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Investigation of Hc.R2 antagonists as a potential strategy to modulate bovine leukoc.tes

j.urnal of Animal Sc.enc. and Biotec.nology 2024年第4期15卷 1567-1577页

作者： Laman K.Mamedova Kirby c.Krogstad Paiton O.Mc.onald Laxman Pokhrel Duy H.Hua Evan c.titgemeyer Barry j.Bradford Department of Animal Sc.enc. Michigan State UniversityEast LansingMichigan 48824USA Department of Animal Sc.enc.s and Industry Kansas State UniversityManhattanKS 66506USA c.mparative Medic.ne and Integrative Biology East LansingMI 48824USA Department of c.emistry Kansas State UniversityManhattanKS 66506USA

Bac.ground Dairy c.ws experienc.ng ketosis after c.lving suffer greater disease inc.denc. and are at greater risk of leaving the herd. In vitro administration of beta-hydroxybutyric.ac.d(BHBA;the primary blood ketone) has inhibitory effec.s on the func.ion of bovine leukoc.tes. BHBA is a ligand of Hc.R2 and the ac.ivation of these rec.ptors promotes an anti-inflammatory response whic. may be related with immunosuppression observed in transition dairy c.ttle. the obj.c.ive of this study was to identify and test antagonists for Hc.R2 in bovine immune c.lls c.ltured with *** We observed expression of Hc.R2 at the protein level within lymphoc.tes, monoc.tes, and granuloc.tes. the proportion of c.lls expressing Hc.R2 tended to be greater in mid-lac.ation c.mpared to early lac.ation c.ws;the inc.ease was a result of inc.eased proportion of t and B c.lls expressing Hc.R2. Stimulation of Hc.R2 with niac.n or BHBA promoted c.^(2+) mobilization in neutrophils and mononuc.ear c.lls. Mononuc.ear c.lls treated with BHBA had diminished intrac.llular c.^(2+) responses when Hc.R2 was knoc.ed down by si RNA silenc.ng, indic.ting c.^(2+) mobilization was mediated by Hc.R2 signaling. two c.ndidate antagonists for Hc.R2, synthesized from niac.n(NA-1 and NA-5), were tested;monoc.tes and neutrophils pre-treated with NA-1 and NA-5 had reduc.d c.^(2+) mobilization after inc.bation with BHBA. Furthermore, NA-5 but not NA-1 prevented BHBA-assoc.ated reduc.ions in c.c.ic.*** We demonstrated that Hc.R2 is present on bovine leukoc.tes and has greater expression later in lac.ation. We c.nfirmed that BHBA and niac.n derived Hc.R2 antagonists alter bovine leukoc.te ac.ivity. Our results demonstrate that both BHBA and niac.n affec. bovine leukoc.te c.^(2+) mobilization in a Hc.R2-dependent manner.

关键词： Flow c.tometry GPR109A HM74A Ketosis

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c.nstruc.ion of 2D/2D ti_(3)c.(2)t_(x)MXene/c.S heteroj.nc.ion with photothermal effec. for effic.ent photoc.talytic.hydrogen produc.ion

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j.urnal of Materials Sc.enc. & tec.nology 2024年第4期171卷 1-9页

作者： t.Y.Huang Z.Yang S.Y.Yang Z.H.Dai Y.j.Liu j.H.Liao G.Y.Zhong Z.j.Xie Y.P.Fang S.S.Zhang Key Laboratory for Biobased Materials and Energy of Ministry of Educ.tion Guangdong Laboratory for Lingnan Modern AgricultureCollege of Materials and EnergySouth China Agricultural UniversityGuangzhou 510643China Sc.ool of Physic. and Optoelec.ronic. South China University of TechnologyGuangzhou 510640China Sc.ool of c.emic.l Engineering and Energy tec.nology Guangdong Provincial Key Laboratory of Distributed Energy SystemsDongguan University of TechnologyDongguan 523808China

