检索结果-南通市图书馆

Low-radiation and high image quality coronary computed tomography angiography in “real-world” unselected patients

在线全文

学校读者我要写书评

暂无评论

World Journal of Radiology 2018年第10期10卷 135-142页

作者： Caryl Elizabeth Richards Stephen Dorman Patricia John Anthony Davies Sharon evans Tishi Ninan david Martin Sriranj Kannoly gail Roberts-Davies Mark Ramsey Daniel Rhys Obaid Swansea University Medical School Swansea University Department of Cardiology Morriston Hospital Department of Radiology Morriston Hospital Department of Radiology Singleton Hospital Department of Cardiology Singleton Hospital

AIM To determine the radiation dose and image quality in coronary computed tomography angiography(CCTA)using state-of-the-art dose reduction methods in unselected"real world"*** In this single-centre study,consecutive patients in sinus rhythm underwent CCTA for suspected coronary artery disease(CAD)using a 320-row detector CT *** patients underwent the standard CT acquisition protocol at our institute(Morriston Hospital)a combination of dose saving advances including prospective electrocardiogram-gating,automated tube current modulation,tube voltage reduction,heart rate reduction,and the most recent novel adaptive iterative dose reconstruction 3D(AIDR3D)*** cohort comprised real-world patients for routine CCTA who were not selected on age,body mass index,or heart *** image quality was graded on a 4-point scale(4=excellent,1=non-diagnostic).RESULTS A total of 543 patients were included in the study with a mean body weight of 81±18 kg and a pre-scan mean heart rate of 70±11 beats per minute(bpm).When indicated,patients received rate-limiting medication with an oral beta-blocker followed by additional intravenous beta-blocker to achieve a heart rate below 65 *** median effective radiation dose was 0.88 mSv(IQR,0.6-1.4 mSv)derived from a Dose Length Product of61.45 ***(IQR,42.86-100.00 ***).This also includes what we believe to be the lowest ever-reported radiation dose for a routine clinical CCTA(0.18 mSv).The mean image quality(SD)was 3.65±0.61,with a subjective image quality score of 3("good")or above for 93%of patient *** Combining a low-dose scan protocol and AIDR3D with a 320-detector row CT scanner can provide high quality images at exceptionally low radiation dose in unselected patients being investigated for CAD.

关键词： Effective radiation dose Tube voltage Tube current Iterative reconstruction Coronary computed tomography angiography Image quality Prospectively electrocardiogram gating

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Vaughan ***爵士(1952-2020)

数学译林 2021年第3期40卷 262-263,245页

作者： david evans Sorin Popa 马雨湫(译) 陆柱家(校) 英国威尔士Cardif大学洛杉矶加州大学不详

由于严重耳部感染后的并发症,Vaughan Jones(琼斯)爵士于2020年9月6日去世,享年67岁.他是一位富有灵感和启发性的数学家,具有非凡的原创性和广度.他持久的工作,涉猎了数学的几个完全不同的领域,从算子代数分析到低维拓扑,统计力学和量... 详细信息

由于严重耳部感染后的并发症,Vaughan Jones(琼斯)爵士于2020年9月6日去世,享年67岁.他是一位富有灵感和启发性的数学家,具有非凡的原创性和广度.他持久的工作,涉猎了数学的几个完全不同的领域,从算子代数分析到低维拓扑,统计力学和量子场论,这些工作产生了重大影响和意想不到的惊人应用。

关键词：统计力学算子代数量子场论原创性 Jones 爵士启发性

Cu-DNAzyme facilitates highly sensitive immunoassay

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Chinese Chemical Letters 2019年第9期30卷 1652-1654页

作者： Zhi Shan Mingsheng Lyu Dennis Curry david Oakley Ken Oakes Xu Zhang Verschuren Centre for Sustainability in Energy & the Environment Cape Breton University Sydney Now Scotia B1P 612 Canada College of Life Science Sichuan Agriculture University Yaan 625014 China Jiangsu Key Laboratory of Marine Bioresources and Environment Huaihai Institute of Technology Lianyungang 222005 China Department of Biology Cape Breton University Sydney Nova Scotia BJP 612 Canada Department of Chemistry Cape Breton University Sydney Nova Scotia B1P 612 Canada

Fast and sensitive antigen detection is important in biomedical research and development. Despite, being invented 48 years ago, the enzyme-linked immunosorbent assay(ELISA) remains one of the most successful and widely employed bioanalytical techniques in research and clinical diagnostics due to its reliability and simplistic design. Recently, nanotechnology has offered efficient signal reporting. In spite of some improvements in these systems, there are typically increased material costs involved and the need for expensive equipment or complicated chemical processes, thus negating any possible benefits over ELISA. Herein, we communicate a simple Cu-DNAzyme system for signal transduction of a CuO nanoparticle-labeled immunoassay. The reported immunoassay amplifies signal generation similar to traditional ELISA and is fast, simple, cost-effective, and sensitive, holding promise for biomedical applications and point-of-care testing.

