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Anemia and iron deficiency in gastrointestinal and liver conditions

World Journal of Gastroenterology 2016年第35期22卷 7908-7925页

作者： Jürgen Stein Susan Connor Garth Virgin david eng hui ong Lisandro Pereyra Interdisciplinary Crohn Colitis Centre Rhein-Main Frankfurt am Main Department of Gastroenterology and Clinical Nutrition DGD Clinics Sachsenhausen Frankfurt am Main60594 Frankfurt Germany Department of Gastroenterology and Hepatology Liverpool Hospital South Western Clinical School University of New South Wales Vifor Pharma Flughofstrasse 61 CH-8152 Zurich Switzerland Division of Gastroenterology and Hepatology University Medicine Cluster National University Hospital Servicio de Gastroenterología y Endoscopia Hospital Alemán

Iron deficiency anemia(IDA) is associated with a number of pathological gastrointestinal conditions other than inflammatory bowel disease, and also with liver disorders. Different factors such as chronic bleeding, malabsorption and inflammation may contribute to IDA. Although patients with symptoms of anemia are frequently referred to gastroenterologists, the approach to diagnosis and selection of treatment as well as follow-up measures is not standardized and suboptimal. Iron deficiency, even without anemia, can substantially impact physical and cognitive function and reduce quality of life. Therefore, regular iron status assessment and awareness of the clinical consequences of impaired iron status are critical. While the range of options for treatment of IDA is increasing due to the availability of effective and well-tolerated parenteral iron preparations, a comprehensive overview of IDA and its therapy in patients with gastrointestinal conditions is currently lacking. Furthermore, definitions and assessment of iron status lack harmonization and there is a paucity of expert guidelines on this topic. This review summarizes current thinking concerning IDA as a common co-morbidity in specific gastrointestinal and liver disorders, and thus encourages a more unified treatment approach to anemia and iron deficiency, while offering gastroenterologists guidance on treatment options for IDA in everyday clinical practice.

关键词： Iron deficiency anemia Gastrointestinal bleeding Nonsteroidal anti-inflammatory drugs Gastritis Infection Bariatric surgery Celiac disease Gastrointestinal neoplasm Chronic hepatitis Nonalcoholic fatty liver disease

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Recent advances in graphene-based phase change composites for thermal energy storage and management

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Nano Materials Science 2024年第2期6卷 115-138页

作者： Qiang Zhu Pin Jin ong Si hui Angela Goh Reuben J.Yeo Suxi Wang Zhiyuan Liu Xian Jun Loh Institute of Materials Research and engineering A*STAR(Agency for ScienceTechnology and Research)2 Fusionopolis WayInnovis#08-03138634Singapore Institute of Sustainability for Chemicals Energy and EnvironmentA*STAR(Agency for ScienceTechnology and Research)1 Pesek RoadJurong Island627833Singapore School of Chemistry Chemical Engineering and BiotechnologyNanyang Technological University21 Nanyang Link637371Singapore Shenzhen Institutes of Advanced Technology(SIAT) Chinese Academy of Sciences(CAS)1068 Xueyuan AvenueShenzhen518055China Department of Material Science and engineering National University of Singapore9 Engineering Drive 1#03-09 EA117575Singapore

Energy storage and conservation are receiving increased attention due to rising global energy ***,the development of energy storage materials is *** energy storage(TES)systems based on phase change materials(PCMs)have increased in prominence over the past two decades,not only because of their outstanding heat storage capacities but also their superior thermal energy regulation ***,issues such as leakage and low thermal conductivity limit their applicability in a variety of ***-based materials such as graphene and its derivatives can be utilized to surmount these *** study examines the recent advancements in graphene-based phase change composites(PCCs),where graphene-based nanostructures such as graphene,graphene oxide(GO),functionalized graphene/GO,and graphene aerogel(GA)are incorporated into PCMs to substantially enhance their shape stability and thermal conductivity that could be translated to better storage capacity,durability,and temperature response,thus boosting their attractiveness for TES *** addition,the applications of these graphene-based PCCs in various TES disciplines,such as energy conservation in buildings,solar utilization,and battery thermal management,are discussed and summarized.

