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化学位移张量及分子结构的关联(英文)

化学位移张量及分子结构的关联(英文)

第八届全国波谱学学术会议

作者： david m.grant Department of Chemistry University of UtahSalt Lake CityUtah 84112

＜正＞The chemical shift tensor,obtained in solid state NmR,reflects the electronic structure of molecules and is very sensitive to small variations in atomic *** relationship between NmR resonance frequencies and mol...

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甲基葡糖苷中的C-13化学位移张量（英文）

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甲基葡糖苷中的C-13化学位移张量（英文）

第八届全国波谱学学术会议

作者：刘芳 Julio Facelli D.W.Alderman david m.grant Department of Chemistry University of UtahSalt Lake CityUtah 84112

＜正＞A two-dimensional chemical shift correlation technique has been used to measure the complete carbon-13 chemical shift tensors in single crystals of methylα-D- glucopyranoside,methylβ-D-glucopyranoside,methylα...

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2D-INADEQUATE谱的自动分析（英文）

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2D-INADEQUATE谱的自动分析（英文）

第八届全国波谱学学术会议

作者： Charles L.mayne Reinhard Dunkel Ronald J.Pugmire david m.grant University of Utah Department of Chemistry and Fuels Engineering

＜正＞Structure elucidation of natural products has become an important application of *** one- and two-dimensional techniques are routinely applied to this ***,the 2D-INADEQUATE experiment is seldom used because the ...

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用魔角慢旋转的多维谱学(英文)

用魔角慢旋转的多维谱学(英文)

第八届全国波谱学学术会议

作者：胡建治 D.W.Alderman 叶朝辉 R.J.Pugmire david m.grant Department of Chemistry University of Utah Salt Lake CityUtah 84112 U.S.A.and Wuhan Institute of Physics ChineseAcademy of SciencesP.O.Box 71010Wuhan 430071 China

＜正＞By spinning the sample about an angle at the magic angle relativc to the magnetic field at a rate larger than the width of the chemical shift anisotropy （CSA）,a solution-like high resolution isotropic chemical...

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天然产物结构的核磁共振法测定：二维INADEQUATE方法(英文)

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天然产物结构的核磁共振法测定：二维INADEQUATE方法(英文)

第八届全国波谱学学术会议

作者：李笃 Charles L．mayne Noel L．Owen Ronald J．Pugmire david m.grant 兰州大学化学系 University of Utah Salt Lake CityUtah 84112USA

尽管自二维NmR技术问世以来分子结构的NmR研究已发生了重大的变化,但迄今所报导的大多数天然产物结构的阐明仍在很大程度上依赖于研究者的化学知识及经验判断。与此相对应,本文讨论一种严格的非经验NmR结构测定手法,并以多个天然产物(E-...

尽管自二维NmR技术问世以来分子结构的NmR研究已发生了重大的变化,但迄今所报导的大多数天然产物结构的阐明仍在很大程度上依赖于研究者的化学知识及经验判断。与此相对应,本文讨论一种严格的非经验NmR结构测定手法,并以多个天然产物(E-21,B-1,PT-2等,分子量在200-1100之间)结构的测定及H,C谱全归属为例证。此手法强调耦合信息、特别是二维INADEQUATE实验方法的利用,同时配合由NmR实验信息导引的分子模拟计算(molecular modeling)以给出分子立体结构。

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The role of N-glycosylation in cancer

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Acta Pharmaceutica Sinica B 2024年第3期14卷 1098-1110页

作者： Yu Lin david m.Lubman Department of Surgery University of Michigan Medical CenterAnn ArborMI 48109USA

Despite advances in understanding the development and progression of cancer in recent years,there remains a lack of comprehensive characterization of the cancer *** play an important role in medicine and are involved in various human disease conditions including ***-moieties participate in fundamental cancer processes like cell signaling,invasion,angiogenesis,and *** N-glycosylation significantly impacts cancer processes and targeted therapies in ***,understanding N-glycosylation in a tumor is essential for comprehending disease progression and discovering anti-cancer targets and biomarkers for therapy monitoring and *** review presents the fundamental process of protein N-glycosylation and summarizes glycosylation changes in tumor cells,including increased terminal sialylation,N-glycan branching,and ***,the role of N-glycosylation in tumor signaling pathways,migration,and metabolism are *** and glycopeptides as potential biomarkers for early detection of cancer based on site specificity have been ***,understanding and exploring the cancer glycoproteome,along with its role in medicine,implication in cancer and other human diseases,highlights the significance of N-glycosylation in tumor processes,necessitating further research for potential anticancer targets and biomarkers.