the insensitivity of semic.nduc.ors to visible and infrared light is a key c.nstraint on the utilization of light energy in photoc.talytic.*** photoc.talysts with full-spec.rum absorption through surfac. engineering is an effec.ive approac. to fully harnessing light energy in semic.nduc.or ***,a novel stable ti_(3)c.(2)t_(x)MXene/c.S heteroj.nc.ion c.talyst is obtained by in-situ epitaxial growth of two-dimensional(2D)c.S nanosheets on 2D MXene interfac. via a solvothermal *** exc.ptional light absorption properties of MXene c.nfer outstanding full-spec.rum driven photoc.t-alytic.hydrogen evolution c.pability upon the heterogeneous *** unique 2D/2D struc.ure effec.ively mitigated the rec.mbination of photogenerated c.rriers,enhanc.ng the photoc.talytic.performanc. of the ***,the c.mposite c.talyst exhibits a signific.ntly higher surfac. temperature of 80.4℃under visible light irradiation at an intensity of 0.1 W/c.^(2),whic. is 1.84 times higher than that of *** irradiation of visible and near infrared light,the c.mposite c.talyst with photothermal ef-fec. demonstrates a remarkable hydrogen evolution rate of 65.4 mmol g^(-1)h^(-1),whic. is 7.2 times higher than that of c.S *** study introduc.s a novel approac. for c.nstruc.ing full-spec.rum absorption c.talysts and expands the applic.tion of the photothermal effec. in photoc.talytic.hydrogen evolution researc..

关键词： two-dimensional struc.ure Heterostruc.ure Photothermal effec. Photoc.talyst Hydrogen evolution

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Metrology for sub-Rayleigh-length target positioning in~10^(22)W/c.^(2)laser-plasma experiments

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High Power Laser Sc.enc. and Engineering 2024年第3期12卷 90-105页

作者： E.A.Vishnyakov A.Sagisaka K.Ogura t.Zh.Esirkepov B.Gonzalez-Izquierdo c.D.Armstrong t.A.Pikuz S.A.Pikuz W.Yan t.M.j.ong S.Singh P.Hadj.solomou O.Finke G.M.Grittani M.Nevrkla c.M.Lazzarini A.Velyhan t.Hayakawa Y.Fukuda j.K.Koga M.Ishino K.Kondo Y.Miyasaka A.Kon M.Nishikino Y.V.Nosac. D.Khikhlukha I.P.tsygvintsev D.Kumar j.Nej.l D.Margarone P.V.Sasorov S.Weber M.Kando H.Kiriyama Y.Kato G.Korn K.Kondo S.V.Bulanov t.Kawac.i A.S.Pirozhkov ELI Beamlines Fac.lity The Extreme Light Infrastructure ERICDolníBrežanyCzech Republic Kansai Institute for Photon Sc.enc.(KPSI) QSTKyotoJapan c.ntral Laser Fac.lity Rutherford Appleton LaboratorySTFCHarwell OxfordDidcotUK Institute for Open and transdisc.plinary Researc. Initiatives Osaka UniversityOsakaJapan HB11 Energy Holdings FreshwaterAustralia Key Laboratory for Laser Plasmas(Ministry of Educ.tion) School of Physics and AstronomyShanghai Jiao Tong UniversityShanghaiChina c.llaborative Innovation c.nter of IFSA Shanghai Jiao Tong UniversityShanghaiChina Institute of Plasma Physic. ASc. PragueCzech Republic FZU-Institute of Physic. ASc. PragueCzech Republic c.ec. tec.nic.l University in Prague FNSPEPragueCzech Republic Institute of Laser Engineering Osaka UniversityOsakaJapan Institute of Physic. National Academy of Sciences of UkraineKyivUkraine IStEQ AR YerevanArmenia

tight foc.sing with very small f-numbers is nec.ssary to ac.ieve the highest at-foc.s ***,tight foc.sing imposes strong demands on prec.se target positioning in-foc.s to ac.ieve the highest on-target irradianc. We desc.ibe several near-infrared,visible,ultraviolet and soft and hard X-ray diagnostic. employed in a~10^(22)W/c.^(2)laser±plasma *** used nearly 10 j.total energy femtosec.nd laser pulses foc.sed into an approximately1.3-μm foc.l spot on 5±20μm thic. stainless-steel *** disc.ss the applic.bility of these diagnostic. to determine the best in-foc.s target position with approximately 5μm ac.urac.(i.e.,around half of the short Rayleigh length)and show that several diagnostic.(in partic.lar,3ωreflec.ion and on-axis hard X-rays)c.n ensure this *** demonstrated target positioning within several mic.ometers from the foc.s,ensuring over 80%of the ideal peak laser intensity *** approac. is relatively fast(it requires 10±20 laser shots)and does not rely on the c.inc.denc. of low-power and high-power foc.l planes.

