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Extensive adhesion formation in a total knee replacement in the setting of a gastrointestinal stromal tumor:A case report

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World Journal of Orthopedics 2022年第5期13卷 538-543页

作者： Steven Mitchell Anderson lee Ryan Stenquist david YatsonskyⅡ Megan L Mooney Vithal B Shendge Department of Orthopaedic Surgery The University of Toledo Medical CenterToledoOH 43614United States

BACKGROUND Gastrointestinal stromal tumors(GISTs)are rare primary neoplasms of the gastrointestinal tract,accounting for 1%to 2%of all gastrointestinal neoplasms *** are frequently discovered incidentally during workup for other diagnosis or intestinal obstruction,as they can present with few or no ***,GISTs confer a high degree of malignant transformation,with a progression in about 10%to 30%of *** SUMMARY A 63-year-old healthy female presented to our institution with complaints of right knee pain and limited passive and active motion in the setting of a previous right total knee arthroplasty(TKA).One year after TKA,the patient was incidentally diagnosed with a GIST,which was successfully *** removal,the patient continued to have limited range of motion of the right knee and subsequently underwent revision *** significant fibrotic adhesions were found encapsulating the femoral and tibial *** patient’s pain improved postoperatively,however,she continued to have decreased range of motion with difficulty *** We propose that this case may demonstrate a proinflammatory milieu arising from a GIST,which had a direct influence on the outcome of recent total knee *** proposed mechanism between neoplastic cytokinetic activity and adhesion formation could have implications on preoperative and postoperative orthopedic management of total knee arthroplasty.

关键词： Gastrointestinal stromal tumor Adhesion formation Total knee arthroplasty Inflammatory response Decreased range of motion Case report

Differential Expression of mGluR2 in the Developing Cerebral Cortex of the Mouse

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Journal of Biomedical Science and Engineering 2014年第13期7卷 1030-1037页

作者： Pooja S. Venkatadri charles C. lee Department of Comparative Biomedical Sciences School of Veterinary Medicine Louisiana State University Baton Rouge USA

Glutamatergic synaptic transmission is an essential component of neural circuits in the central nervous system. Glutamate exerts its effects by binding to various types of glutamate receptors, which are found distributed on neurons throughout the central nervous system. These receptors are broadly classified into two main groups, ionotropic glutamate receptors (iGluRs) and metabo-tropic glutamate receptors (mGluRs). Unlike iGluRs, the mGluRs are G-protein coupled receptors that exert their effects on postsynaptic membrane conductance indirectly through the downstream modification of ion channels. A subtype of mGluRs, the Group II mGluRs, are particularly interesting since their activation by glutamate results in a hyperpolarizing response. Thus, glutamate can act potentially as an inhibitory neurotransmitter, by binding to postsynaptic Group II mGluRs. Given the potential importance of these receptors in synaptic processing, the development of the central nervous system, and neurological disorders, we sought to characterize the expression of mGluR2 in the developing neocortex of the mouse. Therefore, we examined the distribution of mGluR2 in the developing cerebral cortex. We found a general caudal to rostral gradient in the expression of these receptors, with ventral cortical regions labeled caudally and dorsal regions labeled rostrally. Limbic regions highly expressed mGluR2 throughout the brain, as did sensory and motor cortical areas. Finally, other non-cortical structures, such as the thalamic reticular nucleus, amygdala, and mammillary bodies were found to have significant expression of the receptor. These results suggest that mGluR2 may play important roles in mediating glutamatergic inhibition in these structures and also could have a role in shaping the development of mature neural networks in the forebrain.

关键词： Metabotropic Glutamate Receptor Mouse Cortex mGluR2 Group II mGluR

Prognostic impact of the Bismuth-Corlette classification:Higher rates of local unresectability in stageⅢb hilar cholangiocarcinoma

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Hepatobiliary & Pancreatic Diseases International 2020年第2期19卷 157-162页

作者： Michael J Passeri Maria R Baimas-George Jesse K Sulzer david A Iannitti John B Martinie Erin H Baker lee M Ocuin Dionisios Vrochides Division of HPB Surgery Department of SurgeryCarolinas Medical Center1025 Morehead Medical Dr.Suite 600CharlotteNC 28204USA

Background:The Bismuth-Corlette(BC)classification is used to categorize hilar cholangiocarcinoma by proximal extension along the biliary *** the right hepatic artery crosses just behind the left bile duct,we hypothesized that BCⅢb tumors would have a higher likelihood of local unresectability due to involvement of the contralateral ***:A retrospective review of a prospectively maintained database identified patients with hilar cholangiocarcinoma taken to the operating room for intended curative resection between April 2008 and September *** were assigned BC stages based on preoperative ***:Sixty-eight patients were included in the *** underwent staging laparoscopy after which 16 cases were aborted for metastatic *** the remaining 52 cases,14 cases were explored and aborted for locally advanced ***-eight underwent attempt at curative *** exclud-ing cases aborted for metastatic disease,the chance of proceeding with resection was 55.6%for BCⅢb staged lesions compared to 80.0%of BCⅢa lesions and to 82.4%for BCⅠ-Ⅲa staged lesions(P<0.05).About 44.4%of BCⅢb lesions were aborted for locally advanced disease versus 17.6%of remaining BC ***:When hilar cholangiocarcinoma is preoperatively staged as BCⅢb,surgeons should antici-pate higher rates of locally unresectable disease,likely involving the right hepatic artery.

