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应用多参数MRI和DNA全外显子基因组测序对前列腺癌病人前列腺微环境的多区域放射基因组学评价

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国际医学放射学杂志 2017年第5期 588-588页

作者： N.Jamshidi D.J.Margolis s.Raman J.Huang R.E.Reiter M.D.Kuo 杨晓旭 Department of Radiological sciences University of CaliforniaLos Angeles-David Geffen School of Medicine

摘要目的结合多参数MRI与全外显子基因组测序正常和异常区域组织病理学评价,评价前列腺癌病人前列腺微环境的潜在基因变异。材料与方法收集6例接受机器人前

关键词： MRI 多参数前列腺癌 DNA 基因组学外显子微环境

第16章温带气旋:气象学100年来的研究核心

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气象科技进展 2019年第S1期9卷 254-274页

作者：大卫·舒尔茨 LANCE F.BOsART BRIAN A.COLLE HUW C.DAVIEs CHRIsTOPHER DEARDEN DANIEL KEYsER OLIVIA MARTIUs PAUL J.ROEBBER W.JAMEs sTEENBURGH HANs VOLKERT ANDREW C.WINTERs 张萌(编译) 贾朋群(编译) 曼彻斯特大学纽约州立大学奥尔巴尼分校纽约州立大学石溪分校苏黎世联邦理工学院利兹大学伯尔尼大学威斯康星大学密尔沃基分校犹他大学德国宇航中心大气物理研究所不详

1919年在气象学上是重要的一年,不仅因为美国气象学会成立于这一年,同时还有其他两个原因。其中之一是J.皮叶克尼斯关于温带气旋结构的论文于1919年发表,建立了著名的挪威气旋模型。也是在那一年,一系列会议的举办促进了温带气旋研究所... 详细信息

1919年在气象学上是重要的一年,不仅因为美国气象学会成立于这一年,同时还有其他两个原因。其中之一是J.皮叶克尼斯关于温带气旋结构的论文于1919年发表,建立了著名的挪威气旋模型。也是在那一年,一系列会议的举办促进了温带气旋研究所需的国际合作和科学交流组织的形成,这必然包括跨越国界的空间尺度。本章主要描述针对温带气旋的形成、演变和动力过程,它们构成的锋,以及伴随而来的急流和风暴路径进行科学探究的历史。我们将这些现象统称为气象学的核心,因为在此期间,其在促进气象学研究方面发挥着核心作用。这个成果丰硕的世纪使得温带气旋研究成为可能,是因为1)解决不良预报的实际挑战具有巨大的社会经济影响,2)理论、观测和诊断(包括动力模式)的结合提供了改进的物理解释和概念模型,以及3)强有力的国际合作。气旋的概念框架产生于对气旋分类和理解的渴望;它们包括挪威气旋模型和shapiro-Keyser气旋模型。理解气旋动力学的挑战引申出诸如准地转、斜压不稳定、半地转和锋生等理论框架。预测爆发性温带气旋的挑战尤其带来了新的理论发展,如位势涡度(PV)理论和上游效应。对可预报性的局限性的更深层次的认识源于混沌决定论的演变。最后,观测的洞察力成就了详细的气旋和锋面结构、风暴路径及雨带分类。

关键词：美国气象学会风暴路径气象学斜压不稳定皮叶克尼斯可预报性位势涡度温带气旋

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临床上可用于肺癌CT筛查的CAD

国际医学放射学杂志 2015年第1期 84-84页

作者： M.s.Brown P.Lo J.G.Goldin E.Barnoy G.H.J.Kim M.F.Mc Nitt-Gray Department of Radiological sciences David Geffen School of Medicine at UCLA

目的本研究目的是确定基于最近筛查试验的临床适用的计算机辅助肺结节检测(CAD)的必要条件和方案。本文介绍一种基于公开获得的、被注释的CT影像数据库

关键词： CAD 注释结节影像数据库 LIDC CT 筛查试验

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中国林蛙卵油的抗焦虑作用

沈阳药科大学学报 2004年第1期21卷 41-44,69页

作者：佟岩徐峰陈侠王天成刘广宣彭飞沈阳药科大学药学院辽宁沈阳110016 辽宁省人民医院辽宁沈阳110016 辽宁省肿瘤医院辽宁沈阳110042

目的研究中国林蛙卵油 (eggoilofRanatemporariachensinensisdavid ,EORTCD)的抗焦虑作用。方法应用高架十字迷路和小鼠爬梯实验评价中国林蛙卵油的抗焦虑活性及其量效、时效关系。结果与对照组比较 ,EORTCD 2 0、4 0 g·kg-1能显著延... 详细信息