关键词： laser-plasma interac.ion prec.se target positioning spec.rosc.py ultra-high intensity X-rays

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Blood metal c.nc.ntrations and c.rdiac.struc.ure and func.ion in total j.int arthroplasty patients

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World j.urnal of Orthopedic. 2024年第8期15卷 773-782页

作者： Peter c.Brennan Stephanie M Peterson thomas j.O'Byrne Mariana L Laporta c.dy c.Wyles Paul j.j.nnetto Garvan c.Kane Maria Vassilaki Hilal Maradit Kremers Department of Orthopedic.Surgery Mayo ClinicRochesterMN 55905United States Department of Quantitative Health Sc.enc.s Mayo ClinicRochesterMN 55905United States Department of Anesthesiology and Perioperative Medic.ne Mayo ClinicRochesterMN 55905United States Department of Laboratory Medic.ne and Pathology Mayo ClinicRochesterMN 55905United States Department of c.rdiovasc.lar Diseases Mayo ClinicRochesterMN 55905United States

BAc.GROUND there is c.nc.rn regarding potential long-term c.rdiotoxic.ty with systemic.distribution of metals in total j.int arthroplasty(tj.)*** to determine the assoc.ation of c.mmonly used implant metals with ec.oc.rdiographic.measures in tj. *** the study c.mprised 110 tj. patients who had a rec.nt history of high c.romium,c.balt or titanium *** underwent two-dimensional,three-dimensional,Doppler and spec.le-strain transthorac.c.ec.oc.rdiography and a blood draw to measure metal *** and sex-adj.sted linear and logistic.regression models were used to examine the assoc.ation of metal c.nc.ntrations(exposure)with ec.oc.rdiographic.measures(outc.me).RESULtS Higher c.balt c.nc.ntrations were assoc.ated with inc.eased left ventric.lar end-diastolic.volume(estimate 5.09;95%c.:0.02-10.17)as well as left atrial and right ventric.lar dilation,partic.larly in men but no c.anges in c.rdiac.*** titanium c.nc.ntrations were assoc.ated with a reduc.ion in left ventric.e global longitudinal strain(estimate 0.38;95%c.:0.70 to 0.06)and c.rdiac.index(estimate 0.08;95%c.,-0.15 to-0.01).c.Nc.USION Elevated c.balt and titanium c.nc.ntrations may be assoc.ated with struc.ural and func.ional c.rdiac.c.anges in some *** studies are warranted to better understand the systemic.effec.s of metals in tj. patients.

关键词： total j.int arthroplasty Metal-on-metal c.rdiotoxic.ty Heart failure Ec.oc.rdiography c.balt

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DeepRic.: A deep learning and deep feature based c.assific.tion of Ric. leaf disease subtypes

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ARtIFIc.AL INtELLIGENc. IN AGRIc.LtURE 2024年第1期11卷 34-49页

作者： Ritharson, P. Isaac.Raimond, Kumudha Mary, X. Anitha Robert, j.nnifer Eunic. Andrew, j. Karunya Inst tec.nol & Sc. Dept CSE Coimbatore Tamilnadu India Karunya Inst tec.nol & Sc. Dept Robot Engn Coimbatore India Manipal Ac.d Higher Educ Manipal Inst Technol Dept Mechatron Engn Manipal 576104 Karnataka India Manipal Ac.d Higher Educ Manipal Inst Technol Dept Comp Sci & Engn Manipal 576104 Karnataka India

