seeds Treatment Trichoderma asperellum Ear Rot Yield

Level of Contamination of Fishponds Water in Pesticide Residues and Metallic Trace Elements (Pb, Cd, As, Hg): Case of Fishponds of ZEPREGUHE (Daloa, Côte d’Ivoire)

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Journal of Agricultural Chemistry and Environment 2022年第4期11卷 307-317页

作者： Kacou Alain Paterne Dalogo Ano Guy Serge Ehouman James Halbin Kouadio david Leonce Kouadio Edi Jean Frejus Ehui Karim Sory Traore Laboratory of Environmental Sciences and Technology Jean Lorougnon GUEDE University Daloa C&ocirc te d’Ivoire Laboratory of Environmental Sciences Nangui Abrogoua University Abidjan C&ocirc te d’Ivoire Agroforestry Training and Research Unit Biochemistry-microbiology Department Agrovalorisation Laboratory Jean Lorougnon GUEDE University Daloa C&ocirc te d’Ivoire

Fishponds waters intended to satisfy the nutritional needs of the populations in terms of supply of fish resources are strongly and unfortunately exposed to the mobility and dispersion of metallic trace elements (TMEs) or to the persistence in the environment and in the form of pesticide residues from human activities. The objective of this work is to evaluate, on the one hand, the levels of identified pesticide residues and, on the other hand, those of researched TMEs (lead, cadmium, mercury and arsenic) in the waters of ponds used for fish farming in Zépréguhé, a locality located 9 km from the town of Daloa in the centre-west of Côte d’Ivoire. The dosage of the samples carried out by means of a gas chromatograph coupled to a mass spectrometer (GC/MS) made it possible to detect nine (9) pesticide molecules, including eight (8) organochlorines and a single molecule from the pyrethroid family, obtained from the detection limit of 0.006 μg/L and the quantification limit of 0.018 μg/L. The maximum average concentration was obtained with α-endosulfan for a content reaching 0.8038 μg/L and well above the maximum admissible concentration of 0.1 μg/L. The TMEs were quantified using an atomic absorption spectrophotometer (AAS). Arsenic is the most abundant metal with an average concentration of 9.497 μg/L. With the exception of lead, these measured levels are above the acceptable limit values for freshwater. This study showed that human activities such as the use of fertilisers and plant protection products in plantations, sand extraction and road traffic have a negative impact on the quality of the water in ponds used for fish breeding.

关键词： Fishpond Water Metallic Trace Elements Pesticide Residues Maximum Residue Levels

Desorption of Methylene Blue Adsorbed on Activated Carbon from Cocoa Pod Shell

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Open Journal of Applied Sciences 2023年第5期13卷 605-617页

作者： david Léonce Kouadio Yapo Aristide Hermann Yapi Djedjess Essoh Jules César Meledje Kacou Alain Paterne Dalogo Djamatché Paul Valery Akesse Brou Dibi Karim Sory Traore Laboratoire des Sciences et Technologie de l’Environnementale Université Jean Lorougnon Guede C&#244te d’Ivoire Laboratoire des Sciences Physiques Fondamentales et appliquées école Normale Supérieure (Abidjan) Abidjan C&#244te d’Ivoire Laboratoire des Sciences de l’Environnement Université Nangui Abrogoua C&#244te d’Ivoire

Environmental protection has become a concern for the world. For this reason, the objective of this work is to remove methylene blue adsorbed on activated carbon. The coal used comes from cocoa pod shells. Before pyrolysis, the shells were ground, sieved and impregnated with orthophosphoric acid. Before desorption, the activated carbons were initially saturated with MB. These saturated coals were brought into contact with a sodium chloride (NaCl) solution and then stirred. The evolution of the resorbed MB concentration was monitored by spectrophotometry. The desorption tests showed a remarkable elimination from the first 10 minutes. The desorption kinetics comprises two phases: a rapid kinetics between 0 and 30 minutes and a slow kinetics between 30 and 60 minutes. The desorption of the dye reaches a concentration aqual to 0.84 mg/l at pH = 4 at temperature = 80°C. For modeling, the coefficient of the Langmuir II model is greater than or equal to O.9893. The model of Langmuir III is less than or equal to 0.9373. The Freundlich model coefficient is 0.9842 or less. The desorption is thefore carried out on energy-homogeneous adsorption sites and without any interaction between the adsorbed cations of the dye. Experimental parameters such as pH, temperature and concentration of sodium chloride (NaCl) solution influence the desorption of MB. And the model of Langmuir II describes well the process of desorption of the MB.

关键词： Desorption Activated Carbon Methylene Blue Isotherm Sodium Chloride