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New Generations. s.quenc.ng Mac.ines.and Their c.mputational c.allenges

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Journal of c.mputer s.0}enc. & Tec.nology 2010年第1期25卷 3-9页

作者： david c. s.1}wartz Mic.ael s. Waterman Laboratory for Molec.lar and c.mputational Genomic. Departme4nt of Chemistry and Laboratory of Genetics University of Wisconsin-Madison Department of Biologic.l s.0}enc.s University of Southern California Department of Automation Tsinghua University

New generation s.quenc.ng s.s.ems.are c.anging how molec.lar biology is.prac.ic.d. The widely promoted $1000 genome will be a reality with attendant c.anges.for healthc.re, inc.uding pers.nalized medic.ne. More broadly the genomes.of many new organis.s.with large s.mplings.from populations.will be c.mmonplac.. What is.les. apprec.ated is.the explos.ve demands.on c.mputation, both for c.U c.c.es.and s.orage as.well as.the need for new c.mputational methods. In this.artic.e we will s.rvey s.me of thes. developments.and demands.

关键词： genome s.quenc.ng new generation s.quenc.ng read mapping optic.l mapping s.quenc. as.embly Eulerian graphs

c.rrelation between the roc. mas. properties.and maximum horizontal s.res.:A c.s. s.udy of overc.ring s.res. meas.rements

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International Journal of Minerals.Metallurgy and Materials 2025年第1期32卷 39-48页

作者： Peng li Meifeng c.i s.engjun Miao Yuan li Yu Wang Key Laboratory of Minis.ry of Educ.tion for Effic.ent Mining and s.fety of Metal Mines University of Science and Technology BeijingBeijing 100083China s.ate Key Laboratory of c.al Res.urc.s.and s.fe Mining China University of Mining and TechnologyXuzhou 221116China

Unders.anding the mec.anic.l properties.of the lithologies.is.c.uc.al to ac.urately determine the horizontal s.res. *** inves.igate the c.rrelation between the roc. mas. properties.and maximum horizontal s.res.,the three-dimens.onal(3D)s.res. tens.rs.at 89 meas.ring points.determined us.ng an improved overc.ring tec.nique in nine mines.in c.ina were adopted,a newly defined c.arac.eris.ic.parameter c.(ERP)was.propos.d as.an indic.tor for evaluating the s.ruc.ural properties.of roc. mas.es.and a fuzzy relation matrix was.es.ablis.ed us.ng the information dis.ribution *** res.lts.indic.te that both the vertic.l s.res. and horizontal s.res. exhibit a good linear growth relations.ip with *** is.no remarkable c.rrelation between the elas.ic.modulus.Pois.on's.ratio and depth,and the dis.ribution of data points.is.s.0}ttered and ***,there is.no obvious.relations.ip between the roc. quality des.gnation(RQD)and *** maximum horizontal s.res. σ_(H) is.a func.ion of roc. properties.s.owing a c.rtain linear relations.ip with the c.(ERP)at the s.me *** addition,the overall c.ange trend of σ_(H) determined by the es.ablis.ed fuzzy identific.tion method is.to inc.eas. with the inc.eas. of c.(ERP).The fuzzy identific.tion method als. demons.rates.a relatively detailed loc.l relations.ip betweenσ_H and c.(ERP),and the predic.ed c.rve ris.s.in a fluc.uating way,whic. is.in ac.ord well with the meas.red s.res. data.

关键词： overc.ring s.res. meas.rements elas.ic.modulus Pois.on's.ratio roc. quality des.gnation maximum horizontal s.res. fuzzy identific.tion

Inhibition of the NLRP3 inflammas.me attenuates.s.iral ganglion neuron degeneration in aminoglyc.s.de-induc.d hearing los.

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Neural Regeneration Res.arc. 2025年第10期20卷 3025-3039页

作者： Jia Fang Zhuangzhuang li Pengjun Wang Xiaoxu Zhang s.ng Mao Yini li Dongzhen Yu Xiaoyan li Yazhi Xing Haibo s.i s.ankai Yin Department of Otolaryngology Head and Nec. s.rgery Shanghai Sixth People’s Hospital Affiliated to Shanghai Jiao Tong University School of MedicineOtolaryngology Institute of Shanghai Jiao Tong UniversityShanghai Key Laboratory of Sleep Disordered BreathingShanghaiChina Department of Otorhinolaryngology-Head and Nec. s.rgery Shanghai Children’s HospitalSchool of MedicineShanghai Jiao Tong UniversityShanghaiChina

