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Deep Insight of Design,Mechanism,and Cancer Theranostic Strategy of Nanozymes

Nano-Micro Letters 2024年第2期16卷 165-217页

作者： Lu Yang Shuming Dong Shili Gai Dan Yang he Ding Lili Feng Guixin Yang Ziaur Rehman Piaoping Yang Key Laboratory of Superlight Materials and Surface Technology Ministry of EducationCollege of Materials Science and Chemical EngineeringHarbin Engineering UniversityHarbin 150001People’s Republic of China Yantai Research Institute Harbin Engineering UniversityYantai 264000People’s Republic of China Key Laboratory of Green Chemical engineering and Technology of heilongjiang Province College of Material Science and Chemical EngineeringHarbin University of Science and TechnologyHarbin 150040People’s Republic of China Department of Chemistry Quaid-i-Azam UniversityIslamabad 45320Pakistan

Since the discovery of enzyme-like activity of Fe3O4 nanoparticles in 2007,nanozymes are becoming the promising substitutes for natural enzymes due to their advantages of high catalytic activity,low cost,mild reaction conditions,good stability,and suitable for large-scale ***,with the cross fusion of nanomedicine and nanocatalysis,nanozyme-based theranostic strategies attract great attention,since the enzymatic reactions can be triggered in the tumor microenvironment to achieve good curative effect with substrate specificity and low side ***,various nanozymes have been developed and used for tumor *** this review,more than 270 research articles are discussed systematically to present progress in the past five ***,the discovery and development of nanozymes are ***,classification and catalytic mechanism of nanozymes are ***,activity prediction and rational design of nanozymes are focused by highlighting the methods of density functional theory,machine learning,biomimetic and chemical ***,synergistic theranostic strategy of nanozymes are ***,current challenges and future prospects of nanozymes used for tumor theranostic are outlined,including selectivity,biosafety,repeatability and stability,in-depth catalytic mechanism,predicting and evaluating activities.

关键词： Nanozymes Classification Prediction and design Catalytic mechanism Tumor theranostics

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UHPC框架结构的抗车辆冲击性能研究

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力学季刊 2024年第1期45卷 119-131页

作者：和文超邓锷长治职业技术学院土木工程系山西长治046000 香港理工大学土木及环境工程学系中国香港九龙999077 国家轨道交通电气化与自动化工程技术研究中心(香港分中心) 中国香港九龙999077

随着我国交通系统的发展及汽车车速的日益提升,坐落于道路两旁的框架建筑承受的车辆碰撞风险也与日俱增.超高性能混凝土(Ultra-High Performance Concrete, UHPC)由于其超高的材料断裂能以及抗拉能力逐渐被应用于框架结构中以提高其使... 详细信息

随着我国交通系统的发展及汽车车速的日益提升,坐落于道路两旁的框架建筑承受的车辆碰撞风险也与日俱增.超高性能混凝土(Ultra-High Performance Concrete, UHPC)由于其超高的材料断裂能以及抗拉能力逐渐被应用于框架结构中以提高其使用性能.UHPC框架结构同样承受较高的车辆撞击风险.本文建立了三维动力非线性的车辆-UHPC三层框架结构碰撞模型并采用Ansys/LS-DYNA进行求解.采用已发表的落锤撞击普通混凝土(Normal Concrete, NC)与超高性能混凝土(UHPC)梁试验对材料参数与接触算法的正确性进行了验证.基于三维动力非线性碰撞模型,从结构损伤、碰撞力特性及结构耗能机理三方面对NC及UHPC框架结构进行了全面对比.主要结论如下:(1) UHPC框架结构的抗车辆冲击性能远高于NC框架结构.UHPC框架结构的损伤仅存在于被撞柱,其他部位混凝土的使用性能几乎不受影响.(2)高车速条件下(80~120 km/h),NC柱的损伤分布为剧烈的冲切损伤并伴有明显的塑性变形,框架节点出现明显的受拉及受剪损伤;UHPC柱的背面始终不出现受拉区域,最终发展成贯通框架柱截面的冲剪破坏.(3) NC柱的混凝土内能均比UHPC柱的混凝土内能高,导致NC柱的损伤程度比UHPC柱严重.(4)当车辆保险杠撞击框架柱时,碰撞力产生第一个峰值;当车辆引擎与框架柱撞击时,碰撞力产生第二个峰值.引擎撞击产生的碰撞力峰值均远高于保险杠撞击.UHPC柱的碰撞力峰值平均比NC柱高22.6%,二者碰撞力峰值最大差异可达32.1%.本文研究结果有助于促进UHPC框架结构的抗冲击合理化设计,并保障其安全健康运营.

