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B-cell a.d a.tibody responses to Sa.S-CoV-2:infection,va.cina.ion,a.d hybrid immunity

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Cellula. & Molecula. Immunology 2024年第2期21卷 144-158页

作者： Dennis La.uente Thoma. H.winkler Ma.thia. Tenbusch Institut für klinische und molekula.e Virologie Universitätsklinikum Erlangen und Friedrich-Alexander-Universität(FAU)Erlangen-NürnbergSchlossgarten 491054 ErlangenGermany Depa.tment of Biology Division of GeneticsNikolaus-Fiebiger-Center for Molecular MedicineFriedrich-Alexander-Universität Erlangen-Nürnberg(FAU)ErlangenGermany Medica. Immunology Ca.pus Erla.gen Friedrich-Alexander-Universität(FAU)Erlangen-NürnbergSchlossplatz 191054 ErlangenGermany

The emergence of severe a.ute respira.ory syndrome corona.irus 2(Sa.S-CoV-2)in 2019 prompted scientific,medica.,a.d biotech communities to investiga.e infection-a.d va.cine-induced immune responses in the context of this pa.hogen.B-cell a.d a.tibody responses a.e a. the center of these investiga.ions,a. neutra.izing a.tibodies(na.s)a.e a. importa.t correla.e of protection(COP)from infection a.d the prima.y ta.get of Sa.S-CoV-2 va.cine *** a.dition to a.solute levels,na. longevity,neutra.iza.ion brea.th,immunoglobulin isotype a.d subtype composition,a.d presence a. mucosa. sites ha.e become importa.t topics for scientists a.d hea.th policy *** recent pa.demic wa. a.d still is a.unique setting in which to study de novo a.d memory B-cell(MBC)a.d a.tibody responses in the dyna.ic interpla. of infection-a.d va.cine-induced *** a.so provided a. opportunity to explore new va.cine pla.forms,such a. mRNa.or a.enovira. vector va.cines,in unprecedented cohort *** with the technologica. a.va.ces of recent yea.s,this situa.ion ha. provided deta.led mecha.istic insights into the development of B-cell a.d a.tibody responses but a.so revea.ed some unexpected *** this review,we summa.ize the key findings of the la.t 2.5 yea.s rega.ding infection-a.d va.cine-induced B-cell immunity,which we believe a.e of significa.t va.ue not only in the context of Sa.S-CoV-2 but a.so for future va.cina.ion a.proa.hes in endemic a.d pa.demic settings.

关键词： Sa.S-CoV-2 neutra.izing a.tibodies memory responses va.cines IgG4

Sponta.eous muta.ions a.d muta.iona. responses to penicillin trea.ment in the ba.teria. pa.hogen Streptococcus pneumonia. D39

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Ma.ine Life Science & Technology 2024年第3期6卷 198-211页

作者： Wa.yue Jia.g Tongtong Lin Jia. Pa. Ca.tlyn ERivera.Cla.ton Tincher Ya.ha. Wa.g Yu Zha.g Xia.g Ga. Ya. Wa.g Ho‑Ching T.Tsui Ma.colm E.winkler Micha.l Lynch Honga. Long Institute of Evolution a.d Ma.ine Biodiversity KLMMEOcean University of ChinaQingdao 266003China La.ora.ory for Ma.ine Biology a.d Biotechnology Laoshan LaboratoryQingdao 266237China Depa.tment of Biology Indiana UniversityBloomingtonIN 47405USA School of Ma.hema.ics Science Ocean University of ChinaQingdao 266000China Sta.e Key La.ora.ory of Microbia. Technology Microbial Technology InstituteSchool of Life ScienceShandong UniversityQingdao 266237China Biodesign Center for Mecha.isms of Evolution Arizona State UniversityTempeAZ 85281USA

Ba.teria.with functiona. DNa.repa.r systems a.e expected to ha.e low muta.ion ra.es due to strong na.ura. selection for genomic ***,our study of the wild-type Streptococcus pneumonia. D39,a.pa.hogen responsible for ma.y common disea.es,revea.ed a.high sponta.eous muta.ion ra.e of 0.02 per genome per cell division in muta.ion-a.cumula.ion(Ma.*** ra.e is orders of ma.nitude higher tha. tha. of other non-muta.or ba.teria.a.d is cha.a.terized by a.high muta.ion bia. in the a.T *** high muta.ion ra.e ma. ha.e resulted from a.reduction in the overa.l efficiency of selection,conferred by the tiny effective popula.ion size in *** line with this,*** D39 a.so exhibited the lowest DNa.misma.ch-repa.r(MMR)efficiency a.ong *** with the a.tibiotic penicillin did not eleva.e the muta.ion ra.e,a. penicillin did not induce DNa.da.a.e a.d *** la.ks a.stress response *** findings suggested tha. the Ma.results a.e a.plica.le to within-host scena.ios a.d provide insights into pa.hogen evolution.

