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Clinical outcome of open ankle fractures in patients above 70 years of age

World Journal of Orthopedics 2023年第7期14卷 554-561页

作者： Wajiha Zahra Mina Seifo Paul Cool david ford Tosan Okoro Department of Trauma and Orthopedics Royal Shrewsbury HospitalShrewsbury SY38XQUnited Kingdom Department of Trauma and Orthopedics Robert Jones and Agnes Hunt Orthopaedic Hospital NHS Foundation TrustOswestry SY107AGUnited Kingdom Department of Trauma and Orthopedics Keele UniversityStafford ST55BGUnited Kingdom

BACKGROUND Open fractures of the ankle are complex injuries requiring multidisciplinary input and are associated with significant morbidity and ***,data on the clinical outcomes of open ankle fracture management in patients older than 70 is *** To evaluate the clinical outcomes following open ankle fracture management in patients older than *** secondary aim is to look at predictors of poor *** Following local research and audit department registration,22 years of prospectively collated data from an electronic database in a district general hospital were *** patients older than 70 years of age with an open ankle fracture requiring surgical intervention were *** information,the nature,and the number of surgical interventions were ***,including surgical site infection(SSI),venous thromboembolic events(VTEs)during hospital stay,and mortality rate,were *** A total of 37 patients were identified(median age:84 years,range:70-98);n=30 females median age:84 years,range:70-97);n=7 males median age:74 years,range:71-98))who underwent surgical intervention after an open ankle *** patients developed SSIs(43%).Superficial SSIs(n=8)were managed without surgical intervention and treated with antibiotics and regular dressing *** SSIs(n=8;20%)required a median of 3(range:2-9)surgical interventions,with four patients requiring multiple washouts and one patient having metalwork *** incidence was 5%during the hospital *** patients died within 30 d,and mortality at one year was 19%.The 10-year mortality rate was 57%.The presence of a history of stroke,cancer,or prolonged inpatient stay was found to be predictive of lower survivorship in this population(log-rank test:cancer P=0.008,stroke P=0.001,length of stay>33 d P=0.015).The presence of a cardiac history was predictive of wound complications(logistic regression,P=0.045).Age,number of operations,and di

关键词： Fragility fracture Open fracture Clinical outcome Mortality Infection Survival

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New insights into the role of Lith genes in the formation of cholesterol-supersaturated bile

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Liver Research 2017年第1期1卷 42-53页

作者： Helen H.Wang Tiangang Li Piero Portincasa david A.ford Brent A.Neuschwander-Tetri Patrick Tso david Q-H.Wang Department of Internal Medicine Division of Gastroenterology and HepatologySaint Louis University School of MedicineSt.LouisMOUSA Department of Pharmacology Toxicology and TherapeuticsKansas University Medical CenterKansas CityKSUSA Clinica Medica“A.Murri” Department of Biomedical Sciences and Human OncologyUniversity of Bari“Aldo Moro”Medical SchoolBariItaly Department of Biochemistry and Molecular Biology Saint Louis University School of MedicineSt.LouisMOUSA Department of Pathology and Laboratory Medicine University of Cincinnati College of MedicineCincinnatiOHUSA

Cholesterol gallstone formation represents a failure of biliary cholesterol homeostasis in which the physical-chemical balance of cholesterol solubility in bile is *** bile is mainly caused by persistent hepatic hypersecretion of biliary cholesterol and sustained cholesterol-supersaturated bile is an essential prerequisite for the precipitation of solid cholesterol monohydrate crystals and the formation of cholesterol *** metabolic determinants of the supply of hepatic cholesterol molecules that are recruited for biliary secretion are dependent upon the input-output balance of cholesterol and its catabolism in the *** sources of cholesterol for hepatic secretion into bile have been extensively investigated;however,to what extent each cholesterol source contributes to hepatic secretion is still unclear both under normal physiological conditions and in the lithogenic *** it has been long known that biliary lithogenicity is initiated by hepatic cholesterol hypersecretion,the genetic mechanisms that cause supersaturated bile have not been defined *** of the Lith genes that determine hepatic cholesterol hypersecretion should provide novel insights into the primary genetic and pathophysiological defects for gallstone *** this review article,we focus mainly on the pathogenesis of the formation of supersaturated bile and gallstones from the viewpoint of genetics and pathophysiology.A better understanding of the molecular genetics and pathophysiology of the formation of cholesterol-supersaturated bile will undoubtedly facilitate the development of novel,effective,and noninvasive therapies for patients with gallstones,which would reduce the morbidity,mortality,and costs of health care associated with gallstones,a very prevalent liver disease worldwide.