关键词：超高性能混凝土框架结构抗冲击性能能量机理

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Multifunctional nanoparticle-mediated combining therapy for human diseases

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Signal Transduction and Targeted Therapy 2024年第2期9卷 343-375页

作者： Xiaotong Li Xiuju Peng Makhloufi Zoulikha George Frimpong Boafo Kosheli Thapa Magar Yanmin Ju Wei he School of Pharmacy China Pharmaceutical UniversityNanjing 2111198PR China Xiangya School of Pharmaceutical Sciences Central South UniversityChangsha 410013PR China Shanghai Skin Disease Hospital Tongji University School of MedicineShanghai 200443China

Combining existing drug therapy is essential in developing new therapeutic agents in disease prevention and *** preclinical investigations,combined effect of certain known drugs has been well established in treating extensive human *** to synergistic effects by targeting various disease pathways and advantages,such as reduced administration dose,decreased toxicity,and alleviated drug resistance,combinatorial treatment is now being pursued by delivering therapeutic agents to combat major clinical illnesses,such as cancer,atherosclerosis,pulmonary hypertension,myocarditis,rheumatoid arthritis,inflammatory bowel disease,metabolic disorders and neurodegenerative *** therapy involves combining or co-delivering two or more drugs for treating a specific ***(NP)-mediated drug delivery systems,i.e.,liposomal NPs,polymeric NPs and nanocrystals,are of great interest in combinatorial therapy for a wide range of disorders due to targeted drug delivery,extended drug release,and higher drug stability to avoid rapid clearance at infected *** review summarizes various targets of diseases,preclinical or clinically approved drug combinations and the development of multifunctional NPs for combining therapy and emphasizes combinatorial therapeutic strategies based on drug delivery for treating severe clinical ***,we discuss the challenging of developing NP-codelivery and translation and provide potential approaches to address the *** review offers a comprehensive overview for recent cutting-edge and challenging in developing NP-mediated combination therapy for human diseases.

关键词： drugs diseases prevention

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Development and formation of wing cuticle based on transcriptomic analysis in Locusta migratoria during metamorphosis

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Journal of Integrative Agriculture 2024年第4期23卷 1285-1299页

作者： Jing Zhang Zhaochen Wu Shuo Li he Huang Suning Liu Weimin Liu Xiaoming Zhao Jianzhen Zhang Shanxi Key Laboratory of Nucleic Acid Biopesticides Institute of Applied BiologyShanxi UniversityTaiyuan 030006China College of Life Science Shanxi UniversityTaiyuan 030006China Guangmeiyuan R&D Center/Guangdong Provincial Key Laboratory of Insect Developmental Biology and Applied Technology South China Normal UniversityMeizhou 514779China

