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Comparison of four scanning mobility particle sizers at the Fresno Supersite

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Particuology 2011年第3期9卷 204-209页

作者： John G. Watson Judith C. Chow david A. Sodeman Douglas H. Lowenthal M.-C. Oliver chang kihong Park Xiaoliang Wang Desert Research Institute 2215 Raggio Parkway Reno NV 89512 USA Institute of Earth Environment Chinese Academy of Sciences 10 Fenghui South Road Xi'an High Tech Zone Xi'an 710075 China San Diego Air Pollution Control District San Diego CA USA. California Air Resources Board El Monte CA USA. Gwangju Institute of Science and Technology Gwangju Korea.

Size distributions of ambient aerosols at the Fresno Supersite were measured with four commercially available scanning mobility particle sizers （SMPS）. TSI nano, TSI standard, Grimm, and MSP instruments were collocated at the Fresno Supersite and particle size distributions were measured continuously from August 18 through September 18, 2005. For particles with diameters between 10 and 200 nm, differences among hourly-average ambient particle concentrations ranged from 0% between the TSI nano and Grimm in the 30-50 nm size range to 39% between the Grimm and MSP in the 10-30 nm size range. MSP concentrations were 10-33% lower than those measured with the TSI standard for particles smaller than 200 nm. The TSI nano and TSI standard agreed to within 5% in their overlapping size range （10-84 nm）. The TSI nano and Grimm agreed to within 40% for 5-10 nm particles.

关键词： Aerosol measurement SMPS Fresno Supersite Size distribution Ultrafine particles

Efficacy of adjuvant XELOX and FOLFOX6 chemotherapy after D2 dissection for gastric cancer

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World Journal of Gastroenterology 2013年第21期19卷 3309-3315页

作者： Ying Wu Zhe-Wei Wei Yu-Long He Roderich E Schwarz david D Smith Guang-kai Xia chang-Hua Zhang Department of Gastrointestinopancreatic Surgery of the FirstAffiliated Hospital of Sun Yat-Sen University Gastric Cancer Center of Sun Yat-Sen University IU Health Goshen Center for Cancer Care Indiana UniversityGoshenIN 46526United States Division of Biostatistics City of Hope National Medical CenterDuarteCA91010United States

AIM: To compare the efficacy of capecitabine and oxaliplatin (XELOX) with 5-fluorouracil, folinic acid and oxaliplatin (FOLFOX6) in gastric cancer patients after D2 dissection. METHODS: Between May 2004 and June 2010, patients in our gastric cancer database who underwent D2 dissection for gastric cancer at the First Affiliated Hospital of Sun Yat-Sen University were retrospectively analyzed. A total of 896 patients were enrolled into this study according to the established inclusion and exclusion criteria. Of these patients, 214 received the XELOX regimen, 48 received FOLFOX6 therapy and 634 patients underwent surgery only without chemotherapy. Overall survival was compared among the three groups using Cox regression and propensity score matchedpair analyses. RESULTS: Patients in the XELOX and FOLFOX6 groups were younger at the time of treatment (median age 55.2 years; 51.2 years vs 58.9 years), had more undifferentiated tumors (70.1%; 70.8% vs 61.4%), and more lymph node metastases (80.8%; 83.3% vs 57.7%), respectively. Overall 5-year survival was 57.3% in the XELOX group which was higher than that (47.5%) in the surgery only group (P = 0.062) and that (34.5%) in the FOLFOX6 group (P = 0.022). Multivariate analysis showed that XELOX therapy was an independent prognostic factor (hazard ratio = 0.564, P < 0.001). After propensity score adjustment, XELOX significantly increased overall 5-year survival compared to surgery only (58.2% vs 44.2%, P = 0.025) but not compared to FOLFOX6 therapy (48.5% vs 42.7%, P = 0.685). The incidence of grade 3/4 adverse reactions was similar between the XELOX and FOLFOX6 groups, and more patients suffered from hand-foot syndrome in the XELOX group (P = 0.018). CONCLUSION: Adjuvant XELOX therapy is associated with better survival in patients after D2 dissection, but does not result in a greater survival benefit compared with FOLFOX6 therapy.