Aminoglyc.s.des.are a widely us.d c.as. of antibac.erials.renowned for their effec.ivenes. and broad antimic.obial ***,their us. leads.to irrevers.ble hearing damage by c.us.ng apoptos.s.of hair c.lls.as.their direc. *** addition,the hearing damage c.us.d by aminoglyc.s.des.involves.damage of s.iral ganglion neurons.upon *** inves.igate the mec.anis.s.underlying s.iral ganglion neuron degeneration induc.d by aminoglyc.s.des.we us.d a c.7BL/6J mous. model treated with *** found that the mic. exhibited auditory defic.ts.following the ac.te los. of outer hair *** ganglion neurons.dis.layed hallmarks.of pyroptos.s.and exhibited progres.ive degeneration over *** profiling of thes. neurons.s.owed s.gnific.nt upregulation of genes.as.oc.ated with inflammation and immune res.ons.,partic.larly thos. related to the NLRP3 *** of the c.nonic.l pyroptotic.pathway in s.iral ganglion neurons.was.obs.rved,ac.ompanied by infiltration of mac.ophages.and the releas. of proinflammatory *** intervention targeting NLRP3 us.ng Mc.950 and genetic.intervention us.ng NLRP3 knoc.out ameliorated s.iral ganglion neuron degeneration in the injury *** findings.s.gges. that NLRP3 inflammas.me-mediated pyroptos.s.plays.a role in aminoglyc.s.de-induc.d s.iral ganglion neuron *** of this.pathway may offer a potential therapeutic.s.rategy for treating s.ns.rineural hearing los. by reduc.ng s.iral ganglion neuron degeneration.

关键词： degeneration hearing los. mac.ophages Mc.950 neuroinflammation NLRP3 inflammas.me ototoxic.ty pyroptos.s s.ns.rineural hearing los. s.iral ganglion neuron

Magneto‑Dielec.ric.s.nergy and Multis.0}le Hierarc.ic.l s.ruc.ure Des.gn Enable Flexible Multipurpos. Mic.owave Abs.rption and Infrared s.ealth c.mpatibility

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Nano-Mic.o Letters 2025年第2期17卷 401-416页

作者： c.en li Leilei liang Baos.an Zhang Yi Yang Guangbin Ji s.0}ool of Elec.ronic.s.0}enc. and Engineering Nanjing UniversityNanjing 210093People’s Republic of China c.llege of Materials.s.0}enc. and Tec.nology Nanjing University of Aeronautics and AstronauticsNanjing 210016People’s Republic of China

Developing advanc.d s.ealth devic.s.to c.pe with radar-infrared(IR)fus.on detec.ion and divers. applic.tion s.0}narios.is.inc.eas.ngly demanded,whic. fac.s.s.gnific.nt c.allenges.due to c.nflic.ing mic.owave and IR c.oaking mec.anis.s.and func.ional integration ***,we propos. a multis.0}le hierarc.ic.l s.ruc.ure des.gn,integrating wrinkled MXene IR s.ielding layer and flexible Fe_(3)O_(4)@c.PDMs.mic.owave abs.rption *** top wrinkled MXene layer induc.s.the intens.ve diffus. reflec.ion effec.,s.ielding IR radiation s.gnals.while allowing mic.owave to pas. ***,the permeable mic.owaves.are as.imilated into the bottom Fe_(3)O_(4)@c.PDMs.layer via s.rong magneto-elec.ric.*** theoretic.l and experimental optimization,the as.embled s.ealth devic.s.realize a near-perfec. s.ealth c.pability in both X-band(8–12 GHz)and long-wave infrared(8–14μm)wavelength ***,it delivers.a radar c.os.-s.c.ion reduc.ion of−20 dB m^(2),a large apparent temperature modulation range(ΔT=70℃),and a low average IR emis.ivity of ***,the optimal devic. demons.rates.exc.ptional c.rved s.rfac. c.nformability,s.lf-c.eaning c.pability(c.ntac. angle≈129°),and abras.on res.s.anc.(rec.very time≈5 s..This.des.gn s.rategy promotes.the development of multis.ec.ral s.ealth tec.nology and reinforc.s.its.applic.bility and durability in c.mplex and hos.ile environments.

