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Support Vector Machines for Regression: A Succinct Review of Large-Scale and Linear Programming Formulations

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International Journal of Intelligence Science 2013年第1期3卷 5-14页

作者： Pablo Rivas-Perea Juan Cota-Ruiz david garcia chaparro Jorge Arturo Perez Venzor Abel Quezada Carreón Jose Gerardo Rosiles Department of Computer Science School of Engineering & Computer Science Baylor University Waco USA Department of Electrical & Computer Engineering Autonomous University of Ciudad Juárez Ciudad Juárez México Rosiles Consulting El Paso USA

Support Vector-based learning methods are an important part of Computational Intelligence techniques. Recent efforts have been dealing with the problem of learning from very large datasets. This paper reviews the most commonly used formulations of support vector machines for regression (SVRs) aiming to emphasize its usability on large-scale applications. We review the general concept of support vector machines (SVMs), address the state-of-the-art on training methods SVMs, and explain the fundamental principle of SVRs. The most common learning methods for SVRs are introduced and linear programming-based SVR formulations are explained emphasizing its suitability for large-scale learning. Finally, this paper also discusses some open problems and current trends.

关键词： Support Vector Machines Support Vector Regression Linear Programming Support Vector Regression

Forecasting the Demand of Short-Term Electric Power Load with Large-Scale LP-SVR

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Smart Grid and Renewable Energy 2013年第6期4卷 449-457页

作者： Pablo Rivas-Perea Juan Cota-Ruiz david garcia chaparro Abel Quezada Carreón Francisco J. Enríquez Aguilera Jose-Gerardo Rosiles Department of Computer Science School of Engineering and Computer Science Baylor University Waco USA Department of Electrical and Computer Engineering Autonomous University of Ciudad Juárez (UACJ) Ciudad Juárez México Science Applica- tions International Corporation El Paso USA.

This research studies short-term electricity load prediction with a large-scalelinear programming support vector regression (LP-SVR) model. The LP-SVR is compared with other three non-linear regression models: Collobert’s SVR, Feed-Forward Neural Networks (FFNN), and Bagged Regression Trees (BRT). The four models are trained to predict hourly day-ahead loads given temperature predictions, holiday information and historical loads. The models are trained on-hourly data from the New England Power Pool (NEPOOL) region from 2004 to 2007 and tested on out-of-sample data from 2008. Experimental results indicate that the proposed LP-SVR method gives the smallest error when compared against the other approaches. The LP-SVR shows a mean absolute percent error of 1.58% while the FFNN approach has a 1.61%. Similarly, the FFNN method shows a 330 MWh (Megawatts-hour) mean absolute error, whereas the LP-SVR approach gives a 238 MWh mean absolute error. This is a significant difference in terms of the extra power that would need to be produced if FFNN was used. The proposed LP-SVR model can be utilized for predicting power loads to a very low error, and it is comparable to FFNN and over-performs other state of the art methods such as: Bagged Regression Trees, and Large-Scale SVRs.

关键词： Power Load Prediction Linear Programming Support Vector Regression Neural Networks for Regression Bagged Regression Trees

Intense pulsed light‑based treatment for the improvement of symptoms in glaucoma patients treated with hypotensive eye drops

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Eye and Vision 2024年第2期10卷 12-21页

作者： Jose Maria Martinez‑de‑la‑Casa Carlos Oribio‑Quinto Almudena Milans‑del‑Bosch Pilar Perez‑garcia Laura Morales‑Fernandez Javier garcia‑Bella Jose Manuel Benitez‑del‑Castillo Julian garcia‑Feijoo david P.Pinero Ophthalmology Unit Department of Ophthalmology and ORLFaculty of MedicineHospital Clinico San-CarlosUniversidad Complutense de MadridInstituto de Investigacion Sanitaria del Hospital Clinico San-Carlos(IdISSC)28040 MadridSpain Department of Immunology Ophthalmology and ORLSchool of MedicineInstituto de Investigaciones Oftalmologicas Ramon CastroviejoUniversidad Complutense de MadridMadridSpain Department of Optics Pharmacology and AnatomyUniversity of AlicanteAlicanteSpain