关键词： Gastric cancer D2 dissection Adjuvant Capecitabine and oxaliplatin 5-fluorouracil, folinic acid and oxaliplatin

Acute cerebrovascular disease following COVID-19: a single center, retrospective, observational study

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Stroke & Vascular Neurology 2020年第3期5卷 279-284页

作者： Yanan Li Man Li Mengdie Wang Yifan Zhou Jiang chang Ying Xian david Wang Ling Mao Huijuan Jin Bo Hu Department of Neurology Union Hospital Tongji Medical CollegeHuazhong University of Science and TechnologyWuhanChina Department of Epidemiology and Biostatistics Key Laboratory for Environment and HealthSchool of Public HealthTongji Medical CollegeHuazhong University of Science and TechnologyWuhanChina Duke Clinical Research Institute and Department of Neurology Duke University Medical CenterDurhamNorth CarolinaUSA Neurovascular Division Department of NeurologyBarrow Neurological Institute/Saint Joseph Hospital Medical CenterPhoenixArizonaUSA

Background and purpose COVID-19 is an infectious disease caused by Severe Acute Respiratory Syndrome Coronavirus 2(SARS-CoV-2).Apart from respiratory complications,acute cerebrovascular disease(CVD)has been observed in some patients with ***,we described the clinical characteristics,laboratory features,treatment and outcomes of CVD complicating SARS-CoV-2 *** and methods Demographic and clinical characteristics,laboratory findings,treatments and clinical outcomes were collected and *** characteristics and laboratory findings of patients with COVID-19 with or without new-onset CVD were *** Of 219 patients with COVID-19,10(4.6%)developed acute ischaemic stroke and 1(0.5%)had intracerebral ***-19 with new onset of CVD were significantly older(75.7±10.8 years vs 52.1±15.3 years,pkely to present with severe COVID-19(81.8%vs 39.9%,pkely to have cardiovascular risk factors,including hypertension,diabetes and medical history of CVD(all pkely to have increased inflammatory response and hypercoagulable state as reflected in C reactive protein(51.1(1.3-127.9)vs 12.1(0.1-212.0)mg/L,pke;6 received antiplatelet treatment with aspirin or clopidogrel;and 3 of them *** other four patients received anticoagulant treatment with enoxaparin and 2 of them *** of 24 March 2020,six patients with CVD died(54.5%).Conclusion Acute CVD is not uncommon in *** findings suggest that older patients with risk factors are more likely to develop *** development of CVD is an important negative prognostic factor which requires further study to identify optimal management strategy to combat the COVID-19 outbreak.

关键词： Acute acute likely

神农架国家公园居民可持续旅游感知空间分异及影响机理研究

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长江流域资源与环境 2021年第12期30卷 2854-2865页

作者：龚箭刘畅 david knight 华中师范大学城市与环境科学学院湖北武汉430079 华中师范大学中国旅游研究院武汉分院湖北武汉430079 地理过程分析与模拟湖北省重点实验室湖北武汉430079 科罗拉多州立大学人文资源系科罗拉多州柯林斯堡80523-1024

在我国生态文明建设的背景下,国家公园已成为我国自然保护地管理体系改革的重中之重。居民作为国家公园的核心利益相关者,是自然生态系统保护的主体,也是可持续旅游发展的关键。通过引入可持续旅游棱镜模型,构建居民可持续感知与支持度... 详细信息

在我国生态文明建设的背景下,国家公园已成为我国自然保护地管理体系改革的重中之重。居民作为国家公园的核心利益相关者,是自然生态系统保护的主体,也是可持续旅游发展的关键。通过引入可持续旅游棱镜模型,构建居民可持续感知与支持度的结构关系模型。以神农架国家公园3个典型社区(木鱼、红坪、下谷坪土家族乡)为研究对象,对不同空间区位社区居民的可持续感知差异及影响机理进行探讨。研究发现:(1)相较于旅游经济影响感知在过渡及边缘社区发挥主导作用,政策制度影响感知在核心社区成为影响居民满意度的关键因素;(2)国家公园建设对居民的生活质量和环境认知产生显著影响,并表现出明显的地域分异;(3)旅游发展满意度对支持度有显著正向影响,且满意度的中介效用随距离增加而衰减;(4)国家公园社区居民可持续评价的空间分异呈现出独特规律。即核心区和边缘区的经济和社会文化影响感知均高于过渡区;而环境和制度影响感知则由核心区向边缘区递增。为此,在神农架国家公园建设过程中,应全面衡量旅游发展效果,注重居民核心诉求,健全社区参与机制。要完善利益分配制度,将发展成果惠及所有居民。同时通过差异化社区发展路径,提高所有居民对旅游发展的认可和支持。

关键词：居民可持续旅游感知空间分异神农架国家公园

Selective serotonin reuptake inhibitors in the treatment of premature ejaculation

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Chinese Medical Journal 2007年第11期120卷 1000-1006页

作者： WANG Wei-fu chang Le Suks Minhas david J Ralph Department of Urology People＇s Hospital of Hainan Province Haikou 570311 China Department of Gynaecology People＇s Hospital of Hainan Province Haikou 570311China St Peter＇s Department of Andrology Institute of Urology Middlesex Hospital UCL London UK W1T 3AA