关键词： Cu-DNAzyme Immunoassay ELISA CuO Nanoparticles

在线全文

学校读者我要写书评

暂无评论

多边平台反垄断分析框架的基本原则

网络法律评论 2020年第1期20卷 21-46页

作者：戴维·埃文斯雷琦(译) 马萨诸塞州波士顿全球经济集团 Jevons竞争法和经济研究所北京大学法学院

一、引言以罗切特和梯若尔共同发布开创性论文肇始,多边平台的经济学研究于世纪之交郑重拉开序幕。1与此同时,由于科技变革,特别是互联网的出现,平台企业迅速形成,增长速度急剧上升。此后,随着平台企业蓬勃发展、经济影响力不断扩大,相... 详细信息

一、引言以罗切特和梯若尔共同发布开创性论文肇始,多边平台的经济学研究于世纪之交郑重拉开序幕。1与此同时,由于科技变革,特别是互联网的出现,平台企业迅速形成,增长速度急剧上升。此后,随着平台企业蓬勃发展、经济影响力不断扩大,相关理论和实证文献如雨后春笋般涌现。世界上几家最大上市公司的价值有很大一部分都要归功于基于平台的运营部门.

关键词：科技变革增长速度互联网经济影响力运营部门多边平台上市公司经济学研究

在线全文

学校读者我要写书评

暂无评论

上海26万妇女乳房自我检查随机试验

中华肿瘤杂志 2005年第6期27卷 350-354页

作者：高道利 david BThomas Roberta M Ray 王文婉 Charlene J Allison 陈范良 Peggy Porter 胡永伟赵关林潘雷达李雯瑾武春园 Zakia Coriaty Ilonka evans 林明纲 Helge Stalsberg Steven gself 复旦大学中山医院分部肿瘤流行病学研究室上海200052

目的论证指导妇女进行乳房自我检查(BSE)是否能有效降低乳腺癌患者的死亡率。方法自1989年10月起,上海26.6万名年龄在30～64岁的妇女,随机进入指导组(132979名)和对照组(133085名)。在指导组,最初先由医务人员做规范的BSE手法演示,随后... 详细信息

目的论证指导妇女进行乳房自我检查(BSE)是否能有效降低乳腺癌患者的死亡率。方法自1989年10月起,上海26.6万名年龄在30～64岁的妇女,随机进入指导组(132979名)和对照组(133085名)。在指导组,最初先由医务人员做规范的BSE手法演示,随后的4年中,使用BSE录像带进行二次强化教育,并定期进行BSE指导和在医务人员监察下进行BSE操作。本研究进行5年,全部活动均被记录。队列人群随访到2000年7月,乳腺癌患者的生存状况随访到2001年12月。统计分析采用Kaplan-Meier方法、Logrank检验以及Cox模型。结果指导组检出乳腺癌864例,其中死于乳腺癌133例;对照组检出乳腺癌896例,其中死于乳腺癌130例。两组乳腺癌病例的肿块大小、TNM分期和累积死亡率的差异均无统计学意义(P均>0.05)。但是指导组比对照组有较多和较小的纤维腺瘤被检出(P<0.01)。结论对人群开展BSE教育和指导,未能降低人群的乳腺癌死亡率;接受BSE教育的妇女比没有接受教育的妇女可检出较多的和较小的良性乳房肿块。

关键词：上海妇女乳房自我检查随机试验乳腺癌流行病学

在线全文

学校读者我要写书评

暂无评论

选择性减胎术新进展

中国产前诊断杂志（电子版） 2010年第1期2卷 19-25页

作者： MarkI evans Doina Ciorica david W.Britt John C.Fleter 郝克红美国纽约西奈山医学院妇产科学教授综合遗传系美国胎儿医学基金会美国夏洛茨维尔弗吉尼亚大学生物伦理中心

在过去的25年用减胎术来降低过度应用不孕症治疗技术所致的高数量的多胎妊娠的风险。近几十年多胎妊娠的人口统计学数据已经发生了如下变化:由于反对诱导排卵,导致IVF的比例增加;患者年龄偏大;使用捐赠卵子的比例增加。在行减胎术之前... 详细信息

在过去的25年用减胎术来降低过度应用不孕症治疗技术所致的高数量的多胎妊娠的风险。近几十年多胎妊娠的人口统计学数据已经发生了如下变化:由于反对诱导排卵,导致IVF的比例增加;患者年龄偏大;使用捐赠卵子的比例增加。在行减胎术之前进行基因诊断越来越普遍,由有经验的医师来做又非常安全。对包括双胎妊娠在内的所有多胎妊娠的患者来说,减少胎儿数可以降低流产率、早产率、及胎儿死亡率和发病率。

