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Accuracy of double contrast-enhanced ultrasonography in preoperative Lauren classification of advanced gastric carcinoma:correlation with pathological findings

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Accuracy of double contrast-enhanced ultrasonography in preo...

第二届长三角超声医学论坛暨2009年浙江省超声医学学术...

作者： david cosgrove Department of Ultrasonography The Second Affiliated Hospital of Wenzhou Medical College

Objective To investigate the clinical value of double contrast-enhanced ultrasonography(DCUS) in determining the Lauren classification of advanced gastric carcinoma. Methods Fifty-eight patients with gastric cancer proved by endoscopic biopsy underwent preoperative DCUS examination in which an oral contrast agent is combined with an intravenous agent,and the findings were

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Analysis of Neovascularization Within Carotid Plaques in Patients with Ischemic Stroke Using Contrast-enhauced Ultrasound

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Analysis of Neovascularization Within Carotid Plaques in Pat...

2008年浙江省超声医学学术年会

作者： david cosgrove Imaging Sciences Departmen Imperial CollegeHammersmith HospitalLondonUK

Objective To assess the neovascularization within human carotid atherosclerotic soft plaques in patients with ischemic stroke using real-time contrast-enhanced ultrasonography. Methods Eighty-six patients with ischemic stroke confirmed by computed tomography or magnetic resonance imaging who had soft atherosclerotic plaques in the carotid artery were enrolled. Ninety-seven controls with soft carotid atherosclerotic plaques but no clinical stroke were recruited at the same hospital and matched

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Assessment of neovascularization within carotid plaques in patients with ischemic stroke

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World Journal of Cardiology 2010年第4期2卷 89-97页

作者： Wilbert S Aronow Chandra K Nair david cosgrove Division of Cardiology New York Medical CollegeValhalla Center of Creighton University OmahaNE 68131United States Department of Imaging Sciences Imperial CollegeHammersmith Hospital

AIM:To assess neovascularization within human ca-rotid atherosclerotic soft plaques in patients with isch-emic ***:Eighty-one patients with ischemic stroke and 95 patients without stroke who had soft athero-sclerotic plaques in the internal carotid artery were *** thickest soft plaque in each patient was examined using contrast-enhanced ***-intensity curves were collected from 5 s to 3 min after contrast *** neovascularization within the plaques in the internal carotid artery was evaluated using the ACQ software built into the scanner by 2 of the experienced investigators who were blinded to the clinical history of the ***:Ischemic stroke was present in 7 of 33 patients(21%) with grade Ⅰ plaque,in 14 of 51 pa-tients(28%) with grade Ⅱ plaque,in 26 of 43 patients(61%) with grade Ⅲ plaque,and in 34 of 49 patients(69%) with grade Ⅳ plaque(P < 0.001 comparing grade Ⅳ plaque with grade I plaque and with grade Ⅱ plaque and P = 0.001 comparing grade Ⅲ plaque with grade Ⅰ plaque and with grade Ⅱ plaque).Analysis of the time intensity curves revealed that patients with ischemic stroke had a significantly higher intensity of enhancement(IE) than those without ischemic stroke(P < 0.01).The wash-in time(WT) of plaque was signifi-cantly shorter in stroke patients(P < 0.05).The sensi-tivity and specificity for IE in the plaque were 82% and 80%,respectively,and for WT were 68% and 74%,*** was no significant difference in the peak intensity or time to peak between the 2 ***:This study shows that the higher the grade of plaque enhancement,the higher the risk of ischemic *** data suggest that the presence of neovascularization is a marker for unstable plaque.

关键词： Carotid artery plaques Cerebral infarction Contrast-enhanced ultrasonography Ischemic stroke Neovascularization

Enhancement Patterns of Gastric Carcinoma on Contrast-enhanced Ultrasonography:Relationship with Clinicopathological Features

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Enhancement Patterns of Gastric Carcinoma on Contrast-enhanc...

