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Genetic alteration and mutation profiling of circulating cell-free tumor DNA(cfDNA) for diagnosis and targeted therapy of gastrointestinal stromal tumors

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Chinese journal of Cancer 2016年第7期35卷 342-349页

作者： Weixin Yan Aiguo Zhang Michael j.powell Robotics Research Institute School of Mechanical EngineeringShanghai Jiao Tong UniversityShanghai 200240P.R. China DiaCarta Inc. 2600 Hilltop Drive Richmond CA 94806USA

Gastrointestinal stromal tumors(GISTs) have been recognized as a biologically distinctive type of tumor,different from smooth muscle and neural tumors of the gastrointestinal *** identification of genetic aberrations in proto-oncogenes that drive the growth of GISTs is critical for improving the efficacy of cancer therapy by matching targeted drugs to specific *** into the oncogenic mechanisms of GISTs has found that these tumors frequently contain activating gene mutations in either platelet-derived growth factor receptor A(PDGFRA) or a receptor tyrosine protein associated with a mast cell growth factor receptor encoded by the KIT *** cancer subpopulations have the potential to disrupt durable patient responses to molecularly targeted therapy for GISTs,yet the prevalence and size of subpopulations remain largely *** of the cancer subpopulations that harbor low-frequency mutant alleles of target proto-oncogenes through the use of molecular genetic methods,such as polymerase chain reaction(PCR) target amplification technology,is hampered by the high abundance of wildtype alleles,which limit the sensitivity of detection of these minor mutant *** is especially true in the case of mutant tumor DNA derived "driver" and "drug-resistant" alleles that are present in the circulating cell-free tumor DNA(cfDNA) in the peripheral blood circulation of GIST ***-called "liquid biopsy" allows for the dynamic monitoring of the patients' tumor status during treatment using minimally invasive *** methodologies,such as a technology that employs a xenonucleic acid(XNA) clamping probe to block the PCR amplification of wild-type templates,have allowed improved molecular detection of these low-frequency alleles both in tissue biopsy samples and in *** new methodologies could be widely applied for minimally invasive molecular testing in the therapeutic management of GISTs.

关键词：基因突变检测肿瘤治疗靶向治疗遗传变异肥大细胞胃肠道 DNA 间质

A Ring-Reinforced Right Ventricle to Pulmonary Artery Conduit Is Associated with Better Regional Mechanics after Stage I Norwood Operation

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Congenital Heart Disease 2022年第5期17卷 591-603页

作者： Benjamin Zielonka David M.Harrild Sunil j.Ghelani Eleni G.Elia Christopher W.Baird Andrew j.powell Rahul H.Rathod Department of Cardiology Boston Children’s HospitalBostonUSA Department of Pediatrics Harvard Medical SchoolBostonUSA Department of Cardiothoracic Surgery Boston Children’s HospitalBostonUSA Department of Surgery Harvard Medical SchoolBostonUSA

Background:The right ventricle to pulmonary artery conduit(RVPAC)may impair right ventricular(RV)function in patients with functional single right *** of the RVPAC using a ring-reinforced end with dunked insertion into the RV through a limited ventriculotomy may reduce the impact on RV *** compared RV segmental strain between patients with a traditional RVPAC and ring-reinforced RVPAC using feature tracking cardiovascular magnetic resonance(CMR)***:Patients with CMR examinations after Stage I operation with RVPAC between 2000 and 2018 were *** mass,volumes,late gadolinium enhancement(LGE),and peak radial and circumferential strain of the 4 segments near the RVPAC insertion site were ***:The study included 71 CMR examinations in 61 patients(30 traditional RVPAC,31 ring-reinforced RVPAC).Prior to Stage II,the ring-reinforced RVPAC group had better peak radial strain and circumferential strain in 1 of 4 segments proximal to the RVPAC insertion site compared to the traditional RVPAC *** to Stage III operation,the ring-reinforced group had better peak radial and circumferential strain in 2 of 4 *** at the RVPAC insertion site was observed in 97%of patients before Stage II and 95%of patients before Stage *** type and regional strain were not associated with transplant-free survival during a median follow-up of 6.3 ***:Compared to a traditional RVPAC,the ring-reinforced RVPAC is associated with improved regional mechanics at the conduit insertion *** investigation of long-term outcomes after ring-reinforced RVPAC is warranted.