关键词： Phase change material Nanocomposites Solar energy Sustainable energy Thermo-regulation

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Construction and performance test of charged particle detector array for MATE

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Nuclear Science and Techniques 2024年第8期35卷 92-100页

作者： Xiao‑Bin Li Long‑hui Ru Zhi‑Chao Zhang Bing‑Feng Lv Ning‑Tao Zhang Jin‑Long Zhang Chen‑Gui Lu Bing‑Shui Gao Jun‑Bing Ma Fu‑Shuai Shi Satoru Terashima Xiao‑Dong Xu Zhen Bai Shi‑Wei Xu Yan‑Yun Yang Hooi‑Jin ong Xiao‑Dong Tang Institute of Modern Physics(IMP) Chinese Academy of SciencesLanzhou 730000China School of Nuclear Science and Technology University of Chinese Academy of SciencesBeijing 100049China Research Center for Nuclear Physics Osaka UniversityIbarakiOsaka 567‑0047Japan RIKEN Nishina Center WakoSaitama 351‑0198Japan Joint Department for Nuclear Physics Lanzhou University and Institute of Modern PhysicsChinese Academy of SciencesLanzhou 730000China

A charged particle array named MATE-PA,which serves as an auxiliary detector system for a Multi-purpose Active-target Time projection chamber used in nuclear astrophysical and exotic beam Experiments(MATE),was *** array comprised of 20 single-sided strip-silicon detectors covering approximately 10%of the solid *** detectors facilitated the detection of reaction-induced charged particles that penetrate the active volume of the *** performance of MATE-PA has been experimentally studied using an alpha source and a 36-MeV 14 N beam injected into the MATE chamber on the radioactive ion beam line in Lanzhou(RIBLL).The chamber was filled with a gas mixture of 95%4 He and 5%CO_(2) at a pressure of 500 *** results indicated good separation of light-charged particles using the forward double-layer silicon detectors of *** energy resolution of the Si detectors was deduced to be approximately 1%(σ)for an energy loss of approximately 10 MeV caused by theα*** inclusion of MATE-PA improves particle identification and increases the dynamic range of the kinetic energy of charged particles,particularly that of theαparticles,up to approximately 15 MeV.

关键词： Silicon detector array Active target Time projection chamber

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基于教学场景的书刊印刷工业虚拟仿真系统设计研究

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印刷与数字媒体技术研究 2024年第4期 27-36页

作者：郭渝慧罗允龙杭州电子科技大学人文艺术与数字媒体学院杭州310018

随着印刷数智化推进,应用虚拟仿真技术来交互呈现印刷工业场景及设备运行是设计、印刷、出版等相关人才培养的现实需求和亟待解决的关键技术热点。本研究针对国内涉及印刷制作流程与工艺的相关专业实习实践中,因学校资源有限、建立实际... 详细信息

随着印刷数智化推进,应用虚拟仿真技术来交互呈现印刷工业场景及设备运行是设计、印刷、出版等相关人才培养的现实需求和亟待解决的关键技术热点。本研究针对国内涉及印刷制作流程与工艺的相关专业实习实践中,因学校资源有限、建立实际印刷工业场景和印刷作业流程难度大、软硬件更新速度慢、合作工厂无法满足学生印刷实践的共性难题,设计并开发了基于教学场景的印刷工业虚拟仿真系统。采用三维模型构建印刷厂场景及设备,搭建出学习模块、实验模块、练习题模块相互协同的立体化印刷工业虚拟仿真教学系统。应用Unity3D交互与实时渲染技术打造出学练考一体化的印刷工业场景及其书刊印刷工艺的教学实践交互场景,突破了学校软硬件资源约束,有效解决了学生印刷实践的现实问题。

关键词：虚拟仿真书刊印刷工业系统设计教学

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石墨含量对车用镀Ni石墨/Cu复合材料摩擦磨损性能的影响

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材料热处理学报 2024年第9期45卷 77-83页

作者：王汇龙李丕毅高希瑞刘洋赈浙江工业职业技术学院交通学院浙江绍兴312099 上海交通职业技术学院汽车工程学院上海201900 暨南大学化学与材料学院广东广州510632

石墨添加量是影响Cu基复合材料摩擦学性能的关键因素之一。为此,研究了镀Ni石墨含量(2、4、6和8 mass%)对镀Ni石墨/Cu复合材料摩擦学行为的影响,分析了石墨含量与复合材料的微观组织、物理性能及硬度的关系,以确定最佳的石墨添加量。结... 详细信息