目的研究中国林蛙卵油 (eggoilofRanatemporariachensinensisdavid ,EORTCD)的抗焦虑作用。方法应用高架十字迷路和小鼠爬梯实验评价中国林蛙卵油的抗焦虑活性及其量效、时效关系。结果与对照组比较 ,EORTCD 2 0、4 0 g·kg-1能显著延长大鼠在十字迷路开放通路连续停留时间 ,增加大鼠进入开放通路次数 ,而对封闭通路连续停留时间和进入封闭通路次数无明显影响 ;小鼠爬梯实验中 ,EORTCD 1 4～5 6g·kg-1组小鼠站立数明显减少而爬梯数无显著差异 ;EORTCD抗焦虑时效实验表明在给药后 3 0、60min抗焦虑活性较强 ;γ 氨基丁酸 (γ aminobutyricacid ,GABA) 5 0、1 0 0mg·kg-1分别与EORTCD 1 2 g·kg-1联合给药组的小鼠站立数显著降低而爬梯数无显著减少 ,且比单独给予EORTCD组小鼠站立数少。结论中国林蛙卵油有明显抗焦虑作用。

关键词：卵油中国林蛙抗焦虑高架十字迷路小鼠爬梯

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Feasibility and physics potential of detecting ^(8)B solar neutrinos at JUNO

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Chinese Physics C 2021年第2期45卷 93-110页

作者： Angel Abusleme Thomas Adam shakeel Ahmad sebastiano Aiello Muhammad Akram Nawab Ali Fengpeng An Guangpeng An Qi An Giuseppe Andronico Nikolay Anfimov Vito Antonelli Tatiana antoshkina Burin Asavapibhop João Pedro Athayde Marcondes de André Didier Auguste Andrej Babic Wander Baldini Andrea Barresi Eric Baussan Marco Bellato Antonio Bergnoli Enrico Bernieri david Biare Thilo Birkenfeld sylvie Blin david Blum simon Blyth Anastasia Bolshakova Mathieu Bongrand Clément Bordereau Dominique Breton Augusto Brigatti Riccardo Brugnera Riccardo Bruno Antonio Budano Max Buesken Mario Buscemi Jose Busto Ilya Butorov Anatael Cabrera Hao Cai Xiao Cai Yanke Cai Zhiyan Cai Antonio Cammi Agustin Campeny Chuanya Cao Guofu Cao Jun Cao Rossella Caruso Cédric Cerna Jinfan Chang Yun Chang Pingping Chen Po-An Chen shaomin Chen shenjian Chen Xurong Chen Yi-Wen Chen Yixue Chen Yu Chen Zhang Chen Jie Cheng Yaping Cheng Alexander Chepurnov davide Chiesa Pietro Chimenti Artem Chukanov Anna Chuvashova Gérard Claverie Catia Clementi Barbara Clerbaux selma Conforti Di Lorenzo Daniele Corti salvatore Costa Flavio Dal Corso Christophe De La Taille Jiawei Deng Zhi Deng Ziyan Deng Wilfried Depnering Marco Diaz Xuefeng Ding Yayun Ding Bayu Dirgantara sergey Dmitrievsky Tadeas Dohnal Georgy Donchenko Jianmeng Dong Damien Dornic Evgeny Doroshkevich Marcos Dracos Frédéric Druillole shuxian Du stefano Dusini Martin Dvorak Timo Enqvist Heike Enzmann Andrea Fabbri Lukas Fajt Donghua Fan Lei Fan Can Fang Jian Fang Marco Fargetta Anna Fatkina Dmitry Fedoseev Vladko Fekete Li-Cheng Feng Qichun Feng Richard Ford Andrey Formozov Amélie Fournier Haonan Gan Feng Gao Alberto Garfagnini Alexandre Göttel Christoph Genster Marco Giammarchi Agnese Giaz Nunzio Giudice Franco Giuliani Maxim Gonchar Guanghua Gong Hui Gong Oleg Gorchakov Yuri Gornushkin Marco Grassi Christian Grewing Maxim Gromov Vasily Gromov Minghao Gu Xiaofei Gu Yu Gu Mengyun Guan Nunzio Guardone Maria Gul Cong Guo Jingyuan Guo Wanlei Guo Xinheng Guo Yuhang Guo Paul Hackspacher Caren Hagner Ran Han Yan Yerevan Physics Institute YerevanArmenia UniversitéLibre de Bruxelles BrusselsBelgium Universidade Estadual de Londrina LondrinaBrazil Pontificia Universidade Catolica do Rio de Janeiro RioBrazil Pontificia Universidad Católica de Chile SantiagoChile Universidad Tecnica Federico santa Maria ValparaisoChile Beijing Institute of spacecraft Environment Engineering BeijingChina Beijing Normal University BeijingChina China Institute of Atomic Energy BeijingChina Institute of High Energy Physics BeijingChina North China Electric Power University BeijingChina school of Physics Peking UniversityBeijingChina Tsinghua University BeijingChina University of Chinese Academy of sciences BeijingChina Jilin University ChangchunChina College of Electronic science and Engineering National University of Defense TechnologyChangshaChina Chongqing University ChongqingChina Dongguan University of Technology DongguanChina Jinan University GuangzhouChina sun Yat-sen University GuangzhouChina Harbin Institute of Technology HarbinChina University of science and Technology of China HefeiChina The Radiochemistry and Nuclear Chemistry Group in University of south China HengyangChina Wuyi University JiangmenChina shandong University JinanChina Institute of Modern Physics Chinese Academy of SciencesLanzhouChina Nanjing University NanjingChina Guangxi University NanningChina East China University of science and Technology ShanghaiChina school of Physics and Astronomy Shanghai Jiao Tong UniversityShanghaiChina Tsung-Dao Lee Institute Shanghai Jiao Tong UniversityShanghaiChina Institute of Hydrogeology and Environmental Geology Chinese Academy of Geological SciencesShijiazhuangChina Nankai University TianjinChina Wuhan University WuhanChina Xi’an Jiaotong University Xi’anChina Xiamen University XiamenChina school of Physics and Microelectronics Zhengzhou UniversityZhengzhouChina Institute of Physics National Chiao-Tung University Hsinchu National United University Miao-Li Department of Physics National T

