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CD5 expression promotes IL-10 production through activation of the MAPK/Erk pathway and upregulation of TRPC1 channels in B lymphocytes

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Cellular & Molecular Immunology 2018年第2期15卷 158-170页

作者： Soizic Garaud Taher E Taher Marjolaine Debant Miguel Burgos Sarra Melayah Christian Berthou Kaushal Parikh Jacques-Olivier Pers Damien Luque-Paz Gilles Chiocchia Maikel Peppelenbosch david a isenberg Pierre Youinou Olivier Mignen Yves Renaudineau Rizgar A Mageed INSERM ERI29/EA2216 réseau epigenetique and réseau canaux ioniques du Cancéropôle Grand OuestBrest University Medical SchoolBrest29609France Centre for Experimental Medicine and Rheumatology William Harvey Research InstituteBarts and the London School of Medicine and DentistryQueen Mary University of LondonLondonEC1M 6BQUK Canalopathy and Calcium Signaling INSERM UMR1078Brest29238France Centre for Experimental and Molecular Medicine Academic Medical CenterMeibergdreef 9Amsterdam1105 AZThe Netherlands Laboratory of Immunology and Immunotherapy CHU MorvanBrest29609France Institut Cochin INSERM U567Paris75014France Department of Gastroenterology and Hepatology Erasmus MCGravendijkwal 230Rotterdam015 CERotterdamThe Netherlands Centre for Rheumatology University College LondonLondonWC1E 6JFUK

CD5 is constitutively expressed on T cells and a subset of mature normal and leukemic B cells in patients with chronic lymphocytic leukemia(CLL).Important functional properties are associated with CD5 expression in B cells,including signal transducer and activator of transcription 3 activation,IL-10 production and the promotion of B-lymphocyte survival and ***,the pathway(s)by which CD5 influences the biology of B cells and its dependence on B-cell receptor(BCR)co-signaling remain *** this study,we show that CD5 expression activates a number of important signaling pathways,including Erk1/2,leading to IL-10 production through a novel pathway independent of BCR *** pathway is dependent on extracellular calcium(Ca2+)entry facilitated by upregulation of the transient receptor potential channel 1(TRPC1)*** also show that Erk1/2 activation in a subgroup of CLL patients is associated with TRPC1 *** this subgroup of CLL patients,small inhibitory RNA(siRNA)for CD5 reduces TRPC1 ***,siRNAs for CD5 or for TRPC1 inhibit IL-10 *** findings provide new insights into the role of CD5 in B-cell biology in health and disease and could pave the way for new treatment strategies for patients with B-CLL.

关键词： B cells calcium CD5 MAPK/Erk TRPC1

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Risk factors for clinical coronary events in patients with SLE:a multicentre case-control study

Risk factors for clinical coronary events in patients with S...

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The 8th International Congress on SLE

作者： Sahena Haque Donna Taylor-Fesler Caroline Gordon Veronica Toescu david isenberg Anisur Rahman Aubrey Bell Peter Lanyon Neil McHugh david GI Scott Paul Emery Lee Suan Teh Jacqueline Andrews Hazem Youssef Bridget Griffiths John McLaren Ian Bruce The University of Manchester Oxford RoadManchesterMI3 910 The University of Manchester Oxford RoadManchesterMI3 910 British Isles Lupus Assessment Group BSR Lupus Special Interest Group BSR Lupus Special Interest Group British Isles Lupus Assessment Group BSR Lupus Special Interest Group British Isles Lupus Assessment Group BSR Lupus Special Interest Group BSR Lupus Special Interest Group BSR Lupus Special Interest Group British Isles Lupus Assessment Group BSR Lupus Special Interest Group BSR Lupus Special Interest Group British Isles Lupus Assessment Group BSR Lupus Special Interest Group British Isles Lupus Assessment Group BSR Lupus Special Interest Group BSR Lupus Special Interest Group BSR Lupus Special Interest Group BSR Lupus Special Interest Group BSR Lupus Special Interest Group The University of Manchester Oxford RoadManchesterM139HJ British Isles Lupus Assessment Group BSR Lupus Special Interest Group

＜正＞Purpose:To identify risk factors（RF）for clinical coronary heart disease（CHD）in SLE and to study the role of traditional RF,SLE disease distribution,serology and therapy. Methods:This was a multicentre case,control *** recruited 48 SLE patients with verified clinical CHD （myocardial infarction or angina pectoris）and 78 SLE