关键词： Single ventricle hypoplastic left heart syndrome cardiovascular magnetic resonance feature tracking

Radioactive Ion Beams at Berkeley

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近代物理研究所和兰州重离子加速器实验室年报：英文版 2000年第1期 136-137页

作者： XuXiaoji j.powell 不详 LawrenceBerkeleyNationallaboratory CA94720USA

Mass transport in a highly immiscible alloy on extended shear deformation

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journal of Materials Science & Technology 2023年第3期134卷 197-208页

作者： Miao Song jia Liu Xiaolong Ma Qin Pang Matthew j.Olszta joshua Silverstein Madhusudhan R.Pallaka Peter V.Sushko Suveen N.Mathaudhu Cynthia powell Arun Devaraj Bharat Gwalani Physical and Computational Sciences Directorate Pacific Northwest National Laboratory902 Battelle BoulevardRichlandWA 99354USA Energy and Environmental Directorate Pacific Northwest National Laboratory902 Battelle BoulevardRichlandWA 99354USA Material Science and Engineering Program University of CaliforniaRiversideCA92521USA Colorado School of Mines 1500 Illinois St.GoldenCO 8040USA Department of Materials Science and Engineering North Carolina State UniversityRaleighNC27695-7907USA State Key Laboratory of Powder Metallurgy Central South Uni-versityChangsha 410083China

Forced mixing to a single-phase or supersaturated solid solution(SSS)and its prerequisite microstructure evolution in immiscible systems has been a focus of research for fundamental science and practical *** the formation of SSS by shear deformation could enable a material design beyond conventional equilibrium microstructure in immiscible ***,a highly immiscible Cu-50 at.%Cr binary alloy(mixing enthalpy of∼20 kj mol^(−1))was employed to investigate the microstructure evolution and localized tendencies of SSS during severe shear *** results demonstrate the dislocation mediated microstructural refinement process in each phase of the binary alloy and the mechanisms associated with localized solute supersaturation as a function of shear *** grain refinement in the softer Cu phase occurs owing to the strain localization driving the preferential dynamic *** grain refinement of the Cr phase,however,is enabled by the progressive evolution of grain lamination,splitting,and fragmentation as a function of shear *** solute supersaturation is found to be strongly dependent on the local environments that affect the dislocation activity,including the level of microstructure refinement,the interfacial orientation relationship,the mechanical incompatibility,and the localized preferential phase *** initio simulations confirm that it is more favorable to oxidize Cr than Cu at incoherent Cu/Cr interfaces,limiting the mass transport on an incoherent *** results unveil the mechanism underpinning the non-equilibrium mass transport in immiscible systems upon severe deformation that can be applied to produce immiscible alloys with superior mechanical properties.

关键词： Tribology Immiscible alloys Nanostructures Shear deformation Forced mixing Atom probe

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后桥钢板激光-MIG复合焊接优化研究

汽车技术 2008年第1期 54-57页

作者：姚远 M．Wouters j.powell K．Nilsson A．Kaplan 中国第一汽车集团公司技术中心瑞典Lulea工业大学英国Laser Expertise有限公司

研究了两种后桥桥壳用低合金钢板在激光-MIG复合焊接中,接头形状、接头间隙及MIG参数变化(大、中、小MIG参数)对焊缝形状及焊缝喉厚的影响。研究结果表明,MIG参数应设置成大、中MIG参数水平,以保证在一定的接头间隙下有充足的焊接材料... 详细信息

研究了两种后桥桥壳用低合金钢板在激光-MIG复合焊接中,接头形状、接头间隙及MIG参数变化(大、中、小MIG参数)对焊缝形状及焊缝喉厚的影响。研究结果表明,MIG参数应设置成大、中MIG参数水平,以保证在一定的接头间隙下有充足的焊接材料填入间隙而形成部分焊透的焊缝,使焊缝喉厚满足焊接强度要求;过高的MIG输入能量和过多的焊料(丝)填入将导致焊缝横截面积增大,但对焊缝喉厚的影响不是很明显;当MIG参数设置成小MIG参数水平时,0.5 mm的接头间隙或切角面为3 mm×2 mm时,对获得较大的焊缝喉厚有利。

关键词：激光焊 MIG焊复合焊接钢板

外源性细胞因子对优化嵌合抗原受体修饰的T细胞抗肿瘤作用的研究

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外源性细胞因子对优化嵌合抗原受体修饰的T细胞抗肿瘤作用的研究

2015年浙江省血液病学学术年会

作者：徐晓军宋德刚 Mathilde Poussi 汤永民 Daniel j.powell jr. 浙江大学医学院附属儿童医院 Ovarian Cancer Research Center Department of Obstetrics and GynecologyPerelman School of Medicine University of Pennsylvania

目的:嵌合抗原受体(CAR)修饰的T细胞是肿瘤过继免疫治疗颇具前景的手段,在淋巴系肿瘤的治疗中已经取得了具有令人鼓舞的疗效。细胞因子被广泛应用于CAR-T细胞扩增和治疗过程,以IL-2最为常用。目前尚无系统性研究比较各细胞因子对CAR-T...

