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Prevalence of Helicobacter pylori infection among patients with esophageal carcinoma

World Journal of gastroenterology 2024年第29期30卷 3479-3487页

作者： Miriam López-gómez Maria Morales rebeca Fuerte Marta Muñoz Pedro-david Delgado-López Jorge Francisco gómez-Cerezo Enrique Casado Department of Medical Oncology Precision Oncology LaboratoryInfanta Sofía University HospitalSan Sebastián de los Reyes 28231MadridSpain Department of Medical Oncology Infanta Sofía University HospitalSan Sebastián de los Reyes 28702Spain Department of Internal Medicine Infanta Sofía University HospitalSan Sebastián de los Reyes 28703MadridSpain Department of Pathology Infanta Sofía University HospitalSan Sebastián de los Reyes 28702Spain Department of Neurosurgery Burgos University HospitalBurgos 09006Spain Department of Internal Medicine Infanta Sofía University Hospital and Henares University Hospital Foundation for Biomedical Research and InnovationSan Sebastian de los Reyes 28702MadridSpain Department of Medical Oncology Infanta Sofia University Hospital and Henares University Hospital Foundation for Biomedical Research and InnovationSan Sebastian de los Reyes 28702MadridSpain

BACKgrOUND Helicobacter pylori(***)is a widespread microorganism related to gastric adenocarcinoma(AC).In contrast,it has been reported that an inverse association exists between *** infection and esophageal *** mechanisms underlying this supposedly protective effect remain *** To determine the prevalence of *** infection in esophageal carcinoma patients,we performed a retrospective observational study of esophageal tumors diagnosed in our *** We retrospectively reviewed the prevalence of *** infection in a cohort of patients diagnosed with esophageal *** or previous proton pump inhibitor(PPI)usage was also *** A total of 89 patients with esophageal carcinoma(69 males,77.5%),with a mean age of 66 years(range,26-93 years)were *** was the most frequent pathological variant(n=47,52.8%),followed by squamous cell carcinoma(n=37,41.6%).Fourteen ACs(29.8%)originated in the gastroesophageal junction and 33(70.2%)in the esophageal ***,54 patients(60.7%)presented at stages III and *** *** infection occurred only in 4 patients(4.5%),3 with AC(6.3%of all ACs)and 1 with squamous cell carcinoma(2.7%of all squamous cell tumors).All patients with previous *** infection had stage *** one patient had received prior *** eradication therapy,whereas 86(96.6%)had received previous or concomitant PPI *** In our cohort of patients,and after histologic evaluation of paraffin-embedded primary tumors,we found a very low prevalence of previous *** *** also reviewed the medical history of the patients,concluding that the majority had received or were on PPI *** minimal prevalence of *** infection found in this cohort of patients with esophageal carcinoma suggests a protective role.

关键词： Helicobacter pylori Eradication Esophageal tumor Dysbiosis Proton pump inhibitors Carcinogenesis Microbiota Incidence

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Lifestyles of Older Adults in Castilla-La Mancha(Spain):Influence of Sex,Age,and Habitat

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Fudan Journal of the Humanities and Social Sciences 2024年第2期17卷 313-335页

作者： Esther Portal Martínez Juan Lirio Castro david Alonso gonzález JoséLuis gómez ramos University of Castilla-La Mancha Talavera de la ReinaSpain Complutense University MadridSpain

This paper presents the quantitative research results of a comprehensive study titled“Current Profle of Older Adults in Castilla-La Mancha(Spain).”The study aims to understand and describe the characteristics of individuals aged 65 and above within this autonomous region,with a focus on the variables of sex,age,and habitat.A cross-sectional approach was employed,utilizing quantitative methods to collect *** gather information,a customized questionnaire was developed to address the study objectives,covering various aspects such as sociodemographic factors,living conditions,leisure activities,social participation,and cultural *** survey was conducted via telephone,ensuring representation by employing gender quotas,age-group stratifcation,and considerations for habitat size.A representative sample of 1,065 participants was included in the *** fndings reveal a degree of homogeneity in the lifestyles of older adults,with discernible variations infuenced by factors such as sex,habitat,and *** results shed light on the diverse habits and experiences of older adults,emphasizing the signifcance of habitat conditions,social participation,and the aging process.

