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Making bridges between preclinical and clinical insights into age-related cognitive decline

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Neural Regeneration Research 2025年第8期20卷 2321-2322页

作者： david VC Brito Clévio Nóbrega Algarve Biomedical Center-Research Institute(ABC-RI) Campus GambelasFaroPortugal Algarve Biomedical Center-(ABC) Campus GambelasFaroPortugal Faculty of Medicine and Biomedical Sciences(FMCB) University of AlgarveGambelas CampusFaroPortugal

With people living longer,the societal impact of age-related cognitive decline is becoming more pronounced(Crimmins,2015).Thus,it is increasingly important to comprehend the cognitive shifts linked to aging-whether th... 详细信息

关键词： bridges becoming insight

Women in visual neural regeneration research

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Neural Regeneration Research 2025年第2期20卷 489-490页

作者： Tonia S.Rex david J.Calkins Vanderbilt Eye Institute Vanderbilt University Medical CenterNashvilleTNUSA

The year 2024 marks the 60^(th)anniversary of Title IX and 25 years since the New York Times revealed bias against female faculty members at the Massachusetts Institute of *** take an opportunity here to examine the state of gender bias in a relatively new yet already prominent field,neural regeneration in the visual system,for which there is a well-defined context useful for this *** National Eye Institute(NEI)provided the first round of research funding for its Audacious Goals Initiative(AGI)on visual neural regeneration in 2013 and the last round in ***,we focus on this *** sources included PubMed,the National Science Foundation(NSF),the NEI,the Blue Ridge Institute for Medical Research and data from the major professional organization for eye and vision research,the Association for Research in Vision and Ophthalmology(ARVO).

关键词： neural visual Times

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是否应该保留无麸质食品处方？

英国医学杂志中文版 2017年第7期20卷 370-372页

作者： Matthew Kurien Sarah sleet david S Sanders James Cave 符天旭周国鹏 Academic Unit of Gastroenterology Departments of Infection and Immunity and Cardiovascular Science University of Sheffield UK Department of Gastroenterology Royal Hallamshire Hospital Sheffield UK Coeliac UK High Wycombe UK Newbury UK 北京大学第一医院内科

Matthew Kurien及其同事撰写文章提出无麸质食品处方可改善乳糜泻患者预后，但JamesCave则抨击这一昂贵的供应系统可能使患者和医生均感到失望。正方——Matthew Kurien,Sarah sleet，david Sanders由于近三分之二的信托机构存在赤字，... 详细信息

Matthew Kurien及其同事撰写文章提出无麸质食品处方可改善乳糜泻患者预后，但JamesCave则抨击这一昂贵的供应系统可能使患者和医生均感到失望。正方——Matthew Kurien,Sarah sleet，david Sanders由于近三分之二的信托机构存在赤字，英国国家健康体系（NHS）正面临着前所未有的财政和运营压力。英国医疗保健支出占国内生产总值的比例目前低于其他西欧邻国，这更加剧了上述压力。政府通过责令医疗专业人员提高生产力、工作效率和分配制度来恢复财政平衡。

关键词：无麸质食品处方食品安全发展现状

维普期刊数据库评论

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维普期刊数据库

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美国疾病预防控制中心伤害预防工作

伤害医学（电子版） 2015年第2期4卷 44-53页

作者： david sleet 蔡颖 Erin Sauber-Schatz 美国疾病预防控制中心国家伤害预防与控制中心非故意伤害处美国乔治亚州亚特兰大市美国疾病预防控制中心中国办事处北京100600

在美国，每年有超过18万人死于各类伤害，也就是说，每3分钟就有1人因此丧命。暴力与伤害威胁着每个人，无论性别、种族或贫富。在1~44岁年龄段的美国人中，死于机动车事故、跌倒或凶杀等暴力和伤害的人数比所有由于其它原因死亡的人数... 详细信息

在美国，每年有超过18万人死于各类伤害，也就是说，每3分钟就有1人因此丧命。暴力与伤害威胁着每个人，无论性别、种族或贫富。在1~44岁年龄段的美国人中，死于机动车事故、跌倒或凶杀等暴力和伤害的人数比所有由于其它原因死亡的人数［1］的总和还要多，包括传染性和非传染性疾病(图1)。而且伤害后死亡的人仅占所有遭受伤害的人中很少的一部分。每年都有数百万的美国人在遭受伤害后幸存。其中很多人都将在其余生面对各种卫生、社会与财务问题。

