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Immune Profile of COVId-19 Survivors and Contacts during 9 Months:A Cohort Study

Infectious diseases & Immunity 2023年第4期3卷 163-175页

作者： Valentina V.Tatarnikova Natalya O.Kiseleva Valentina I.dubrovina Vladimir A.Vishnyakov darya d.bryukhova Anna B.Pyatidesyatnikova Konstantin M.Korytov Munko B.Sharakshanov Sergey V.Balakhonov Irkutsk Antiplague Research Institute of Siberia and Far East of Rospotrebnadzor Irkutsk 664047Russia

Background:Severe acute respiratory syndrome coronavirus 2(SARS-CoV-2)causes a multi-organ systemic damage that can lead to long-term *** is known about the possible long-term effects of COVId-19 on circulating leukocyte kinetics and functional T-cell activity after *** investigate immune system changes,we designed a cohort ***:Volunteer screening and sample collectionwere performed at the Irkutsk Research Anti-Plague Institute of ***-four volunteers who have had COVId-19(recovered volunteers(RVs))betweenMay 2020 andMay 2021,33 volunteers who had been in contact with COVId-19 patients(contact volunteers(CVs))within the family setting but had not become ill,and 47 healthy volunteers(HVs)participated in the *** performed immunophenotyping of peripheral blood cells using flow *** was tested for SARS-CoV-2 anti-nucleocapsid immunoglobulin G antibodies by enzyme-linked immunosorbent assay(Ab(+),people with specific anti-N antibodies to SARS-CoV-2;Ab(−),people without specific antibodies).Results:There were no serious disturbances in the internal environment of the body in RVs and *** the evaluation of the general state of the immune system,the most informative indicator was the index of the ratio of neutrophils to bloodmonocytes–decreased on the 1st terms of observation(1 and 3 months post-symptom onset(PSO)/post-contact onset(PCO)),on average,1.3 times compared with HVs(8.6%(7.5%–10.5%),Pd by the 6th month of *** of the cells responsible for the development of the adaptive immune response was noted only in RVs–increased B-lymphocyte content(HVs,9.1%(6.4%–10.2%))and immunoregulatory index ratio(HVs,1.6%(1.2%–2.1%))due to redistribution of T-helper and cytotoxic T cells throughout the follow-up period by an average of 1.2-fold compared with HVs(Pdies to SARS-CoV-2 N-protein also had an increased proportion of Cd3−Cd19+c

关键词： COVId-19 Flow cytometry Immunity Specific IgG T cells B cells

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Garg incontinence scores: New scoring system on the horizon to evaluate fecal incontinence. Will it make a difference?

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World Journal of Gastroenterology 2024年第3期30卷 204-210页

作者： Petr Tsarkov Inna Tulina Parvez Sheikh darya d Shlyk Pankaj Garg department of Colorectal Surgery Sechenov First Moscow State Medical UniversityMoscow 119991Russia department of Oncologic Colorectal Surgery Sechenov First Moscow State Medical UniversityMoscow 119991Russia department of Colorectal Surgery Saifee HospitalMumbai 400004MaharashtraIndia department of Colorectal Surgery Garg Fistula Research InstitutePanchkula 134113HaryanaIndia

The main aim of this opinion review is to comment on the recent article published by Garg et al in the World Journal of Gastroenterology 2023;29:4593–*** authors in the published article developed a new scoring system,Garg incon-tinence scores(GIS),for fecal incontinence(FI).FI is a chronic debilitating disease that has a severe negative impact on the quality of life of the *** IV criteria define FI as multiple episodes of solid or liquid stool passed into the clothes at least twice a *** associated social stigmatization often leads to significant under-reporting of the condition,which further impairs *** important point is that the complexity and vagueness of the disease make it difficult for the patients to properly define and report the magnitude of the problem to their *** to this,the management becomes even more *** issue is resolved up to a considerable extent by a scoring *** were several scoring systems in use for the last three *** prominent of them were the Cleveland Clinic scoring system or the Wexner scoring system,*** Hospital or Vaizey’s scores,and the FI severity ***,there were several shortcomings in these scoring *** the opinion review,we tried to analyze the strength of GIS and compare it to the existing scoring *** main pitfalls in the existing scoring systems were that most of them gave equal weightage to different types of FI(solid,liquid,flatus,etc.),were not comprehensive,and took only the surgeon’s perception of FI into *** GIS,almost all shortcomings of previous scoring systems had been addressed:different weights were assigned to different types of FI by a robust statistical methodology;the scoring system was made comprehensive by including all types of FI that were previously omitted(urge,stress and mucus FI)and gave priority to patients’rather than the physicians’perceptions while developing the scoring *** to this,GIS in