关键词： Lifestyle habits Older adults Habitat conditions Social participation Aging experience

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Low-power SiPM readout BETA ASIC for space applications

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Nuclear Science and Techniques 2024年第3期35卷 153-169页

作者： Anand Sanmukh Sergio gómez Albert Comerma Joan Mauricio rafel Manera Andreu Sanuy Daniel guberman roger Catala Albert Espinya Marina Orta Oscar de la Torre david gascon Departament de Física Quàntica i Astrofísica(FQA) Institut de Ciències del Cosmos(ICCUB)Universitat de Barcelona(UB)08028 BarcelonaSpain Institut d’Estudis Espacials de Catalunya(IEEC) 08034 BarcelonaSpain Electronics Department Serra Hunter fellow at Polytechnic University of Catalonia(UPC)08019 BarcelonaSpain

The BETA application-specific integrated circuit(ASIC)is a fully programmable chip designed to amplify,shape and digitize the signal of up to 64 Silicon photomultiplier(SiPM)channels,with a power consumption of approximately~1 mW/*** to its dual-path gain,the BETA chip is capable of resolving single photoelectrons(phes)with a signal-to-noise ratio(SNr)>5 while simultaneously achieving a dynamic range of~4000 ***,BETA can provide a cost-effective solution for the readout of SiPMs in space missions and other applications with a maximum rate below 10 *** this study,we describe the key characteristics of the BETA ASIC and present an evaluation of the performance of its 16-channel version,which is implemented using 130 nm *** ASIC also contains two discriminators that can provide trigger signals with a time jitter down to 400 ps FWHM for 10 *** linearity error of the charge gain measurement was less than 2%for a dynamic range as large as 15 bits.

关键词： radiation detectors Silicon photomultipliers Photon sensors Front-end electronics Mixed-mode ASICs Space technology

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The great catastrophe: causes of the Permo-Triassic marine mass extinction

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National Science review 2024年第1期11卷 37-50页

作者： Paul B.Wignall david P.g.Bond School of Earth & Environment University of Leeds School of Environmental Sciences University of Hull

The marine losses during the Permo-Triassic mass extinction were the worst ever experienced. All groups were badly affected, especially amongst the benthos(e.g. brachiopods, corals, bryozoans, foraminifers,ostracods). Planktonic populations underwent a fundamental change with eukaryotic algae being replaced by nitrogen-fixing bacteria, green-sulphur bacteria, sulphate-reducing bacteria and prasinophytes. Detailed studies of boundary sections, especially those in South China, have resolved the crisis to a ～55 kyr interval straddling the Permo-Triassic boundary. Many of the losses occur at the beginning and end of this interval painting a picture of a two-phase extinction. Improved knowledge of the extinction has been supported by numerous geochemical studies that allow diverse proposed extinction mechanisms to be studied. A transition from oxygenated to anoxic-euxinic conditions is seen in most sections globally, although the intensity and timing shows regional variability. Decreased ocean ventilation coincides with rapidly rising temperatures and many extinction scenarios attribute the losses to both anoxia and high *** kill mechanisms include ocean acidification for which there is conflicting support from geochemical proxies and, even less likely, siltation(burial under a massive influx of terrigenous sediment) which lacks substantive sedimentological evidence. The ultimate driver of the catastrophic changes at the end of the Permian was likely Siberian Trap eruptions and their associated carbon dioxide emissions with consequences such as warming, ocean stagnation and acidification. Volcanic winter episodes stemming from Siberian volcanism have also been linked to the crisis, but the short-term nature of these episodes(rwhelming evidence for rapid warming during the crisis makes this an unlikely cause. Finally, whilst the extinction is well studied in equatorial latitudes, a different history is found in northern Boreal latitudes

关键词： ocean anoxia ocean acidification siltation productivity collapse volcanic winter

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Soil security and global food security

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Frontiers of Agricultural Science and Engineering 2024年第2期11卷 297-302页