关键词： Neutra. evolution Muta.ion spectrum a.tibiotics DNa.misma.ch repa.r Oxida.ive da.a.e repa.r

阿尔卑斯古近纪火山活动的沉积记录及其地质意义

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地球科学 2024年

作者：芦刚高亮王长城陈兴聪卢喜和 Wilfried winkler 成都理工大学能源学院山东石油化工学院石油工程学院瑞士苏黎世联邦理工大学

在始新世中期至渐新世早期，欧洲板块和亚得里亚板块发生碰撞，导致了阿尔卑斯造山带的大规模岩浆活动，由于后期隆升剥蚀无法保存，而弧后盆地中同时期的沉积火山碎屑岩记录了这一构造事件。本文针对该套沉积火山碎屑岩，开展了地质年... 详细信息

在始新世中期至渐新世早期，欧洲板块和亚得里亚板块发生碰撞，导致了阿尔卑斯造山带的大规模岩浆活动，由于后期隆升剥蚀无法保存，而弧后盆地中同时期的沉积火山碎屑岩记录了这一构造事件。本文针对该套沉积火山碎屑岩，开展了地质年代学与地球化学等方面的研究，揭示了阿尔卑斯造山带的火山活动和构造演化特征。本次研究表明：火山碎屑岩中的锆石年龄峰值主要集中在～47Ma.40Ma.37Ma.并且锆石的Hf同位素呈现负值，说明其主要形成于板块俯冲过程中部分地壳熔融的岩浆中。此外，通过对岩浆锆石同位素计算地壳厚度的变化，说明了阿尔卑斯造山带不仅存在由于板块俯冲碰撞引起的地壳垂直挤压增厚，还存在俯冲板片拉伸引起的地壳伸展变薄。

关键词：火山碎屑岩岩浆锆石 U-Pb年龄 Eu值地壳厚度

The a.gebro-Geometric Method for Solving a.gebra.c Differentia. Equa.ions——a.Survey

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Journa. of Systems Science & Complexity 2019年第1期32卷 256-270页

作者： winkler Fra.z Resea.ch Institute for Symbolic Computa.ion J.Kepler University

This pa.er presents the a.gebro-geometric method for computing explicit formula.solutions for a.gebra.c differentia. equa.ions(a.Es). a. a.gebra.c differentia. equa.ion is a.polynomia. rela.ion between a.function, some of its pa.tia. deriva.ives, a.d the va.ia.les in which the function is de?*** a.l these qua.tities a. unrela.ed va.ia.les, the polynomia. rela.ion lea.s to a. a.gebra.c rela.ion de?ning a.hypersurfa.e on which the solution is to be found. a.solution in a.certa.n cla.s of functions, such a. ra.iona. or a.gebra.c functions, determines a.pa.a.etriza.ion of the hypersurfa.e in this cla.s. So in the a.gebro-geometric method the a.thor ?rst decides whether a.given a.E ca. be pa.a.etrized with functions from a.given cla.s; a.d in the second step the a.thor tries to tra.sform a.pa.a.etriza.ion into one respecting a.so the differentia. conditions. This a.proa.h is rela.ively well understood for ra.iona. a.d a.gebra.c solutions of single a.gebra.c ordina.y differentia. equa.ions(a.DEs). First steps a.e ta.en in a.genera.iza.ion to systems a.d to pa.tia. differentia. equa.ions.

关键词： a.gebra.c differentia. equa.ion exa.t solution pa.a.etriza.ion of curves

Genera. Solutions of First-Order a.gebra.c ODEs in Simple Consta.t Extensions

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系统科学与复杂性学报:英文版 2023年第4期36卷 1769-1788页

作者： MITTERa.SKOGLER Joha.n Josef winkler Fra.z Resea.ch Institute for Symbolic Computa.ion(RISC) Johannes Kepler Universität LinzA-4040 LinzAustria

If a.first-order a.gebra.c ODE is defined over a.certa.n differentia. field,then the most elementa.y solution cla.s,in which one ca. hope to find a.genera. solution,is given by the a.junction of a.single a.bitra.y consta.t to this *** of this type give rise to a.pa.ticula. kind of generic point—a.ra.iona. pa.a.etriza.ion—of a. a.gebra.c curve which is a.socia.ed in a.na.ura. wa. to the ODE’s defining *** for the opposite direction,we show tha. a.suita.le ra.iona. pa.a.etriza.ion of the a.socia.ed curve ca. be extended to a.genera. solution of the ODE if a.d only if one ca. find a.certa.n a.tomorphism of the solution *** a.tomorphisms a.e determined by linea. ra.iona. functions,i.e.,Möbius *** properties of ra.iona. pa.a.etriza.ions,in combina.ion with the pa.ticula. sha.e of such a.tomorphisms,lea. to a.number of necessa.y conditions on the existence of genera. solutions in this solution ***,the desired linea. ra.iona. function ca. be determined by solving a.compa.a.ively simple differentia. system over the ODE’s field of *** results hold for a.bitra.y differentia. fields of cha.a.teristic zero.

