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Geomechanical properties will constrain cO_(2)injection into the lower Ordovician Rose Run sandstone deep saline reservoir,Appalachian Basin,Kentucky,USA

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Journal of Rock Mechanics and Geotechnical Engineering 2021年第5期13卷 947-960页

作者： John Richard Bowersox Stephen F.Greb Junfeng Zhu david c.harris Kentucky Geological Survey University of KentuckyLexingtonKY40506-0107USA

The Kentucky Geological Survey(KGS)1 Hanson Aggregates stratigraphic research well,carter county,Kentucky,USA,was drilled to a total depth of 1474 m as a field-scale test of potential cO2 storage reservoir properties in the central Appalachian *** properties of the Rose Run sandstone(upper Ordovician Knox group)were tested for its suitability as a storage reservoir.A 9.8-m thick section of the Rose Run was penetrated at 1000 m drilled depth and a whole-diameter core and rotary sidewall cores were *** porosity and permeability measured in core plugs were 9.1%and 44.6 mD,*** vertical stress gradient calculated in the wellbore was 26 MPa/*** fractures in dolomites underlying and overlying the Rose Run follow the contemporary N53E Appalachian Basin stress *** Rose Run elastic geomechanical properties were calibrated to values measured in core plugs to evaluate its fracturing risk as a cO2 storage *** Young’s modulus and Poisson’s ratio values of the Rose Run were 45 GPa and 0.23,respectively,whereas Young’s modulus and Poisson’s ratio values were 77.1 GPa and 0.28,respectively,in the overlying Beekmantown dolomite,suggesting the Rose Run may fracture if overpressured during cO2 injection but be confined by the *** compressive strength measured in core plugs found the Rose Run and Beekmantown fractured at mean axial stresses of 156.5 MPa and 282.2 MPa,respectively,confirming the Beekmantown as suitable for confining cO2 injected into the Rose Run.A step-rate test was conducted in a mechanically-isolated 18.6-m interval bracketing the Rose *** Rose Run reservoir pressure was 9.3 MPa,and fracture gradient under injection was 13.6 MPa/km,suggesting step-rate testing before cO2 injection,and subsequent pressure monitoring to ensure *** the region around the KGS 1 Hanson Aggregates well is underpressured and adjacent to faulted Precambrian basement,further research is neede

关键词： Appalachian Basin Rose Run sandstone Geomechanics carbon sequestration Step-rate testing

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Exercise immunology:Novel insights

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Journal of Sport and Health Science 2024年第3期13卷 277-279,I0001页

作者： david c.Nieman Human Performance Laboratory Appalachian State UniversityNorth Carolina Research CampusKannapolisNC 28081USA

The coronavirus disease 2019(cOVID-19)pandemic heightened worldwide attention on the influence of exercise on the immune *** were raised about whether regular moderate-to-vigorous physical activity(MVPA)could help prevent cOVID-19 or mitigate symptoms when *** MVPA bolster immunity among those most prone to cOVID-19 including the elderly,obese,and immunocompromised patients?Does regular MVPA dampen systemic inflammation,thereby lessening the cOVID-19 cytokine storm?

关键词： immunity inflammation thereby

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Artificial intelligence analysis of videos to augment clinical assessment:an overview

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Neural Regeneration Research 2024年第4期19卷 717-718页

作者： david c.Wong Stefan Williams University of Leeds Leeds Teaching Hospitals Trust LeedsUK

Observation is a fundamental part of the practice of clinical *** of movement is particularly important for the *** such as Parkinson’s disease,multiple sclerosis,stroke,epilepsy,and many others affect a person’s movement in characteristic *** some conditions,changes in the patient’s voice can be included in this-changes in sound caused by changes in the movements of *** clinician’s detection of a characteristic abnormality,and their judgment of its severity,plays a central role in both diagnosis and the assessment of prognosis or response to ***,that practice depends upon a limited resource of experienced *** addition,these experts are limited by human visual judgment,which cannot reliably or precisely detect and measure small or subtle changes in movement(Williams et al.,2023).

