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Impact of exercise on markers of b cell-related immunity:A systematic review

Journal of Sport and Health Science 2024年第3期13卷 339-352,I0002页

作者： david Walzik Sergen belen Karen Wilisch Marie Kupjetz Silvana Kirschke Tobias Esser Niklas Joisten Alexander Schenk Sebastian Proschinger Philipp Zimmer Division of Performance and Health(Sports Medicine) Institute for Sport and Sport ScienceTU Dortmund UniversityDortmund 44227Germany

background:b cells represent a crucial component of adaptive immunity that ensures long-term protection from infection by generating pathogen-specific *** alters b cell counts and immunoglobulin levels,but evidence-based conclusions on potential benefits for adaptive immunity are *** systematic review assessed current literatures on the impact of acute exercise and exercise training on b cells,immunoglobulins,and markers of secretory immunity in human ***:According to the Preferred Reporting Items for Systematic Reviews and Meta-Analyses(PRISMA)guidelines,MEDLINE,Web of Science,and Embase were searched on March 8,***-randomized controlled trials and crossover trials investigating the impact of acute exercise or exercise training on b cell counts and proportions,immunoglobulin levels,salivary flow rate,or secretory immunoglobulin A secretion rate were *** and reporting of exercise training studies were assessed using the Tool for the Assessment of Study Quality and reporting in *** characteristics,outcome measures,and statistically significant changes were summarized ***:Of the 67 eligible studies,22 applied acute exercise and 45 applied exercise *** included outcomes revealed significant alterations over time in acute exercise and exercise training context,but only a few investigations showed significant differences compared to control *** and plasma immunoglobulin A levels were most consistently increased in response to exercise ***:b cell-related outcomes are altered by acute exercise and exercise training,but evidence-based conclusions cannot be drawn with high confidence due to the large heterogeneity in populations and exercise ***-designed trials with large sample sizes are needed to clarify how exercise shapes b cell-related immunity.

关键词： Antibody b-lymphocyte Exercise Humoral immunity Immune system

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Anti-N-methyl-D-aspartate receptor-associated encephalitis: A review of clinicopathologic hallmarks and multimodal imaging manifestations

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World Journal of Radiology 2024年第1期16卷 1-8页

作者： bryce david beutler Alastair E Moody Jerry Mathew Thomas benjamin Phillip Sugar Mark b Ulanja Daniel Antwi-Amoabeng Lucas Anthony Tsikitas Department of Radiology University of Southern CaliforniaKeck School of MedicineLos AngelesCA 90033United States Department of Anesthesiology University of UtahSalt Lake CityUT 84132United States Department of Internal Medicine Christus Ochsner St.Patrick HospitalLake CharlesLA 70601United States

Anti-N-methyl-D-aspartate receptor-associated encephalitis(NMDARE)is a rare immune-mediated neuroinflammatory condition characterized by the rapid onset of neuropsychiatric symptoms and autonomic *** mechanism of pathogenesis remains incompletely understood,but is thought to be related to antibodies targeting the GluN1 subunit of the NMDA receptor with resultant downstream dysregulation of dopaminergic *** adults are most frequently affected;the median age at diagnosis is 21 *** is a strong female predilection with a female sex predominance of 4:*** often develops as a paraneoplastic process and is most commonly associated with ovarian ***,NMDARE has also been described in patients with small cell lung cancer,clear cell renal carcinoma,and other benign and malignant *** is based on correlation of the clinical presentation,electro-encephalography,laboratory studies,and *** tomography,positron emission tomography,and magnetic resonance imaging are essential to identify an underlying tumor,exclude clinicopathologic mimics,and predict the likelihood of long-term functional *** imaging may be of value for prognostication and to assess the response to *** may involve high-dose corticosteroids,intravenous immunoglobulin,and plasma ***,we review the hallmark clinicopathologic features and imaging findings of this rare but potentially devastating condition and summarize diagnostic criteria,treatment regimens,and proposed pathogenetic mechanisms.