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The Einstein-Scalar Field Constraints on Asymptotically Euclidean Manifolds

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Chinese Annals of Mathematics,Series B 2006年第1期27卷 31-52页

作者： Yvonne CHOQUET-BRUHAT James isenberg Daniel POLLACK Dedicated to the memory of Shiing-Shen Chern

By using the conformal method, solutions of the Einstein-scalar ficld gravitational constraint equations are obtained. Handling scalar fields is a bit more challenging than handling matter fields such as fluids, Maxwell fields or Yang-Mills fields, because the scalar field introduces three extra terms into the Lichnerowicz equation, rather than just one. The proofs are constructive and allow for arbitrary dimension （〉 2） as well as low regularity initial data.

关键词： Einstein-scalar field Constraints Asymptotically Euclidian

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Effects of polydimethylsiloxane membrane surface treatments on human uterine smooth muscle cell strain response

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Bioactive Materials 2024年第2期32卷 415-426页

作者： Elizabeth E.Marr Brett C.isenberg Joyce Y.Wong Boston University Division of Materials Science and EngineeringUnited States Charles Stark Draper Laboratory Bioengineering DivisionUnited States Boston University Department of Biomedical EngineeringUnited States

In the United States,1 in 10 infants are born *** majority of neonatal deaths and nearly a third of infant deaths are linked to preterm *** birth is initiated when the quiescent state of the uterus ends prematurely,leading to contractions and parturition beginning as early as 32 weeks,though the origins are not well *** enable research and discovery of therapeutics with potential to better address preterm birth,the capability to study isolated cell processes of pregnant uterine tissue in vitro is *** development of an in vitro model of the myometrium utilizing human uterine smooth muscle cells(uSMCs)responsible for contractions provides a methodology to examine cellular mechanisms of late-stage pregnancy potentially involved in preterm *** discuss culture of uSMCs on a flexible polydimethylsiloxane(PDMS)substrate functionalized with cationic poly-L-lysine(PLL),followed by extracellular matrix(ECM)protein *** work exploring uSMC behavior on PDMS substrates have utilized collagen-I coatings,however,we demonstrated the first exploration of human uSMC response to strain on fibronectin-coated flexible membranes,importantly reflecting the significant increase of fibronectin content found in the myometrial ECM during late-stage *** the model we developed,we conducted proof-of-concept studies to investigate the impact of substrate strain on uSMC cell morphology and gene *** was found that PLL and varied ECM protein coatings(collagen I,collagen III,and fibronectin)altered cell nuclei morphology and density on PDMS ***,varied strain rates applied to uSMC substrates significantly impacted uSMC gene expression of IL-6,a cytokine associated with instances of preterm *** results suggest that both surface and mechanical properties of in vitro systems impact primary human uSMC phenotype and offer uSMC culture methodologies that can be utilized to further the understanding of cellu

关键词： Uterine Myometrium Bioengineered in vitro models Strain Pregnancy Nuclei Interleukin 6 Preterm labor

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Gender and tachycardia： independent modulation of platelet reactivity in patients with atrial fibrillation

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Journal of Geriatric Cardiology 2016年第3期13卷 202-208页

作者： Nathan EK Procter Jocasta Ball Doan TM Ngo Jeffrey S isenberg Elaine M Hylek Yuliy Y Chirkov Simon Stewart John D Horowitz Basil Hetzel Institute for Translational Research Queen Elizabeth Hospital University of Adelaide Adelaide Australia National Health and Medical Research Council(HMRC) Centre of Research Excellence to Reduce Inequality in Heart Disease Mary MacKillop Institutefor Health Research Australian Catholic University Melbourne Australia Heart Lung Blood and Vascular Medicine Institute Division of Pulmonary Allergy and Critical Care Medicine Department University of Pittsburgh Pitts-burgh Pennsylvania USA Department of Medicine Boston University School of Medicine Boston Massachusetts USA