石墨添加量是影响Cu基复合材料摩擦学性能的关键因素之一。为此,研究了镀Ni石墨含量(2、4、6和8 mass%)对镀Ni石墨/Cu复合材料摩擦学行为的影响,分析了石墨含量与复合材料的微观组织、物理性能及硬度的关系,以确定最佳的石墨添加量。结果表明:复合材料中石墨与Cu之间的结合性较好,没有出现明显的空隙和裂纹;随镀Ni石墨由2 mass%增加到8 mass%,复合材料的致密度和导电率分别减小了3.7%和43.5%,硬度先由60.3 HV0.1增大到63.4 HV0.1后再减小到59.7 HV0.1,其中转折点在6 mass%镀Ni石墨,而摩擦系数和磨损率均为先减小后增大。因此,理想的镀Ni石墨添加量为6 mass%,此时,复合材料的磨损机制以磨粒磨损为主,粘着和氧化磨损为辅。

关键词： Cu基复合材料镀Ni石墨磨损机制

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Ultrahard X-ray multifunctional application beamline at the SSRF

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Nuclear Science and Techniques 2024年第6期35卷 14-25页

作者： Ke Yang Zhao-hui Dong Chun-Yin Zhou Zi-Long Zhao Dong-Xu Liang Sai-Chao Cao Ai-Guo Li Shanghai Advanced Research Institute Chinese Academy of SciencesShanghai 201210China

The ultrahard X-ray multifunctional application beamline(BL12SW)is a phase-II beamline project at the Shanghai Syn-chrotron Radiation *** primary X-ray techniques used at the beamline are high-energy X-ray diffraction and imaging using white and monochromatic *** main scientific objectives of ultrahard X-ray beamlines are focused on two research *** is the study of the structural properties of Earth’s interior and new materials under extreme high-temperature and high-pressure conditions,and the other is the characterization of materials and processes in near-real service *** beamline utilizes a superconducting wiggler as the light source,with two diamond windows and SiC discs to filter out low-energy light(primarily below 30 keV)and a Cu filter assembly to control the thermal load entering the subsequent optical *** beamline is equipped with dual *** first was a meridional bending Laue monochromator cooled by liquid nitrogen,achieving a full-energy coverage of 30-162 *** second was a sagittal bending Laue monochromator installed in an external building,providing a focused beam in the horizontal direction with an energy range of 60-120 *** were four experimental hutches:two large-volume press experimental hutches(LVP1 and LVP2)and two engineering material experimental hutches(eng1 and eng2).Each hutch was equipped with various near-real service conditions to satisfy different *** example,LVP1 and LVP2 were equipped with a 200-ton DDIA press and a 2000-ton dual-mode(DDIA and Kawai)press,***1 and eng2 provide in situ tensile,creep,and fatigue tests as well as high-temperature *** June 2023,the BL12SW has been in trial *** is expected to officially open to users by early 2024.

关键词： Shanghai Synchrotron Radiation Facility Ultrahard X-ray High energy diffraction High energy imaging engineering materials Earth science

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虚拟仿真技术在舞蹈编创与教学中的应用

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印刷与数字媒体技术研究 2024年第4期 15-26页

作者：钟祎洵许伟姚日晖宁洪龙华南理工大学艺术学院广州510640

舞蹈教学与编创向信息化和数字化发展是时代潮流。随着虚拟仿真技术的快速发展,其在舞蹈领域中的游戏娱乐、演出、教学和编舞等方面已经得到了广泛地研究和应用。本文从上述方面的研究现状出发,归纳介绍了舞蹈虚拟仿真中的动作捕捉、舞... 详细信息

舞蹈教学与编创向信息化和数字化发展是时代潮流。随着虚拟仿真技术的快速发展,其在舞蹈领域中的游戏娱乐、演出、教学和编舞等方面已经得到了广泛地研究和应用。本文从上述方面的研究现状出发,归纳介绍了舞蹈虚拟仿真中的动作捕捉、舞蹈数据库、建模和动作编创等技术,分析了这些技术的实现机理和特点,最后展望了虚拟仿真技术在舞蹈教学与编创中的发展前景。

关键词：舞蹈仿真动作捕捉虚拟现实舞蹈编排

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CoMFA Study on Anti-proliferative Activity of Fluoroquinolone Amide Derivatives

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Chinese Journal of Structural Chemistry 2022年第3期41卷 241-247,I0014页