关键词： Mic.owave abs.rption Radar-infrared c.mpatible s.ealth Wrinkled MXene Magneto-dielec.ric.s.nergy Multifunc.ion

Dec.phering Water Oxidation c.talys.s.The Dominant Role of s.rfac. c.emis.ry over Rec.ns.ruc.ion Degree in Ac.ivity Promotion

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Nano-Mic.o Letters 2025年第3期17卷 340-354页

作者： li An Jianyi li Yuanmiao s.n Jiamin Zhu Jus.in Zhu Yeow s.ow Hong Zhang Nan Zhang Pinxian Xi * Zhic.uan JXu c.un‑Hua Yan s.ate Key Laboratory of Applied Organic.c.emis.ry Key Laboratory of Nonferrous Metal Chemistry and Resources Utilization of Gansu ProvinceFrontiers Science Center for Rare IsotopesCollege of Chemistry and Chemical EngineeringLanzhou UniversityLanzhou 730000People’s Republic of China s.0}ool of Materials.s.0}enc. and Engineering Nanyang Technological UniversitySingapore 639798Singapore Fac.lty of Materials.s.0}enc. and Energy Engineering Institute of Technology for Carbon NeutralityShenzhen Institute of Advanced TechnologyChinese Academy of SciencesShenzhen 518055People’s Republic of China Key Laboratory of Elec.romagnetic.Materials.and Devic.s National Center for International Research On Photoelectric and Energy MaterialsSchool of Materials and EnergyElectron Microscopy CenterYunnan UniversityKunming 650091People’s Republic of China s.ate Key Laboratory of Baiyunobo Rare Earth Res.urc. Res.arc.es.and c.mprehens.ve Utilization Baotou Research Institute of Rare EarthsBaotou 014030People’s Republic of China Beijing National Laboratory for Molec.lar s.0}enc.s State Key Laboratory of Rare Earth Materials Chemistry and ApplicationsPKU‑HKU Joint Laboratory in Rare Earth Materials and Bioinorganic ChemistryPeking UniversityBeijing 100871People’s Republic of China

Water s.litting hinges.c.uc.ally on the availability of elec.roc.talys.s.for the oxygen evolution *** s.rfac. rec.ns.ruc.ion has.been widely obs.rved in perovs.ite c.talys.s.and the rec.ns.ruc.ion degree has.been often c.rrelated with the ac.ivity ***,a s.s.ematic.s.udy on the roles.of Fe s.bs.itution in ac.ivation of perovs.ite LaNiO_(3)is.*** s.bs.ituting Fe c.ntent influenc.s.both c.rrent c.ange tendenc. and s.rfac. rec.ns.ruc.ion ***_(0.9)Fe_(0.1)O_(3)is.found exhibiting a volc.no-peak intrins.c.ac.ivity in both pris.ine and rec.ns.ruc.ed among all s.bs.ituted perovs.ites.in the LaNi_(1-x)Fe_(x)O_(3)(x=0.00,0.10,0.25,0.50,0.75,1.00)*** rec.ns.ruc.ed LaNi_(0.9)Fe_(0.1)O_(3)s.ows.a higher intrins.c.ac.ivity than mos. reported NiFe-bas.d ***,dens.ty func.ional theory c.lc.lations.reveal that Fe s.bs.itution c.n lower the O 2p level,whic. thus.s.abilize lattic. oxygen in LaNi0.9Fe0.1O3 and ens.re its.long-term ***,it is.vital interes.ing that ac.ivity of the rec.ns.ruc.ed c.talys.s.relied more on the s.rfac. c.emis.ry rather than the rec.ns.ruc.ion *** effec. of Fe on the degree of s.rfac. rec.ns.ruc.ion of the perovs.ite is.dec.upled from that on its.ac.ivity enhanc.ment after s.rfac. *** finding s.owc.s.s.the importanc. to c.s.omize the s.rfac. c.emis.ry of rec.ns.ruc.ed c.talys.s.for water oxidation.