关键词：美国疾病预防控制中心伤害预防非传染性疾病机动车事故财务问题美国人受伤害暴力

Silk-based nerve guidance conduits with macroscopic holes modulate the vascularization of regenerating rat sciatic nerve

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Neural Regeneration Research 2025年第6期20卷 1789-1800页

作者： Carina Hromada Patrick Heimel Markus Kerbl LászlóGál Sylvia Nürnberger Barbara Schaedl James Ferguson Nicole Swiadek Xavier Monforte Johannes C.Heinzel Antal Nógrádi Andreas H.Teuschl-Woller david Hercher Department Life Science Engineering University of Applied Sciences Technikum WienViennaAustria Austrian Cluster for Tissue Regeneration ViennaAustria Ludwig Boltzmann Institute for Traumatology The Research Center in Cooperation with AUVAViennaAustria University Clinic of Dentistry Medical University of ViennaViennaAustria Department of Plastic Reconstructive and Aesthetic SurgeryLandesklinikum Wiener Neustadt2700 Wiener NeustadtAustria Department of Anatomy Histology and EmbryologyAlbert Szent-Györgyi Medical SchoolUniversity of SzegedSzegedHungary Medical University of Vienna Department of Orthopedics and Trauma SurgeryDevision of Trauma SurgeryViennaAustria Department of Hand- PlasticReconstructive and Burn SurgeryBG Unfallklinik TuebingenUniversity of TuebingenTuebingenGermany

Peripheral nerve injuries induce a severe motor and sensory deficit. Since the availability of autologous nerve transplants for nerve repair is very limited, alternative treatment strategies are sought, including the use of tubular nerve guidance conduits(tNGCs). However, the use of tNGCs results in poor functional recovery and central necrosis of the regenerating tissue, which limits their application to short nerve lesion defects(typically shorter than 3 cm). Given the importance of vascularization in nerve regeneration, we hypothesized that enabling the growth of blood vessels from the surrounding tissue into the regenerating nerve within the tNGC would help eliminate necrotic processes and lead to improved regeneration. In this study, we reported the application of macroscopic holes into the tubular walls of silk-based tNGCs and compared the various features of these improved silk^(+) tNGCs with the tubes without holes(silk^(–) tNGCs) and autologous nerve transplants in an 8-mm sciatic nerve defect in rats. Using a combination of micro-computed tomography and histological analyses, we were able to prove that the use of silk^(+) tNGCs induced the growth of blood vessels from the adjacent tissue to the intraluminal neovascular formation. A significantly higher number of blood vessels in the silk^(+) group was found compared with autologous nerve transplants and silk^(–), accompanied by improved axon regeneration at the distal coaptation point compared with the silk^(–) tNGCs at 7 weeks postoperatively. In the 15-mm(critical size) sciatic nerve defect model, we again observed a distinct ingrowth of blood vessels through the tubular walls of silk^(+) tNGCs, but without improved functional recovery at 12 weeks postoperatively. Our data proves that macroporous tNGCs increase the vascular supply of regenerating nerves and facilitate improved axonal regeneration in a short-defect model but not in a critical-size defect model. This study suggests that further optimizatio

关键词： axon regeneration blood vessel functional recovery macroporous nerve lesion peripheral nerve repair sciatic nerve silk-based nerve guidance conduit vascularization

Complement-dependent neuroinflammation in spinal cord injury:from pathology to therapeutic implications

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Neural Regeneration Research 2025年第5期20卷 1324-1335页

作者： Hassan Saad Bachar El Baba Ali Tfaily Firas Kobeissy Juanmarco Gutierrez Gonzalez Daniel Refai Gerald R.Rodts Christian Mustroph david Gimbel Jonathan Grossberg Daniel L.Barrow Matthew F.Gary Ali M.Alawieh Department of Neurosurgery Emory University School of MedicineAtlantaGAUSA Department of Neurology Yale UniversityNew HavenCTUSA Center for Neurotrauma Multiomics&Biomarkers(CNMB)Morehouse School of MedicineAtlantaGAUSA

Spinal cord injury remains a major cause of disability in young adults,and beyond acute decompression and rehabilitation,there are no pharmacological treatments to limit the progression of injury and optimize recovery in this *** the thorough investigation of the complement system in triggering and propagating cerebral neuroinflammation,a similar role for complement in spinal neuroinflammation is a focus of ongoing *** this work,we survey the current literature investigating the role of complement in spinal cord injury including the sources of complement proteins,triggers of complement activation,and role of effector functions in the *** study relevant data demonstrating the different triggers of complement activation after spinal cord injury including direct binding to cellular debris,and or activation via antibody binding to damage-associated molecular *** effector functions of complement have been implicated in spinal cord injury,and we critically evaluate recent studies on the dual role of complement anaphylatoxins in spinal cord injury while emphasizing the lack of pathophysiological understanding of the role of opsonins in spinal cord *** this pathophysiological review,we systematically review the different translational approaches used in preclinical models of spinal cord injury and discuss the challenges for future translation into human *** review emphasizes the need for future studies to dissect the roles of different complement pathways in the pathology of spinal cord injury,to evaluate the phases of involvement of opsonins and anaphylatoxins,and to study the role of complement in white matter degeneration and regeneration using translational strategies to supplement genetic models.