中华医学会第十三次全国超声医学学术会议

作者： Pintong Huang Fang Wei Shiyan Li Jian Chen Ying Zhang Yurong Hong Shumei Wei cosgrove david Department of Ultrasound the 2nd Affiliated Hospital of Zhejiang University College of Medicine

Objective The aim of this study was to assess the relationship between the enhancement patterns and clini-copathological features of gastric cancer using intravenous contrast-enhanced ultrasonography(CEUS .Methods In ...

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共聚物在超声介导基因转染中的新功能

中华超声影像学杂志 2005年第11期14卷 858-862页

作者：陈云超张青萍 LIANG Hai-Dong david O. cosgrove Martin JK Blomley Qi-Long Lu 430030 武汉华中科技大学同济医学院附属同济医院超声影像科 Ultrasound Group Imaging Sciences Department Clinical Sciences Centre Imperial College Hammersmith Hospital UK Muscle Cell Biology MRC Clinical Sciences Centre Imperial College Hammersmith HospitalLondonUK

目的探讨超声和共聚物在促进基因转染中是否有协同作用.方法应用3种水溶性不同的共聚物F127,L61和P85.超声参数设定为1 MHz,1～3 W/cm2,脉冲作功周期为20%.选用C2C12,3T3-MDEI,和CHO 3种细胞系为研究对象.质粒DNA为可产生绿色荧光蛋白的... 详细信息

目的探讨超声和共聚物在促进基因转染中是否有协同作用.方法应用3种水溶性不同的共聚物F127,L61和P85.超声参数设定为1 MHz,1～3 W/cm2,脉冲作功周期为20%.选用C2C12,3T3-MDEI,和CHO 3种细胞系为研究对象.质粒DNA为可产生绿色荧光蛋白的GFP.应用荧光显微镜和流式细胞仪(FACS)评价转染率,台盼蓝染色评价细胞的成活率.每一实验结果至少重复3次以上.结果与以前的研究结果相同,超声可介导基因转染,但随着超声能量的增加,细胞的破坏也增加;单独应用3种共聚物未观察到基因转染.但当与超声同时应用,在较低浓度时共聚物可使超声介导的基因转染率提高2～4倍.结论在较低浓度时,共聚物可显著提高超声介导的基因转染作用.

关键词：超声检查基因转移生物聚合物

Correlation between enhanced intensity of contrast-enhanced ultrasound and microvessel density in rabbit atherosclerotic plaques

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Correlation between enhanced intensity of contrast-enhanced ...

中华医学会第十三次全国超声医学学术会议

作者： Chao Zhang Pintong Huang Minghui Wang Ying Zhang Yurong Hong Dan Ge Yao Wang Chunmei Liu Zhaoxia Pu Shuyuan Chen cosgrove david Department of Ultrasonography the Second Affiliated Hospital of Zhejiang University School of Medicine Baylor Research Institute Baylor university medical center at dallas

Objective To evaluate the correlation between enhanced intensity(EI) of contrast-enhanced ultrasound (CEUS) andmicrovessel density(MVD) of rabbit atherosclerotic *** The abdominal aortas of twenty-six male New Zealand...

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肝门部胆管癌的诊断、治疗选择与处理策略

中国普通外科杂志 2014年第8期23卷 1011-1023页

作者： Kevin C.Soares Ihab Kamel david P.cosgrove Joseph M.Herman Timothy M.Pawlik 冯铁成李新营美国霍普金斯大学医学院肿瘤外科美国霍普金斯大学医学院放射科美国霍普金斯大学医学院肿瘤科美国霍普金斯大学医学院肿瘤放疗科不详

肝门部胆管癌（HC）是一种少见的疾病,通常在60岁左右发病,预后较差;在美国,每年约有3 000例患者被诊断为该病,但仅有不到一半的人可以行手术治疗;有多种因素与HC的发病有关,最常见的有原发性硬化性胆管炎（PSC）,胆石症以及寄生虫肝病... 详细信息