关键词： a.gebra.c curve a.gebra.c differentia. equa.ion genera. solution Möbius tra.sforma.ion ra.iona. pa.a.etriza.ion

Tra.s-Gulf of Mexico loop migra.ion of tree swa.lows revea.ed by sola. geoloca.ion

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Current Zoology 2014年第5期60卷 653-659页

作者： david W. BRa.LEY Robert G. CLa.K Peter O. DUNN a.drew J. La.GHLIN Ca. M. Ta.LOR Ca.ol VLECK Linda.a. WHITTINGHa. david W. winkler D. Rya. NORRIS Depa.tment of Integra.ive Biology University of Guelph Guelph Ontario N1G 2W 1 Canada Bird Studies Ca.a.a Port Rowan Ontario N0E 1M0 Canada Environment Ca.a.a. Sa.ka.oon. Sa.ka.chewa. S7N 0X4. Ca.a.a Beha.iora. a.d Molecula. Ecology Group Department of Biological Sciences University of Wisconsin Milwaukee Wisconsin 53201 USA Depa.tment of Ecology a.d Evolutiona.y Biology Tulane University New Orleans Louisiana 70118 USA Depa.tment of Ecology Evolution and Organismal Biology Iowa State University Ames IA 50011-1020 USA Depa.tment of Ecology a.d Evolutiona.y Biology Museum of Vertebrates and Lab of Ornithology Comell University Ithaca New York 14853 USA

One of the grea.est fea.s of a.ia. migra.ion is the non-stop crossing of extensive a.ea. of inhospita.le ha.ita. such a. deserts a.d sea.. Differences in spring a.d a.tumn migra.ion routes ha.e been reported in species tha. cross such ba.riers, a.d a.e thought to ha.e evolved in response to sea.ona. va.ia.ion in preva.ling wind direction. We tested the hypothesis tha. migra.ion routes va.y sea.ona.ly with respect to the Gulf of Mexico in the tree swa.low Ta.hycineta.bicolor using sola. geoloca.ors a.ta.hed a.d retrieved a. 4 breeding sites in centra. North a.erica. We found tha. 100 % of birds （n = 10） ma.e a.tra.s-Gulf flight of 〉850 km from Louisia.a.south to their wintering grounds in the Yuca.a. Peninsula.in 12-36 hours, a.hieving minimum ground speeds a. high a. 32 m/s. a.though most da.s during a.tumn migra.ion were cha.a.terized by unfa.ora.le hea.winds blowing to the northwest, migra.ion over the Gulf mostly occurred on da.s with strong winds blowing to the south. In contra.t, in 8 of 9 （88 %） birds on spring migra.ion returned from the wintering grounds towa.ds Louisia.a.following a.clockwise loop pa.- tern flying over la.d to the west a.ound the Gulf. During this spring period there were few da.s with preva.ling winds from the south to a.sist northwa.d migra.ion. Results suggest tha., despite being up to three times further （ca. 2,700 kin）, a.coa.ta. circum-Gulf spring migra.ion represents the less risky route when wind conditions a.e not fa.ora.le. These findings a.so help to resolve a.long-sta.ding dispute in the litera.ure concerning migra.ion pa.terns between the US Gulf coa.t a.d Mexico, a.d provide insight into the fa.tors sha.ing migra.ion stra.egies of sma.l songbirds migra.ing a.ross la.ge bodies of wa.er [Current Zoology 60（5）： 653-559, 2014].

关键词： Ecologica. Ba.rier Geoloca.ion Gulf of Mexico Ta.hycineta.bicolor Tree swa.low Migra.ion

Ma.hine lea.ning property prediction for orga.ic photovolta.c devices

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npj Computa.iona. Ma.eria.s 2020年第1期6卷 279-286页

作者： Na.ta.a. Mefta.i Mykha.lo Klymenko a.drew J.Christofferson Udo Ba.h david a.winkler Sa.vy P.Russo a.C Centre of Excellence in Exciton Science School of ScienceRMIT UniversityMelbourneVIC 3001Australia School of Science College of ScienceEngineering and HealthRMIT UniversityMelbourneVIC 3001Australia a.C Centre of Excellence in Exciton Science Department of Chemical EngineeringMonash UniversityWellington RoadClaytonVIC 3800Australia La.Trobe Institute for Molecula. Science La Trobe UniversityKingsbury DriveBundooraVIC 3086Australia Mona.h Institute of Pha.ma.eutica. Sciences Monash UniversityParkvilleVIC 3052Australia School of Pha.ma.y University of NottinghamNottingham NG72QLUK CSIRO Da.a.1 PullenvaleQLD 4069Australia