Wings are an important flight organ of *** development is a complex process controlled by a series of *** flightless wing pad transforms into a mature wing with the function of migratory flight during the nymphto-adult ***,the mechanism of wing morphogenesis in locusts is still *** study analyzed the microstructures of the locust wing pads at pre-eclosion and the wings after eclosion and performed the comparative transcriptome ***-seq identified 25,334 unigenesand 3,430 differentially expressed genes(DeGs)(1,907 up-regulated and 1,523 down-regulated).The DeGs mainly included cuticle development(LmACPs),chitin metabolism(Lm Idgf4),lipid metabolism-related genes,cell adhesion(Integrin),zinc finger transcription factors(LmSalm,LmZF593 andLmZF521),and *** analysis based on RNA interference and hematoxylin and eosin(H&e)staining showed that the three genes encoded zinc finger transcription factors are essential for forming wing cuticle and maintaining morphology in Locusta ***,the study found that the LmSalm regulates the expression of LmACPs in the wing pads at pre-eclosion,and LmZF593 and LmZF521 regulate the expression of LmIntegrin/LmIdgf4/LmHMT420 in the wings after *** study revealed that the molecular regulatory axis controls wing morphology in nymphal and adult stages of locusts,offering a theoretical basis for the study of wing development mechanisms in hemimetabolous insects.

关键词： Locusta migratoria wing development metamorphosis RNA-seq

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Monte Carlo method for evaluation of surface emission rate measurement uncertainty

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Nuclear Science and Techniques 2024年第7期35卷 126-136页

作者： Yuan-Qiao Li Min Lin Li-Jun Xu Rui Luo Yu-he Zhang Qian-Xi Ni Yun-Tao Liu China Institute of Atomic energy Beijing102413China National Key Laboratory for Metrology and Calibration Techniques Beijing102413China Department of Radiation Oncology Hunan Cancer HospitalChangsha410031China The Affiliated Cancer Hospital of Xiangya School of Medicine Central South UniversityChangsha410031China

The aim of this study is to evaluate the uncertainty of 2πcx and 2πβsurface emission rates using the windowless multiwire proportional counter *** study used the Monte Carlo method(MCM)to validate the conventional Guide to the expression of Uncertainty in Measurement(GUM)method.A dead time mea surement model for the two-source method was established based on the cha racteristics of a single--channel measurement systemn,and the voltage threshold correction factor measurement function was indi rectly obtained by fitting the threshold correction *** uncertainty in the surface emission rate was calculated using the GUM method and the law of propagation of *** MCM provided clear definitions for each input quantity and its uncertainty distribution,and the simulation training was realized witha complete and complex mathematical *** results of the surface emission rate uncertainty evaluation for four radioactive plane sources using both methods showed the uncertainty's consistency e_(n)he comparison of each source,and the uncertainty results ofthe GUM were all lower than those of the ***,the MCM has a more objective evaluation process and can serve as a validation tool for GUM results.

关键词： Surface emission rate Monte Carlo method Metrology Probability distribution function Dead time Low-energy loss correction Least-squares method

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Regulating interfacial behavior of zinc metal anode via metal-organic framework functionalized separator

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Journal of energy Chemistry 2024年第6期93卷 213-220,I0006页

作者： Ruotong Li Liang Pan Ziyu Peng Ningning Zhao Zekun Zhang Jing Zhu Lei Dai Ling Wang Zhangxing he School of Chemical engineering North China University of Science and TechnologyTangshan 063210HebeiChina

Aqueous zinc ion batteries(AZIBs)are one of the promising energy storage ***,uncontrolled dendrite and side reactions have seriously hindered its further *** this study,the metal-organic framework(MOF)functionalized glass fiber separator(GF-PFC-31)was used to regulate interfacial behavior of zinc metal anode,enabling the development of high-performance *** PFC-31,there areπ-πinteractions between two adjacent benzene rings with a spacing of 3.199 *** spacing can block the passage of[Zn(H_(2)O)_6]^(2+)(8.6 A in diameter)through the GF-PFC-31 separator to a certain extent,which promotes the deposition process of Zn *** addition,the sulfonic acid group(-S03H)contained in GF-PFC-31 can form a hydrogen bonding network with H_(2)O,which can provide a desolvation effect and reduce the side ***,GF-PFC-31 separator achieves uniform deposition of Zn *** Zn‖GF-PFC-31‖Zn symmetric cell exhibits stable cycle life(3000 h at 1.2 mA cm^(-2),2000 h at 0.3 mA cm^(-2),and 2000 h at 5.0 mA cm^(-2)),and Zn‖GF-PFC-31‖MnO_(2) full cell with GF-PFC-31 separator can cycle for 1000 cycles at 1.2 A g^(-1)with capacity retention rate of 82.5%.This work provides a promising method to achieve high-performance AZIBs.

