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The Utility of Voided Urine Samples as a Proxy for the Vaginal Microbiome and for the Prediction of Bacterial Vaginosis

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Infectious Microbes & Diseases 2022年第4期4卷 149-156页

作者： Bin Zhu Christopher Diachok Laahirie Edupuganti david J.edwards Jeffrey R.Donowitz Katherine Tossas Andrey Matveyev Katherine M.Spaine Vladimir Lee Myrna G.Serrano Gregory A.Buck Department of Microbiology and Immunology School of MedicineVirginia Commonwealth UniversityRichmondVirginiaUSA Center for Microbiome Engineering and Data Analysis Virginia Commonwealth UniversityRichmondVirginiaUSA Department of Statistical Sciences and Operations Research College of Humanities and SciencesVirginia Commonwealth UniversityRichmondVirginiaUSA Department of Pediatric Infectious Diseases Children's Hospital of Richmond at Virginia Commonwealth UniversityRichmondVirginiaUSA Department of Infectious Diseases and International Health University of VirginiaCharlottesvilleVirginiaUSA Department of Health Behavior and Policy School of MedicineVirginia Commonwealth UniversityRichmondVirginiaUSA Department of Family Medicine and Population Health School of MedicineVirginia Commonwealth UniversityRichmondVirginiaUSA Computer Science Department College of EngineeringVirginia Commonwealth UniversityRichmondVirginiaUSA Genomics Core Virginia Commonwealth UniversityRichmondVirginiaUSA

Recent work has shown that the vaginal microbiome exerts a strong impact on women's gynecological ***,collection of vaginal specimens is invasive and requires previous clinical training or the involvement of a trained *** contrast,urine sample collection is routine and noninvasive and does not require involvement of a *** sought to compare the vaginal and urogenital microbiomes to assess the utility of voided urine samples as a proxy for the vaginal *** urogenital and vaginal samples were collected from pregnant women and characterized by 16S rRNA taxonomic *** examined diversities and compositions of paired urogenital and vaginal microbiomes using five discrete strategies to explore the similarity between the vaginal and urogenital microbiomes.A strategy comparing the paired urogenital and vaginal microbiomes in which taxa were assigned using the STIRRUPS database and urine-specific taxa were removed showed no significant difference in diversity and composition between the paired urogenital and vaginal ***,the relative abundances of common vaginal taxa were linearly correlated with those in the paired *** similarities suggest that voided urine samples could represent a noninvasive protocol for accurate profiling of the vaginalmicrobiome with likely clinical ***,a machine learning model was established in which the voided urine microbiome was compared favorably to the vaginal microbiome in predicting bacterial vaginosis.

关键词： 16S rRNA vaginal microbiome urine microbiome bacterial vaginosis reproductive and gynecologic health

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SCREENING OF MARINE BACTERIA OF PAKISTAN COAST FOR DRUG DISCOVERY POTENTIAL

SCREENING OF MARINE BACTERIA OF PAKISTAN COAST FOR DRUG DISC...

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The 3rd Session of 2009 Workshop of Pakistan Academy of Sciences

作者： Bushra Uzair Nuzhat Ahmed Faryal Vali Mohammad Viqar Uddin Ahmad david edwards Centre for Molecular Genetics University of Karachi H.E.J. Research Institute of Chemistry International Centre for Chemical and Biological Sciences University of Karachi Department of Molecular and Cellular pathology University of Dundee Ninewells Hospital and Medical School

The use of microorganisms for biological purpose has become an effective alternative to control pathogens. A total of 100 bacteria were isolated from marine samples of Sindh and Baluchistan coast of Pakistan and screened for antibacterial activity. One strain CMG1066, identified as Pseudomonas aeruginosa, showed antibacterial activity, capable of inhibiting growth of clinical isolates such as methicillin resistant Staphylococcus aureus, Staphylococcus epidermidis, Escherichia coli, Serratia marcesence, Salmonella typhi, Shigella flexnerie, Enterococcus faecalis, Enterococcus faecium, Streptococcus group G, Clostridium perfringens, Clostridium sporogenes, as well as indigenous marine bacteria such as Shewanella putrifacians, Vibrio alginolyticus, Micrococcus luteus and Bacillus subtilis. The inhibitory activity was stable at temperatures of 80°, 90° and 100°C, but was partially inactivated at 121°C. Analysis of Pseudomonas aeruginosa established that antibacterial activity could be detected in an ethyl acetate fraction of the crude extract, and this suggests that the substance was not bound to cell surface. Microscopic examination of exponentially growing cells of S. aureus and B. subtilis treated with crude extract of P. aeruginosa showed some very interesting morphological changes.