关键词： Bile flow Bile acid Biliary secretion Lith gene Micelle Vesicle

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Making bridges between preclinical and clinical insights into age-related cognitive decline

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Neural Regeneration Research 2025年第8期20卷 2321-2322页

作者： david VC Brito Clévio Nóbrega Algarve Biomedical Center-Research Institute(ABC-RI) Campus GambelasFaroPortugal Algarve Biomedical Center-(ABC) Campus GambelasFaroPortugal Faculty of Medicine and Biomedical Sciences(FMCB) University of AlgarveGambelas CampusFaroPortugal

With people living longer,the societal impact of age-related cognitive decline is becoming more pronounced(Crimmins,2015).Thus,it is increasingly important to comprehend the cognitive shifts linked to aging-whether th... 详细信息

关键词： bridges becoming insight

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Women in visual neural regeneration research

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Neural Regeneration Research 2025年第2期20卷 489-490页

作者： Tonia S.Rex david J.Calkins Vanderbilt Eye Institute Vanderbilt University Medical CenterNashvilleTNUSA

The year 2024 marks the 60^(th)anniversary of Title IX and 25 years since the New York Times revealed bias against female faculty members at the Massachusetts Institute of *** take an opportunity here to examine the state of gender bias in a relatively new yet already prominent field,neural regeneration in the visual system,for which there is a well-defined context useful for this *** National Eye Institute(NEI)provided the first round of research funding for its Audacious Goals Initiative(AGI)on visual neural regeneration in 2013 and the last round in ***,we focus on this *** sources included PubMed,the National Science Foundation(NSF),the NEI,the Blue Ridge Institute for Medical Research and data from the major professional organization for eye and vision research,the Association for Research in Vision and Ophthalmology(ARVO).

关键词： neural visual Times

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陶氏——平衡广纳财源

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化工文摘 2003年第1期 51-51页

作者： david ford

2001年陶氏公司收购联合碳化使之成为北美表面活性剂市场的主要竞争者。在陶氏原有的Dowfax和Hamposyl系列阴离子表面活性剂的基础上,又增加了联合碳化公司的Triton和Tergitol系列阴离子和非离子产品。Hamposyl系列阴离子表面活性剂是陶... 详细信息

2001年陶氏公司收购联合碳化使之成为北美表面活性剂市场的主要竞争者。在陶氏原有的Dowfax和Hamposyl系列阴离子表面活性剂的基础上,又增加了联合碳化公司的Triton和Tergitol系列阴离子和非离子产品。Hamposyl系列阴离子表面活性剂是陶氏1997年并购南非Sentrachem公司后接手过来的。

关键词：陶氏化学公司收购联合碳化公司分离非核心业务表面活性剂

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Ignorance but not bliss： too little is known about the determinants of semen quality

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Asian Journal of Andrology 2013年第2期15卷 174-178,I0004页

作者： WCL ford Division of Reproductive & Child Health University ofBirmingham Birmingham B15 2TT UK

Criticisms of the data that have been presented to demonstrate a decline in sperm counts over time reveal problems with semen analysis methods and a lack of understanding of the genetic and environmental factors that determine a man＇s sperm count. Potential sources of error in the WHO semen analysis protocol and some areas of ignorance about the biological and environmental factors which can influence sperm counts are briefly discussed. I con- clude that there is a need to include semen analyses in a large cohort study to fill the gaps in our knowledge.

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Divergence of carbon dioxide fluxes in different trophic areas of Taihu Lake,China

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Journal of Environmental Sciences 2003年第4期15卷 433-442页

作者： FANCheng-xin PhillipW.ford NaniingInstituteofGeography&Linmology ChineseAcademyofSciencesNanjing210008 CSIROLand&Water GPOBox821CanberraACT2601Australia)

Carbon dioxide partial pressures(pCO 2) and CO 2 fluxes on air water interface in different trophic level areas of Taihu Lake were calculated and corrected using alkalinity, pH, ionic strength, active coefficient, water temperature and wind speed on the basis of the data sets of monthly sampling in 1998 The mean values of pCO 2 in the hypertrophic, eutrophic, and mesotrophic areas are 1807 8±1025 8(mean±standard deviation) μatm, 416 3±207 8 μatm, and 448 5±194 0 μatm,respectively. A maximum and minimum pCO\-2 values were found in the hypertrophic(4053 7 μatm) and the eutrophic(3 2 μatm) areas. There was about one magnitude order of difference in mean CO\-2 fluxes between the hypertrophic area(27 3±17 4 mmol/(m\+2·d)) and the eutrophic(1 99±4 50 mmol/(m\+2·d)) and mesotrophic (2 22±4 31 mmol/(m\+2·d)) areas. But there was no significant difference between eutrophic and mesotrophic areas in pCO 2 and the flux of CO 2 In respect to CO 2 equilibrium, input of the rivers will obviously influence inorganic carbon distribution in the riverine estuary. An exponential relationship between the pCO 2 values and chlorophyll a concentrations was obtained( r =0 8356, n =60) in eutrophic bay. Results suggested that lake ecosystems, also may be considered as unique aggregation, which can contain and be patient of different components that have their relative independence so long as its size enough to large. A productive lake, though it has positive fluxes of CO 2 to atmosphere during the most of time, is a huge and permanent sink of carbon in terrestrial ecosystems through receiving a great quantity of carbon materials via rivers, precipitation, and biological production.