关键词： Aqueous zinc ion batteries Interfacial behavior Metal-organic framework Sulfonic acid group Separator

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Preparation of single atom catalysts for high sensitive gas sensing

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International Journal of extreme Manufacturing 2024年第3期6卷 216-248页

作者： Xinxin he Ping Guo Xuyang An Yuyang Li Jiatai Chen Xingyu Zhang Lifeng Wang Mingjin Dai Chaoliang Tan Jia Zhang Key Laboratory of Microsystems and Microstructure Manufacturing Ministry of EducationHarbin Institute of TechnologyHarbin 150080People’s Republic of China Institute for Frontier Materials Deakin UniversityWaurn Ponds CampusLocked Bag 20000Victoria 3220Australia School of electrical and electronic engineering Nanyang Technological UniversitySingapore 639798Singapore Department of electrical and electronic engineering The University of Hong KongPokfulam RoadHong Kong Special Administrative Region of China 999077People’s Republic of China Chongqing Research Institute Harbin Institute of TechnologyChongqing 401120People’s Republic of China

Single atom catalysts(SACs)have garnered significant attention in the field of catalysis over the past decade due to their exceptional atom utilization efficiency and distinct physical and chemical *** the semiconductor-based electrical gas sensor,the core is the catalysis process of target gas molecules on the sensitive *** this context,the SACs offer great potential for highly sensitive and selective gas sensing,however,only some of the bubbles come to the *** facilitate practical applications,we present a comprehensive review of the preparation strategies for SACs,with a focus on overcoming the challenges of aggregation and low *** research efforts have been devoted to investigating the gas sensing mechanism,exploring sensitive materials,optimizing device structures,and refining signal post-processing ***,the challenges and future perspectives on the SACs based gas sensing are presented.

关键词： single atom catalysts preparation sensing mechanism gas sensing

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Digital monitoring of rotary-percussive drilling with down-the-hole hammer for profiling weathered granitic ground

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Journal of Rock Mechanics and Geotechnical engineering 2024年第5期16卷 1615-1636页

作者： Wendal Victor Yue Siyuan Wu Manchao he Yafei Qiao Zhongqi Quentin Yue Department of Geotechnical engineering College of Civil EngineeringTongji UniversityShanghai200092China Department of Civil engineering Faculty of EngineeringThe University of Hong KongPokfulam RoadHong KongChina State Key Laboratory for Geomechanics and Deep Underground engineering China University of Mining and TechnologyBeijing100083China Key Laboratory of Geotechnical and Underground engineering of Ministry of education Tongji UniversityShanghai200092China

Rock and geotechnical engineering investigations involve drilling holes in ground with or without retrieving soil and rock samples to construct the subsurface ground *** the basis of an actual soil nailing drilling for a slope stability project in Hong Kong,this paper further develops the drilling process monitoring(DPM)method for digitally profiling the subsurface geomaterials of weathered granitic rocks using a compressed airflow driven percussive-rotary drilling machine with down-the-hole(DTH)*** transducers are installed on the drilling machine and record the chuck displacement,DTH rotational speed,and five pressures from five compressed airflows in real-time *** mechanism and operations of the drilling machine are elaborated in detail,which is essential for understanding and evaluating the drilling data.A MATLAB program is developed to automatically filter the recorded drilling data in time series and classify them into different drilling processes in sub-time *** processes include penetration,push-in with or without rod,pull-back with or without rod,rod-tightening and *** drilling data are further reconstructed to plot the curve of drill-bit depth versus the net drilling time along each of the six *** curve is found to contain multiple linear segments with a constant penetration rate,which implies a zone of homogenous geomaterial with different weathering *** effect from fluctuation of the applied pressures is evaluated *** analyses are presented for accurately assess and verify the underground profiling and strength in weathered granitic rock,which provided the basis of using DPM method to confidently assess drilling measurements to interpret the subsurface profile in real time.

