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6-巯基嘌呤治疗炎症性肠病的单中心10年治疗经验

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世界核心医学期刊文摘（胃肠病学分册） 2005年第7期1卷 40-41页

作者： Glazier k.D. Palance A.L. Griffel L.H. das k.m. 樊菁 UmDNJ- Robert Wood Johnson med. Sch. 1 Robert Wood Johnson Place New Brunswick NJ 08903 United States Dr.

Goals: To report the 10- year experience of a single center in treating pati ents with refractory inflammatory bowel disease (IBD) with relatively lower dose of 6- mercaptopurine (6- mP). Study: The charts of 285 patients with IBD (Cro hn’ s disease 160 and ulcerative colitis 125) receiving 6- mP were reviewed. C linical response, subsequent breakthrough while taking 6- mP, and relapse rates when 6- mP was discontinued and side effects were assessed. Results: Ninety- three percent of the patients were taking 50 to 75 mg/day of 6- mP. Complete re mission was achieved in 62% , partial remission in 14.5% , and failure to achi eve remission in 23.5% of the patients. Of complete responders, 27.5% had br eakthrough while continuing 6- mP. Nine percent of those that achieved a comple te remission experienced a relapse after 6- mP was discontinued. Side effects i ncluded leukopenia (11.2% ), abnormal liver function tests (3.8% ), various in fections, including pneumonia (3.1% ), pancreatitis (2.5% ), nausea (2.1% ), headache (2.8% ), fever (1.4% ), hair loss (1% ), and rash (0.7% ). Two canc ers occurred while taking 6- mP: melanoma on the finger and a fatal colonic lym phoma. Four patients continued 6- mP throughout pregnancies and had normal outc omes. Conclusions: In our experience 6- mP is relatively safe and appears to be as effective at a lower dosage (0.84 mg/kg per day) compared with the recommend ed higher dosage (1- 1.5 mg/kg per day), when leukopenia was more frequent. Ser ious side effects, although rare, need to be monitored.

关键词：炎症性肠病单中心克罗恩病溃疡性结肠炎结肠淋巴瘤临床反应复发率黑色素瘤白细胞减少正常分娩

magnesium oxide(mgO)nanoadsorbents in wastewater treatment:A comprehensive review

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Journal of magnesium and Alloys 2024年第5期12卷 1709-1773页

作者： H.C.S.Perera V.Gurunanthanan Anoop Singh m.m.m.G.P.G.mantilaka G.das Sandeep Arya Department of Physics Khalifa UniversityAbu Dhabi12788United Arab Emirates Postgraduate Institute of Science University of PeradeniyaPeradeniyaSri Lanka Department of Humanities and Sciences Guru Nanak Institutions Technical CampusIbrahimpatnamHyderabad501506India Centre for Global Health Research Saveetha Medical College and HospitalsSaveetha Institute of Medical and Technical SciencesChennai602105Tamil NaduIndia Department of Physics University of JammuJammu and Kashmir180006India

Wastewater contamination by heavy metals and synthetic dyes presents a significant environmental challenge,necessitating effective and sustainable separation *** review article provides a detailed examination of magnesium oxide(mgO)nanoparticles as an innovative nanoadsorbent for wastewater treatment,with a specific focus on heavy metal and dye *** review comprehensively explores various aspects of mgO nanoparticles,including their structural characteristics and synthesis *** article delves into the morphology and crystallographic arrangement of mgO nanoparticles,offering insights into their structural *** the complexity of adsorption processes,the review identifies and analyzes parameters influencing the adsorption efficiency of mgO nanoparticles,such as temperature,pH,contact time,initial concentration,and co-existing *** interplay between these parameters and the adsorption capability of mgO nanoparticles emphasizes the importance of optimizing operational ***,the review assesses various synthesis methods for mgO nanoparticles,including sol-gel,hydrothermal,precipitation,green synthesis,solvothermal,and template-assisted *** discusses the advantages,limitations,and resulting nanoparticle characteristics of each method,enabling readers to grasp the implications of synthesis processes on adsorption *** comprehensive review consolidates current insights into the effectiveness of mgO nanoparticles as a potent nanoadsorbent for removing heavy metals and dyes from wastewater covering a wide spectrum of aspects related to mgO ***,there is a need to investigate the use of mgO in the treatment of actual wastewater or river water,in order to leverage its cost-effectiveness and high efficiency for practical water treatment applications in real-time.