The Jiangmen Underground Neutrino Observatory(JUNO)features a 20 kt multi-purpose underground liquid scintillator sphere as its main *** of JUNO's features make it an excellent location for^8B solar neutrino measurements,such as its low-energy threshold,high energy resolution compared with water Cherenkov detectors,and much larger target mass compared with previous liquid scintillator *** this paper,we present a comprehensive assessment of JUNO's potential for detecting^8B solar neutrinos via the neutrino-electron elastic scattering process.A reduced 2 MeV threshold for the recoil electron energy is found to be achievable,assuming that the intrinsic radioactive background^(238)U and^(232)Th in the liquid scintillator can be controlled to 10^(-17)g/*** ten years of data acquisition,approximately 60,000 signal and 30,000 background events are *** large sample will enable an examination of the distortion of the recoil electron spectrum that is dominated by the neutrino flavor transformation in the dense solar matter,which will shed new light on the inconsistency between the measured electron spectra and the predictions of the standard three-flavor neutrino oscillation *** m^(2)_(21)=4.8times10^(-5);(7.5times10^(-5))eV^(2),JUNO can provide evidence of neutrino oscillation in the Earth at approximately the 3sigma(2sigma)level by measuring the non-zero signal rate variation with respect to the solar zenith ***,JUNO can simultaneously measureDelta m^2_(21)using^8B solar neutrinos to a precision of 20% or better,depending on the central value,and to sub-percent precision using reactor antineutrinos.A comparison of these two measurements from the same detector will help understand the current mild inconsistency between the value of Delta m^2_(21)reported by solar neutrino experiments and the KamLAND experiment.

关键词： neutrino oscillation solar neutrino JUNO

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吉兰-巴雷综合征诊治的10个步骤(Diagnosis and management of Guillain-Barrésyndrome in ten steps全译)

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中华诊断学电子杂志 2023年第3期11卷 198-211页

作者： sonja E Leonhard Melissa R Mandarakas Francisco AA Gondim Kathleen Bateman Maria LB Ferreira david R Cornblath Pieter A van Doorn Mario E Dourado Richard AC Hughes Badrul Islam susumu Kusunoki Carlos A Pardo Ricardo Reisin James J sejvar Nortina shahrizaila Cristiane soares Thirugnanam Umapathi 王玉忠 Eppie M Yiu Hugh J Willison Bart C Jacobs 伊拉斯姆斯大学医疗中心神经内科鹿特丹市3015 CE 福塔莱萨联邦大学沃尔特·坎迪奥大学医院塞阿拉州60430-370 开普敦大学格鲁特·舒尔医院开普敦市7925 累西腓市康复医院神经内科伯南布哥州52171-011 约翰·霍普金斯大学医学院神经病学系马里兰州21218 北里奥格兰德州联邦大学奥诺弗雷卢佩斯医院综合医学部纳塔尔市59012-300 伦敦大学学院皇后广场神经病学研究所伦敦市WC1N 3BG 国际腹泻病研究中心达卡市1212 金代大学医学院大阪市589-8511 不列颠医院布宜诺斯艾利斯市C1280AEB 亚特兰大市疾病预防控制中心乔治亚州30329 马来亚大学神经病学系吉隆坡市50603 埃斯塔多联邦医院里约热内卢市20221-903 国家神经科学研究所新加坡308433 济宁医学院附属医院神经内科济宁272029 墨尔本皇家儿童医院神经内科维多利亚州3052 默多克儿童研究所神经科学研究组维多利亚州3052 墨尔本大学儿科学系维多利亚州3052 格拉斯哥大学医学、兽医学与生命科学学院格拉斯哥市G611QH 伊拉斯姆斯大学医疗中心免疫科鹿特丹市3015 GD