Background Female patients with atrial fibrillation （AF） experience increased risk of thromboembolism compared to males, an observation that is reflected by its inclusion in the CHA2DS2VASc score. New onset AF （often associated with tachycardia） also confers upon patients increased thromboembolic risk. The mechanisms underlying this risk are uncertain, but new onset AF is associated with profound impairment of platelet nitric oxide （NO） signalling. Given that cardiovascular responses to catecholamines are gender-dependent, and that the presence of tachycardia in new onset AF may represent a response to catecholaminergic stimulation, we explored the potential impact of gender and tachycardia on platelet aggregation and NO signalling. Methods Interactions were sought in 87 AF patients between the extent of adenosine diphosphate （ADP）-induced platelet aggregation, the anti-aggregatory effects of the NO donor, sodium nitroprusside, gender, and admission heart rate. The potential impact of platelet expression of thioredoxin-interacting protein （Txnip） was also evaluated. Results Analysis ofcovariance confLrmed the presence of physiological antagonism between platelet ADP and NO responses [F （1, 74） = 12.212, P 〈 0.01 ], while female sex correlated with impaired NO responses independent of platelet aggregability [F （2, 74） = 8.313, P 〈 0.01]. Admission heart rate correlated directly with platelet aggregation （r = 0.235, P 〈 0.05）, and inversely with NO response （r = -0.331, P 〈 0.01）. Txnip expression varied neither with gender nor with heart rate. Conclusions These results indicate, that gender and heart rate are independent determinants of platelet fimction. Prospective studies of the putative benefit of reversal of tachycardia on restoration of normal platelet function are therefore a priority.

关键词： Atrial fibrillation Gender Heart rate Nitric oxide Platelet aggregation

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Small bowel capsule endoscopy in patients with cardiac pacemakers and implantable cardioverter defibrillators:Outcome analysis using telemetry review

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World Journal of Gastrointestinal Endoscopy 2012年第3期4卷 87-93页

作者： Justin R Cuschieri Mohammed N Osman Richard CK Wong Amitabh Chak Gerard A isenberg Division of Gastroenterology Department of MedicineAlbert Einstein Medical Center5401 Old York RoadKlein building suite 363PhiladelphiaPA 19141United States Division of Cardiology Department of MedicineUniversity Hospitals Case Medical Center11100 Euclid AvenueClevelandOH 44106United States Division of Gastroenterology and Liver Disease Department of MedicineUniversity Hospitals Case Medical Center11100 Euclid AvenueClevelandOH 44016United States

AIM:To determine if there were any interactions between cardiac devices and small bowel capsules secondary to electromagnetic interference (EMI) in patients who have undergone small bowel capsule endoscopy (SBCE).METHODS:Authors conducted a chart review of 20 patients with a cardiac pacemaker (CP) or implantable cardioverter defibrillator (ICD) who underwent continuous electrocardiographic monitoring during their SBCE from *** searched for unexplained electrocardiogram (ECG) findings,changes in CP andICD set parameters,any abnormality in transmitted capsule data,and adverse clinical ***:There were no adverse events or hemodynamically significant arrhythmias *** and ICD set parameters were *** majority of ECG abnormalities were also found in pre-or post-SBCE ECG tracings and the CP behavior during arrhythmias appeared *** patients seemed to have episodes of undersensing by the ***,similar findings were documented in ECGs taken outside the time frame of the *** patient was observed to have a low signal encountered from the capsule resulting in lack of localization,but no images were ***:Capsule-induced EMI remains a possibility but is unlikely to be clinically *** interference of SBCE is also possible,but is infrequent and does not result in loss of images transmitted by the capsule.

关键词： Small bowel capsule endoscopy Cardiac pacemakers Implantable cardioverter defibrillators Electromagnetic interference Telemetry review

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准时制生产和先进的信息技术对工厂组织的影响

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国外石油机械 1995年第1期7卷 80-85页

作者：陈家巽 Randolf isenberg 中国石油天然气总公司重大项目办公室

剧烈的市场竞争要求机械制造企业建立新的生产战略,引入先进的信息技术。这对企业内部的组织机构、生产管理、以及企业与外部世界的关系都将产生巨大冲击。本文简要介绍了集中控制法(MRP)和准时制(JIT)两种生产战备的特点及其差别,论述... 详细信息

剧烈的市场竞争要求机械制造企业建立新的生产战略,引入先进的信息技术。这对企业内部的组织机构、生产管理、以及企业与外部世界的关系都将产生巨大冲击。本文简要介绍了集中控制法(MRP)和准时制(JIT)两种生产战备的特点及其差别,论述了JIT生产制对企业生产组织和工作人员提出的新要求,介绍了一些优化生产的系统。

关键词：工厂管理计算机管理信息计划

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