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Journal of Bionic Engineering 2017年第4期14卷 791-803页

作者： david bach Tom Masselter Thomas Speck Plant Biomechanics Group Freiburg Botanic Garden Faculty of Biology University of Freiburg Schginzlestr. 1 79104 Freiburg Germany Freiburg Materials Research Center (FMF) Stefan-Meier-StraBe 21 79104 Freiburg Germany Competence Networks Biomimetic and BIOKON e. V. Schainzlestr. 1 79104 Freiburg Germany

The present study evaluates the potential of a bio-inspired pulsation damper in a vane pump used in mobile hydraulic ap- plications. Pressure pulsations caused by such positive displacement pumps can lead to malfunctions and noise in a hydraulic system. A common measure to reduce pressure pulsations is the integration of pressure pulsation dampers downstream of the pump. This type of damping measure can also be found in biology as e.g. in the human blood circulatory system. Such working principles found in living organisms offer a high potential for a biomimetic transfer into technical applications. The newly developed bio-inspired damper consists of cellular rubbers with non-linear viscoelastic material properties. In order to evaluate the new damping method, pressure pulsations were measured at two different back pressures and at a wide engine speed range of the vane pump. For further assessment, different setups, varying the stiffness of the cellular rubber materials and the damper volume, were tested. Within the tested back pressures, the pressure pulsations could be reduced by up to 40%. The developed integrated pulsation damper offers a high potential to dampen pressure pulsations of positive displacement pumps used in mobile hydraulic applications ooeratin~ below 10 bar.

关键词： pressure pulsations pressure ripple vane pump bio-inspired pulsation damping cellular rubbers flexible foams

Machine learning property prediction for organic photovoltaic devices

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npj Computational Materials 2020年第1期6卷 279-286页

作者： Nastaran Meftahi Mykhailo Klymenko Andrew J.Christofferson Udo bach david A.Winkler Salvy P.Russo ARC Centre of Excellence in Exciton Science School of ScienceRMIT UniversityMelbourneVIC 3001Australia School of Science College of ScienceEngineering and HealthRMIT UniversityMelbourneVIC 3001Australia ARC Centre of Excellence in Exciton Science Department of Chemical EngineeringMonash UniversityWellington RoadClaytonVIC 3800Australia La Trobe Institute for Molecular Science La Trobe UniversityKingsbury DriveBundooraVIC 3086Australia Monash Institute of Pharmaceutical Sciences Monash UniversityParkvilleVIC 3052Australia School of Pharmacy University of NottinghamNottingham NG72QLUK CSIRO Data61 PullenvaleQLD 4069Australia

Organic photovoltaic(OPV)materials are promising candidates for cheap,printable solar ***,there are a very large number of potential donors and acceptors,making selection of the best materials ***,we show that machine-learning approaches can leverage computationally expensive DFT calculations to estimate important OPV materials properties quickly and *** generate quantitative relationships between simple and interpretable chemical signature and one-hot descriptors and OPV power conversion efficiency(PCE),open circuit potential(Voc),short circuit density(Jsc),highest occupied molecular orbital(HOMO)energy,lowest unoccupied molecular orbital(LUMO)energy,and the HOMO–LUMO *** most robust and predictive models could predict PCE(computed by DFT)with a standard error of±0.5 for percentage PCE for both the training and test *** model is useful for pre-screening potential donor and acceptor materials for OPV applications,accelerating design of these devices for green energy applications.

关键词： occupied property prediction

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理财不怕马后炮

全球商业经典 2006年第3期 116-126页

作者：戴维·巴哈（david bach）

即使你在30、40、50或60岁前，一直没做好退休规划，还是可能把自己的钱财打理好，追求富裕的退休生活。说得明确些，你现在可以用以下五个简单策略回到正轨，不再担心往后的财务状况：

关键词：理财退休生活财务状况钱财富裕

Bipolar and Schizophrenia Disorders Diagnosis Using Artificial Neural Network

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Neuroscience & Medicine 2018年第4期9卷 209-220页

作者： Mateus Beck Fonseca Renan Soares de Andrades Suelen de Lima bach Carolina david Wiener Jean Pierre Oses Engineer Center Federal University of Pelotas Pelotas Brazil Department of Health and Behavior Clinical Neuroscience Lab Catholic University of Pelotas Pelotas Brazil Anhanguera Educacional Rio Grande Brazil Department of Electronic Engineering and Computer Catholic University of Pelotas Pelotas Brazil