吉兰-巴雷综合征(GBs)是一种少见但可危及生命的、自身免疫介导的周围神经病。GBs通常由感染引发,发病率可在感染性疾病暴发期间增加,如2013年法属波利尼西亚和2015年拉丁美洲的寨卡病毒流行期间,该病的发病率明显上升。由于GBs的临床... 详细信息

吉兰-巴雷综合征(GBs)是一种少见但可危及生命的、自身免疫介导的周围神经病。GBs通常由感染引发,发病率可在感染性疾病暴发期间增加,如2013年法属波利尼西亚和2015年拉丁美洲的寨卡病毒流行期间,该病的发病率明显上升。由于GBs的临床表现和病程多种多样,其诊疗存在一定的复杂性,而目前尚无可用的国际性临床诊疗指南。本文作者撰写了一份适用于全球的GBs诊疗指南,特别是在疾病暴发期间,以期为临床医生提供指导。本指南根据当前文献和专家共识撰写而成,采用10步式结构,以便在临床实践中更好地应用。本文首先介绍了GBs的诊断标准、临床变异和鉴别诊断;其次,通过10个步骤介绍了GBs的早期识别和诊断、收治重症监护室的指征、治疗指征和选择、疾病进展的监测和处理、临床病程和结局的预测,以及并发症和后遗症的处理。

关键词：吉兰-巴雷综合征诊断治疗

间隔1周的CT复查对肺气肿容积和密度测量的可重复性

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国际医学放射学杂志 2012年第2期 197-197页

作者： D.Chong M.s.Brown H.J.Kim E.M.van Rikxoort L.Guzman M.F.McNitt-Gray 肖立志 Center for Computer Vision and Imaging Biomarkers David Geffen School of MedicineUCLA924 Westwood BLVD.Ste.615Los AngelesCAUSA

目的肺气肿病人CT肺容积和密度测量1周后重复评估。评估屏气对重复性的影响。方法 44例病人间隔7d在吸气状态行HRCT检查,计算CT肺容积、密度在-950HU(RA950-raw)以下相关区,第15百分位数密度(PD15-raw)。通

关键词：慢性阻塞性肺疾病肺气肿 CT 密度测量法重复性

The impact of COVID-19 on the birth rate in Nigeria:a report from population-based registries

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Infectious Diseases Research 2023年第1期4卷 14-18页