关键词： clinical epilepsy diagnosis

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Balancing machine learning and artificial intelligence in soil science with human perspective and experience

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Pedosphere 2024年第1期34卷 9-12页

作者： david c.WEINDORF Somsubhra cHAKRABORTY Department of Earth and Atmospheric Science Central Michigan Universityount Pleasant M148859USA Agricultural and Food Engineering Department Indian Institute of TechnologyKharagpur 721302India

Machine learning and artificial intelligence continue to evolve at a rapid pace, with many potential applications related to soil science. Even so, human experience and perception play an invaluable role in characterizing soil properties, especially qualitative properties that may elude sensing/computer-based modeling approaches. The elegant solution to this conundrum relies on the synthesis of computer-aided predictive modeling with human insight and *** global population surpasses 8 billion, the importance of optimized agronomic production to feed a hungry world has never been more important.

关键词： soil elude qualitative

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mRNA vaccines:a new era in vaccine development

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Oncology Research 2024年第10期32卷 1543-1564页

作者： SHUBHRA cHANDRA JENNIFER c.WILSON david GOOD MING Q.WEI School of Pharmacy&Medical Sciences Gold Coast campusGriffith UniversityBrisbaneQLD-4222Australia Menzies Health Institute Queensland(MHIQ) Gold Coast CampusGriffith UniversityBrisbaneQLD-4215Australia School of Allied Health Australian Catholic UniversityBrisbaneQLD-4014Australia

The advent of RNA therapy,particularly through the development of mRNA cancer vaccines,has ushered in a new era in the field of *** article provides a concise overview of the key principles,recent advancements,and potential implications of mRNA cancer vaccines as a groundbreaking modality in cancer *** cancer vaccines represent a revolutionary approach to combatting cancer by leveraging the body’s innate immune *** vaccines are designed to deliver specific mRNA sequences encoding cancer-associated antigens,prompting the immune system to recognize and mount a targeted response against malignant *** personalized and adaptive nature of mRNA vaccines holds immense potential for addressing the heterogeneity of cancer and tailoring treatments to individual *** breakthroughs in the development of mRNA vaccines,exemplified by the success of cOVID-19 vaccines,have accelerated their application in *** mRNA platform’s versatility allows for the rapid adaptation of vaccine candidates to various cancer types,presenting an agile and promising avenue for therapeutic *** trials of mRNA cancer vaccines have demonstrated encouraging results in terms of safety,immunogenicity,and *** candidates,such as BioNTech’s BNT111 and Moderna’s mRNA-4157,have exhibited promising outcomes in targeting melanoma and solid tumors,*** successes underscore the potential of mRNA vaccines to elicit robust and durable anti-cancer immune *** the field holds great promise,challenges such as manufacturing complexities and cost considerations need to be addressed for widespread *** development of scalable and cost-effective manufacturing processes,along with ongoing clinical research,will be pivotal in realizing the full potential of mRNA cancer ***,mRNA cancer vaccines represent a cutting-edge therapeutic approach that holds the promise of transforming cancer treatment.

关键词： cancer immunotherapy Immune checkpoint Preventive&therapeutic vaccine Delivery system mRNA

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Airway management of a patient with linear immunoglobulin A bullous dermatosis:A case report

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World Journal of clinical cases 2024年第13期12卷 2263-2268页

作者： Olga c Nin Robert Hutnik Neil N chheda david Hutchinson Department of Anesthesiology University of Florida College of MedicineGainesvilleFL 32610United States Department of Otolaryngology University of Florida College of MedicineGainesvilleFL 32610United States

BAcKGROUND There is limited literature on managing the airway of patients with linear immunoglobulin A(IgA)bullous dermatosis,a rare mucocutaneous disorder that leads to the development of friable *** clinical decision making is necessary when there is a risk of bleeding into the airway,and a multidisciplinary team approach may lead to decreased patient morbidity during these high-risk scenarios,especially when confronted with an unusual cause for *** SUMMARY A 45-year-old African American female presented to our ambulatory surgical center for right corneal transplantation due to corneal perforation after blunt trauma in the setting of cicatricial conjunctivitis and diffuse corneal neovascularization from linear IgA bullous *** diagnosis of IgA dermatosis was recent,and the patient had been lost to *** severity of the disease and extent of airway involvement was unknown at the time of the *** airway bleeding was noticed upon intubation and the otorhinolaryngology team had to be called to the operating *** patient required transfer to the intensive care unit where a multidisciplinary team was involved in her *** patient was extubated on postoperative day *** A multidisciplinary approach to treating this disease is the best course of action before a surgical *** our case,key communication between the surgery,anesthesia,and dermatology teams led to the quick and safe treatment of our patient’s *** surgery should not be considered for these cases unless they are in full remission and there is no mucous membrane involvement.