关键词： Anti-N-methyl-D-aspartate receptor-associated encephalitis Autoimmune encephalitis Encephalitis Ovarian teratoma Paraneoplastic syndrome Teratoma

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Evaluation of Human Impacts on bartlett Pond Ecosystem, Laredo, Southern Texas, USA, through Empirical Modeling

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Journal of Environmental Protection 2024年第4期15卷 497-526页

作者： Maya P. bhatt Amede Rubio Ganesh b. Malla Cristobal Lopez Virginia Morales Erick Vazquez Cano david Marquez Orlando berumen Alvarez Alfred Addo-Mensah Department of biology and Chemistry Texas A&M International University Laredo USA Department of Mathematics Computer Geology and Physics University of Cincinnati-Clermont College Batavia USA

The trace elements chemistry of bartlett Pond, a small shallow wetland pond in Laredo, Southern Texas, was sampled to evaluate the dynamics of trace elements impacts on water quality and ecosystems ecology of the pond. Two types of fish (bass and tilapia) were also sampled to see the trace element accumulation in different parts of their body. The concentrations of trace elements in water samples were found in the following order: Fe ≫Sb > Pb > As ≫Co > Tl > Cr > Cd within bartlett Pond. Overall, the water quality of the pond is unacceptable for drinking and any other purposes as trace element concentrations (e.g. As, Cd, Co, Cr, Pb, Fe, Sb and Tl) are exceedingly higher (several fold) than the WHO and US EPA guidelines. Predictive and correlation analysis shows that most trace elements exhibit a strong positive correlation among them indicating the same anthropogenic sources and biogeochemical processes regulate these trace elements within the pond. Distributions of the trace elements in water exhibit different shapes mostly as positively skewed distribution for As, Cd, Co, Cr, and Tl, symmetrical distribution for Fe and almost symmetrical distribution for Pb and Sb. Concentrations of As, Co and Tl accumulated much higher in different parts of the bass than Tilapia fish. The concentrations of As, Tl, Co, and Sb appeared significantly higher in different parts of the body of both bass and Tilapia than the maximum SRM certified values. Accumulation of these contaminants in fish tissues pose increased health risks to humans who consume these contaminated fish although fishing is prohibited. Anthropogenic activities in the region primarily degrade the whole pond ecosystem ecology of the bartlett Pond and waters of this pond to be not recommended for any use. These findings may be useful for the scientific community and concerned authorities to improve understanding about these precious natural resources and conservation of the ecosystem ecology.

关键词： Trace Elements bartlett Pond Laredo Southern Texas Wetlands Ecosystem Ecology

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Stress enhances expression of calcium-binding proteins and NMDAR subunit genes in the rat hippocampus

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Neuroprotection 2024年第2期2卷 167-178页

作者： Aravind Parthasarathy Ramesha Hanumanthappa Sarojini R.bulbule Kiran P.C. Hemalatha Nanjaiah Gopinath G. Siddaiah b.M. david Muniswamy Devaraju Kuramkote Shivanna Neurochemistry Lab Department of BiochemistryKarnatak UniversityDharwadIndia Department of Microbiology and Immunology University of Maryland School of MedicineBaltimoreMarylandUSA Department of Zoology Karnatak UniversityDharwadIndia

backgrounds:Oxidative stress impairs the function of calcium-binding proteins and deregulates calcium signaling in living *** have previously explored the overexpression of calcium-binding protein genes in a reactive oxygen and nitrogen species-induced in vitro cell model of stress that leads to ***,in in vivo models,low levels of stress leads to depressive-like ***,we aimed to analyze gene expression of major calcium-binding proteins(calcineurin,calmodulin,calsyntenin,synaptotagmin,and calreticulin)and N-methyl-D-aspartic acid(NMDA)receptor subunits(glutamate receptor ionotropic[GluN]GluN1,GluN2A,and GluN2b)in the hippocampus of stress-induced ***:Six-week-old male Wistar rats were assigned to two stress induction groups and a control group without stress(n=6).Stress was induced by using H_(2)O_(2)(3%in water)or by immobilization(using a sticky mat)over a period of 30 *** of calcium-binding protein genes in the hippocampus,antioxidant assays,structural alterations in hippocampal neurons,and depressive-like behavior were ***:Expression of genes encoding calcium-binding proteins calcineurin,calsyntenin,synaptotagmin and NMDA receptor subunit GluN1 was enhanced in both chemical and physical stress-induced rats compared with control rats(4.25±0.05 vs.1.03±0.02,pbility and lower sucrose preference in behavioral studies compared with control ***:Lower levels of reactive oxygen and nitrogen species(RONS)can also lead to stress in rats by affecting their calcium signaling,buffering capacity in the neurons leading to depressive symptoms.