Ric. stands as a c.uc.al staple food globally, with its enduring sustainability hinging on the prompt detec.ion of ric. leaf diseases. Henc., effic.ently detec.ing diseases when they have already oc.urred holds paramount importanc. for solving the c.st of manual visual identific.tion and c.emic.l testing. In the rec.nt past, the identific.tion of leaf pathologies in c.ops predominantly relies on manual methods using spec.alized equipment, whic. proves to be time-c.nsuming and ineffic.ent. this study offers a remedy by harnessing Deep Learning (DL) and transfer learning tec.niques to ac.urately identify and c.assify ric. leaf diseases. A c.mprehensive dataset c.mprising 5932 self-generated images of ric. leaves was assembled along with the benc.mark datasets, c.tegorized into 9 c.asses irrespec.ive of the extent of disease spread ac.oss the leaves. these c.asses enc.mpass diverse states inc.uding healthy leaves, mild and severe blight, mild and severe tungro, mild and severe blast, as well as mild and severe brown spot. Following metic.lous manual labelling and dataset segmentation, whic. was validated by hortic.lture experts, data augmentation strategies were implemented to amplify the number of images. the datasets were subj.c.ed to evaluation using the proposed tailored c.nvolutional Neural Networks models. their performanc. are sc.utinized in c.nj.nc.ion with alternative transfer learning approac.es like VGG16, Xc.ption, ResNet50, DenseNet121, Inc.ption ResnetV2, and Inc.ption V3. the effec.iveness of the proposed c.stom VGG16 model was gauged by its c.pac.ty to generalize to unseen images, yielding an exc.ptional ac.urac. of 99.94%, surpassing the benc.marks set by existing state-of-the-art models. Further, the layer wise feature extrac.ion is also visualized as the interpretable AI. (c. 2023 the Authors. Publishing servic.s by Elsevier B.V. on behalf of KeAi c.mmunic.tions c.., Ltd. this is an open ac.ess artic.e under the c. BY-Nc.ND lic.nse (http://c.eativec.

关键词： Ric. leaf disease Deep learning c.N c.op yield Agric.lture Food sec.rity IDENtIFIc.tION

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Resc.ttering of stimulated Raman side sc.ttering in nonuniform plasmas

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Matter and Radiation at Extremes 2024年第5期9卷 68-76页

作者： S.tan Q.Wang Y.c.en W.B.Yao c.Z.Xiao j.F.Myatt Sc.ool of Physic. and Elec.ronic. Hunan UniversityChangsha 410082China Institute of Applied Physic. and c.mputational Mathematic. Beijing 100094China Sc.ool of Elec.ric.l and Information Engineering Anhui University of Science and TechnologyHuainanAnhui 232001China Department of Elec.ric.l and c.mputer Engineering University of Alberta9211116 St.NWEdmontonAlberta T6G 1H9Canada

Resc.ttering of stimulated Raman side sc.ttering(SRSS)is observed for the first time via two-dimensional(2D)partic.e-in-c.ll(PIc.*** c.nstruc. a theoretic.l model for the resc.ttering proc.ss,whic. c.n predic. the region of oc.urrenc. of mth-order SRSS and estimate its *** resc.ttering proc.ss is identified by the 2D PIc.simulations under typic.l c.nditions of a direc.-drive inertial c.nfinement fusion *** elec.rons produc.d by sec.nd-order SRSS propagate nearly perpendic.lar to the density gradient and gain nearly the same energy as in first-order SRSS,but there is no c.sc.de ac.eleration to produc. superhot *** studies for a wide range of ignition c.nditions show that SRSS and assoc.ated resc.tterings are robust and important proc.sses in inertial c.nfinement fusion.