关键词： Marine bacteria antibacterial Pseudomonas antibacterial activity thin layer chromatography zone of inhibition

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渲染王3ds Max+VRay室内效果图技术精粹

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1000年

作者： david edwards zhu Miao Qing Gong Liqun Liu Lanxin yi.

来源：畅想之星图书光盘版（南... 评论

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High pressure and temperature phase stabilities of dolomite and ankerite

High pressure and temperature phase stabilities of dolomite ...

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第八届“从原子到地球”——高压科学与地球科学研讨会

作者： Fei Qin Oliver T.Lord James W.E.Drewitt david edwards Michael J.Walter School of Earth Sciences and Resources China University of Geosciences (Beijing) School of Earth Sciences University of Bristol Geophysical Laboratory Carnegie Institute for Science

The fate of subducted carbonate has profound implications for the global carbon cycle and great importance for the geodynamic and geochemical evolution of Earth‘s deep interior. Understanding the structural evolution and stability of key carbonate phases is thus important for understanding the carbon cycleand redox conditions in the mantle1-3. Dolomite (Ca,Mg)(CO), is thought to constitute up to 0% of the Earth‘s accessible carbonate reserviors4. Since there is evidence of dolomite inclusions in ultra-deep diamonds, new high pressure-temperature polymorphs of dolomite could be crucial carbon-containing phases in the Earth‘s mantle5-8.

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TAOS/STEP卫星

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控制工程（北京） 1997年第1期 48-54,39页

作者： david J.edwards Robert W.Hosken 陈小军

1996年3月13日,自主运行生存能力/空间试验实验平台(TAOS/STEP)技术卫星由金牛座(TAURUS)火箭从范登堡空军基地发射到105°倾角的近圆形轨道上。这颗卫星有两个用途:1)试验多途径获取快速一跟踪模块化卫星的新概念;2)在空间试验一套菲... 详细信息

1996年3月13日,自主运行生存能力/空间试验实验平台(TAOS/STEP)技术卫星由金牛座(TAURUS)火箭从范登堡空军基地发射到105°倾角的近圆形轨道上。这颗卫星有两个用途:1)试验多途径获取快速一跟踪模块化卫星的新概念;2)在空间试验一套菲利普实验室的有效载荷。TAOS有效载荷包括MICROCOSM公司的自主导航系统(MANS),两个巴恩斯工程公司的双圆锥扫描器,两台霍尼韦尔的通用超大规模集成电路(VHSIC)星载计算机,一台洛克韦尔全球定位系统接收器,一个军标1553B数据总线,两个激光敏感器和一个雷达敏感器。有效载荷的实验周期大约一年半,尽管STEP卫星的惯性测试元件、TAOS有效负载的一台通用VHSIC星载计算机以及GPS接收器的射频链路出了故障,但实验仍取得极大的成功。

关键词：工程试验卫星人造卫星美国空间试验平台

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新一代油藏模拟技术

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石油工业计算机应用 2014年第1期22卷 46-54页

作者： david A.edwards Dayal Gunasekera Paul A.Fjerstad Jessica Franco Viet Hoang Lisette Quettier 雪佛龙能源技术公司道达尔公司

复杂的地质情况、高昂的资源开发成本促使油藏模拟技术不断发展。新一代油藏模拟软件采用数百万个非结构化网格模型模拟渗透率差异较大的地质构造。通过采用更加接近实际情况的模型。新型模拟软件有助于提高新老油田的最终采收率。

关键词：油藏模拟技术油藏模拟软件非结构化网格模型模拟最终采收率地质情况开发成本地质构造

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Multi-omic Microbiome Profiles in the Female Reproductive Tract in Early Pregnancy

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Infectious Microbes & Diseases 2019年第2期1卷 49-60页

