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Making bridges between preclinical and clinical insights into age-related cognitive decline

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Neural Regeneration Research 2025年第8期20卷 2321-2322页

作者： david VC Brito Clévio Nóbrega Algarve Biomedical Center-Research Institute(ABC-RI) Campus GambelasFaroPortugal Algarve Biomedical Center-(ABC) Campus GambelasFaroPortugal Faculty of Medicine and Biomedical Sciences(FMCB) University of AlgarveGambelas CampusFaroPortugal

With people living longer,the societal impact of age-related cognitive decline is becoming more pronounced(Crimmins,2015).Thus,it is increasingly important to comprehend the cognitive shifts linked to aging-whether th... 详细信息

关键词： bridges becoming insight

Women in visual neural regeneration research

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Neural Regeneration Research 2025年第2期20卷 489-490页

作者： Tonia S.Rex david J.Calkins Vanderbilt eye Institute Vanderbilt University Medical CenterNashvilleTNUSA

The year 2024 marks the 60^(th)anniversary of Title IX and 25 years since the New York Times revealed bias against female faculty members at the Massachusetts Institute of *** take an opportunity here to examine the state of gender bias in a relatively new yet already prominent field,neural regeneration in the visual system,for which there is a well-defined context useful for this *** National eye Institute(NeI)provided the first round of research funding for its Audacious Goals Initiative(AGI)on visual neural regeneration in 2013 and the last round in ***,we focus on this *** sources included PubMed,the National Science Foundation(NSF),the NeI,the Blue Ridge Institute for Medical Research and data from the major professional organization for eye and vision research,the Association for Research in Vision and Ophthalmology(ARVO).

关键词： neural visual Times

Constrained bilinear control problem： Application to a cancer chemotherapy model

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International Journal of Biomathematics 2017年第4期10卷 189-209页

作者： e1 Hassan Zerrik Nihale e1 Boukhari MA CS Team Faculty of Sciences Moulay Ismail University Meknes Morocco

The aim of this paper is to investigate the optimal control problem for finite-dimensional bilinear systems and its application to a chemotherapy model. We characterize an opti- mal control that minimizes a quadratic cost functional in two cases of constrained admis- sible controls, then we give sufficient conditions for the uniqueness of such a control, and we derive useful algorithms for the computation of the optimal control. The established results are applied to a cancer chemotherapy bilinear model in order to simulate the opti- mal treatment protocol using two different approaches： one based on a limited instant toxicity, and the other on a limited cumulative toxicity along the therapy session.

关键词： Bilinear systems optimal control chemotherapy instant toxicity cumulativetoxicity.

experimental determination of interfacial energies for Ag_2Al solid solution in the CuAl_2-Ag_2Al system

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Chinese Physics B 2009年第9期18卷 3952-3959页

作者： Ocak Y Akbulut S Keslioglu K Marasl1 N ad1rl1 e Kaya H Department of Physics Faculty of Arts and SciencesErciyes University Department of Physics Institute of Science and TechnologyErciyes University Department of Physics Faculty of Arts and SciencesNigde University Department of Science education Education FacultyErciyes University

The equilibrated grain boundary groove shapes of solid solution Ag2Al in equilibrium with an AI-Cu-Ag liquid were observed from a quenched sample with a radial heat flow apparatus. The Gibbs Thomson coefficient, solid liquid interfacial energy and grain boundary energy of the solid solution Ag2Al have been determined from the observed grain boundary groove shapes. The thermal conductivity of the solid phase and the thermal conductivity ratio of the liquid phase to solid phase for Ag2Al-28.3 at the %CuAl2 alloy at the melting temperature have also been measured with a radial heat flow apparatus and Bridgman type growth apparatus, separately.

关键词： solid-liquid interfaces metals and alloys surface energy thermal conductivity

A CONJUGATe GRADIeNT MeTHOD FOR DISCReTe-TIMe OUTPUT FeeDBACK CONTROL DeSIGN

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Journal of Computational Mathematics 2012年第3期30卷 279-297页

作者： e1-Sayed M.e. Mostafa Department of Mathematics Faculty of Science Alexandria University Alexandria Egypt

In this paper, the discrete-time static output feedback control design problem is con- sidered. A nonlinear conjugate gradient method is analyzed and studied for solving an unconstrained matrix optimization problem that results from this optimal control prob- lem. In addition, through certain parametrization to the optimization problem an initial stabilizing static output feedback gain matrix is not required to start the conjugate gradi- ent method. Finally, the proposed algorithms are tested numerically through several test problems from the benchmark collection.

关键词： Output feedback control Nonlinear conjugate gradient methods Nonlinearprogramming.