关键词： Bismuth-Corlette stage Cholangiocarcinoma Biliary tract surgical procedures Biliary tree Liver surgery

Redox sensor QSOX1 regulates plant immunity by targeting GSNOR to modulate ROS generation

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Molecular Plant 2021年第8期14卷 1312-1327页

作者： Ho Byoung Chae Min Gab Kim Chang Ho Kang Joung Hun Park Eun Seon lee Sang-Uk lee Yong Hun Chi Seol Ki Paeng Su Bin Bae Seong Dong Wi Byung-Wook Yun Woe-Yeon Kim Dae-Jin Yun david Mackey Sang Yeol lee Division of Applied Life Sciences(BK21)and PMBBRC Gyeongsang National UniversityJinju 52828Korea College of Pharmacy Research Institute of Pharmaceutical ScienceGyeongsang National UniversityJinju 52828Korea School of Applied Biosciences College of Agriculture and Life SciencesKyungpook National UniversityDaegu 41566Korea Department of Biomedical Science and Engineering Konkuk UniversitySeoul 05029Korea Department of Horticulture and Crop Science Department of Molecular Geneticsand Center for Applied Plant SciencesThe Ohio State UniversityColumbusOH 43210USA College of Life Sciences Qingdao Agricultural UniversityQingdao 266109P.R.China Plant Propagation Team Plant Production DivisionSejong National ArboretumSejong 30106Korea

Reactive oxygen signaling regulates numerous biological processes,including stress responses in *** sensors transduce reactive oxygen signals into cellular ***,we present biochemical evidence that a plant quiescin sulfhydryl oxidase homolog(QSOX1)is a redox sensor that negatively regulates plant immunity against a bacterial *** expression level of QSOX1 is inversely correlated with pathogen-induced reactive oxygen species(ROS)***,QSOX1 both senses and regulates ROS levels by interactingn with and mediating redox regulation of S-nitrosoglutathione reductase,which,consistent with previous findings,influences reactive nitrogen-mediated regulation of ROS ***,our data indicate that QSOX1 is a redox sensorthat negatively regulates plant immunity by linking reactive oxygen and reactive nitrogen signaling to limit ROS production.

关键词： redox sensor plant immu nity QSOX1 GSNOR reactive oxygen species(ROS) reactive nitrogen species(RNS)

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Walking on a DRAGON

空中英语教室（初级版．大家说英语） 2017年第11期 43-45,56页

作者： Ruth Devlin david lee

Vegetarian diets,circulating miRNA expression and healthspan in subjects living in the Blue Zone

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Precision Clinical Medicine 2020年第4期3卷 245-259页

作者： Tiantian Liu Nicole M.Gatto Zhong Chen Hongyu Qiu Grace lee Penelope Duerksen-Hughes Gary Fraser charles Wang Center for Genomics School of MedicineLoma Linda UniversityLoma LindaCA 92350USA School of Community and Global Health Claremont Graduate UniversityClaremontCA 91711USA Center of Molecular and Translational Medicine Institution of Biomedical ScienceGeorgia State UniversityAtlantaGA 30303USA Department of Psychology School of Behavioral HealthLoma Linda UniversityLoma LindaCA 92350USA Department of Basic Sciences School of MedicineLoma Linda UniversityLoma LindaCA 92350USA School of Public Health Loma Linda UniversityLoma LindaCA 92350USA

A long-term vegetarian diet plays a role in the longevity and maintenance of the healthspan,but the underlying mechanisms for these observations are largely ***,it is not known whether a longterm vegetarian dietary pattern may affect the circulating miRNA expression in such a way as to modulate the *** Adventist Health Study-2(AHS-2)cohort includes a large number of older adults who primarily follow vegetarian dietary patterns and reside in Loma Linda,California,one of five“Blue Zones”in the world in which a higher proportion of the population enjoys a longer than average *** performedmiRNA-seq in 96 subjects selected from the AHS-2 cohort with different dietary *** identified several differentially expressed miRNAs between vegetarians and non-vegetarians,which are involved in immune response and cytokine signaling,cell growth and proliferation as well as age-related diseases such as cardiovascular diseases and neurodegenerative ***,our study showed that a vegetarian diet modulates aging-associated circulating miRNAs in a sex-dependent manner of differential expression for certain miRNAs,which may be related in a beneficial manner to the *** investigation is needed to validate these miRNAs as potential biomarkers for diet-modulated longevity in humans.