关键词： Drilling process monitoring(DPM) Down-the-hole(DTH)hammer Percussive-rotary drilling Weathering granitic rocks

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High temperature polyimide nanocomposites containing twodimensional nanofillers for improved thermal stability and capacitive energy storage performance

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Nano Research 2024年第8期17卷 7746-7755页

作者： Ding Ai Yuting Han Zongliang Xie Xi Pang Yuan Chang he Li Chenglong Wu Yonghong Cheng Guanglei Wu State Key Laboratory of electrical Insulation and Power equipment School of Electrical EngineeringXi’an Jiaotong UniversityXi’an 710049China Institute of Materials for energy and environment State Key Laboratory of Bio-Fibers and Eco-TextilesCollege of Materials Science and EngineeringQingdao UniversityQingdao 266071China

Future electronic devices toward high integration and miniaturization demand reliable operation of dielectric materials at high electric fields and elevated ***,the electrical deterioration caused by Joule heat generation remains a persistent challenge to ***,the solution-processed polyimide(PI)nanocomposites with unique two-dimensional(2D)alumina nanoplates are *** improvements in the breakdown strength,charge–discharge efficiency and discharged energy density at elevated temperatures have been demonstrated in the composites,owing to simultaneously suppressed conduction loss and increased thermal conductivity upon the incorporation of 2D Al2O3 nanofillers possessing excellent dielectric insulation and thermophysical *** predominance of Al2O3 nanoplates in enhancing thermal stability and high-temperature capacitive performance over nanoparticles and nanowires is validated experimentally and is further rationalized via finite element ***,the Al2O3 nanoplates filled PI nanocomposite exhibits a hightemperature capability up to 200℃and remarkable efficiency(e.g.≥95%at 200 MV/m)over a wide temperature range,which outperforms commercial dielectric polymers and rivals the state-of-the-art polyimide nanocomposites.

关键词： capacitors polymer nanocomposites high temperature energy storage thermal stability

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Research progress on rare earth up-conversion and near-infrared Ⅱ luminescence in biological applications

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Chinese Chemical Letters 2024年第2期35卷 87-96页

作者： Miao Yang Haijiang Gong Dan Yang Lili Feng Shili Gai Fangmei Zhang he Ding Fei he Piaoping Yang Key Laboratory of Superlight Materials and Surface Technology Ministry of EducationCollege of Materials Science and Chemical EngineeringHarbin Engineering UniversityHarbin 150001China Yantai Research Institute Harbin Engineering UniversityYantai 264000China School of Pharmaceutical Sciences Zhengzhou UniversityZhengzhou 450001China

Rare earth luminescence has attracted widespread attention for several decades, among which nearinfrared(NIR) light-related up-conversion luminescence and NIR-Ⅱ luminescence are widely used in the biomedical field. The NIR-related luminescence is widely studied due to the excellent performance, such as good biocompatibility, deep tissue penetration depth, low self-fluorescence and minimal light damage to organisms. In this review, we mainly introduce the mechanism for rare earth up-conversion luminescence, NIR-Ⅱ luminescence and conclude their advantages compared with traditional *** excellent priorities provide the basis for NIR-related luminescence bioimaging in vivo. Additionally,we hilglight the scheme for the sensitive detection of substances in organisms and various methods for biological therapy. In spite of the existing research, it is outlined that NIR-related luminescence has great potential to be applied in different aspects, expanding perspectives and future challenges of research in related fields. Based on the current scientific achievements, this review can provide reference for research in the areas mentioned above, expand the research direction and arouse a broad interest in different disciplines to pay attention to rare earth luminescence.

关键词： Rare earth Up-conversion NIR-Ⅱ Imaging Biosensor Therapy

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