关键词： complement neuroinflammation neuroplasticity regeneration spinal cord injury targeted therapy

Redox physiology in animal function:The struggle of living in an oxidant environment

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Current Zoology 2010年第6期56卷 687-702页

作者： david COSTANTINI Division of Ecology and Evolutionary Biology Faculty of Biomedical and Life SciencesUniversity of Glasgow

A strong focus of ecological research for several decades has been to understand the factors underlying the variation in animal life-histories. In recent times, ecological studies have begun to show that oxidative stress may represent another important modulator of competitive trade-offs among fitness traits or of positively integrated patterns of traits. Therefore, incorporating mechanisms underlying oxidative physiology into evolutionary ecology has the potential to help understand variation in life-history strategies. In this review, I provide a general overview of oxidative stress physiology, and subsequently focus on topics that have been neglected in previous ecological reviews on oxidative stress. Specifically, I introduce and discuss the adaptations that animals have evolved to cope with oxidative stress; the environmental stressors that can generate changes in oxidative balance; the role of reactive species in transduction of environmental stimuli and cell signaling; and the range of hormetic responses to oxidative stress [Current Zoology 56 （6）： 687-702, 2010].

关键词： Antioxidants Free radicals Life-history Oxidative stress Stress response Vertebrates

Software, Software Engineering and Software Engineering Research: Some Unconventional Thoughts

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Journal of Computer Science & Technology 2009年第2期24卷 189-197页

作者： david Notkin Computer Science and Engineering University of Washington Seattle

Software engineering is broadly discussed as falling far short of expectations. Data and examples are used to justify how software itself is often poor, how the engineering of software leaves much to be desired, and how research in software engineering has not made enough progress to help overcome these weaknesses. However, these data and examples are presented and interpreted in ways that are arguably imbalanced. This imbalance, usually taken at face value, may be distracting the field from making significant progress towards improving the effective engineering of software, a goal the entire community shares. Research dichotomies, which tend to pit one approach against another, often subtly hint that there is a best way to engineer software or a best way to perform research on software. This, too, may be distracting the field from important classes of progress.

关键词： software engineering/general software engineering process/life cycle

The functional properties of synapses made by regenerated axons across spinal cord lesion sites in lamprey

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Neural Regeneration Research 2022年第10期17卷 2272-2277页

作者： david Parker Department of Physiology Developmentand NeuroscienceUniversity of CambridgeCambridgeUK

While the anatomical properties of regenerated axons across spinal cord lesion sites have been studied extensively,little is known of how the functional properties of regenerated synapses compared to those in unlesioned *** study aims to compare the properties of synapses made by regenerated axons with unlesioned axons using the lamprey,a model system for spinal injury research,in which functional locomotor recovery after spinal cord lesions is associated with axonal regeneration across the lesion *** synapses below the lesion site did not differ from synapses from unlesioned axons with respect to the amplitude and duration of single excitatory postsynaptic *** also showed the same activity-dependent depression over spike ***,regenerated synapses did differ from unlesioned synapses as the estimated number of synaptic vesicles was greater and there was evidence for increased postsynaptic quantal *** axons above the lesion site,the amplitude and duration of single synaptic inputs also did not differ significantly from unlesioned ***,in this case,there was evidence of a reduction in release probability and inputs facilitated rather than depressed over spike *** inputs from single regenerated axons below the lesion site thus do not increase in amplitude to compensate for the reduced number of descending axons after functional ***,the postsynaptic input was maintained at the unlesioned level using different synaptic ***,the facilitation from the same initial amplitude above the lesion site made the synaptic input over spike trains functionally *** may help to increase propriospinal activity across the lesion site to compensate for the lesion-induced reduction in supraspinal *** animal experiments were approved by the Animal Ethics Committee of Cambridge University.

关键词： electrophysiology lamprey plasticity regeneration reticulospinal axon spinal cord spinal injury synapse