作者： david r.MONTgOMErY Department of Earth and Space Sciences University of Washington townSeattleWA 98105USA

Over the course of the postglacial period has managed to add degrade a substantial portion of the world's potential agricultural land. The soil loss and degradation that has repeatedly impacted regional societies around the world resulted from agricultural practices that increased the physical loss of soil(erosion), reduced soil organic matter, changed p H(acidification) or salinity,and disrupted or altered communities of soil life. In the coming century, as continued soil degradation threatens global food security while the global population keeps rising it is imperative that farmers develop and adopt soilhealth building(regenerative) practices to solve a problem that has plagued societies throughout history. growing evidence suggests that agricultural systems that combine cover crops, reduced tillage, and diverse crop rotations can reduce erosion, enhance soil health and rebuild soil organic matter to cultivate beneficial soil life and harvest both economic and environmental benefits. In the coming post-oil world, global food security would benefit from a global effort to promote soil restoration to help addresses the challenge of sustainably feeding the world, increase soil-based carbon sequestration,protect on-farm biodiversity and reduce off-farm water pollution. Because soil security sets a solid foundation for global food security, agricultural policies and subsidies should be reformed to encourage farmers to adopt regenerative,soil-building practices.

关键词： Agriculture soil security food security regenerative

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Origins of perturbations in dayside equatorial ground magnetograms

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Earth and Planetary Physics 2024年第1期8卷 215-221页

作者： Syau-Yun W.Hsieh david g.Sibeck The Johns Hopkins University Applied Physics Laboratory LaurelMarylandUSA NASA goddard Space Flight Center GreenbeltMarylandUSA

To determine the cause(s)of perturbations seen in dayside equatorial ground magnetograms,we conducted a systematic survey of simultaneous ground-based and geosynchronous satellite-based observations during the 90-day period from December 1,2020 to February 28,*** examined Huancayo ground magnetometer observations from 14:00:00 to 20:00:00 UT each day,during which Huancayo passed through local *** those data we chose perturbation events selected on the basis of large(>20 nT)event amplitude and classified the selected events as responding primarily to solar wind pressure,or to variations in the north/south component of the interplanetary magnetic field(IMF Bz),or perhaps in part to *** results show that an equivalent number of events were identified for each model during this 90-day *** in the lagged solar wind dynamic pressure routinely correspond to nearly simultaneous sudden impulses recorded at both geosynchronous orbit and on the *** in IMF Bz produce erosion signatures at geosynchronous orbit and can correspond to ground events if lag times for reconnection to enhance convection in the magnetosphere are taken into account.

关键词： dayside magnetosphere dayside equatorial ionosphere geosynchronous magnetic field

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Hybrid LES/rANS Simulations of Compressible Flow in a Linear Cascade of Flat Blade Profiles

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Journal of Thermal Science 2024年第5期33卷 1839-1850页

作者： Jaromír PrIHODA Petr STrAKA david SIMUrDA Petr SIDLOF Jan LEPICOVSKY Institute of Thermomechanics of the Czech Academy of Sciences Dolejskova 1402/518200 Prague 5Czech Republic Aerospace research and Test Centre Beranovych 13019905 PragueCzech Republic Technical University of Liberec Faculty of MechatronicsStudentska 246117 Liberec 1Czech Republic

The paper reports on 3D numerical simulations of unsteady compressible airflow in a blade cascade consisting of flat profiles using a hybrid LES/rANS approach including a transition *** a first step towards simulation of blade flutter in turbomachinery,various incidence angle offsets of the middle blade were *** simulations were run for the flow regime characterized by outlet isentropic Mach number M_(is)=0.5and zero *** results of the LES/rANS simulations(pressure and Mach number distributions)were compared to a baseline rANS model,and to experimental data measured in a high-speed wind *** numerical results show that both methods overpredict flow separation taking place at the leading *** this regard,the hybrid LES/rANS method does not provide superior results compared to the traditional rANS ***,the LES/rANS results also capture vortex shedding from the blunt trailing *** frequency of the trailing edge vortex shedding in CFD simulations matches perfectly the spectral peak recorded during wind tunnel measurements.