关键词： carbon dioxide flux trophic difference chlorophyll a Taihu Lake

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Development and Application of Universal Formability Technology

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Journal of Materials Science & Technology 2001年第4期17卷 471-472页

作者： Yanwu Xu ford Motor Company,USA ford Motor Co. Detroit Michigan United States

Using mathematical plasticity theories, universal formability (UF) technology has been developed and applied in the automotive stamping engineering and production. As a formability analysis tool, this technology is the major methodology for the development of stamping expert system (solution provider) for (a) product design and feasibility analysis, (b) material automatic selection using nomograms, (c) draw die design using pre-models, and (d) UF and robustness analysis of die performance in finite element analysis (FEA) environment.

关键词： Development and Application of Universal Formability Technology mode

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Fuel and vegetation changes in southwestern, unburned portions of Great Smoky Mountains National Park, USA, 2003-2019

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Journal of Forestry Research 2022年第5期33卷 1459-1470页

作者： T.Adam Coates W.Mark ford Department of Forest Resources and Environmental Conservation Virginia Polytechnic Institute and State UniversityBlacksburgVA 24061USA U.S.Geological Survey Virginia Cooperative Fish and Wildlife Research UnitDepartment of Fisheries and Wildlife ConservationVirginia Polytechnic Institute and State UniversityBlacksburgVA 24061USA

Overstory basal area,ericaceous shrub cover(Kalmia latifolia *** Rhododendron maximum L.),and fuels(i.e.,woody fuel loads and depths and O Horizon thickness) were assessed within Great Smoky Mountains National Park,USA,in *** to recent wildfire activity within the southern Appalachian Mountain region(including Great Smoky Mountains National Park),the potential spread and expansion of ericaceous shrubs,and the impacts of the hemlock woolly adelgid(Adelges tsugae Annand) on eastern hemlock(Tsuga canadensis(L.) Carrière),these same ecosystem components were again assessed in *** and moisture regime(xeric,intermediate,and mesic) were included in this assessment as potential influential *** evaluation of repeated measurements from 40 plots suggested that O Horizon thickness did not change significantly over the 16-year period,but increased as elevation increased,and moisture regime(xeric O Horizon thickness> mesic O Horizon thickness) was a significant,related *** sum of 1-,10-,and 100-h fuel loads(fuels less 7.6 cm diameter),total woody fuel loads,ericaceous shrub cover,total basal area,or live *** basal area were *** *** basal area decreased with increasing ***,standing *** basal area increased from 2003-2019,and that increase was most pronounced as elevation increased on xeric and intermediate ***,we found that:*** increases in total woody fuel loads and ericaceous shrub cover were not present;and *** and moisture regime were most related to observed changes in vegetation and fuel condition.

关键词： Eastern hemlock Hemlock woolly adelgid Mountain laurel Rhododendron

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Transformation of leather waste into microwave-activated and N-doped carbon for Li-S batteries

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新型炭材料(中英文) 2025年

作者： Carolina Pano-Azucena Roberto Rosas-Rangel Miguel Olvera-Sosa david Salvador González-González Rene Rangel-Mendez Luis Felipe Chazaro-Ruiz Miguel Avalos-Borja Javier Antonio Arcibar-Orozco CIATEC.Center for Applied Innovation in Competitive Technologies Tecnologico de Monterrey School of Engineering and Sciences Instituto Potosino de Investigación Científica y Tecnológica Universidad Autónoma de Coahuila Facultad de SistemasCiudad Universitaria

The use of carbon from waste biomass has the potential to buffer the drawbacks of Li-S batteries and improve their overall performance. Chrome-Tanned-LeatherShavings(CTLS) are undesirable wastes, highly available for transformation into porous carbon. Microwave activation is an efficient state-of-the-art procedure to obtain unique porous structures and nitrogen incorporation can improve the performance of porous carbons. This study proposes the transformation of CTLS into a microwave activated porous carbon, and then was modified to introduce nitrogen. A microporous activated carbon with a specific surface area of 556 m2g-1 with honeycomb-like structure was obtained. Both urea thermal decomposition and ethanolamine impregnation improves the nitrogen and amine presence of surface groups. However,the results indicated that only urea treatment was effective in improving the initial capacity of the cell(1363 mAhg-1), which is probably linked with the sorption of long-chain polysulfides. This investigation confirms that it is possible to obtain carbon materials from CTLS, for use as sulfur-host cathodes in Li-S batteries, and improve their performance with urea thermal decomposition. Furthermore, a Radial basis function neural network was fitted to provide statistical support to the experimental results. The trained model corroborated the importance of nitrogen content of the carbons in the discharge capacity of the cells.

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