作者： Sophonie Jean Bernice Huang Hardik I.Parikh david J.edwards J.Paul Brooks Naren Gajenthra Kumar Nihar U.Sheth Vishal Koparde Ekaterina Smirnova Snehalata Huzurbazar Philippe H.Girerd Dayanjan S.Wijesinghe Jerome F.StraussIII Myrna G.Serrano Jennifer M.Fettweis Kimberly K.Jefferson Gregory A.Buck Department of Microbiology and Immunology Virginia Commonwealth UniversityRichmondVA Center for Microbiome Engineering and Data Analysis Virginia Commonwealth UniversityRichmondVA Department of Statistical Sciences and Operations Research Virginia Commonwealth UniversityRichmondVA Supply Chain Management and Analytics School of BusinessVirginia Commonwealth UniversityRichmondVA Life Sciences Virginia Commonwealth UniversityRichmondVA DNAnexus Inc. Mountain ViewCA Frederick National Laboratory for Cancer Research FrederickMD Department of Biostatistics Virginia Commonwealth UniversityRichmondVA Department of Statistics University of WyomingLaramieWY Obstetrics and Gynecology Virginia Commonwealth UniversityRichmondVA Pharmacotherapy and Outcomes Science Virginia Commonwealth UniversityRichmondVA Department of Computer Science Virginia Commonwealth UniversityRichmondVA.

The vaginal microbiome likely influences host signaling compounds within the reproductive tract,including pro-inflammatory signals,which may play an important role during *** lactobacilli are associated with positive pregnancy outcome,whereas bacterial vaginosis,a dysbiosis of the vaginal microbiome,is associated with an increased risk of adverse pregnancy outcomes including preterm *** the host response could be predicted based on the taxonomic composition of the vaginal microbiome,particularly early in pregnancy,then those predictions could potentially be used to personalize intervention methods to reduce preterm birth and other adverse *** this proof of principle study,we apply multivariate strategies to analyze 16S rRNA-based taxonomic surveys in conjunction with targeted immuno-proteomic and lipidomic data from vaginal samples from 58 women enrolled in the Multi-Omic Microbiome Study-Pregnancy Initiative during early *** between the vaginal microbiome and the vaginal lipidome have not been previously *** from this study reveal significant multiple pairwise associations between microbial taxa,specific eicosanoids and sphingomyelins,and *** the biologic significance of these associations is not yet known,these results support the utility of such multi-omic approaches as a means to predict the impact of the microbiome on the host.

关键词： vaginal microbiome preterm birth multi-omics metagenomics cytokine profiles lipidomics

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水的奥秘

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人与自然 2012年第4期 38-55页

作者：付琦古解晓丹赵希 Jupiterimages John Tina Reid Matthieu Paley Hans Strand 江本胜 Jesús Gabán Philip Lee Harvey ANTHONY KO Patrizia Savarese david edwards Kerrick James Photog Arctic-Images NASA/SPL TPG 昵图网

地球是太阳系八大行星之中唯一被液态水所覆盖的星球，水不仅拥有特殊的本质，更创造了地球生命的奇迹。浩瀚的海洋，万年的冰霜与天空中漂浮的彩云都是水幻化成的各种形态。水循环把大气圈、水圈、岩石圈、生物圈相互联系起来，维持了... 详细信息

地球是太阳系八大行星之中唯一被液态水所覆盖的星球，水不仅拥有特殊的本质，更创造了地球生命的奇迹。浩瀚的海洋，万年的冰霜与天空中漂浮的彩云都是水幻化成的各种形态。水循环把大气圈、水圈、岩石圈、生物圈相互联系起来，维持了地球万物的动态与平衡。

关键词：液态水地球生命大行星太阳系大气圈水循环岩石圈生物圈

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Chronic effects of stretching on range of motion with consideration of potential moderating variables:A systematic review with meta-analysis

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Journal of Sport and Health Science 2024年第2期13卷 186-194页

作者： Andreas Konrad Shahab Alizadeh Abdolhamid Daneshjoo Saman Hadjizadeh Anvar Andrew Graham Ali Zahiri Reza Goudini Chris edwards Carina Scharf david George Behm Institute of Human Movement Science Sport and HealthGraz UniversityGraz A-8010Austria School of Human Kinetics and Recreation Memorial University of NewfoundlandSt.John’sNL A1C 5S7Canada Department of Sport Injuries and Corrective Exercises Faculty of Sport SciencesShahid Bahonar University of KermanKerman 76169-13439Iran