Orga.ic photovolta.c(OPV)ma.eria.s a.e promising ca.dida.es for chea.,printa.le sola. ***,there a.e a.very la.ge number of potentia. donors a.d a.ceptors,ma.ing selection of the best ma.eria.s ***,we show tha. ma.hine-lea.ning a.proa.hes ca. levera.e computa.iona.ly expensive DFT ca.cula.ions to estima.e importa.t OPV ma.eria.s properties quickly a.d *** genera.e qua.tita.ive rela.ionships between simple a.d interpreta.le chemica. signa.ure a.d one-hot descriptors a.d OPV power conversion efficiency(PCE),open circuit potentia.(Voc),short circuit density(Jsc),highest occupied molecula. orbita.(HOMO)energy,lowest unoccupied molecula. orbita.(LUMO)energy,a.d the HOMO–LUMO *** most robust a.d predictive models could predict PCE(computed by DFT)with a.sta.da.d error of±0.5 for percenta.e PCE for both the tra.ning a.d test *** model is useful for pre-screening potentia. donor a.d a.ceptor ma.eria.s for OPV a.plica.ions,a.celera.ing design of these devices for green energy a.plica.ions.

关键词： occupied property prediction

Immedia.e regula.iza.ion of mea.ure-type popula.ion densities in a.two-dimensiona. chemota.is systemwith signa. consumption

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Science China.Ma.hema.ics 2021年第4期64卷 725-746页

作者： Yula. Wa.g Micha.l winkler Zha.yin Xia.g School of Science Xihua UniversityChengdu 610039China Institut für Ma.hema.ik Universität PaderbornPaderbom 33098Germany School of Ma.hema.ica. Sciences University of Electronic Science and Technology of ChinaChengdu 611731China

This pa.er dea.s with the Neuma.n initia.-bounda.y va.ue problem for a.cla.sica. chemota.is system with signa. consumption in a.*** contra.t to previous studies which ha.e esta.lished a.comprehensive theory of globa. cla.sica. solutions for suita.ly regula. nonnega.ive initia. da.a.the focus in the present work is on the question to which extent initia.ly prescribed singula.ities ca. be regula.ized despite the presence of the nonlinea. cross-diffusive *** ma.n result in this pa.er a.serts tha. a. lea.t in the fra.ework of ra.ia. solutions immedia.e regula.iza.ion occurs under a. essentia.ly optima. condition on the initia. distribution of the popula.ion *** precisely,it will turn out tha. for a.y ra.ia.ly symmetric initia. da.a.belonging to the spa.e of regula. signed Borel mea.ures for the popula.ion density a.d to L^(2) for the signa. density,there exists a.cla.sica. solution to the Neuma.n initia.-bounda.y va.ue problem,which is smooth a.d a.proa.hes the given initia. da.a.in a. a.propria.e tra.e sense.

关键词： chemota.is mea.ure va.ued initia. da.a insta.ta.eous smoothing globa. existence

a.Sma.lness Condition Ensuring Boundedness in a.Two-dimensiona. Chemota.is-Na.ier-Stokes System involving Dirichlet Bounda.y Conditions for the Signa.

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a.ta.Ma.hema.ica.Sinica.English Series 2022年第6期38卷 985-1001页

作者： Yu La. Wa.G Micha.l winkler Zha. Yin XIa.G School of Science Xihua UniversityChengdu 610039P.R.China Institut fur Ma.hema.ik Universitat Paderborn33098 PaderbornGermany School of Ma.hema.ica. Sciences University of Electronic Science and Technology of ChinaChengdu 611731P.R.China

The chemota.is-Na.ier-Stokes system{nt+u・∇n=Δn−∇・(n∇c),ct+u・∇c=Δc−nc,ut+(u・∇)u=Δu+∇P+n∇φ,∇・u=0is considered in a.smoothly bounded pla.a. doma.nΩunder the bounda.y conditions(∇n−n∇c)・ν=0,c=c,u=0,x∈∂Ω,t>0,with a.given nonnega.ive consta.t c_(*).It is shown tha. if(n_(0),c_(0),u_(0))is sufficiently regula. a.d such tha. the product||n_(0)||L^(1)(Ω)||c_(0)||^(2)L^(∞)(Ω)is suita.ly sma.l,a. a.socia.ed initia. va.ue problem possesses a.bounded cla.sica. solution with(n,c,u)|_(t=0)=(n_(0),c_(0),u_(0)).

关键词： Chemota.is Na.ier-Stokes system Dirichlet bounda.y condition