关键词： circulating miRNA aging miRNA sequencing vegetarian diet Blue Zone

Portal hypertension: Imaging of portosystemic collateral pathways and associated image-guided therapy

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World Journal of Gastroenterology 2017年第10期23卷 1735-1746页

作者： Murad Feroz Bandali Anirudh Mirakhur Edward Wolfgang lee Mollie Clarke Ferris david James Sadler Robin Ritchie Gray Jason Kam Wong Department of Radiology Foothills Medical Centre University of Calgary Division of Interventional Radiology Department of Radiology UCLA Medical Center

Portal hypertension is a common clinical syndrome, defined by a pathologic increase in the portal venous pressure. Increased resistance to portal blood flow, the primary factor in the pathophysiology of portal hypertension, is in part due to morphological changes occurring in chronic liver diseases. This results in rerouting of blood flow away from the liver through collateral pathways to low-pressure systemic veins. Through a variety of computed tomographic, sonographic, magnetic resonance imaging and angiographic examples, this article discusses the appearances and prevalence of both common and less common portosystemic collateral channels in the thorax and abdomen. A brief overview of established interventional radiologic techniques for treatment of portal hypertension will also be provided. Awareness of the various imaging manifestations of portal hypertension can be helpful for assessing overall prognosis and planning proper management.

关键词： Portal hypertension Diagnostic imaging Portosystemic collaterals Image-guided therapy

Experimental evaluation of the effect of storm movement on peak discharge

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International Journal of Sediment Research 2015年第2期30卷 167-177页

作者： Jin Liang charles S.Melching Department of Civil Construction and Environmental EngineeringMarquette University

The hypothesis that downstream moving storms with storm length less than watershed length（L;/L< 1.0） magnify the peak discharges as indicated by kinematic-wave models in previous studies was evaluated in an analysis of the dimensionless peak discharge and dimensionless storm *** unpublished experimental data collected for a V-shaped watershed in the Watershed Experimentation System（WES） at the University of Illinois at Urbana-Champaign,were used in comparison with the simulation results of a kinematic-wave *** is found that downstream moving storms with L;/L < 1.0 increase the peak discharges to a limited extent compared to stationary storms,and the kinematic-wave model overstates the increase in the peak flows resulting from downstream moving storms with L;/L < *** evaluate the importance of the backwater effects in the experimental watershed,the accuracy of kinematic-wave and dynamic-wave models for the simulation of surface runoff resulting from upstream and downstream moving storms was evaluated utilizing the same experimental *** kinematic-wave model simulates the upstream moving storms pretty well,***-Sutcliffe coefficient of model fit efficiency equal to 0.948 and 0.831 for storms lengths equal to and not equal to the watershed length,***,the kinematic wave model substantially overestimates the peak discharge of downstream moving storms,and yields generally poorer fits than for upstream moving storm,*** equal to 0.867 and 0.674 for storms with lengths equal to and not equal to the watershed length,*** dynamic-wave model simulates the downstream moving storms pretty well,*** equal to 0.843 and 0.879 for storms with lengths equal to and not equal to the watershed length,respectively,indicating backwater significantly affects runoff for even this simple experimental *** that storm movement did not substantially magnify peak discharge,the assumption of stationary storms made

关键词： Moving storms Kinematic-wave Dynamic-wave Experimental data Dimensional analysis

Epithelial cell adhesion efficacy of a novel peptide identified by panning on a smooth titanium surface

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International Journal of Oral Science 2018年第3期10卷 174-181页

作者： Hidemichi Kihara david M.Kim Masazumi Nagai Toshiki Nojiri Shigemi Nagai Chia-Yu Chen Cliff lee Wataru Hatakeyama Hisatomo Kondo John Da Silva Harvard School of Dental Medicine BostonMAUSA School of Dental Medicine Iwate Medical UniversityIwateJapan University of California San FranciscoCAUSA

Epithelial attachment via the basal lamina on the tooth surface provides an important structural defence mechanism against bacterial invasion in combating periodontal disease. However, when considering dental implants, strong epithelial attachment does not exist throughout the titanium-soft tissue interface, making soft tissues more susceptible to peri-implant disease. This study introduced a novel synthetic peptide(A10) to enhance epithelial attachment. A10 was identified from a bacterial peptide display library and synthesized. A10 and protease-activated receptor 4-activating peptide(PAR4-AP, positive control) were immobilized on commercially pure titanium. The peptide-treated titanium showed high epithelial cell migration ability during incubation in platelet-rich plasma. We confirmed the development of dense and expanded BL(stained by Ln5) with pericellular junctions(stained by ZO1) on the peptide-treated titanium surface. In an adhesion assay of epithelial cells on A10-treated titanium, PAR4-AP-treated titanium, bovine root and non-treated titanium, A10-treated titanium and PAR4-AP-treated titanium showed significantly stronger adhesion than non-treated titanium. PAR4-AP-treated titanium showed significantly higher inflammatory cytokine release than non-treated titanium. There was no significant difference in inflammatory cytokine release between A10-treated and non-treated titanium. These results indicated that A10 could induce the adhesion and migration of epithelial cells with low inflammatory cytokine release. This novel peptide has a potentially useful application that could improve clinical outcomes with titanium implants and abutments by reducing or preventing peri-implant disease.

关键词： PAR OBA Epithelial cell adhesion efficacy of a novel peptide identified by panning on a smooth titanium surface AP