Background:Ocular surface disease in glaucoma patients is a significant ocular co-morbidity that can affect 40%to 59%of these patients *** current study was aimed at evaluating the potential clinical benefit of an intense pulsed light(IPL)-based treatment in glaucomatous patients with ocular surface disease due to prolonged hypotensive eyedrop *** our knowledge,this is the first series analyzing the therapeutic effect of this treatment option in this type of ***:This non-comparative prospective case series study enrolled a total of 30 glaucoma patients ranging in age from 57 to 94 years old and treated with hypotensive eyedrops for years with dry eye *** patients received four sessions of IPL treatment using the Optima IPL system(Lumenis,Yokneam,Israel)adjusted to the official optimized Lumenis *** in symptomatology,corneal staining,conjunctival hyperemia,non-invasive break-up time(NIBUT),tear osmolarity,tear meniscus height(TMH),meiboscore and meibomian gland expressibility was analyzed after ***:Statistically significant reductions were observed after IPL treatment in the symptomatology scores measured with different questionnaires[ocular surface disease index(OSDI),standard patient evaluation of eye dryness(SPEED)and symptom assessment questionnaire in dry eye(SANDE)]as well as with the visual analogue scale(P<0.001).Mean change in OSDI was−15.0±11.3.A significant reduction was found after treatment in the corneal staining score(P<0.001).A significant reduction was found in tear film meniscus height(P=0.012),as well as in tear film osmolarity(P=0.001).A significant reduction was also found in meibomian gland expressibility(P=0.003),changing the percentage of grade 3 eyes from 44.4%before IPL to 17.2%after ***:IPL therapy combined with meibomian gland expression(MGX)seems to be an effective option to improve symptomatology in glaucomatous patients with ocular surface diseas

关键词： Glaucoma Intense pulsed light Dry eye Meibomian glands

Breaking paradigms: Long non-coding RNAs forming gene fusions with potential implications in cancer

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Genes & Diseases 2024年第3期11卷 311-323页

作者： david Sanchez-Marin Macrina Beatriz Silva-Cazares Fany Iris Porras-Reyes Rebeca garcia-Roman Alma D.Campos-Parra Posgrado en Ciencias Biologicas Facultad de MedicinaUniversidad Nacional Autonoma de MexicoCiudad de MexicoC.P.04360Mexico Unidad Academica Multidisciplinaria Region Altiplano Universidad Autonoma de San Luis Potost(UASLP)Carretera a Cedral Km 5+600Ejido San Jose de la TrojesMatehualaSan Luis PotosiC.P.78760Mexico Servicio de Anatomia Patologica Instituto Nacional de Cancerologia(INCan)Nino JesuisTlalpanCiudaddeMexicoC.P.14080Mexico Instituto de Salud Publica Universidad Veracruzana(UV)Av.Dr LuisDr.Castelazo Ayala s/nCol.Industrial AnimasXalapaVeracruzC.P.91190Mexico

Long non-coding RNAs(lncRNAs)are non-coding RNAs longer than 200 nucleotides with dynamic regulatory *** interact with a wide range of molecules such as DNA,RNA,and proteins to modulate diverse cellular functions through several mechanisms and,if deregulated,they can lead to cancer development and ***,it has been described that IncRNAs are susceptible to form gene fusions with mRNAs or other IncRNAs,breaking the paradigm of gene fusions consisting mainly of protein-coding ***,their biological significance in the tumor phenotype is still ***,their recent identification opens a new line of research to study their biological role in tumor-igenesis,and their potential as biomarkers with clinical relevance or as therapeutic *** present study aimed to review the IncRNA fusions identified so far and to know which of them have been associated with a potential *** address the current challenges to deepen their study as well as the reasons why they represent a future therapeutic window incancer.

关键词： Cancer Genefusions IncRNAs ncRNAs Therapy

Unilateral rNurr1-V5 transgene expression in nigral dopaminergic neurons mitigates bilateral neuropathology and behavioral deficits in parkinsonian rats withα-synucleinopathy

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Neural Regeneration Research 2024年第9期19卷 2057-2067页