Objective To review and assess the update studies regarding selective serotonin reuptake inhibitors （SSRIs） in the treatment of premature ejaculation （PE） and then provide practical recommendations and possible mechanisms concerning state of the art knowledge for the use of SSRIs in alleviating PE. Data sources Using the Medline, 48 articles published from January 1st, 1996 to August 1st, 2006 concerning the use of SSRIs and their possible mechanisms in alleviating PE were found and reviewed. Study selection PE, rapid ejaculation, early ejaculation and SSRIs were employed as the keywords, and relevant articles about the use of SSRIs and their possible mechanisms in the treatment of PE were selected. Results Many kinds of SSRIs, such as fluoxetine, sertraline, paroxetine and citalopram, have widely been employed to treat PE. However, their effects are moderate and there is no a universal agreement about the kind, dose, protocol and duration. Dapoxetine, as the first prescription treatment of PE, may change this bottle-neck situation. SSRIs are suggested to be used in young men with lifelong PE, and acquired PE when etiological factors are removed but PE still exists. Phosphodiesterase 5 inhibitors （PDE5-ls） are suggested to be employed alone or combined with SSRIs when SSRIs fail to treat PE or sexual dysfunction associated with SSRIs occurs. The protocol of taking drugs on demand based on taking them daily for a suitable period is proposed to be chosen firstly. The possible mechanisms include increasing serotonergic neurotransmission and activating 5-hydroxytryptamine 2C （5-HT2c） receptors, then switching the ejaculatory threshold to a higher level, decreasing the penile sensitivity and their own effect of antidepression. Conclusion The efficacies of the current SSRIs are moderate in the treatment of PE and they have not been approved by the FDA, therefore new SSRI like dapoxetine needs to be further evaluated.

关键词： premature ejaculation selective serotonin reuptake inhibitions

基于网络药理学和分子对接探讨丹红注射液治疗急性心肌梗死的作用机制

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中国临床药理学杂志 2024年第5期40卷 668-672页

作者：柯昌虎吴亚晴黄慧敏严慧湖北医药学院附属国药东风总医院药学部湖北十堰442008 湖北医药学院附属国药东风总医院实验中心湖北十堰442008 湖北医药学院附属国药东风总医院妇产科湖北十堰442008 湖北医药学院药学院湖北十堰442000

目的利用网络药理学和分子对接探讨丹红注射液治疗急性心肌梗死的分子机制。方法通过中药系统药理学数据库和分析平台(TCMSP)检索丹红注射液的化学成分,借助Swiss Target Prediction数据库获取药物成分对应的相关靶点;在人类基因数据... 详细信息

目的利用网络药理学和分子对接探讨丹红注射液治疗急性心肌梗死的分子机制。方法通过中药系统药理学数据库和分析平台(TCMSP)检索丹红注射液的化学成分,借助Swiss Target Prediction数据库获取药物成分对应的相关靶点;在人类基因数据库(GeneCards)、在线人类孟德尔遗传数据库(OMIM)和基因疾病关联数据库(DisGeNET)中检索急性心肌梗死的相关靶点;利用Venny 2.1在线软件获取药物与疾病的共同靶点;由Cytoscape 3.8.2绘制药物-成分-靶点-疾病网络;应用STRING数据库构建蛋白相互作用网络;借助注释、可视化和集成发现数据库(david)进行基因本体论(GO)功能富集与京都基因和基因组百科全书(kEGG)通路富集分析;运用AutoDock软件对关键的活性成分和作用靶点进行分子对接验证。结果丹红注射液中63个有效成分通过调控137个靶点和132条通路对急性心肌梗死产生作用,紫丹参素C、木犀草素、黄芩素、香紫苏醇、山柰酚、槲皮万寿菊素等成分可以通过肿瘤坏死因子、外消旋-α丝氨酸/苏氨酸蛋白激酶、白细胞介素1β、类固醇受体共激活因子、丝裂原活化蛋白激酶3、信号转导和转录激活因子3等关键靶点介导C型凝集素受体、肿瘤坏死因子、内分泌抵抗、催乳素、磷脂酰肌醇-3-激酶-丝氨酸/苏氨酸蛋白激酶、Janus激酶-信号传导和转录激活因子等信号通路来治疗急性心肌梗死。分子对接结果显示靶点蛋白与活性成分具有较好的结合能力。结论丹红注射液可以通过多成分、多靶点、多途径参与急性心肌梗死的治疗,为其临床应用及其治疗急性心肌梗死的机制深入研究提供了理论依据。

关键词：丹红注射液急性心肌梗死网络药理学分子对接作用机制

Effects of water-based binders on electrochemical performance of manganese dioxide cathode in mild aqueous zinc batteries

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Carbon Energy 2021年第3期3卷 473-481页