Motivation: Bipolar disorder (BD) and schizophrenia (SZ) has a difficult diagnosis, so the main objective of this article is to propose the use of Artificial Neural Networks (ANNs) to classify (diagnose) groups of patients with BD or SZ from a control group using sociodemographic and biochemical variables. Methods: Artificial neural networks are used as classifying tool. The data from this study were obtained from the array collection from Stanley Neuropathology Consortium databank. Inflammatory markers and characteristics of the sampled population were the inputs variables. Results: Our findings suggest that an artificial neural network could be trained with more than 90% accuracy, aiming the classification and diagnosis of bipolar, schizophrenia and control healthy group. Conclusion: Trained ANNs could be used to improve diagnosis in Schizophrenia and Bipolar disorders.

关键词： Bipolar Disorder Schizophrenia Disorder Biomarkers Artificial Neural Network

Hepatic decompensation/serious adverse events in post-liver transplantation recipients on sofosbuvir for recurrent hepatitis C virus

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World Journal of Gastroenterology 2016年第9期22卷 2844-2854页

作者： Neal Patel Kian Bichoupan Lawrence Ku Rachana Yalamanchili Alyson Harty Donald Gardenier Michel Ng david Motamed Viktoriya Khaitova Nancy bach Charissa Chang Priya Grewal Meena Bansal Ritu Agarwal Lawrence Liu Gene Im Jennifer Leong Leona Kim-Schluger Joseph Odin Jawad Ahmad Scott Friedman Douglas Dieterich Thomas Schiano Ponni Perumalswami Andrea Branch Division of Liver Diseases Icahn School of Medicine at Mount Sinai Recanati Miller Transplant Institute Icahn School of Medicine at Mount Sinai

AIM: To determine the safety profile of new hepatitis C virus (HCV) treatments in liver transplant (LT) recipients with recurrent HCV ***: Forty-two patients were identified with recurrent HCV infection that underwent LT at least 12 mo prior to initiating treatment with a Sofosbuvir-based regimen during December 2013-June 2014. Cases were patients who experienced hepatic decompensation and/or serious adverse events (SAE) during or within one month of completing treatment. Controls had no evidence of hepatic decompensation and/or SAE. HIV-infected patients were excluded. Cumulative incidence of decompensation/SAE was calculated using the Kaplan Meier method. Exact logistic regression analysis was used to identify factors associated with the composite ***: Median age of the 42 patients was 60 years [Interquartile Range (IQR): 56-65 years], 33% (14/42) were female, 21% (9/42) were Hispanic, and 9% (4/42) were Black. The median time from transplant to treatment initiation was 5.4 years (IQR: 2.1-8.8 years). Thirteen patients experienced one or more episodes of hepatic decompensation and/or SAE. Anemia requiring transfusion, the most common event, occurred in 62% (8/13) patients, while 54% (7/13) decompensated. The cumulative incidence of hepatic decompensation/SAE was 31% (95%CI: 16%-41%). Risk factors for decompensation/SAE included lower pre-treatment hemoglobin (OR = 0.61 per g/dL, 95%CI: 0.40-0.88, P 2, 95%CI: 0.90-0.99, P = 0.01), and higher baseline serum total bilirubin (OR = 2.43 per mg/dL, 95%CI: 1.17-8.65, P < 0.01). The sustained virological response rate for the cohort of 42 patients was 45%, while it was 31% for ***: Sofosbuvir/ribavirin will continue to be used in the post-transplant population, including those with HCV genotypes 2 and 3. Management of anemia remains an important clinical challenge.

关键词： Hepatitis C virus Sofosbuvir Ribavirin Anemia Hepatic decompensation Serious adverse event Liver transplant

In vivo IVUS-based 2D and 3D coronary plaque models had good agreement for plaque progression analysis

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In vivo IVUS-based 2D and 3D coronary plaque models had good...

Multi-risk-factor decision-making strategy for improved coronary plaque burden increase prediction:A patient-specific IVUS follow-up study using 3D FSI models

第十一届全国生物力学学术会议暨第十三届全国生物流变学学术会议

作者： Hongjian Wang Liang Wang Jie Zheng Jian Zhu Akiko Maehara Chun Yang Richard bach david Muccigrosso Gary S.Mintz Dalin Tang School of Biological Science & Medical Engineering Southeast University Mathematical Sciences Department Worcester Polytechnic Institute Mallinckrodt Institute of Radiology Washington University Department of Cardiology Zhongda HospitalSoutheast University Columbia University The Cardiovascular Research Foundation Network Technology Research Institute China United Network Communications Co.Ltd. Cardiovascular Division Washington University School of Medicine

Image-based 3D computational models have been used for atherosclerotic plaque progression and vulnerability research and considerable progress has been ***,a major obstacle exists when implementing these research results for patient screening and clinical applications.3D plaque model construction is really time consuming and not practical for implementation at present *** this paper,2D structure-only and 3D fluid-

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Multi-risk-factor decision-making strategy for improved coro...

