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Sitagliptin,sitagliptin and metformin,or sitagliptin and amitriptyline attenuate streptozotocin-nicotinamide induced diabetic neuropathy in rats

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The Journal of Biomedical Research 2012年第3期26卷 200-210页

作者： Ashish Kumar Sharma Akash Sharma Rita Kumari Kunal Kishore Divya Sharma Bharthu Parthsarthi Srinivasan Ashok Sharma Santosh Kumar singh Samir Gaur Vijay singh Jatav Prashant Sharma Varnika Srivastava Sneha Joshi Megha Joshi Prashant Kumar Dhakad davender singh kanawat Akanksha Mishra Anil Sharma Dharmendra singh Ravinder Pal singh Himmat singh Chawda Rambir singh Sachin Kumar Raikwar Muneem Kumar Kurmi Pankaj Khatri Ashutosh Agarwal Arshee Munajjam Department of Pharmacology Gyan Vihar School of PharmacySuresh Gyan Vihar UniversityJagatpuraJaipur(Rajasthan)302025India Department of Pharmacology Delhi Institute of Pharmaceutical Sciences&ResearchPushpviharNew Delhi 110017India Department of Pharmacology Kota Collage of PharmacyRIICO Industrial AreaRanpurKota(Rajasthan)Pincode 302025India

Diabetic neuropathies are a family of nerve disorders caused by diabetes. Symptoms of the disease include nerve palsy, mononeuropathy, mononeuropathy multiplex, diabetic amyotrophy, painful polyneuropathy, autonomic neu- ropathy, and thoracoabdominal neuropathy. In this study, type 2 diabetes in rats was induced with nicotinamide- streptozotocin. Drug treatment was initiated on the d 15, with the combination regimen of metformin, pioglitazone and glimipiride or metformin and sitagliptin or sitagliptin, amitriptyline and sitagliptin and led to significantly im- proved glycemic control, increased grip strength and paw jumping response on d 21, 28 and 35 （P 〈 0.001）. Signif- icant increases in blood protein levels and decreases in urinary protein levels were observed in the animals treated with the different regimens on d 21, 28 and 35 （P 〈 0.001）. Combined treatment of streptozotocin and nicotinamide caused marked degeneration of nerve cells, while administration of metformin and sitagliptin showed tissue regen- eration and no body weight gain. In conclusion, treatment with sitagliptin and sitagliptin combined with metformin or amitriptyline results in no body weight gain, but causes an increase in grip strength and pain sensitivity, exhibits neural protection, and reverses the alteration of biochemical parameters in rats with streptozotocin-nicotinamide induced type 2 diabetes.

关键词： diabetic neuropathy nicotinamide-streptozotocin metformin pioglitazone glimipiride sitagliptin amitriptyline

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Contribution of microbial phytases to the improvement of plant growth and nutrition: A review

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Pedosphere 2020年第3期30卷 295-313页

作者： Bijender singh Ines BOUKHRIS PRAGYA Vinod KUMAR Ajar Nath YADAV Ameny FARHAT-KHEMAKHEM Anil KUMAR davender singh Monia BLIBECH Hichem CHOUAYEKH Othman AALGHAMDI Laboratory of Bioprocess Technology Department of MicrobiologyMaharshi Dayanand UniversityRohtak 124001India Department of Biotechnology Central University of HaryanaJant-PaliMahendergarh 123031India Laboratoire de Microorganismes et de Biomolécules Centre de Biotechnologie de SfaxRoute de Sidi Mansour Km 6BP“1177”Sfax 3018(Tunisia Department of Biochemistry College of Basic Sciences&HumanitiesCCS Haryana Agricultural UniversityHisar 125004India Department of Biotechnology Akal College of AgricultureEternal UniversityBaru SahibSirmour 173101India Department of Botany Pt.N.R.S.Govt.CollegeRohtak 124001India Department of Physics RPS Degree CollegeBalanaSatnali RoadMahendergarh 123029India Department of Biological Sciences Faculty of SciencesUniversity of JeddahJeddah 21959(Kingdom of Saudi Arabia

Phytases belong to the class of phosphohydrolases that begin the step-wise hydrolysis of phosphates from phytates. Phytates are a derivative of myo-inositol, which is the primary storage form of organic phosphorus in plant cells. Phytase has been used globally to diminish phosphorus pollution and to enhance nutrition in monogastrics. In this review, the classification, sources, and diversity of microbial phytases, and their practical applications, as well as supplementation of the soil with transgenic and wild types of microbial strains, which can release phytase to enhance phosphorus availability for plant uptake and reduce the need for fertilizers, are discussed. The overexpressed microbial phytases in transgenic plants enhance the growth capacity of co-cultivated plants and can therefore be employed in agricultural and biotechnological practices, such as intercropping. The introduction of phytases into the soil for improved plant growth and enhanced crop yield can be accomplished without extra cost. A diverse group of photoautotrophic microalgae can synthesize phytase and will likely be useful in many human food and animal industries.

关键词： anti-nutrient factor environmental protection food and feed nutrition microalgae phosphohydrolases phosphorus availability phytates soil fertility transgenic plant

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