作者： Charlotte Blanche Oguejiofor Kenechi Miracle Ebubechukwu George Uchenna Eleje Emmanuel Onyebuchi Ugwu Joseph Tochukwu Enebe Kingsley Emeka Ekwuazi Chukwuemeka Chukwubuikem Okoro Boniface Chukwuneme Okpala Charles Chukwunomunso Okafor Nnanyelugo Chima Ezeora Emeka Ifeanyi Iloghalu Chidebe Christian Anikwe Chigozie Geoffrey Okafor Polycarp Uchenna Agu Emeka Philip Igbodike Iffiyeosuo Dennis Ake Arinze Anthony Onwuegbuna Osita samuel Umeononihu Onyedika Promise Anaedu Odigonma Zinobia Ikpeze david Chibuike Ikwuka Henry Ifeanyi Nwaolisa Ekene Agatha Emeka Jude Ogechukwu Okoye Ihechinyerem Kelechi Osuagwu Angela Ogechukwu Ugwu Toochukwu Benjamin Ejikeme Eziamaka Pauline Ezenkwele Chijioke Ogomegbunam Ezeigwe Malarchy Ekwunife Nwankwo Gerald Okanandu Udigwe Joseph Ifeanyichukwu Ikechebelu Grace Agbaeze Chukwuebuka Divine Nwanja Ahizechukwu Chigoziem Eke Department of Obstetrics and Gynecology Nnamdi Azikiwe University Teaching HospitalNnewi PMB 5025Nigeria Preventive Medicine and Research Department Clina-Lancet LaboratoriesVictoria IslandLagos 101241Nigeria Effective Care Research Unit Department of Obstetrics and GynecologyNnamdi Azikiwe UniversityNnewi Campus 435001Nigeria Department of Obstetrics and Gynecology College of MedicineUniversity of Nigeria Enugu CampusEnuguEnugu State 400102Nigeria Department of Obstetrics and Gynecology University of Nigeria Teaching HospitalItuku OzallaEnugu State 400102Nigeria Department of Obstetrics and Gynecology ESUT Teaching HospitalParklaneEnugu 400102Nigeria Medical Department Divine Medical CentreSouth West IkoyiLagos 1001233Nigeria Department of Obstetrics and Gynecology Havana Specialist HospitalSurulereLagos 100011Nigeria Clinical Trial Division Drug Evaluation and Research DirectorateNAFDAC office ComplexLagos 100011Nigeria Department of Ophthalmology Nnamdi Azikiwe UniversityNnewi campus 435001Nigeria Department of Human Physiology Nnamdi Azikiwe University NnewiAnambra State 435001Nigeria Department of Family Medicine Faculty of MedicineNnamdi Azikiwe UniversityAwka 435001Nigeria Department of Medical Laboratory science Faculty of Health Sciences and TechnologyNnamdi Azikiwe UniversityAwka 435001Nigeria Department of Health services Federal University of TechnologyOwerri 460103Nigeria Department of Haematology and Immunology College of MedicineUniversity of Nigeria Enugu CampusEnuguEnugu State 400102Nigeria Musgrove Park Hospital somerset NHs Foundation TrustUnited Kingdom TLTp Medical(UHs) Southampton WS15United Kingdom Division of Maternal Fetal Medicine Department of Gynecology and ObstetricsJohns Hopkins University School of MedicineBaltimore 21201U.S.A

Background and objectives:Coronavirus disease 2019(COVID-19)is a pandemic that has become a major source of morbidity and mortality worldwide,affecting the physical and mental health of individuals influencing *** the threat,it poses to maternal health in sub-saharan Africa and Nigeria,there is little or no data on the impact it has on fertility,conception,gestation and *** compare the birth rate between pre-COVID and COVID times using selected months of the *** and methods:This was a secondary analysis of cross-sectional analytical study data from the birth registries of three tertiary hospitals,comparing two years[2019(Pre-COVID)]versus[2020(COVID era)]using three months of the year(October to December).The data relied upon was obtained from birth registries in three busy maternity clinics all within tertiary hospitals in south-East Nigeria and we aimed at discussing the potential impacts of COVID-19 on fertility in *** secondary outcome measures were;mode of delivery,booking status of the participants,maternal age and ***:There was a significant decrease in tertiary-hospital based birth rate by 92 births(P=0.0009;95%CI:-16.0519 to-4.1481)among mothers in all the three hospitals in 2020 during the COVID period(post lockdown months)of October to *** was a significant difference in the mode of delivery for mothers(P=0.0096)with a 95%confidence interval of 1.0664 to 1.5916,as more gave birth through vaginal delivery during the 2020 COVID-19 period than ***:Tertiary-hospital based birth rates were reduced during the *** multi-centre study extrapolated on possible factors that may have played a role in this decline in their birth rate,which includes but is not limited to;decreased access to hospital care due to the total lockdowns/curfews and worsening inflation and economic recession in the country.

关键词： birth rates COVID-19 lockdown Nigeria pandemic pre-COVID

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胰腺移植：供者的故事

英国医学杂志中文版 2018年第9期21卷 538-539页

作者：菅朝慧(译) 包玉倩(校) 上海交通大学附属第六人民医院内分泌代谢科

胰腺及胰岛移植在Dean及其同事最新的综述（见本刊2017年第20卷第9期518页）中得到了国际上前所未有的重视，这是非常令人耳目一新的。由于目前转诊至英国胰腺移植中心,的比例较低，不能反映通过手术干预获益的人数．因此，改善转诊医... 详细信息

胰腺及胰岛移植在Dean及其同事最新的综述（见本刊2017年第20卷第9期518页）中得到了国际上前所未有的重视，这是非常令人耳目一新的。由于目前转诊至英国胰腺移植中心,的比例较低，不能反映通过手术干预获益的人数．因此，改善转诊医生对胰腺移植潜在获益的认识和理解非常重要。Dean的综述侧重介绍了胰腺及胰岛移植的适应证和结局。但这只代表了受者一方的过程，而并未了解供者所面临的主要挑战。

关键词：故事施主移植