关键词： Fecal incontinence Scoring system Urge Stress Flatus

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Sarcopenic obesity in patients awaiting liver transplant: Unique challenges for nutritional recommendations

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World Journal of Transplantation 2024年第2期14卷 40-47页

作者： darya M Herscovici Katherine M Cooper Alessandro Colletta Michelle Rightmyer Alexandra Shingina Lauren d Feld department of Medicine UMass Chan Medical SchoolWorcesterMA 01655United States division of Transplant Nutrition UMass Chan Medical SchoolWorcesterMA 01655United States department of Medicine Vanderbilt University Medical CenterNashvilleTN 37215United States division of Gastroenterology UMass Chan Medical SchoolWorcesterMA 01655United States

Sarcopenic obesity increases the risk of mortality in patients with liver disease awaiting liver transplantation and in the post-transplant *** recommendations for individuals with sarcopenia differ from recommendations for patients with obesity or sarcopenic *** these nutrition guidelines have been established in non-cirrhotic patients,established guidelines for liver transplant candidates with sarcopenic obesity are *** this paper,we review existing literature on sarcopenic obesity in patients with chronic liver disease and address opportunities to improve nutritional counseling in patients awaiting liver transplantation.

关键词： Nutrition Sarcopenia Sarcopenic obesity Liver transplant Cirrhosis Chronic liver disease Body composition Myostatin

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A combined computational/experimental study of anode-concerned voltage drop in aqueous primary Mg-air batteries

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Journal of Magnesium and Alloys 2024年第5期12卷 1854-1866页

作者： Wen Xu Min deng darya Snihirova Linqian Wang Yulong Wu Sviatlana V.Lamaka Mikhail L.Zheludkevich daniel Hoche Institute of Surface Science Helmholtz-Zentrum Hereon21502 GeesthachtGermany School of Materials Science and Engineering Hebei University of Technology300000TianjinChina Institute for Materials Science Faculty of EngineeringKiel University24143 KielGermany

The voltage drop appearing at Mg anode-electrolyte interface is a critical issue for the battery power and energy density of aqueous primary Mg-air *** respective voltage loss is typically assigned to the deposits layer forming on the anode surface during *** this work,we experimentally and computationally investigate the critical factors affecting the voltage drop at Mg anode towards a deeper understanding of the contribution of deposit and its growth.A two-dimensional(2d)mathematical model is proposed to compute the voltage drop of Mg-0.15Ca wt.%alloy(Mg-0.15Ca)by means of a semi-empirical formulas and experiments-based modification model,considering the effect of discharge current density,the negative difference effect(NdE)and surface deposits layer *** model is utilized to simulate the discharge potential of the anode at predefined experimental current *** computed voltage drop(half-cell voltage)is in good agreement with the experimental *** applicability of the mathematical model is successfully validated on the second material(namely high-purity Mg).

关键词： Aqueous Mg-air battery Voltage drop NdE Charge transfer deposits-related resistances

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Two surgical pathways for isolated hip fractures:A comparative study

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World Journal of Orthopedics 2023年第6期14卷 399-410页

作者： Alexander A Fokin Joanna Wycech Knight Maral darya Ryan Stalder Ivan Puente Russell d Weisz Trauma and Critical Care Services Delray Medical CenterDelray BeachFL 33484United States department of Surgery Charles E.Schmidt College of MedicineFlorida Atlantic UniversityBoca RatonFL 33431United States Trauma and Critical Care Services Broward Health Medical CenterFort LauderdaleFL 33316United States Charles E.Schmidt College of Medicine Florida Atlantic UniversityBoca RatonFL 33431United States department of Surgery Herbert Wertheim College of MedicineFlorida International UniversityMiamiFL 33199United States department of Orthopedics South Palm OrthopedicsDelray BeachFL 33445United States