关键词： N-Glycosylated proteins Cancer signaling Cancer angiogenesis Cancer metabolism Cancer biomarkers

Evaluation of hand infections in the emergency department using point-of-care ultrasound

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World Journal of Emergency medicine 2024年第4期15卷 283-288页

作者： david Ahmad Haidar david mintz Brandon m Wubben Omar Rizvi Srikar Adhikari Department of Emergency medicine Michigan MedicineAnn Arbor 48109-1382USA University of Arizona College of medicine Tucson 85724USA Department of Emergency medicine University of IowaIowa City 52242-1009USA Department of Surgery University of Arizona College of MedicineTucson 85724USA Department of Emergency medicine University of Arizona College of MedicineTucson 85724USA

BACKGROUND:We aimed to evaluate the utility of point-of-care ultrasound(POCUS)in the assessment of hand infections that present to the emergency department(ED)and its impact on medical decision making and patient ***:We conducted a retrospective review of patients who presented to two urban academic EDs with clinical presentations concerning for skin and soft tissue infections(SSTI)of the hand between December 2015 and December *** trained POCUS fellowship physicians reviewed an ED POCUS database for POCUS examinations of the *** then reviewed patients’electronic health records(EHR)for demographic characteristics,history,physical examination findings,ED course,additional imaging studies,consultations,impact of POCUS on patient care and final ***:We included a total of 50 cases(28 male,22 female)in the final *** most common presenting symptoms and exam findings were pain(100%),swelling(90%),and erythema(74%).The most common sonographic findings were edema(76%),soft tissue swelling(78%),and fluid surrounding the tendon(57%).POCUS was used in medical decision making 68%of the time(n=34),with the use of POCUS leading to changes in management 38%of the time(n=19).POCUS use led to early antibiotic use(11/19),early consultation(10/19),and led to the performance of a required procedure(8/19).The POCUS diagnosis was consistent with the discharge diagnosis of flexor tenosynovitis 8/12 times,abscess 12/16 times,and cellulitis 14/20 ***:POCUS is beneficial for evaluating of hand infections that present to the ED and can be used as an important part of medical decision making to expedite patient care.

关键词： Ultrasound Point-of-care ultrasound Cellulitis Abscess Flexor tenosynovitis

mitochondrial recruitment in myelin:an anchor for myelin dynamics and plasticity?

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Neural Regeneration Research 2024年第7期19卷 1401-1402页

作者： Jean-david m.Gothié Timothy E.Kennedy Department of Neurology and Neurosurgery Montreal Neurological InstituteMcGill UniversityMontrealQCCanada

Optimal propagation of neuronal electrical impulses depends on the insulation of axons by myelin,produced in the central nervous system by *** is an extension of the oligodendrocyte plasma membrane,which wraps around an axon to form a compact multi-layered *** is composed of a substantially higher proportion of lipids compared to other biological membranes and enriched in a small number of specialized proteins.

关键词： plasticity insulation dynamics

Oryza CLImtools:A genome–environment association resource reveals adaptive roles for heterotrimeric G proteins in the regulation of rice agronomic traits

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Plant Communications 2024年第4期5卷 145-165页

作者： Angel Ferrero-Serrano david Chakravorty Kobie J.Kirven Sarah m.Assmann Biology Department Pennsylvania State University208 Mueller LaboratoryUniversity ParkPA 16802USA Intercollege Graduate Degree Program in Bioinformatics and Genomics Pennsylvania State University208 Mueller LaboratoryUniversity ParkPA 16802USA

modern crop varieties display a degree of mismatch between their current distributions and the suitability of the local climate for their *** address this issue,we present Oryza CLImtools(https://***/CLImtools/oryza_v1.0/),thefirst resource for pan-genome prediction of climate-associated genetic variants in a crop *** CLImtools consists of interactive web-based databases that enable the user to(1)explore the local environments of traditional rice varieties(landraces)in South-East Asia and(2)investigate the environment by genome associations for 658 Indica and 283 Japonica rice landrace accessions collected from georeferenced local environments and included in the 3K Rice Ge-nomes *** demonstrate the value of these resources by identifying an interplay betweenflowering time and temperature in the local environment that is facilitated by adaptive natural variation in OsHD2 and disrupted by a natural variant in *** quantitative trait locus analysis has suggested the impor-tance of heterotrimeric G proteins in the control of agronomic ***,we analyzed the climate associations of natural variants in the different heterotrimeric G protein *** identified a coordi-nated role of G proteins in adaptation to the prevailing potential evapotranspiration gradient and revealed their regulation of key agronomic traits,including plant height and seed and panicle *** conclude by highlighting the prospect of targeting heterotrimeric G proteins to produce climate-resilient crops.

关键词： Oryza sativa rice G by E adaptation flowering time GWAS OsHD2 OsSOC1 heterotrimeric G pro-tein OsRGA1 d1 OsGS3 OsDEP1 OsGGC2