作者： eng hui CAO Jing-Pei Feng Chang-Jun School of Chemical engineering and Technology China University of Mining and TechnologyXuzhou 221116China Key Laboratory of Coal Processing and Efficient Utilization(Ministry of Education) Xuzhou 221116China School of Material&Chemical engineering Xuzhou University of TechnologyXuzhou 221018China

The in vitro anti-proliferative activity(pICi,i=hp,ca,hl)of fluoroquinolone(rhodanineα,β-unsaturated ketone)amide compounds,referred to as“fluoroquinolone amide derivatives(FQADs)”towards Hep-3B,Capan-1 and HL60 cells,was studied by the 3D-QSAR method of comparative molecular field analysis(CoMFA).Based on the training set of 14 compounds,the prediction model was established,which was further verified by the test set of 5 compounds with template molecule *** is found that steric and electrostatic fields contribute 66.8%and 33.2%to pIChp,61.4%and 38.6%to pICca,and 61.5%and 38.5%to pIChl,*** Rcv 2(i.e,cross-validation coefficient)is 0.324,0.381,and 0.421 for pIChp,pICca,and pIChl,respectively,while the corresponding R2(i.e,non-cross-validation coefficient)all reach ***,the models were employed to estimate the activities of the training and test compounds,and the results show that the stability and predictability of developed models are very *** to the contour maps of steric and electronic fields,bulky groups linked to 2-,3-,4-positions of phenyl ring,and electropositive groups near the 4-position and electronegative groups far away may increase the anti-proliferative *** the information provided by the 3D contour maps,four new FQADs owing higher antiproliferative activity were designed,but their effectiveness should be further tested by experiments.

关键词： fluoroquinolone amide derivatives Hep-3B cell Capan-1cell HL60 cell anti-proliferative activity comparative molecular field analysis

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Metabolites change of Scenedesmus obliquus exerted by AgNPs

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Journal of Environmental Sciences 2019年第2期31卷 310-318页

作者： Pu Wang Bo Zhang hui Zhang Yiliang He Choon Nam ong Jun Yang School of Environmental Science & engineering Shanghai Jiaotong University School of Municipal and Environmental engineering Lanzhou Jiaotong University NUS Environmental Research Institute National University of Singapore

With increasing emission of silver nanoparticles(AgNPs) into the environment, it is important to understand the effects of ambient concentration of AgNPs. The biological effects of AgNPs on Scenedesmus obliquus, a ubiquitous freshwater microalgae, was evaluated. AgNPs exerted a minor inhibitory effect at low doses. Non-targeted metabolomic studies were conducted to understand and analyze the effect of AgNPs on algal cells from a molecular perspective. During the 48 hr of exposure to AgNPs, 30 metabolites were identified, of which nine had significant changes compared to the control group. These include D-galactose, sucrose, and *** carbohydrates are involved in the synthesis and repair of cell walls. Glycine, an important constituent amino acid of glutathione, increased with AgNP exposure concentration increasing, likely to counteract an increased intracellular oxidative stress. These results provide a new understanding of the toxicity effects and mechanism of AgNPs. These metabolites could be useful biomarkers for future research, employed in the early detection of environmental risk from AgNPs.

关键词： Silver nanoparticles (AgNPs) Scenedesmus obliquus Metabolomics Molecular mechanism

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Complex strengthening mechanisms in the NbMoTaW multiprincipal element alloy

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npj Computational Materials 2020年第1期6卷 1074-1083页

作者： Xiang-Guo Li Chi Chen hui Zheng Yunxing Zuo Shyue Ping ong Department of Nanoengineering University of California San Diego9500 Gilman DriveMail Code 0448La JollaCA 92093-0448USA

Refractory multi-principal element alloys(MPEAs)have exceptional mechanical properties,including high strength-to-weight ratio and fracture toughness,at high *** we elucidate the complex interplay between segregation,short-range order,and strengthening in the NbMoTaW MPEA through atomistic simulations with a highly accurate machine learning interatomic *** the single crystal MPEA,we find greatly reduced anisotropy in the critically resolved shear stress between screw and edge dislocations compared to the elemental *** the polycrystalline MPEA,we demonstrate that thermodynamically driven Nb segregation to the grain boundaries(GBs)and W enrichment within the grains intensifies the observed short-range order(SRO).The increased GB stability due to Nb enrichment reduces the von Mises strain,resulting in higher strength than a random solid solution *** results highlight the need to simultaneously tune GB composition and bulk SRO to tailor the mechanical properties of MPEAs.

关键词： strengthening alloy toughness

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