作者： Bismark Gatica-garcia Michael J.Bannon Irma Alicia Martínez-Dávila Luis O.Soto-Rojas david Reyes-Corona Lourdes Escobedo Minerva Maldonado-Berny ME Gutierrez-Castillo Armando J.Espadas-Alvarez Manuel A.Fernandez-Parrilla Juan U.Mascotte-Cruz CP Rodríguez-Oviedo Irais E.Valenzuela-Arzeta Claudia Luna-Herrera Francisco E.Lopez-Salas Jaime Santoyo-Salazar Daniel Martinez-Fong Departamento de Fisiología Biofísica y NeurocienciasCentro de Investigación y de Estudios AvanzadosCiudad de MéxicoMéxico Department of Pharmacology Wayne State University School of MedicineDetroitMIUSA Laboratorio de Patogénesis Molecular Carrera Médico CirujanoFacultad de Estudios Superiores IztacalaUniversidad Nacional Autónoma de MéxicoTlalnepantla de BazMéxico Red de Medicina para la Educación y Desarrollo y la Investigación Científica de Iztacala(Red MEDICI) Carrera Médico CirujanoFacultad de Estudios Superiores IztacalaUniversidad Nacional Autónoma de MéxicoTlalnepantla de BazMéxico Nanoparticle Therapy Institute AguascalientesMéxico Departamento de Biociencias e Ingeniería Centro Interdisciplinario de Investigaciones y Estudios sobre Medio Ambiente y DesarrolloInstituto Politécnico NacionalCiudad de MéxicoMéxico Escuela Nacional de Medicina y Homeopatía Instituto Politécnico NacionalCiudad de MéxicoMéxico Departamento de Fisiología Escuela Nacional de Ciencias BiológicasInstituto Politécnico NacionalCiudad de MéxicoMéxico Departamento de Biología Molecular y Biotecnología Instituto de Investigaciones BiomédicasUniversidad Nacional Autónoma de MéxicoCiudad de MéxicoMéxico Departamento de Física Centro de Investigación y de Estudios AvanzadosCiudad de MéxicoMéxico Programa de Nanociencias y Nanotecnología Centro de Investigación y de Estudios AvanzadosCiudad de MéxicoMéxico

Parkinsonism by unilateral,intranigralβ-sitosterolβ-D-glucoside administration in rats is distinguished in that theα-synuclein insult begins unilaterally but spreads bilaterally and increases in severity over time,thus replicating several clinical features of Parkinson’s disease,a typicalα-*** Nurr1 repressesα-synuclein,we evaluated whether unilateral transfected of rNurr1-V5 transgene via neurotensin-polyplex to the substantia nigra on day 30 after unilateralβ-sitosterolβ-D-glucoside lesion could affect bilateral neuropathology and sensorimotor deficits on day 30 *** study found that rNurr1-V5 expression but not that of the green fluorescent protein(the negative control)reducedβ-sitosterolβ-D-glucoside-induced ***,a bilateral increase in tyrosine hydroxylase-positive cells and arborization occurred in the substantia nigra and increased tyrosine hydroxylase-positive ramifications in the *** addition,tyrosine hydroxylase-positive cells displayed less senescence markerβ-galactosidase and more neuron-cytoskeleton markerβIII-tubulin and brain-derived neurotrophic factor.A significant decrease in activated microglia(positive to ionized calcium-binding adaptor molecule 1)and neurotoxic astrocytes(positive to glial fibrillary acidic protein and complement component 3)and increased neurotrophic astrocytes(positive to glial fibrillary acidic protein and S100 calcium-binding protein A10)also occurred in the substantia *** effects followed the bilateral reduction inα-synuclein aggregates in the nigrostriatal system,improving sensorimotor *** results show that unilateral rNurr1-V5 transgene expression in nigral dopaminergic neurons mitigates bilateral neurodegeneration(senescence and loss of neuron-cytoskeleton and tyrosine hydroxylase-positive cells),neuroinflammation(activated microglia,neurotoxic astrocytes),α-synuclein aggregation,and sensorimotor *** neurotrophic astrocytes and

关键词： A1 astrocytes A2 astrocytes gene therapy microglia motor deficits nanoparticles neurodegeneration neuroinflammation senescence α-synuclein aggregates

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CECRE:Supervision and Control of Spanish Renewable Energies in the Last 15 years

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Journal of Modern Power Systems and Clean Energy 2022年第2期10卷 269-276页

作者： Gema garcia Platero Mayte garcia Casado Marta Perez garcia Paula Junco Madero david Alvira Baeza the Red Electrica de Espafia MaridSpain

From its commissioning in 2006 to the present,the Spanish Control Centre for Renewable Energies(CECRE)has been a worldwide pioneer and reference centre in the integration of renewable energies in the electrical *** the last 15 years,CECRE has allowed a high penetration of renewable energies in Spanish electrical system by means of the supervision and control of renewable facilities,while ensuring the power supply *** paper defines the bases of renewable en-ergy operation in CECRE and introduces forecasting systems for renewable ***,this paper describes the participation of renewable energies in balancing services and congestion ***,new challenges for Spanish transmission system operator(TSO)are presented for the integration of renewable energies along with the energy transition and decarbonization.