关键词： Airway management Bleeding risk Linear immunoglobulin A bullous dermatosis Multidisciplinary approach Outpatient procedure case report

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Hepatitis B virus genotypes in precision medicine of hepatitis Brelated hepatocellular carcinoma:Where we are now

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World Journal of Gastrointestinal Oncology 2024年第4期16卷 1097-1103页

作者： caecilia H c Sukowati Sri Jayanti Turyadi Turyadi david H Muljono claudio Tiribelli Eijkman Research center for Molecular Biology Research Organization for HealthNational Research and Innovation Agency of IndonesiaJakarta 10340Indonesia Liver cancer Unit Fondazione Italiana Fegato ONLUSTrieste 34149Italy Faculty of Medicine Hasanuddin UniversityMakassar 90245South SulawesiIndonesia Faculty of Medicine and Health University of SydneySydney 2050Australia

Hepatitis B virus(HBV)infection is a major player in chronic hepatitis B that may lead to the development of hepatocellular carcinoma(Hcc).HBV genetics are diverse where it is classified into at least 9 genotypes(A to I)and 1 putative genotype(J),each with specific geographical distribution and possible different clinical outcomes in the *** diversity may be associated with the precision medicine for HBV-related Hcc and the success of therapeutical approaches against Hcc,related to different pathogenicity of the virus and host *** Editorial discusses recent updates on whether the classification of HBV genetic diversity is still valid in terms of viral oncogenicity to the Hcc and its precision medicine,in addition to the recent advances in cellular and molecular biology technologies.

关键词： Hepatitis B virus Hepatocellular carcinoma Genotypes Pathogenesis Precision medicine

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Kerogen Kinetic Distributions and Simulations Provide Insights into Petroleum Transformation Fraction (TF) Profiles of Organic-Rich Shales

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Journal of Earth Science 2024年第3期35卷 747-757页

作者： david A.Wood DWA Energy Limited Lincoln LN59JPUnited Kingdom

Two hundred and fifty single first-order Arrhenius reactions are simulated to generate S2 pyrograms at three heating rates 25,15,and 5°c·*** activation energy(E)and pre-exponential factor(A)of the reactions simulated follow a long-established trend of those variable values displayed by shales and *** characteristics of the transformation fraction(TF)profiles(product generation window temperatures)of the simulated single reactions are compared to the TF profiles of recorded shale pyrograms generated by multiple reactions with different E-A values lying near the defined E-A *** similarities and differences are observed between the TF profile values of the two *** similarities support the spread of E-A values involved in shale pyrogram best *** differences are most likely explained by the complexity of the multiple kerogen first-order and second-order reactions contributing to the recorded shale pyrograms versus the simplicity and crispness of the single first-order reactions *** results also justify the validity of using the previously described“variable E-A pyrogram-fitting method”of multi-heating-rate shale pyrograms enabling optimizers to choose multiple reactions from an unlimited range of E-A *** contrast,further doubt is cast on the validity of the constant-A pyrogram-fitting method used by the Easy%Ro technique,in that a distribution of reactions with a single A value is unlikely to represent the complex variety of kerogen macerals observed in shale *** profiles generated by the variable E-A pyrogram-fitting method lie close to the established E-A trend and are likely to provide more realistic TF generation window temperatures than TF profiles generated by the constant-A pyrogram-fitting method.

关键词： transformation fraction profiles simulated S2 pyrograms multiple heating rates kerogen/shale kinetics S2 pyrogram fitting techniques kerogen petroleum research.