目的:嵌合抗原受体(CAR)修饰的T细胞是肿瘤过继免疫治疗颇具前景的手段,在淋巴系肿瘤的治疗中已经取得了具有令人鼓舞的疗效。细胞因子被广泛应用于CAR-T细胞扩增和治疗过程,以IL-2最为常用。目前尚无系统性研究比较各细胞因子对CAR-T细胞最终抗肿瘤效果影响的报道。本研究拟比较不同细胞因子包括IL-2、IL-7、IL-15、IL-18和IL-21对体内外CAR-T细胞的扩增效率和抗肿瘤活性的影响。

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来源： cnki会议评论

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可重复使用的无心感应炉筑衬钢模(英)

工业加热 1987年第6期19卷 50-51,33页

作者： j.powell 彭规锦

铸铁车间无心感应炉修筑炉衬,传统上是使用自耗钢模,以手工或振动围绕钢模捣筑耐火材料,钢模在炉衬烧结时加热熔化,成为第一炉铁水的一部分。新炉衬第一炉熔炼时,工频炉钢模中要装入起熔块。自耗钢模的主要缺点是筑一次炉衬就消耗一个... 详细信息

铸铁车间无心感应炉修筑炉衬,传统上是使用自耗钢模,以手工或振动围绕钢模捣筑耐火材料,钢模在炉衬烧结时加热熔化,成为第一炉铁水的一部分。新炉衬第一炉熔炼时,工频炉钢模中要装入起熔块。自耗钢模的主要缺点是筑一次炉衬就消耗一个钢模,增加筑衬费用,特别是大炉子(6吨炉,每个钢模值240英磅;12吨炉,每个钢模值365英磅)。除此之外,还有以下缺点: 1.炉衬尚未完全烧结。坩埚底部先形成熔池,由于铁水过热,使炉衬烧结质量不均匀;

关键词：钢模云母片炉衬烧结无心感应炉可重复使用

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酒与药物滥用咨询辅导要素

中国药物依赖性杂志 2004年第3期13卷 173-177页

作者： David j.powell 敖蕾郭松 International Center for Health Concerns 首都医科大学附属北京安定医院

在世界范围内,药物依赖心理咨询越来越引起人们的兴趣.酒精和药物滥用咨询这个新兴的专业,已得到蓬勃发展.他们专门从事对酒精和药物滥用者的照管和治疗.从事药物滥用治疗的专业人员特别需要跟上这个新专业的发展.当今由于前来就医的患... 详细信息

在世界范围内,药物依赖心理咨询越来越引起人们的兴趣.酒精和药物滥用咨询这个新兴的专业,已得到蓬勃发展.他们专门从事对酒精和药物滥用者的照管和治疗.从事药物滥用治疗的专业人员特别需要跟上这个新专业的发展.当今由于前来就医的患者更年轻化,他们的家属也需要参与治疗,新的药物治疗和干预措施正不断发展,所有这一切都推动着开创药物依赖治疗的新方法。

关键词：咨询辅导药物依赖酒精依赖药物滥用

Comparative efficacy of gypsy moth(Lepidoptera:Erebidae)entomopathogens on transgenic blight-tolerant and wild-type American,Chinese,and hybrid chestnuts(Fagales:Fagaceae)

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Insect Science 2020年第5期27卷 1067-1078页

作者： Aaron j.Brown Andrew E.Newhouse William A.powell Dylan Parry Department of Environmental and Forest Biology College of Environmental Science and ForestryState University of New YorkSyracuseNY13210USA

American chestnut(Castanea dentata[Marsh.]Borkh.)was once the dominant hardwood species in Eastern North America before an exotic fungal pathogen,Cryphonec-tria parasitica(Murrill)Barr,functionally eliminated it across its *** promising approach toward restoring American chestnut to natural forests is development of blight-tolerant trees using genetic ***,transformation and related processes can result in unexpected and unintended phenotypic changes,potentially altering ecologi-cal *** assess unintended tritrophic impacts of transgenic American chestnut on plant herbivore interactions,gypsy moth(Lymantria dispar L.)caterpillars were fed leaf disks excised from two transgenic events,Darling 54 and Darling 58,and four control American chestnut *** disks were previously treated with an LDso dose of either the speces-specific Lymantria dispar multiple nucleopolyhedrovirus(LdMNPV)or the generalist pathogen Bacillus thuringiensis ***(Btk).Mortality was quantified and compared to water blank *** genotype had a strong efect on the efficacies of both *** mortality from Btk-treated foliage from only one transgenic event,Darling 54,differed from its isogenic progenitor,Ellis l,but was similar to an unre-lated wild-type American chestnut *** efficacy was unaffected by genetic *** suggest that although genetic modification of trees may affect interactions with other nontarget organisms,this may be due to insertion effects,and varia-tion amnon diMterent genvtypes(wlether uasgeic ul wild-typc)iupaults a giealci change in response than transgene presence.

关键词： Bacillus thuringiensis LdMNPV nontarget restoration tri-trophic unin-tended effects