关键词： calcineurin H_(2)O_(2) hippocampus immobilization NMDA receptors

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针对逃逸中和抗体的新冠突变体开发基于T细胞抗原的人类冠状病毒疫苗（英文）

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Science bulletin 2024年第15期 2456-2470页

作者：周浩冷平王洋杨凯雯李晨 david M.Ojcius 王鹏飞姜世勃 College of Medical Technology Chengdu University of Traditional Chinese Medicine Chongqing Key Laboratory of Sichuan-Chongqing Co-construction for Diagnosis and Treatment of Infectious Diseases Integrated Traditional Chinese and Western Medicine Chongqing Traditional Chinese Medicine Hospital Shanghai Pudong Hospital Fudan University Pudong Medical Center Shanghai Institute of Infectious Disease and Biosecurity School of Life Sciences Fudan University Department of biomedical Sciences University of the Pacific Arthur Dugoni School of Dentistry Key Laboratory of Medical Molecular Virology of Ministry of Education/Ministry of Health/Chinese Academy of Medical Sciences Shanghai Institute of Infectious Disease and Biosecurity School of Basic Medical Sciences Fudan University

Currently approved vaccines have been successful in preventing the severity of COVID-19 and hospitalization. These vaccines primarily induce humoral immune responses; however, highly transmissible and mutated variants, such as the Omicron variant, weaken the neutralization potential of the vaccines, thus,raising serious concerns about their efficacy. Additionally, while neutralizing antibodies(nAbs) tend to wane more rapidly than cell-mediated immunity, long-lasting T cells typically prevent severe viral illness by directly killing infected cells or aiding other immune cells. Importantly, T cells are more cross-reactive than antibodies, thus, highly mutated variants are less likely to escape lasting broadly cross-reactive T cell immunity. Therefore, T cell antigen-based human coronavirus(HCoV) vaccines with the potential to serve as a supplementary weapon to combat emerging SARS-CoV-2 variants with resistance to n Abs are urgently needed. Alternatively, T cell antigens could also be included in b cell antigen-based vaccines to strengthen vaccine efficacy. This review summarizes recent advancements in research and development of vaccines containing T cell antigens or both T and b cell antigens derived from proteins of SARS-CoV-2 variants and/or other HCo Vs based on different vaccine platforms.

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Universal silicon ring resonator for error-free transmission links

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Photonics Research 2024年第4期12卷 701-711页

作者： JUNbO ZHU WEIWEI ZHANG KE LI bHARAT PANT MARTIN EbERT XINGZHAO YAN MEHDI bANAKAR DEHN T.TRAN CALLUM G.LITTLEJOHNS FUWAN GAN GRAHAM REED david J.THOMSON Optoelectronics Research Centre University of SouthamptonSouthampton SO171BJUK National Key Laboratory of Materials for Integrated Circuits Shanghai Institute of Microsystem and Information TechnologyChinese Academy of SciencesShanghai 200050China University of Chinese Academy of Sciences Beijing 100049China Peng Cheng Laboratory ShenzhenChina

We report the design, fabrication, and characterization of a universal silicon PN junction ring resonator for C band error-free communication links operated up to 50 Gb/s with co-designed optical modulation and detection performance. The universal p-n junction ring device shows co-designed detection responsivity up to 0.84 A/W, in conjunction with a modulation efficiency of -4 V·mm and>8 d b optical modulation extinction ratio, enabling C band 50 Gb/s NRZ communication link with a bit error rate≤3×10^(-12).

关键词： Gb/s resonator communication

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液体活检在肺癌管理中新技术的发展和临床应用的拓展

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Science bulletin 2024年第10期69卷 1556-1568页

作者：陈克终何越王文香袁晓秋 david P.Carbone 杨帆 Department of Thoracic Surgery Peking University People’s HospitalBeijing 100044China Peking University People’s Hospital Thoracic Oncology Institute&Research Unit of Intelligence Diagnosis and Treatment in Early Non-small Cell Lung Cancer Beijing 100044China Peking University Health Science Center Beijing 100191China Thoracic Oncology Center Ohio State UniversityColumbus 43026USA