作者： Hee Jung chang Ismael A.Rodriguez-Pere Matthew Fayette Nathan L.Canfield Huilin Pan Daiwon Choi Xiaolin Li david Reed Energy&Environment Directorate Pacific Northwest National Laboratory(PNNL)RichlandWashingtonUSA

In the majority of rechargeable batteries including lithium-ion batteries,polyvinylidene fluoride(PVdF)binders are the most commonly used binder for both anode and ***,using PVdF binder requires the organic solvent of N-methyl-2-pyrrolidone which is expensive,volatile,combustible,toxic,and has poor ***,switching to aqueous electrode processing routes with non-toxic binders would provide a great leap forward towards the realization of ideally fully sustainable and environmentally friendly electrochemical energy storage *** water-soluble binders(aqueous binders)were characterized and compared to the performance of conventional *** study demonstrates that the electrochemical performance of Zn/MnO_(2) aqueous batteries is significantly improved by using sodium carboxymethyl cellulose(CMC)*** addition,CMC binders offer desirable adhesion,good wettability,homogeneous material distribution,and strong chemical stability at certain pH levels(3.5-5)without any decomposition for long-cycle life.

关键词： aqueous batteries binder carboxymethyl cellulose cost-effective systems PVdF zinc batteries

Polarization-induced photocurrent switching effect in heterojunction photodiodes

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Nano Research 2023年第4期16卷 5503-5510页

作者： Dingbo Chen Yu-chang Chen Guang Zeng Yu-Chun Li Xiao-Xi Li Dong Li Chao Shen Nan Chi Boon S.Ooi david Wei Zhang Hong-Liang Lu State key Laboratory of ASIC and System Shanghai Institute of Intelligent Electronics&SystemsSchool of MicroelectronicsFudan UniversityShanghai 200433China key Laboratory for Information Science of Electromagnetic Waves Department of Communication Science and EngineeringFudan UniversityShanghai 200433China Photonics Laboratory Division of ComputerElectricaland Mathematical Sciences and EngineeringKing Abdullah University of Science and Technology(KAUST)Thuwal 23955-6900Kingdom of Saudi Arabia

The unipolar photocurrent in conventional photodiodes(PDs)based on photovoltaic effect limits the output modes and potential versatility of these devices in *** photodiodes with photocurrent switching are emerging as a promising solution for obtaining photoelectric devices with unique and attractive functions,such as optical logic ***,we design an all-solid-state chip-scale ultraviolet(UV)PD based on a hybrid GaN heterojunction with engineered bipolar polarized electric *** introducing the polarization-induced photocurrent switching effect,the photocurrent direction can be switched in response to the wavelength of incident light at 0 V *** particular,the photocurrent direction exhibits negative when the irradiation wavelength is less than 315 nm,but positive when the wavelength is longer than 315 *** device shows a responsivity of up to−6.7 mA/W at 300 nm and 5.3 mA/W at 340 nm,*** particular,three special logic gates in response to different dual UV light inputs are demonstrated via a single bipolar PD,which may be beneficial for future multifunctional UV photonic integrated devices and systems.

关键词： GaN heterostructure ultraviolet(UV)photodiodes bipolar photocurrent optical logic device

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3D打印水凝胶支架在宫腔粘连防治中的应用

国际妇产科学杂志 2024年第3期51卷 290-297页

作者：史明孙铭辉杨微微黄慧华张昌林邓宇斌中山大学附属第七医院科研中心广东省深圳市518107 中山大学医学院中山大学附属第七医院妇产科深圳市中药活性物质筛选与转化研究重点实验室

宫腔粘连(intrauterine adhesion,IUA)常易引发停经、不孕和复发性流产等问题,严重影响女性身心健康。临床上,对IUA的治疗主要采用手术分离方式,术后易复发,治疗效果欠佳。3D生物打印支架成为治疗IUA的前沿领域,可分隔受损区域防止粘连... 详细信息

宫腔粘连(intrauterine adhesion,IUA)常易引发停经、不孕和复发性流产等问题,严重影响女性身心健康。临床上,对IUA的治疗主要采用手术分离方式,术后易复发,治疗效果欠佳。3D生物打印支架成为治疗IUA的前沿领域,可分隔受损区域防止粘连形成,体内可控降解无需手术取出。该支架可用于药物负载、干细胞移植及外泌体的递送,可将药物或生长因子释放到损伤区域,促进组织修复与再生。将负载干细胞或干细胞外泌体的3D打印水凝胶移植到损伤区域,可有效促进IUA的修复并改善妊娠率。3D生物打印可为患者提供个体化治疗方案,联合干细胞或干细胞外泌体的治疗策略有望成为治疗IUA的有力工具。

关键词：宫腔粘连打印,三维干细胞治疗子宫内膜修复