Background:It is well known that stretch training can induce prolonged increases in joint range of motion(ROM).However,to date more information is needed regarding which training variables might have greater influence on improvements in ***,the purpose of this metaanalysis was to investigate the effects of stretch training on ROM in healthy participants by considering potential moderating variables,such as stretching technique,intensity,duration,frequency,and muscles stretched,as well as sex-specific,age-specific,and/or trained state-specific adaptations to stretch ***:We searched through PubMed,Scopus,Web of Science,and SportDiscus to find eligible studies and,finally,assessed the results from 77 studies and 186 effect sizes by applying a random-effect ***,by applying a mixed-effect model,we performed the respective subgroup *** find potential relationships between stretch duration or age and effect sizes,we performed a ***:We found a significant overall effect,indicating that stretch training can increase ROM with a moderate effect compared to the controls(effect size=-1.002;Z=-12.074;95%confidence interval:-1.165 to-0.840;p<0.001;I^(2)=74.97).Subgroup analysis showed a significant difference between the stretching techniques(p=0.01)indicating that proprioceptive neuromuscular facilitation and static stretching produced greater ROM than did ballistic/dynamic ***,there was a significant effect between the sexes(p=0.04),indicating that females showed higher gains in ROM compared to ***,further moderating analysis showed no significant relation or ***:When the goal is to maximize ROM in the long term,proprioceptive neuromuscular facilitation or static stretching,rather than ballistic/dynamic stretching,should be *** to consider in future research as well as sports practice is that neither volume,intensity,nor frequency of stretching were

关键词： Flexibility Long-term stretching Stretch training

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Micromolded honeycomb scaffold design to support the generation of a bilayered RPE and photoreceptor cell construct

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Bioactive Materials 2023年第12期30卷 142-153页

作者： In-Kyu Lee Ruosen Xie Agustin Luz-Madrigal Seunghwan Min Jingcheng Zhu Jiahe Jin Kimberly L.edwards M.Joseph Phillips Allison L.Ludwig david M.Gamm Shaoqin Gong Zhenqiang Ma Department of Electrical and Computer Engineering University of Wisconsin-MadisonMadisonWI53706USA Wisconsin Institute for Discovery University of Wisconsin-MadisonMadisonWI53715USA Department of Ophthalmology and Visual Sciences University of Wisconsin-MadisonMadisonWI53705USA Department of Biomedical Engineering University of Wisconsin-MadisonMadisonWI53706USA McPherson Eye Research Institute University of Wisconsin-MadisonMadisonWI53705USA Waisman Center University of Wisconsin-MadisonMadisonWI53705USA Department of Comparative Biomedical Sciences University of Wisconsin–MadisonMadisonWI53706USA Department of Materials Science and Engineering University of Wisconsin-MadisonMadisonWI53706USA Department of Engineering Physics University of Wisconsin-MadisonMadisonWI53706USA Grainger Institute for Engineering University of Wisconsin-MadisonMadisonWI53706USA

Age-related macular degeneration(AMD)causes blindness due to loss of retinal pigment epithelium(RPE)and photoreceptors(PRs),which comprise the two outermost layers of the *** the small size of the macula and the importance of direct contact between RPE and PRs,the use of scaffolds for targeted reconstruction of the outer retina in later stage AMD and other macular dystrophies is particularly *** developed microfabricated,honeycomb-patterned,biodegradable poly(glycerol sebacate)(PGS)scaffolds to deliver organized,adjacent layers of RPE and PRs to the subretinal ***,an optimized process was developed to photocure PGS,shortening scaffold production time from days to *** resulting scaffolds robustly supported the seeding of human pluripotent stem cell-derived RPE and PRs,either separately or as a dual celllayered *** advanced,economical,and versatile scaffolds can accelerate retinal cell transplantation efforts and benefit patients with AMD and other retinal degenerative diseases.

关键词： Microfabrication Retina Scaffolds Stem cells Tissue engineering

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