关键词： numerical simulation blade cascade hybrid LES/rANS

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Current state of the art and future directions: Augmented reality data visualization to support decision-making

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Visual Informatics 2024年第2期8卷 80-105页

作者： Mengya Zheng david Lillis Abraham g.Campbell School of Computer Science University College DublinDublinIreland

Augmented reality(Ar),as a novel data visualization tool,is advantageous in revealing spatial data patterns and data-context ***,recent research has identified Ar data visualization as a promising approach to increasing decision-making efficiency and *** a result,Ar has been applied in various decision support systems to enhance knowledge conveying and comprehension,in which the different data-reality associations have been constructed to aid ***,how these Ar visualization strategies can enhance different decision support datasets has not been reviewed *** given the rise of big data in the modern world,this support is critical to decision-making in the coming *** Ar to embed the decision support data and explanation data into the end user’s physical surroundings and focal contexts avoids isolating the human decision-maker from the relevant *** the decision-maker’s contexts and the DSS support in Ar is a difficult *** paper outlines the current state of the art through a literature review in allowing Ar data visualization to support *** facilitate the publication classification and analysis,the paper proposes one taxonomy to classify different Ar data visualization based on the semantic associations between the Ar data and physical *** on this taxonomy and a decision support system taxonomy,37 publications have been classified and analyzed from multiple *** of the contributions of this literature review is a resulting Ar visualization taxonomy that can be applied to decision support *** with this novel tool,the paper discusses the current state of the art in this field and indicates possible future challenges and directions that Ar data visualization will bring to support decision-making.

关键词： Augmented reality Decision support Data visualization Taxonomy

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Single-atom Pt on carbon nanotubes for selective electrocatalysis

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Carbon Energy 2024年第1期6卷 63-71页

作者： Samuel S.Hardisty Xiaoqian Lin Anthony r.J.Kucernak david Zitoun Department of Chemistry Bar Ilan Institute of Nanotechnology and Advanced Materials(BINA)Bar Ilan UniversityRamat GanIsrael Department of Chemistry Molecular Science Research HubImperial College LondonLondonUK

Utilizing supported single atoms as catalysts presents an opportunity to reduce the usage of critical raw materials such as platinum,which are essential for electrochemical reactions such as hydrogen oxidation reaction(HOr).Herein,we describe the synthesis of a Pt single electrocatalyst inside single-walled carbon nanotubes(SWCNTs)via a redox *** via electron microscopy,X-ray photoelectron microscopy,and X-ray absorption spectroscopy show the single-atom nature of the *** electrochemical behavior of the sample to hydrogen and oxygen was investigated using the advanced floating electrode technique,which minimizes mass transport limitations and gives a thorough insight into the activity of the *** single-atom samples showed higher HOr activity than state-of-the-art 30%Pt/C while almost no oxygen reduction reaction activity in the proton exchange membrane fuel cell operating *** selective activity toward HOr arose as the main fingerprint of the catalyst confinement in the SWCNTs.

关键词： confinement electrocatalysis hydrogen platinum single atom catalysts

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A multi-sensor appiproach to calving detection

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Information Processing in Agriculture 2024年第1期11卷 45-64页

作者： Anita Z.Chang david L.Swain Mark g.Trotter Institute for Future Farming Systems School of HealthMedicaland Applied SciencesCentral Queensland UniversityRockhamptonQueensland 4700Australia

The advent of remote livestock monitoring systems provides numerous possibilities for improving on-farm productivity,efficiency,and *** potential application for these systems is for the detection of calving *** study describes the integration of data from multiple sensor sources,including accelerometers,global navigation satellite systems(gNsS),an accelerometer-derived rumination algorithm,a walk-over-weigh unit,and a weather station for parturition detection using a support vector machine *** best performing model utilised data from gNsS,the ruminating algorithm,and weather stations to achieve 98.6%accuracy,with 88.5%sensitivity and 100%*** topranking features of this model were primarily gNSS *** study provides an overview as to how various sensor systems could be integrated on-farm to maximise calving detection for improved production and welfare outcomes.

关键词： Accelerometer gNSS gPS rumination Sensor WOW

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