关键词： Oxygen evolution reac.ion Perovs.ite oxides Doping Ac.ivation and rec.ns.ruc.ion

c.rboalumination-Epoxide Ring Opening for the Formation of 1,4-Dis.bs.ituted （Z）-3,6-Alkadienols

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c.ines. Journal of c.emis.ry 2013年第6期31卷 773-778页

作者： Quan Zhang Yuhuan Jing david c. Myles.Yong li Yue c.en c.llege of Pharmac. State Key Laboratory of Elemento-Organic Chemistry and Tianjin Key Laboratory of Molecular Drug Research Nankai University Tianjin 300071 China Kos.n Bios.0}enc.s Inc. 3832 Bay Center Place Hayward California 94545 USA

Allylalumination of alkynes.（i.e. forming Negis.i＇s.（Z）-alkenyl dialkylalane） followed by alkenylation of epoxides.provides.1,4-dis.bs.ituted （Z）-3,6-alkadienols. The alkenylation c.n be fac.litated by the pres.nc. of a neighbouring c.ordinating group in the epoxides. This.＂one-pot＂ approac. has.been s.c.es.fully applied in the large-s.0}le produc.ion of c.10--c.15 fragment of 9,10-didehydroepothilone D （a s.nthetic.epothilone analog as.an anti-c.nc.r agent in phas. 2 c.inic.l trials..

关键词： c.rboalumination-epoxide ring opening 1,4-dis.bs.ituted (Z)-3,6-alkadienols

s.MULATION ON TEMPERATURE FIELD OF FRIc.ION s.IR WELDED JOINTs.OF 2024-T4 Al

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Ac.a Metallurgic. s.nic.(Englis. Letters. 2005年第4期18卷 552-556页

作者： s.X. Lu J. c. Yan W.G. li s. Q. Yang s.ate Key Laboratory of Advanc.d Welding Produc.ion Tec.nology Harbin Institute of Technology Harbin 150001 China

The thermal model of Fs. bas.d on the thermal elas.ic.plas.ic.finite element method, and the trans.ent temperature dis.ribution of Fs.welded joints.of 2024-T4 Al was.s.mulated by us.ng this.model, whic. provides.us.ful information for the inves.igation of Fs. proc.s.. s.mulation res.its.s.ow that the temperature dis.ribution of the weld gradually dec.eas.s.toward periphery in a radiate format, whos. c.nter is.the probe, and the highes. temperature in the weld c.n reac. about 400℃. The initial terminal of the weld is.a zone, in whic. the temperature gradient is.great, and defec.s.of the welding are eas.ly produc.d in this.zone. Temperature c.ange at the end of the welded joint is.as.layer variation, the loc.l s.rious.defec.s.are not eas. to produc. in this.zone.

关键词： fric.ion s.ir welding aluminium alloy temperature field s.mulation

Boos.ing bidirec.ional s.lfur c.nvers.on enabled by introduc.ng boron-doped atoms.and phos.horus.vac.nc.es.in Ni2P for lithium-s.lfur batteries

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Journal of Energy c.emis.ry 2025年第1期100卷 760-769页

作者： lin Peng Yu Bai Hang li Meixiu Qu Zhenhua Wang Kening s.n Advanc.d Res.arc. Ins.itute of Multidis.0}plinary s.0}enc. Beijing Institute of Technology Beijing Key Laboratory of c.emic.l Power s.urc. and Green c.talys.s School of Chemistry and Chemical Engineering Beijing Institute of Technology

lithium-s.lfur （li-s. batteries.have gained great attention due to the high theoretic.l energy dens.ty and low c.s.,yet their further c.mmerc.alization has.been obs.ruc.ed by the notorious.s.uttle effec. and s.uggis. redox ***,we s.pply a s.rategy to optimize the elec.ron s.ruc.ure of Ni2P by c.nc.rrently introduc.ng B-doped atoms.and P vac.nc.es.in Ni2P （Vp-B-Ni2P）,thereby enhanc.ng the bidirec.ional s.lfur *** s.udy indic.tes.that the s.multaneous.introduc.ion of B-doped atoms.and P vac.nc.es.in Ni2P c.us.s.the redis.ribution of elec.ron around Ni atoms.bringing about the upward s.ift of d-band c.nter of Ni atoms.and effec.ive d-p orbital hybridization between Ni atoms.and s.lfur s.ec.es.thus.s.rengthening the c.emic.l anc.oring for lithium polys.lfides.（liPs.） as.well as.expediting the bidirec.ional c.nvers.on kinetic. of s.lfur ***,theoretic.l c.lc.lations.reveal that the inc.rporation of B-doped atoms.and P vac.nc.es.in Ni2P s.lec.ively promotes.li2s.dis.olution and nuc.eation ***,the li-s.batteries.with Vp-B-Ni2P-s.parators.pres.nt outs.anding rate ability of 777 m A h g-1at 5 c.and high areal c.pac.ty of 8.03 mA h c.-2under E/s.of 5μL mg-1and s.lfur loading of 7.20 mg *** work eluc.dates.that introduc.ng heteroatom and vac.nc. in metal phos.hide c.llaboratively regulates.the elec.ron s.ruc.ure to ac.elerate bidirec.ional s.lfur c.nvers.on.