Real-world cure rates for hepatitis C virus treatments that include simeprevir and/or sofosbuvir are comparable to clinical trial results

第十二届全国生物力学学术会议暨第十四届全国生物流变学学术会议

作者： Liang Wang Dalin Tang Akiko Maehara Zheyang Wu Chun Yang Muccigrosso david Jie Zheng Richard bach Kristen L.Billiar Genshan Ma Gary S.Mintz Southeast University Mathematical Sciences Department Worcester Polytechnic Institute Columbia University The Cardiovascular Research Foundation Mallinckrodt Institute of Radiology Washington University Cardiovascular Division Washington University School of Medicine Department of Biomedical Engineering Worcester Polytechnic Institute Department of Cardiology Zhongda HospitalSoutheast University

Objective Plaque progression and vulnerability are influenced by many risk factors. Our goal is to find a simple way to combine multiple risk factors and achieve better plaque development predictions. Methods A sample size of 254 intravascular ultrasound (IVUS) slices with noticeable change of plaque burden was obtained from 9 patients who underwent baseline and follow-up IVUS, and FSI modeling for plaque mechanical condi-

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World Journal of Virology 2017年第4期6卷 59-72页

作者： Kian Bichoupan Neeta Tandon James F Crismale Joshua Hartman david Del Bello Neal Patel Sweta Chekuri Alyson Harty Michel Ng Keith M Sigel Meena B Bansal Priya Grewal Charissa Y Chang Jennifer Leong Gene Y Im Lawrence U Liu Joseph A Odin Nancy bach Scott L Friedman Thomas D Schiano Ponni V Perumalswami Douglas T Dieterich Andrea D Branch Division of Liver Diseases Icahn School of Medicine at Mount Sinai Janssen Scientific Affairs LLC Division of General Internal Medicine Icahn School of Medicine at Mount Sinai

AIM To assess the real-world effectiveness and cost of simeprevir(SMV), and/or sofosbuvir(SOF)-based therapy for chronic hepatitis C virus(HCV) *** The real-world performance of patients treated with SMV/SOF ± ribavirin(RBV), SOF/RBV, and SOF/RBV with pegylated-interferon(PEG) were analyzed in a consecutive series of 508 patients with chronic HCV infection treated at a single academic medical center. Patients with genotypes 1 through 4 were included. Rates of sustained virological response-the absence of a detectable serum HCV RNA 12 wk after the end of treatment [sustained virological response(SVR) 12]-were calculated on an intention-to-treat basis. Costs were calculated from the payer's perspective using Medicare/Medicaid fees and Redbook Wholesale Acquisition Costs. Patient-related factors associated with SVR12 were identified using multivariable logistic *** SVR 12 rates were as follows: 86%(95%CI: 80%-91%)among 178 patients on SMV/SOF ± RBV; 62%(95%CI: 55%-68%) among 234 patients on SOF/RBV; and 78%(95%CI: 68%-86%) among 96 patients on SOF/PEG/RBV. Mean costs-per-SVR 12 were $174442(standard deviation: ± $18588) for SMV/SOF ± RBV; $223003(± $77946) for SOF/RBV; and $126496(± $31052) for SOF/PEG/RBV. Among patients on SMV/SOF ± RBV, SVR12 was less likely in patients previously treated with a protease inhibitor [odds ratio(OR): 0.20, 95%CI: 0.06-0.56]. Higher bilirubin(OR: 0.47, 95%CI: 0.30-0.69) reduced the likelihood of SVR12 among patients on SOF/RBV, while FIB-4 score ≥ 3.25 reduced the likelihood of SVR 12(OR: 0.18, 95%CI: 0.05-0.59) among those on SOF/PEG/RBV. CONCLUSION SVR 12 rates for SMV and/or SOF-based regimens in a diverse real-world population are comparable to those in clinical trials. Treatment failure accounts for 27% of costs.

关键词： Cirrhosis Cost Sustained virological response Protease inhibitor Polymerase inhibitor

Virtual music : computer synthesis of musical style

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