关键词： mgO nanoparticles Nanoadsorbent Wastewater treatment Heavy metals Dye separation Adsorption Synthesis methods

A review on transition metal oxides based photocatalysts for degradation of synthetic organic pollutants

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Journal of Environmental Sciences 2024年第5期139卷 389-417页

作者： Athira krishnan Anna Swarnalal Divine das midhina krishnan Viswanathan S.Saji SmAShibli Department of Chemistry Amrita Vishwa VidyapeethamAmritapuriKerala690525India Interdisciplinary Research Center for Advanced materials King Fahd University of Petroleum&MineralsDhahran31261Saudi Arabia Department of Chemistry University of KeralaKariavattom CampusThiruvananthapuramKerala695581India

This review provides insight into the current research trend in transition metal oxides(TmOs)-based photocatalysis in removing the organic colouring matters from *** easy understanding,the research progress has been presented in four generations according to the catalyst composition and mode of application,viz:single component TmOs(the firstgeneration),doped TmOs/binary TmOs/doped binary TmOs(the second-generation),inactive/active support-immobilized TmOs(the third-generation),and ternary/quaternary compositions(the fourth-generation).The first two generations represent suspended catalysts,the third generation is supported catalysts,and the fourth generation can be suspended or *** review provides an elaborated comparison between suspended and supported catalysts,their general/specific requirements,key factors controlling degradation,and the methodologies for performance *** the plausible fundamental and advanced dye degradation mechanisms involved in each generation of catalysts were *** existing challenges in TmOs-based photocatalysis and how the researchers approach the hitch to resolve it effectively are *** research trends are also presented.

关键词： Photocatalysis Dye degradation Transition metal oxides and composites Supported catalysts Suspended catalysts

An integrated framework for assessing renewable-energy supply chains using multicriteria decision-making:a study on Bangladesh

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Clean Energy 2024年第3期8卷 1-19页

作者： A.m.Almas Shahriyar Azad Zarin Tasnim Oishi md.Ariful Haque Pronob das Sabbir Ahmed Udoy khaled mohammad Shifullah Bhuiya Department of Industrial&Production Engineering Rajshahi University of Engineering&TechnologyRajshahi-6204Bangladesh Department of mechanical Engineering Rajshahi University of Engineering&TechnologyRajshahi-6204Bangladesh

The depletion in non-renewable energy sources and a fast-growing population in Bangladesh are exacerbating the already existing energy scarcity,highlighting the need for an efficient and robust renewable-energy supply *** primary goal of this study is to evaluate the most optimized renewable-energy supply chain based on natural resource availability and government policies of *** the present study,four renewable energy resources,including solar,biomass,wind and hydropower,are studied and nine subcriteria are defined under four primary criteria for each supply *** for Order Preference by Similarity to Ideal Solution(TOPSIS)and VIsekriterijumska Optimizacija I k.m.romisno Resenje(VIkOR)are multicriteria decision-making approaches used in this study to compare and choose the best renewable-energy supply *** relative significance of four supply-chain criteria for primary renewable energy in this study,namely energy procurement,production,operations and maintenance costs,and social and environmental impact,is gathered via a *** results of this research,supported by a comprehensive sensitivity analysis,indicate that hydropower is the best renewable-energy supply chain,followed by wind as a compromise solution,biomass and *** study also demonstrates that no energy source can satisfy all supply-chain criteria alone;each resource is better for a specific criterion-solar is better for procurement,hydropower is significant for production and wind is remarkable for operations and social ***,to maximize output,renewable energy sources must be *** Bangladesh’s perspective,for the first time,by using TOPSIS and VIkOR together,this study offers significant insights to establish an efficient and sustainable renewable-energy supply chain for practitioners,academics and policymakers.

关键词： renewable-energy supply chain Bangladesh multicriteria decision-making TOPSIS(Technique for Order Preference by Similarity to Ideal Solution) VIkOR(VIsekriterijumska Optimizacija I k.m.romisno Resenje)

Three‐dimensional(3D)‐printed mXene high‐voltage aqueous micro‐supercapacitors with ultrahigh areal energy density and low‐temperature tolerance

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Carbon Energy 2024年第8期6卷 36-48页

作者： Yuanyuan Zhu Qingxiao Zhang Jiaxin ma Pratteek das Liangzhu Zhang Hanqing Liu Sen Wang Hui Li Zhong‐Shuai Wu State key Laboratory of Catalysis Dalian Institute of Chemical PhysicsChinese Academy of SciencesDalianChina key Laboratory of Spin Electron and Nanomaterials of Anhui Higher Education Institutes Suzhou UniversitySuzhouChina Shanghai key Laboratory of Rare Earth Functional materials and Education ministry key Laboratory of Resource Chemistry Shanghai Normal UniversityShanghaiChina University of Chinese Academy of Sciences BeijingChina Dalian National Laboratory for Clean Energy Chinese Academy of SciencesDalianChina