Lung cancer is an exceedingly malignant tumor reported as having the highest morbidity and mortality of any cancer worldwide,thus posing a great threat to global *** the growing demand for precision medicine,current methods for early clinical detection,treatment and prognosis monitoring in lung cancer are hampered by certain *** have found that during the formation and development of a tumor,molecular substances carrying tumor-related genetic information can be released into body *** biopsy(Lb),a method for detecting these tumor-related markers in body fluids,maybe a way to make progress in these *** recent years,Lb technology has undergone rapid ***,this review will provide information on technical updates to Lb and its potential clinical applications,evaluate its effectiveness for specific applications,discuss the existing limitations of Lb,and present a look forward to possible future clinical ***,this paper will introduce technical updates from the prospectives of engineering breakthroughs in the detection of membrane-based Lb biomarkers and other improvements in sequencing ***,it will summarize the latest applications of liquid biopsy for the early detection,diagnosis,treatment,and prognosis of lung *** will present the interconnectedness of clinical and laboratory issues and the interplay of technology and application in Lb today.

关键词： Liquid biopsy techniques Lung cancer Circulating tumor cells Circulating tumor DNA Sequencing technology Clinical application

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SMXL5 attenuates strigolactone signaling in Arabidopsis thaliana by inhibiting SMXL7 degradation

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Molecular Plant 2024年第4期17卷 631-647页

作者： Qingtian Li Haiyang Yu Wenwen Chang Sunhyun Chang Michael Guzman Lionel Faure Eva-Sophie Wallner Heqin Yan Thomas Greb Lei Wang Ruifeng Yao david C.Nelson Department of botany and Plant Sciences University of CaliforniaRiversideRiversideCA 2521USA Yazhouwan National Laboratory Sanya 572025China Hainan Seed Industry Laboratory Sanya 57205China State Key Laboratory of Chemo/biosensing and Chemometrics Hunan Provincial Key Laboratory of Plant Functional Genomics and Developmental RegulationCollege of BiologyHunan UniversityChangsha 410082China Key Laboratory of Seed Innovation Center for Agricultural Resources ResearchInstitute of Genetics and Developmental BiologyChinese Academy of SciencesShijiazhuangHebei 050021China University of Chinese Academy of Sciences Beijing 10004China School of the Sciences Biology DivisionTexas Woman’s UniversityDentonTX 76204USA Centre for Organismal Studies(COS) Heidelberg University6120 HeidelbergGermany

Hormone-activated proteolysis is a recurring theme of plant hormone signaling *** strigolactone signaling,the enzyme receptor DWARF14(D14)and an F-box protein,MORE AXILLARY GROWTH2(MAX2),mark SUPPRESSOR OF MAX21-LIKE(SMXL)family proteins SMXL6,SMXL7,and SMXL8 for rapid *** of these transcriptional corepressors initiates downstream growth *** homologous proteins SMXL3,SMXL4,and SMXL5,however,are resistant to MAX2-mediated *** discovered that the smxl4 smxl5 mutant has enhanced responses to ***5 attenuates strigolactone signaling by interfering with AtD14-SMXL7 ***5 interacts with AtD14 and SMXL7,providing two possible ways to inhibit SMXL7 ***5 function is partially dependent on an ethylene-responsive-element binding-factor-associated amphiphilic repression(EAR)motif,which typically mediates interactions with the TOPLESS family of transcriptional ***,we found that loss of the EAR motif reduces SMXL5-SMXL7 interactions and the attenuation of strigolactone signaling by *** hypothesize that integration of SMXL5 into heteromeric SMXL complexes reduces the susceptibility of SMXL6/7/8 proteins to strigolactone-activated degradation and that the EAR motif promotes the formation or stability of these *** mechanism may provide a way to spatially or temporally fine-tune strigolactone signaling through the regulation of SMXL5 expression or translation.

关键词： Arabidopsis typically inhibiting

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Maternal Group b Streptococcus Infection Correlates Inversely With Preeclampsia in Pregnant African American Women

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Maternal-Fetal Medicine 2024年第1期6卷 23-28页

作者： Keun Soo Kwon Tzu Hsuan Cheng Simone A。Reynolds Jordan Zhou Huchong Cai Sharon Lee Ivan Velickovic Mudar Dalloul david Wlody Ming Zhang Department of Anesthesiology State University of New York-Downstate Health Sciences UniversityNew York 11203USA Department of Epidemiology and biostatistics School of Public HealthState University of New York-Downstate Health Sciences UniversityNew York 11203USA Department of Obstetrics and Gynecology State University of New York-Downstate Health Sciences UniversityNew York 11203USA