关键词： Balancing services controllability forecasting system observability Control Centre for Renewable Energies(CECRE) renewable energy photovoltaic(PV) wind.

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Data model extension for security event notification with dynamic risk assessment purpose

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Science China(Information Sciences) 2013年第11期56卷 36-44页

作者： david LOPEZ Oscar PASTOR Luis Javier garcia VILLALBA Group of Analysis Security and Systems (GASS) Department of Software Engineering and Artificial Intelligence (DISIA) School of Computer Science Universidad Complutense Madrid 28040 Spain

Dynamic risk assessment refers to a risk management framework where frequent updates of risk evaluation information are used to evaluate risk exposure,as close as possible to *** this paper,we present the incident object description exchange format extended model for dynamic risk *** format attempts to overcome the absence of integration and real-time communication between security systems and risk assessment *** model is based on the incident object definition exchange format,which is commonly used in the computer security incident response teams *** data model aims to facilitate a global vision of information systems risk by supplying real-time security events data to risk assessment tools based on renowned *** present a proof-of-concept scenario to demonstrate the usefulness of this integration and the proposed data model,and discuss the expected improvements.

关键词： dynamic risk assessment risk management DRA IODEF-DRA IODEF.

Induced pluripotent stem cells from Huntington's disease patients:a promising approach to define and correct disease-related alterations

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Neural Regeneration Research 2019年第5期14卷 769-770页

作者： Azra Fatima Ricardo Gutiérrez-garcia david Vilchez Institute for Genetics and Cologne Excellence Cluster for Cellular Stress Responses in Aging-Associated Diseases(CECAD) University of Cologne

Adult somatic cells such as skin or blood cells from either health donors or patients can be reprogrammed into induced pluripotent stem cells(iPSCs).Given their unlimited self-renewal and differentiation capacities,iPSCs are an invaluable resource to generate terminally differentiated ***,iPSCs can facilitate the study of human diseases and drug screening,holding great promise for regenerative *** significant advantage of iPSC disease-modeling is that normal and mutant proteins are expressed at endogenous *** addition,subtle phenotypes and the effects of genetic background variations can be assessed by comparison between iPSC lines obtained from different patients and healthy donors as well as isogenic lines,in which disease-related mutations are corrected.

关键词： Adult somatic cells skin or blood cells Huntington’s disease patients

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Li2SnO3 branched nano- and microstructures with intense and broadband white-light emission

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Nano Research 2019年第2期12卷 441-448页

作者： Miguel garcia-Tecedor Javier Bartolome david Maestre Achim Trampert Ana Cremades Dpt. Fisica de Materials Facultad de CC. Fisicas Universidad Complutense de Madrid Madrid 28040 Spain Paul-Drude-Institut fur Festkorperelektronik Hausvogteiplatz 5-7 Berlin 10117 Germany Institute of Advanced Materials (INAM) Universitat Jaume I Castello 12006 Spain Dpt. Fisica de Materiales Facultad de CC. Ftsicas Universidad Complutense de Madrid Madrid 28040 Spain

Exploiting the synergy between microstructure, morphology and dimensions by suitable nanomaterial engineeri ng, can effectively upgrade the physical properties and material performances. Li2SnO3 elongated nano- and microstructures in form of belts, wires, rods and branched structures have been fabricated by a vapor-solid method at temperatures ranging from 700 to 900℃ using metallic Sn and Li2CO3 as precursors. The achievement of these new morphologies can face challenging applications for Li2SnO3, not only in the field of energy storage, but also as building blocks in optoelectronic devices. The micro? and nanostructures grown at 700 and 800℃ correspond to monoclinic Li2SnO3, while at 900℃ complex Li2S nO/SnO2 core-shell microstructures are grow n, as con firmed by X-ray diffractio n and Rama n spectroscopy. Transmission electron microscopy reveals structural disorder related to stacking faults in some of the branched structures, which is associated with the prese nee of the low-temperature phase of L12S nO3. The luminescent resp onse of these structures is domi nated by in tense emissi ons at 2, 2.5 and 3 eV, almost completely covering the whole range of the visible light spectrum. As a result, white-light emission is obtained without the need of phosphors or complex quantum well heterostructures. Enhanced functionality in applications such as in light-emitting devices could be exploited based on the high luminescenee intensity observed in some of the analysed Li2SnO3 structures.

关键词： lithium oxides white light emitters nanostructures luminescenee