关键词：多胎妊娠双胎减胎术伦理问题

澳大利亚对残疾学生教育经费投入的改革及启示

在线全文

学校读者我要写书评

暂无评论

残疾人研究 2019年第1期 32-39页

作者：汪斯斯大卫.埃文斯南京特殊教育师范学院特殊教育研究中心南京210038 澳大利亚悉尼大学教育与社会工作学院

近年来,澳大利亚联邦政府主要通过"优质学校项目"和"全国残疾人保障计划"两项举措,对残疾学生的教育经费投入进行改革。"优质学校项目"是中小学校的经费改革项目,从个体需求出发,主要在于教育投入经费的稳健增长以及重视经费的监管。"... 详细信息

近年来,澳大利亚联邦政府主要通过"优质学校项目"和"全国残疾人保障计划"两项举措,对残疾学生的教育经费投入进行改革。"优质学校项目"是中小学校的经费改革项目,从个体需求出发,主要在于教育投入经费的稳健增长以及重视经费的监管。"全国残疾人保障计划"是对残疾人的长期资助项目,关注按需选择资助服务、与学校合作资助学生、提供长期教育资助和资助残疾人的家人及生活照料者。总结这两个项目中对残疾学生教育经费投入的改革举措,发现它们均存在融合性、个别化、循证性和协作性的特点,这为完善我国残疾学生的教育经费投入体制提供了启示。

关键词：澳大利亚残疾学生教育经费投入按需资助循证实践

Saudi Consensus on the Usage of Sodium-glucose Cotransporter-2 Inhibitors on the Management of Chronic Kidney Diseases

在线全文

学校读者我要写书评

暂无评论

International Journal of Clinical Medicine 2023年第12期14卷 525-539页

作者： Abdulrahman Alsheikh Ahmed Aljedai Hajer Almudaiheem Salwa Alaidarous Ali Alshehri Hussein Elbadawi Saeed Alghamdi Faisal Aljehani Sami Alobaidi Talal A. Altuwaijri Khalid Almatham david Strain Marc evans Emad R. Issak Saud Alsifri King Abdulaziz University Hospital Jeddah Saudi Arabia Ministry of Health Riyadh Saudi Arabia Ministry of National guards Hospital Jeddah Saudi Arabia King Fahad Medical City Riyadh Saudi Arabia My Clinic Jeddah Saudi Arabia College of Medicine University of Jeddah Jeddah Saudi Arabia College of Medicine King Saud University Riyadh Saudi Arabia College of Medicine Alfaisal University Riyadh Saudi Arabia University of Exeter Medical School Exeter UK University Hospital Llandough Cardiff UK College of Medicine Ain Shams University Cairo Egypt Alhada Armed Forces Hospital Taif Saudi Arabia

According to recent epidemiological data, chronic kidney diseases (CKDs) affect approximately 10% of the global population. Like many countries, CKD is a significant public health issue in Saudi Arabia. The prevalence of CKD in Saudi Arabia is estimated to be around 4.5% of the adult population, with a higher prevalence in older age groups. Sodium-glucose cotransporter-2 inhibitors (SgLT2is) are a class of oral medications used to treat type 2 diabetes mellitus (T2DM). In addition to their glucose-lowering effects, SgLT2i have been shown to have beneficial effects on kidney function in patients with or without T2DM. Therefore, a Saudi task force gathered to develop an explicit, evidence-based consensus on SgLT2i use in CKD Saudi patients. A panel of 14 experts made up a task force. An initial concept proposal was obtained. The proposal was divided into several topics discussed on 24 May 2023. A literature review was carried out. The literature search was completed on 3rd June 2023. A drafted report was distributed to the entire panel. Approval of the recommendations required consensus, defined as a majority approval (i.e. above 75%). The recommendations were revised to accommodate any differences of opinion until a consensus was reached. Recommendations were finally formulated on 21st June 2023. Subsequently, the panel reviewed and discussed the supporting rationale of the revised recommendations. This article presents these practical recommendations.

关键词： Chronic Kidney Disease Sodium-glucose Cotransporter-2 Inhibitors Adverse Effects Monitoring Canagliflozin Dapagliflozin Empagliflozin

Biological fractionation of Zn isotopes in aquatic invertebrates

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Chinese Journal Of geochemistry 2006年第B8期25卷 203-203页

作者： R. Douglas evans david C. Lasenby Environmental and Resource Studies Trent University Peterborough Canada Biology Department Trent University Peterborough Canada