Objective:To determine whether an association exists between group b Streptococcus(GbS)colonization and preeclampsia among pregnant black ***:This retrospective cross-sectional study involved black women who gave birth at State University of New York Downstate Hospital between January 2010 and December *** were collected from the Obstetric Department,including delivery date,time,mode of delivery,age of the mother,weeks of gestation at delivery,and antepartum *** GbS test results were originally determined using the eSwab transport *** was defined based on the American College of Obstetricians and Gynecologists criteria for the periods 2010–2012 and 2013–*** primary outcome was whether GbS was associated with the outcome of preeclampsia in the population of black ***,including smoking status,gestational age,parity,body mass index,maternal age,and presence of herpes simplex virus(HSV)and human immunodeficiency virus(HIV)were examined as potential ***-squared test and logistic regression model were used,presenting odds ratios with 95%confidence intervals(Pblack women included in this study,GbS-positive women(n=977)had a 53%reduction in the likelihood of being diagnosed with preeclampsia compared to GbS-negative women(adjusted odds ratio,0.47;95%confidence interval,0.32–0.70).We did not find evidence of differences in the distribution of smoking habits(P=0.783)or maternal age(P=0.107)between GbS-positive and GbS-negative ***,the GbS-positive women tended to be less likely to have a preterm delivery(9.62%(94/977)vs.24.24%(1707/7042),Pbe nulliparous(33.37%(326/977)vs.37.87%(2667/7042),P=0.006),and less likely to be obese(51.38%(502/977)vs.55.30%(3894/7042),PbS-negative *** contrast,GbS-positive women were more likely to have a comorbid infecti

关键词： Pregnancy outcome Preeclampsia GbS colonization African American Afro-Caribbean

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Knowledge, Attitudes and Practices Relating to HIV among Motorbike Taxi Drivers in Parakou, benin, in 2021

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Open Journal of Epidemiology 2024年第2期14卷 260-272页

作者： Luc béhanzin Anicette Yénoukounmè Mahoutin Akodjetin Yessito Corine Nadège Houéhanou-Sonou Virginie Mongbo Phinées Adégbola Menakpo Ferdinand Adounkpè Maurice Togbédji Agonnoudé david Houéto Thierry Adoukonou School of Public Health and Epidemiology University of Parakou (ENATSE) Parakou Benin Department of Health Systems and Policies Regional Institute of Public Health Alfred Comlan QUENUM (IRSP) of Ouidah University of Abomey Calavi Abomey Calavi Benin National Laboratory of Narcotics and Toxicology (LNST) Beninese Center for Scientific Research and Innovation (CBRST) University of Abomey-Calavi Abomey Calavi Benin

background and Objective: HIV infection is a major global Public Health threat worldwide, particularly in Sub-Saharan Africa of which benin. The level of knowledge determines the attitudes and behaviors of the populations towards this infection. The study objective was to assess knowledge, attitudes and practices related to HIV infection among motorbike taxi drivers (MTD) in Parakou in 2021. Methods: This was a descriptive cross-sectional study targeting MTD in Parakou in 2021. Participants were selected by cluster sampling. Pretested Digitized questionnaire using KoboCollect@ applicationserved as a data collection tool. Knowledge, attitudes and practices variable were treated on a score scale. A knowledge score was considered to reflect a good knowledge of HIV if at least two-thirds of the knowledge statements had been correctly answered provided the subject recognized the sexual route as one of modes of HIV transmission, identified at least one preventive measure and meant the incurability of the disease. Quantitative and qualitative variables were appropriately described using the EPI Info 7.***.3.3 software. The participant was classified at positive attitude/practice for HIV prevention, when it has a score of at least 80% and suggests a good preventive measure face a risk of exposure to HIV. Results: A total of 374 subjects were recruited into the study. The mean age was 31.51 ± 7.76 years. Most participants (86.06%) had good knowledge of condom use as an HIV prevention method. The sources of information mentioned were mainly the media (77.07%), relatives or friends (63.38%), and field-workers from non-governmental organizations (37.26%). Routine HIV testing was 50.53%. Among participants, 76.10% reported at least two different sexual partners. Condom use was 59.18 % during the casual sexual intercourse. Within the client-provider relationship with female sex workers, 33.17% had had sexual intercourse with them. The sexual route was the most cited (92.

关键词： Knowledge Practice HIV Motorbike Taxi Drivers benin

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