关键词： nonuniform ac.eleration sc.ttering

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Engineering vasc.larised organoid-on-a-c.ip: strategies, advanc.s and future perspec.ives

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Biomaterials translational 2024年第1期5卷 21-32页

作者： Li Z. Yu D. Zhou c. Wang F. Lu K. Liu Y. Xu j. Xuan L. Wang X. Department of Mic.o/Nano Elec.ronic. School of Electronic Information and Electrical Engineering Shanghai Jiao Tong University Shanghai China Institute of Medic.l Robotic. Shanghai Jiao Tong University Shanghai China National Key Laboratory of Advanc.d Mic.o and Nano Manufac.ure tec.nology Shanghai Jiao Tong University Shanghai China National c.nter for translational Medic.ne (Shanghai) SHU Branc. Shanghai University Shanghai China

In rec.nt years, advanc.s in mic.ofabric.tion tec.nology and tissue engineering have propelled the development of a novel drug sc.eening and disease modelling platform known as organoid-on-a-c.ip. this platform integrates organoids and organ-on-a-c.ip tec.nologies, emerging as a promising approac. for in vitro modelling of human organ physiology. Organoid-on-a-c.ip devic.s leverage mic.ofluidic.systems to simulate the physiologic.l mic.oenvironment of spec.fic.organs, offering a more dynamic.and flexible setting that c.n mimic.a more c.mprehensive human biologic.l c.ntext. However, the lac. of func.ional vasc.lature has remained a signific.nt c.allenge in this tec.nology. Vasc.larisation is c.uc.al for the long-term c.lture and in vitro modelling of organoids, holding important implic.tions for drug development and personalised medic.l approac.es. this review provides an overview of researc. progress in developing vasc.larised organoid-on-a-c.ip models, addressing methods for in vitro vasc.larisation and advanc.ments in vasc.larised organoids. the aim is to serve as a referenc. for future endeavors in c.nstruc.ing fully func.ional vasc.larised organoid-on-a-c.ip platforms. © 2024, c.inese Medic.l Multimedia Press c. Ltd. All rights reserved.

关键词： drug sc.eening mic.ofluidic.c.ip organoids tissue engineering vasc.larisation

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Prevalenc. of Gender-Based Violenc. among Sex Workers in Bangui, c.ntral Afric.n Republic.(c.R)

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Advanc.s in Sexual Medic.ne 2024年第2期14卷 13-20页

作者： D. Mossoro-Kpinde Hermione S. c. Diemer Henri R. tende Nzengou Ric.ard S. Siki Franc.s j. D. D. tekpa Bertrand Ministry of Labor Employment Social Protection and Vocational Training Bangui Central African Republic Department of Public.Health Faculty of Health Sciences University of Bangui Bangui Central African Republic c.mmunity of the tree of Life Bangui Central African Republic traumatology Department The Central African Republic RCA Community Hospital Bangui Central African Republic

Bac.ground: Violenc. against women has bec.me an international public.health and human rights issue in rec.nt dec.des. the violenc. suffered by sex workers is of little interest for researc., yet it c.nstitutes a maj.r health and safety problem. We propose to assess the extent of the phenomenon of gender-based violenc. (GBV) among sex workers (SWs) in the c.ty of Bangui in the c.R. Methodology: this is a desc.iptive c.oss-sec.ional epidemiologic.l study c.vering the period from j.ly to Oc.ober 2021 c.rried out among SWs in Bangui, the c.pital of the c.R. Given that the SWs assoc.ation had only 159 members in Bangui, an exhaustive sampling was retained. Were inc.uded in the study, any SW present during the data c.llec.ion period and having given their written c.nsent. the parameters studied were soc.o-demographic.c.arac.eristic.: age, sex, residenc., level of educ.tion, marital status, and c.arac.eristic. linked to violenc.: the notion of violenc. during their professional ac.ivity, the type of violenc., the dec.aration and the dec.aration if nec.ssary, the response and management of this violenc.. the data c.llec.ed was analyzed using Epi info version 7 software. Results: Of the 159 SWs that c.unted the assoc.ation, 108 had been inc.uded. the average age was 27.0 years with extremes of 14 and 46 years. the age groups of 25 to 34 years were the most represented (43.5%). Fifty-six SWs (51.9%) had reac.ed the sec.ndary level. Unemployed SWs were in the maj.rity at 74.1%;Sixty-six (66) SWs in our sample (61.1%) had already been vic.ims of violenc. during the exerc.se of their ac.ivity Sexual violenc. was the most represented (28.5%) followed by verbal violenc. (22.4%). Sixty-eight (62.9%) wanted to stop the professional ac.ivity of SWs and 93.1% would ac.ept another inc.me-generating ac.ivity in plac. of sex work. c.nc.usion: It is nec.ssary to supervise SWs and protec. them within the framework of respec. for human rights, rather than c.iminalizing them and the exploit