Pyrolysis of olive residue/low density polyethylene mixture：Part Ⅰ Thermogravimetric kinetics

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燃料化学学报 2008年第6期36卷 672-678页

作者： ABOULKAS A e1 HARFI K el BOUADILI A Laboratoire de Recherche sur la Reactivites des Materiaux et l Optimisation des Procedes ＂ReMATOP＂ Departement de chimie Faculte des Sciences Semlalia Universite Cadi Ayyad BP 2390 40001 Marrakech Maroc Departement de chimie Faculte polydisciplinaire de Beni-Mellal Universite Sultan Moulay Slimane BP 592 23000 Beni-Mellal Maroc Laboratoire de Chimie Organique et Analytique Departement de chimie Faculte des Sciences et Techniques de Beni-Mellal Universite Sultan Moulay Slimane BP 523 23000 Beni-Mellal Maroc

This paper demonstrates the thermal pyrolysis of olive residue,low density polyethylene(LDPe) and olive residue/LDPe mixture in an inert atmosphere of N2 using thermogravimetric analysis(TGA).Measurements were carried out in the temperature range 300K^973K at heating rates of 2K/min,10K/min,20K/min and 50K/*** on the results obtained,three temperature regimes were selected for studying the non-isothermal kinetics of olive residue/LDPe *** first two were dominated by the olive residue pyrolysis,while the third was linked to the LDPe pyrolysis,which occurred at much higher *** between the experimental and calculated TG/DTG profiles were considered as a measurement of the extent of interactions occurring on *** maximum degradation temperatures of each component in the mixture were higher than those the individual components;thus an increase in thermal stability was *** kinetic parameters associated with thermal degradation were determined using Friedman isoconversional method.

关键词：高温分解反应低密度聚乙烯动力学 LDPe

Occurrence mechanism of silicate and aluminosilicate minerals in Sarcheshmeh copper flotation concentrate

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International Journal of Minerals,Metallurgy and Materials 2009年第5期16卷 494-499页

作者： H.R.Barkhordari1 e.Jorjani1 A.eslami M.Noaparast Mining engineering Department Science and Research BranchIslamic Azad UniversityPoonakHesarakTehranIran R&D Division-Sarcheshmeh Copper Complex RafsanjanIran School of Mining engineering University College of EngineeringUniversity of TehranTehranIran

The Sarcheshmeh copper flotation circuit is producing 5× 10^4 t copper concentrate per month with an averaging grade of 28% Cu in rougher, cleaner and recleaner stages. In recent years, with the increase in the open pit depth, the content of aluminosilicate minerals increased in plant feed and subsequently in flotation concentrate. It can motivate some problems, such as unwanted consumption of reagents, decreasing of the copper concentrate grade, increasing of Al2O3 and SiO2 in the copper concentrate, and needing a higher temperature in the smelting process. The evaluation of the composite samples related to the most critical working period of the plant shows that quartz, illite, biotite, chlorite, orthoclase, albeit, muscovite, and kaolinite are the major Al2O3 and SiO2 beating minerals that accompany chalcopyrite, chalcocite, and covellite minerals in the plant feed. The severe alteration to clay minerals was a general rule in all thin sections that were prepared from the plant feed. Sieve analysis of the flotation concentrate shows that Al2O3 and SiO2 bearing minerals in the flotation concentrate can be decreased by promoting the size reduction from 53 to 38 μm. Interlocking of the Al2O3 and SiO2 bearing minerals with chalcopyrite and chalcocite is the occurrence mechanism of silicate and aluminosilicate minerals in the flotation concentrate. The dispersed form of interlocking is predominant.

关键词： copper aluminosilicate silicate flotation

A New Fractional Model for the Falling Body Problem

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Chinese Physics Letters 2017年第2期34卷 1-3页

作者： A.ebaid B.Masaedeh e.e1-Zahar Department of Mathematics Faculty of ScienceTabuk UniversityP.O.Box 741Tabuk 71491Kingdom of Saudi Arabia Department of Mathematics Faculty of Sciences and HumanitiesPrince Sattam Bin Abdulaziz UniversityA1kharj11942Kingdom of Saudi Arabia Department of Basic engineering Science Faculty of EngineeringShebin El-Kom32511Menofia UniversityEgypt

Recently, a conformable fractional derivative has been proposed to calculate the derivative of non-integer order of time functions. It has been shown that this new fractional derivative definition obeys many advantages over the preceding definitions. For mathematical models in applied sciences and to preserve the dimensionality of the physical quantities, an auxiliary parameter （~r） which has the dimension of seconds should be implemented in the fractional derivative definition. We obtain analytic solutions for the resulting conformable fractional differential equations describing the vertical velocity and the height of the falling body. It is shown that the dimensions of velocity and height are always correct without any restrictions on the auxiliary parameter cr which contradicts with the results in the literature when applying the Caputo definition to the same problem. This may open the door for many future works either to describe the role of such an auxiliary parameter or to derive a more suitable definition for the fractional derivative.

关键词： A New Fractional Model for the Falling Body Problem

A TRUST-ReGION ALGORITHM FOR SOLVING MINI-MAX PROBLeM

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Journal of Computational Mathematics 2018年第6期36卷 776-791页

作者： Bothina e1-Sobky Abdallah Abotahoun Department of Mathematics Alexandria University Alexandria Egypt

In this paper, we propose an algorithm for solving inequality constrained mini-max optimization problem. In this algorithm, an active set strategy is used together with mul- tiplier method to convert the inequality constrained mini-max optimization problem into unconstrained optimization problem. A trust-region method is a well-accepted technique in constrained optimization to assure global convergence and is more robust when they deal with rounding errors. One of the advantages of trust-region method is that it does not require the objective function of the model to be convex. A global convergence analysis for the proposed algorithm is presented under some conditions. To show the efficiency of the algorithm numerical results for a number of test problems are reported.

关键词： Mini-max problem Active-set Multiplier method Trust-region Global con-vergence