检索结果-南通市图书馆

中国晶体学会第六届学术年会暨会员代表大会（大分子晶体学分会）

作者： Qinyu Zhu david venzke Ameya S.Walimbe Mary E.Anderson Qiuyu Fu Lisa Kinch Wei Wang Xing Chen Nick Grishin Niu Huang Liping Yu Jack E.Dixon Kevin P.Campbell Junyu Xiao The State Key Laboratory of Protein and Plant Gene Research School of Life SciencesAcademy for Advanced Interdisciplinary StudiesPeking-Tsinghua Center for Life SciencesPeking University Howard Hughes Medical Institute Department of Molecular Physiology and BiophysicsDepartment of NeurologyDepartment of Internal MedicineUniversity of Iowa Roy J.and Lucille A.Carver College of Medicine National Institute of Biological Sciences Beijing Department of Biophysics University of TexasSouthwestern Medical Center Beijing National Laboratory for Molecular Sciences College of Chemistry and Molecular EngineeringPeking-Tsinghua Center for Life SciencesSynthetic and Functional Biomolecules CenterKey Laboratory of Bioorganic Chemistry and Molecular Engineering of Ministry of EducationPeking University Medical Nuclear Magnetic Resonance Facility University of Iowa Roy J.and Lucille A.Carver College of Medicine Department of Pharmacology Department of Cellular and Molecular MedicineDepartment of Chemistry and BiochemistryUniversity of California

The"pseudokinase"Sg K196 is a protein O-mannose kinase(POMK)that catalyzes an essential phosphorylation step during biosynthesis of the laminin-binding glycan ***,the catalytic mechanism underlying this activity remains *** we present the crystal structure of Danio rerio POMK in complex with Mg ions,ADP,aluminum fluoride,and

关键词：

来源： cnki会议评论

在线全文

cnki会议

学校读者我要写书评

暂无评论

Synthesis and PAMPA Permeability Assay of New Sulfonyl Hydrazone Derivatives

引用

Journal of Biosciences and Medicines 2019年第9期7卷 111-120页

作者： Luiz Felipe Schmitz de Souza Tiago Tizziani Larissa Sens Dalila venzke Inê s Maria Costa Brighente Moacir Geraldo Pizzolatti Ricardo José Nunes Laborató rio Estrutura e Atividade Departamento de Qu&iacute mica LEAT-CFM-UFSC Universidade Federal de Santa Catarina Campus Trindade Florian&oacute polis SC Brazil Laborató rio de Quí mica de Produtos Naturais Departamento de Qu&iacute mica LQPN-CFM-UFSC Universidade Federal de Santa Catarina Campus Trindade Florian&oacute polis SC Brazil

This work describes the synthesis of seven new sulfonyl hydrazones, which were proposed from the general structure of acyl hydrazones and 2,4-dinitrosulfonamides. Sulfonyl hydrazones are a class of compounds known to exhibit a wide range of biological activity. In this sense, the study of the pharmacokinetic properties of the bioactive molecules is of extreme importance;therefore, in this article the permeability of these compounds with in vitro PAMPA assay mimetizing the permeability through the gastrointestinal tract as well as lipophilicity through miLogP was investigated. All compounds presented good permeability results;it was possible to make a structure-activity relationship with the obtained results and a comparison between the results.

关键词： Sulfonyl Hydrazones PAMPA Permeability Organic Synthesis Medicinal Chemistry

来源：

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

欢迎您,

建议与咨询留下您的常用邮箱和电话号码，以便我们向您反馈解决方案和替代方法

时间限定

文献类型

馆藏选择

核心期刊

语言

文献类型

帮助

文字说明：

检索规则说明：

检索范例：

分类表

所选分类

限定检索结果

文献类型

馆藏范围

日期分布

学科分类号

主题

机构

作者

语言

在线全文

在线全文

请选择保存的检索档案：

请选择收藏分类：

通借通还

欢迎您,

建议与咨询 留下您的常用邮箱和电话号码，以便我们向您反馈解决方案和替代方法

时间限定

文献类型

馆藏选择

核心期刊

语言

文献类型

帮助

文字说明：

检索规则说明：

检索范例：

分类表

所选分类

限定检索结果

文献类型

馆藏范围

日期分布

学科分类号

主题

机构

作者

语言

在线全文

在线全文

请选择保存的检索档案： 新增检索档案 确定 取消

请选择收藏分类： 新增自定义分类 确定 取消

通借通还

建议与咨询留下您的常用邮箱和电话号码，以便我们向您反馈解决方案和替代方法

请选择保存的检索档案：

请选择收藏分类：