The rapid advancement in the miniaturization,integration,and intelligence of electronic devices has escalated the demand for customizable microsupercapacitors(mSCs)with high energy ***,efficient microfabrication of safe and high‐energy mXene mSCs for integrating microelectronics remains a significant challenge due to the low voltage window in aqueous electrolytes(typically≤0.6 V)and limited areal mass loading of mXene ***,we tackle these challenges by developing a highconcentration(18mol kg^(−1))“water‐in‐LiBr”(WiB)gel electrolyte for mXene symmetric mSCs(m‐SmSCs),demonstrating a record high voltage window of 1.8 ***,additive‐free aqueous mXene ink with excellent rheological behavior is developed for three‐dimensional(3D)printing customizable all‐mXene microelectrodes on various *** the synergy of a highvoltage WiB gel electrolyte and 3D‐printed microelectrodes,quasi‐solid‐state mSmSCs operating stably at 1.8 V are constructed,and achieve an ultrahigh areal energy density of 1772μWhcm^(−2)and excellent low‐temperature tolerance,with a long‐term operation at−40℃.Finally,by extending the 3D printing protocol,m‐SmSCs are integrated with humidity sensors on a single planar substrate,demonstrating their reliability in miniaturized integrated microsystems.

关键词： 3D printing aqueous electrolyte high voltage micro‐supercapacitors mXene

2.4 V ultrahigh-voltage aqueous mXene-based asymmetric micro-supercapacitors with high volumetric energy density toward a self-sufficient integrated microsystem

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Fundamental Research 2024年第2期4卷 307-314页

作者： Yuanyuan Zhu Shuanghao Zheng Jieqiong Qin Jiaxin ma Pratteek das Feng Zhou Zhong-Shuai Wu State key Laboratory of Catalysis Dalian Institute of Chemical PhysicsChinese Academy of SciencesDalian 116023China University of Chinese Academy of Sciences Shijingshan DistrictBeijing 100049China College of Science Henan Agricultural UniversityZhengzhou 450002China Dalian National Laboratory for Clean Energy Chinese Academy of SciencesDalian 116023China key Laboratory of Spin Electron and Nanomaterials of Anhui Higher Education Institutes Suzhou UniversitySuzhou 234000China

Two-dimensional mXenes are key high-capacitance electrode materials for micro-supercapacitors(mSCs)catering to integrated ***,the narrow electrochemical voltage windows of conventional aqueous electrolytes(≤1.23 V)and symmetric mXene mSCs(typically≤0.6 V)substantially limit their output voltage and energy *** concentrated aqueous electrolytes exhibit lower water molecule activity,which inhibits water splitting and consequently widens the operating voltage ***,we report ultrahigh-voltage aqueous planar asymmetric mSCs(AmSCs)based on a highly concentrated LiCl-gel quasi-solid-state electrolyte with mXene(Ti3C2Tx)as the negative electrode and mnO_(2) nanosheets as the positive electrode(mXene//mnO_(2)-AmSCs).The mXene//mnO_(2)-AmSCs exhibit a high voltage of up to 2.4 V,attaining an ultrahigh volumetric energy density of 53 mWh cm−***,the in-plane geometry and the quasi-solid-state electrolyte enabled excellent mechanical flexibility and performance uniformity in the serially/parallel connected packs of our ***,the mXene//mnO_(2)-AmSC-based integrated microsystem,in conjunction with solar cells and consumer electronics,could efficiently realize simultaneous energy harvesting,storage,and *** findings of this study provide insights for constructing high-voltage aqueous mXene-based AmSCs as safe and self-sufficient micropower sources in smart integrated microsystems.

关键词： Asymmetric micro-supercapacitors mXene mnO_(2) Aqueous electrolyte High voltage Integrated microsystem

Trigonelline mitigates bleomycin-induced idiopathic pulmonary fibrosis in mice

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Asian Pacific Journal of Tropical Biomedicine 2024年第9期14卷 391-400,I0008-I0291页

作者： Swapnil Gavhane Chandrakant Gawli Sachin k.m.r Biswajit das Gayatri marathe Vishal S.Patil Harun m.Patel Basavaraj Bommanahalli Chanakya Nath kundu Chandragouda R.Patil R.C.Patel Institute of Pharmaceutical Education and Research Karwand NakaShirpurMaharashtra 425405India Department of Pharmacology Delhi Pharmaceutical Sciences and Research UniversityNew Delhi 110017India School of Biotechnology Kalinga Institute of Industrial TechnologyBhubaneshwar 751024India Gadag Institute of medical Sciences GadagKarnataka 582103India