肝门部胆管癌（HC）是一种少见的疾病,通常在60岁左右发病,预后较差;在美国,每年约有3 000例患者被诊断为该病,但仅有不到一半的人可以行手术治疗;有多种因素与HC的发病有关,最常见的有原发性硬化性胆管炎（PSC）,胆石症以及寄生虫肝病。患者通常表现为腹痛、瘙痒、体质量减轻和黄疸。CT、MRI及超声可以用来发现胆道病损;逆行性胰胆管造影术（ERCP）及经皮肝胆管造影术（PTC）在评估肿块位置、长度的同时还可以行治疗性的胆汁引流。MRCP在辨别肿瘤延伸范围时同PTC及ERCP有相同的准确性,并且并发症较前两者少。HC的治疗方式主要为手术切除、放射治疗、化疗及光动力学治疗。残余肝脏胆汁引流有助于降低胆红素水平,进而促进残肝的生长;标准的治疗包括切缘为阴性切除（R0）,范围为肝外胆管切除、肝切除及周围的淋巴结清扫术;局部的切除术是不适当的;淋巴结侵犯的程度、肿瘤的级别以及切缘的性质是重要的预后指标;如果无法行肿瘤切除,那么在经反复选择后的患者中实施肝移植术也是种可行的方式;尽管数据有限,化疗对于不可切除的患者来说仍有一定的作用;经手术切除的HC患者5年生存率约为10%～40%,然而即使为R0切除,复发率也高达50%～70%。由于这种疾病的复杂性,多种学科的综合治疗是较为理想的治疗方式。

关键词：胆管肿瘤诊断胆管肿瘤治疗 Klatskin肿瘤

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超声微泡造影影像学及治疗作用的研究进展

中华医学超声杂志（电子版） 2004年第3期1卷 138-141页

作者：梁海东王兴华 Charles Sennoga Mike Halliwell david O cosgrove Martin JK Blomley Department of Medical Physics and Bioengineering Bristol General Hospital 山西医科大学第二附属医院综检科 Ultrasound Group Imaging Sciences Department Imperial College London Clinical Sciences Centre

包裹型气体微泡已经发展为临床应用的超声造影剂.微泡造影剂不仅已广泛用于血池和组织灌注显像,其治疗作用也日渐突显,例如溶栓和作为药物或基因的载体.造影剂微泡的平均直径小于红细胞直径,因而能够自由运行于微循环.微泡能将生物活性... 详细信息

包裹型气体微泡已经发展为临床应用的超声造影剂.微泡造影剂不仅已广泛用于血池和组织灌注显像,其治疗作用也日渐突显,例如溶栓和作为药物或基因的载体.造影剂微泡的平均直径小于红细胞直径,因而能够自由运行于微循环.微泡能将生物活性物质(例如药物或基因)结合在其内或其外膜表面,并将此物质转运于体内特定组织,例如将抗肿瘤药物转运并结合于特定肿瘤组织.靶向性微泡能将肽段等特定性配体结合于其微泡表面,这种特定性配体可特异性地与血管壁表达的受体相结合,微泡因而在靶组织区域积聚[1].

关键词：微泡治疗作用造影剂影像学临床应用超声药物基因灌注显像血池

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传染性囊病

养禽与禽病防治 1984年第2期 55-58页

作者： david Gerdon 邝明智

传染性囊病(infectious bursal disease,简称 IBD)于1962年由 cosgrove 博士首次报道。他称该病为禽肾变病,因为他见到肾的严重损害,并认为这是由于传染性支气管炎的变异毒株所引起的。几年之后,人们发现那些对传染性支气管炎变异病毒... 详细信息

传染性囊病(infectious bursal disease,简称 IBD)于1962年由 cosgrove 博士首次报道。他称该病为禽肾变病,因为他见到肾的严重损害,并认为这是由于传染性支气管炎的变异毒株所引起的。几年之后,人们发现那些对传染性支气管炎变异病毒株有免疫力的鸡,仍然对禽肾变病易感。

关键词：腔上囊病毒株法氏囊淋巴器官传染性囊病病毒灭活疫苗母源抗体传染性支气管炎 IBDV 马立克氏病马立克病周龄小鸡