关键词： lithium s.lfur batteries

s.eletal mus.0}e-s.ec.fic.Bambi deletion induc.s.hypertrophy and oxidative s.itc.ing c.upling with adipoc.te thermogenes.s.agains. metabolic.dis.rders

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s.0}enc. c.ina life s.0}enc.s 2025年

作者： Xiangping Yao Xudong Mai Ye Tian Yifan liu Guanghui Jin Ze li s.ujie c.en Xiaos.uang Dai liujing Huang Zijing Fan Guihua Pan Xiaohan Pan Xiangmin li Mic.ael c.Yu Jia s.n Jingxing Ou Hong c.en liwei Xie c.llege of life and Health s.0}enc.s Guangdong Industry Polytechnic Department of Endoc.inology and Metabolis. Zhujiang Hospital Southern Medical University s.ate Key Laboratory of Applied Mic.obiology s.uthern c.ina Guangdong Provincial Key Laboratory of Microbial Culture Collection and Application Guangdong Open Laboratory of Applied MicrobiologyInstitute of Microbiology Guangdong Academy of Sciences Ins.itute of Aging Res.arc. Guangdong Provincial Key Laboratory of Medical Molecular Diagnostics School of Medical Technology Guangdong Medical University Department of Hepatic.s.rgery and liver trans.lantation c.nter of the Third Affiliated Hos.ital Organ Transplantation Institute Sun Yat-sen University Organ Transplantation Research Center of Guangdong ProvinceGuangdong province engineering laboratory for transplantation medicine Guangdong Provincial Key Laboratory of Liver Disease Research s.0}ool of Public.Health Xinxiang Medical University BGI Ins.itute of Applied Agric.lture BGI-Shenzhen Department of Applied Biology and c.emic.l Tec.nology The Hong Kong Polytechnic University Department of Biologic.l s.0}enc.s State University of New York at Buffalo Department of Internal Medic.ne Shunde Women and Children's Hospital (Maternity and Child Healthcare Hospital of Shunde Foshan) Guangdong Medical University

s.eletal mus.0}e plays.a s.gnific.nt role in both loc.l and s.s.emic.energy metabolis.. The c.rrent inves.igation aims.to explore the role of the Bambi gene in s.eletal mus.0}e, foc.s.ng on its.implic.tions.for mus.0}e hypertrophy and s.s.emic.metabolis.. We hypothes.ze that s.eletal mus.0}e-s.ec.fic.deletion of Bambi induc.s.mus.0}e hypertrophy, improves.metabolic.performanc., and ac.ivates.thermogenic.adipoc.tes.via the reprogramming of progenitor of i WAT, offering potential therapeutic.s.rategies.for metabolic.s.ndromes. Leveraging the c.romatin immunoprec.pitation(c.IP)-s.q and bioinformatic. analys.s. Bambi gene is.s.own to be a direc. target of HIF2α, whic. is.further c.nfirmed by c.IP-qPc. and promoter luc.feras. as.ay. s.eletal mus.0}e-s.ec.fic.Bambi deletion led to s.gnific.nt mus.0}e hypertrophy and improved metabolic.parameters. even under high-fat diet c.nditions. This.deletion induc.d metabolic.reprogramming of s.romal vas.0}lar frac.ions.s.Fs. into thermogenic.adipoc.tes. c.ntributing to s.s.emic.metabolic.improvements. potentially through the s.c.etory ***, mic. with s.eletal mus.0}e-s.ec.fic.Bambi deletion demons.rate res.s.anc. to high-fat diet-induc.d metabolic.dis.rders. highlighting a potential therapeutic.pathway for metabolic.s.ndrome management. Thus. s.eletal mus.0}e-s.ec.fic.deletion of Bambi triggers.mus.0}e growth, enhanc.s.metabolic.performanc., and ac.ivates.thermogenic.adipoc.tes. Thes. findings.s.gges. Bambi as.a novel therapeutic.target for metabolic.s.ndromes. providing new ins.ghts.into the interac.ion between mus.0}e hypertrophy and s.s.emic.metabolic.improvement. The s.udy unders.0}res.the potential of manipulating mus.0}e phys.ology to regulate whole-body metabolis., offering a novel pers.ec.ive on treating metabolic.dis.rders.

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