Objective:To evaluate the effect of trigonelline on bleomycin-induced idiopathic pulmonary fibrosis(IPF)and to explore its underlying mechanisms using network ***:IPF was induced in C57BL/6 mice by a single intratracheal instillation of bleomycin(5 mg/kg).Trigonelline was administered at doses of 25,50,and 100 mg/kg/day orally from the 2nd day post-bleomycin induction up to the 14th *** IPF-induced mice,lung coefficient,immune cell infiltration in bronchoalveolar lavage fluid,and oxidative stress were *** alterations in lung tissues were also ***,network pharmacology approach was conducted to reveal molecular interactions of bleomycin and trigonelline with targets of ***:Trigonelline treatment reduced bleomycin-induced oxidative stress and immune cell infiltration,and mitigated physiological changes in the lung tissues of ***,trigonelline alleviated bleomycin-induced histological alterations in lung *** pharmacology analysis showed that bleomycin and trigonelline interacted with IPF targets,such as NFkB1,HDAC2,HIF1A,and ***:The interaction of trigonelline with key IPF targets and its ameliorative effects on lung damage and oxidative stress highlight its potential in treating *** may be considered an antifibrotic agent for further clinical development.

关键词： Trigonelline Idiopathic pulmonary fibrosis Antifibrotic Bleomycin Network pharmacology

Effect of B_(2)O_(3)enrichment on microstructural inhomogeneity of high strength steel weldments

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China Welding 2024年第3期33卷 25-32页

作者： Joydeep Roy Pritam das Department of mechanical Engineering National Institute of Technology AgartalaTripura 799035India

The present work attributes the role of boron on the high strength steel submerged arc weld using an undermatching filler *** steel filler wire was used for welding in constant machine parameters setting to evaluate the joint strength due to the enrichment of *** change the chemical composition of the weld metal,boron trioxide powder was blended with virgin flux in various proportions(2.5%−12.5%),which led to an increase in boron weight percentage in the range of 0−*** results show that weld metals(Wm)optical micrographs depict the various types of ferrites,pearlites and secondary phases like martensite-austenite(m-A).Acicular ferrite con-tent was influenced by the boron trioxide *** affected zone(HAZ)micrographs were not showing appreciable changes with oxide *** and toughness of weld metals showed the mixed trend with B_(2)O_(3)enrichment whereas,small reduction in ultimate tensile strength(UTS)and yield strength(YS)was observed.

关键词： high strength steel B_(2)O_(3)flux microstructure hardness toughness ultimate tensile strength

Gas Chromatographic method for Identification and Quantification of Commonly Used Residual Solvents in Pharmaceuticals Products

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American Journal of Analytical Chemistry 2024年第8期15卷 241-252页

作者： Sreekanta Nath Dalal Pranab k.m.r das Department of Applied Chemistry & Chemical Engineering Faculty of Engineering & Technology University of Dhaka Dhaka Bangladesh Department of Applied Chemistry & Chemical Engineering Faculty of Engineering University of Rajshahi Rajshahi Bangladesh

Background: Impurities are not expected in the final pharmaceutical products. All impurities should be regulated in both drug substances and drug products in accordance with pharmacopeias and ICH guidelines. Three different types of impurities are generally available in the pharmaceutical’s product specification: organic impurities, inorganic impurities, and residual solvents. Residual solvents are organic volatile chemicals used or generated during the manufacturing of drug substances or drug products. Purpose: The aim of this study is to develop a cost-effective gas chromatographic method for the identification and quantification of some commonly used solvents—methanol, acetone, isopropyl alcohol (IPA), methylene chloride, ethyl acetate, tetrahydrofuran (THF), benzene, toluene, and pyridine—in pharmaceutical product manufacturing. This method will be able to identify and quantify the multiple solvents within a single gas chromatographic procedure. method: A gas chromatography (GC) equipped with a headspace sampler and a flame ionization detector, and a column DB 624, 30-meter-long × 0.32-millimeter internal diameter, 1,8 μm-thick, Brand-Agilent was used to develop this method. The initial GC oven temperature was 40°C and held for 5 minutes. It was then increase to 80˚C at a rate of 2˚C per minute, followed by a further increase to 225˚C at a rate of 30˚C per minute, with a final hold at 225˚C for 10 minutes. Nitrogen was used as a carrier gas at a flow rate of 1.20 mL per minute. Dimethyl sulfoxide (DmSO) was selected as sample solvent. Results: The developed method is precise and specific. The percent RSD for the areas of six replicate injections of this gas chromatographic method was within 10.0 and the recovery result found within 80.0% to 120.0%.

关键词： method Development Gas Chromatography Compendial method GDP Specificity Recovery