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Evaluation of formation susceptibility and sand production potential in an offshore field,Niger Delta Basin,Nigeria

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Energy Geoscience 2024年第1期5卷 1-11页

作者： david O.Ubuara Yinka A.Olayinka Godwin O.Emujakporue Geoffrey c.Soronnadi-Ononiwu Department of Geology University of Port HarcourtNigeria Mease Energy Nigeria Limited Port HarcourtNigeria Department of Geology University of IbadanNigeria Department of Physics University of Port HarcourtNigeria

Wellbore instability and sand production are all common challenges in the Niger Delta oil province,resulting in high drilling and production cost as well as damage to oil *** vulnerability of lithologic formations to wellbore instability and resultant sand production is investigated in the four delineated reservoirs of the“Areo”field,western part of Niger Delta *** foundation for establishing the geomechanical properties in this study was a 1-dimensional mechanical earth model,using gamma ray(GR),density(RHOB),compressional slowness(DTc),and shear slowness(DTS)*** the Areo oil field,two wells(well 001 and well 002)were *** evaluated formations are still primarily composed of compacted shale and unconsolidated sandstone,with reservoir sand units exhibiting lower elastic and rock strength properties than shale *** compressibility and porosity make sand more brittle,while low compressibility and porosity make shale stiffer due to high *** maximum force that can be applied to a shale unit without causing it to fail is 17.23 MPa,which is the maximum average rock strength of the *** means that shale requires more vertical stress or pressure than sand does in order to deform it(15.06 MPa).The three sand prediction approaches used in the analysis of sand production predictions have cut-off values that are higher than the average values of the *** Schlumberger sand production index method(S/I)indicates that the reservoir has potential for sand influx in the two wells,with the average of the four reservoirs studied in wells 001 and 002 being 1.551012 psi and 1.141012 psi ***,when a formation's sand production index is less than 1.241012 psi,as it is in this study,the formation is likely to produce *** findings support the notion that the defined sandstone units are highly unconsolidated and have a high potential for producing sands;therefore,sand control techniques must be factored in

关键词： Wireline log Stress Geo-mechanicanical characterization Sand prediction Niger delta

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Exploring the associations between skeletal muscle echogenicity and physical function in aging adults:A systematic review with meta-analyses

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Journal of Sport and Health Science 2024年第6期13卷 820-840页

作者： Dustin J.Oranchuk Stephan G.Bodkin Katie L.Boncella Michael O.harris-Love Muscle Morphology Mechanicsand Performance LaboratoryDepartment of Physical Medicine and RehabilitationUniversity of Colorado Anschutz Medical CampusAuroraCO 80045USA Department of Physical Therapy

Background:Assessment and quantification of skeletal muscle within the aging population is vital for diagnosis,treatment,and injury/disease *** clinical availability of assessing muscle quality through diagnostic ultrasound presents an opportunity to be utilized as a screening tool for function-limiting ***,relationships between muscle echogenicity and clinical functional assessments require authoritative ***,we aimed to(a) synthesize the literature to assess the relationships between skeletal muscle echogenicity and physical function in older adults(≥60 years),(b) perform pooled analyses of relationships between skeletal muscle echogenicity and physical function,and(c) perform sub-analyses to determine between-muscle ***:cINAHL,Embase,MEDLINE,PubMed,and Web of Science databases were systematically searched to identify articles relating skeletal muscle echogenicity to physical function in older ***-of-bias assessments were conducted along with funnel plot ***-analyses with and without sub-analyses for individual muscles were performed utilizing Fisher's Z transformation for the most common measures of physical ***'s Z was back-transformed to Pearson's r for ***:Fifty-one articles(n=5095,female=~2759,male=~2301,72.5± 5.8 years,mean±SD(1 study did not provide sex descriptors))were extracted for review,with previously unpublished data obtained from the authors of 13 *** rectus femoris(n=34) and isometric knee extension strength(n=22) were the most accessed muscle and physical qualities,*** relationship between quadriceps echogenicity and knee extensor strength was moderate(n=2924,r=-0.36(95% confidence interval:-0.38 to-0.32),p correlations(r:-0.34 to-0.23,all p ces in predicti

关键词： correlations Echo intensity Elderly Intramuscular fat Strength

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