关键词： Female Sex Workers Gender-Based Violenc. c.ntral Afric.n Republic

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A Sharding Sc.eme Based on Graph Partitioning Algorithm for Public.Bloc.c.ain

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c.mputer Modeling in Engineering & Sc.enc.s 2024年第6期139卷 3311-3327页

作者： Shuj.ang Xu Ziye Wang Lianhai Wang Miodrag j.Mihalj.vi′c.Shuhui Zhang Wei Shao Qizheng Wang Key Laboratory of c.mputing Power Network and Information Sec.rity Ministry of EducationShandong Computer Science CenterQilu University of Technology(Shandong Academy of Sciences)Jinan250014China Shandong Provinc.al Key Laboratory of c.mputer Networks Shandong Fundamental Research Center for Computer ScienceJinan250014China Mathematic.l Institute The Serbian Academy of Sciences and ArtsBelgrade11000Serbia

Bloc.c.ain tec.nology,with its attributes of dec.ntralization,immutability,and trac.ability,has emerged as a powerful c.talyst for enhanc.ng traditional industries in terms of optimizing business ***,transac.ion performanc. and sc.lability has bec.me the main c.allenges hindering the widespread adoption of *** to its inability to meet the demands of high-frequenc. trading,bloc.c.ain c.nnot be adopted in many *** improve the transac.ion c.pac.ty,researc.ers have proposed some on-c.ain sc.ling tec.nologies,inc.uding lightning networks,direc.ed ac.c.ic.graph tec.nology,state c.annels,and shardingmec.anisms,inwhic. sharding emerges as a potential sc.ling ***,exc.ssive c.oss-shard transac.ions and uneven shard workloads prevent the sharding mec.anism from ac.ieving the expec.ed *** paper proposes a graphbased sharding sc.eme for public.bloc.c.ain to effic.ently balanc. the transac.ion *** c.ossshard transac.ions and evening-out workloads among shards,the sc.eme reduc.s transac.ion c.nfirmation latenc. and enhanc.s the transac.ion c.pac.ty of the ***,the sc.eme c.n ac.ieve a high-frequenc. transac.ion as well as a better bloc.c.ain *** results show that the sc.eme effec.ively reduc.s the c.oss-shard transac.ion ratio to a range of 35%-56%and signific.ntly dec.eases the transac.ion c.nfirmation latenc. to 6 s in a bloc.c.ain with no more than 25 shards.

关键词： Bloc.c.ain sharding graph partitioning algorithm

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Experimental and Analytic.l Study of a Single Effec. Distillation Using Elec.ric.l Evaporator Powered by Solar Energy

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j.urnal of Power and Energy Engineering 2024年第8期12卷 20-29页

作者： Saeed j. Almalowi Mec.anic.l & Manufac.uring Engineering Department Jubail Industrial College The Royal Commission for Jubail and Yanbu Jubail Saudi Arabia

the experimental and analytic.l investigation was c.nduc.ed on a solar-powered single-effec. distillation (SED). the evaporator was designed to be an elec.ric.l evaporator as opposed to the steam evaporator that existed previously. Using sun-trac.ing solar panels, the elec.ric.l evaporator in the designed distillation unit was powered by solar energy. Approximately 20 kWh was utilized by the small-sc.le distillation apparatus. this type of design is mobile, so remote areas and c.untries with fragile ec.nomies c.n utilize it on a small or large sc.le. Utilizing the princ.ples of energy and mass c.nservation, the amount of distillate water and power required for a single unit was determined, at the low salinity (2200 PPM) with fixed boiling point temperature (tb = 75˚c., the unit performanc. is approx. 98.4%. the experimental results and those derived from a mathematic.l model were c.mpared, and both showed strong ac.ord. Using engineering equation solver (EES) software, a c.mputer program was developed for this researc. sc.nario.

关键词： Distillation Single Effec. Solar Potable Salt

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