BACKGROUNd Hip fractures(HF)are common among the aging population,and surgery within 48 h is *** can be hospitalized for surgery through different pathways,either trauma or medicine admitting *** To compare management and outcomes among patients admitted through the trauma pathway(TP)vs medical pathway(MP).METHOdS This Institutional Review Board-approved retrospective study included 2094 patients with proximal femur fractures(AO/Orthopedic Trauma Association Type 31)who underwent surgery at a level 1 trauma center between *** were 69 patients admitted through the TP and 2025 admitted through the *** ensure comparability between groups,66 of the 2025 MP patients were propensity matched to 66 TP patients by age,sex,HF type,HF surgery,and American Society of Anesthesiology *** statistical analyses included multivariable analysis,group characteristics,and bivariate correlation comparisons with theχ^(2)test and *** After propensity matching,the mean age in both groups was 75-years-old,62%of both groups were females,the main HF type was intertrochanteric(TP 52%vs MP 62%),open reduction internal fixation was the most common surgery(TP 68%vs MP 71%),and the mean American Society of Anesthesiology score was 2.8 for TP and 2.7 for *** majority of patients in TP and MP(71%vs 74%)were geriatric(≥65-years-old).Falls were the main mechanism of injury in both groups(77%vs 97%,P=0.001).There were no significant differences in pre-surgery anticoagulation use(49%vs 41%),admission day of the week,or insurance *** incidence of comorbidities was equal(94%for both)with cardiac comorbidities being dominant in both groups(71%vs 73%).The number of preoperative consultations was similar for TP and MP,with the most common consultation being cardiology in both(44%and 36%).HF displacement occurred more among TP patients(76%vs 39%,P=0.000).Time to surgery was not statistically different(23 h in both),but length of surgery was sig

关键词： Isolated hip fractures Admitting service Trauma center Time to surgery American Society of Anesthesiologists score Preoperative consultations

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development of 3d Scanning System for Robotic Plasma Processing of Medical Products with Complex Geometries

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Journal of Electronic Science and Technology 2020年第3期18卷 212-222页

作者： darya L.Alontseva Elaheh Ghassemieh Alexander L.Krasavin Albina T.Kadyroldina School of Information Technology and Intelligent Systems D.Serikbayev East Kazakhstan State Technical UniversityUst-Kamenogorsk 070004 Wolfson School of Mechanical Electrical and Manufacturing EngineeringLoughborough UniversityLoughborough LE113TU

This paper describes the development of an intelligent automated control system of a robot manipulator for plasma treatment of medical implants with complex *** two-layer coatings from the Ti wire and hydroxyapatite powders are applied on the surface of Ti medical implants by microplasma spraying to increase the biocompatibility of *** coating process requires precise control of a number of parameters,particularly the plasma spray distance and plasma jet traverse ***,the development of the robotic plasma surface treatment involves automated path *** key idea of the proposed intelligent automatic control system is the use of data of preliminary three-dimensional (3d) scanning of the processed implant by the robot *** segmentation algorithm of the point cloud from laser scanning of the surface is *** methodology is suitable for robotic 3d scanning systems with both non-contact laser distance sensors and video cameras,used in additive manufacturing and medicine.

关键词： Plasma processing point cloud robot manipulator surface segmentation three-dimensional(3d)scanning

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Arachidyl amido cholanoic acid improves liver glucose and lipid homeostasis in nonalcoholic steatohepatitis via AMPK and mTOR regulation

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World Journal of Gastroenterology 2020年第34期26卷 5101-5117页

作者： david Fernández-Ramos Fernando Lopitz-Otsoa Laura delacruz-Villar Jon Bilbao Martina Pagano Laura Mosca Maider Bizkarguenaga Marina Serrano-Macia Mikel Azkargorta Marta Iruarrizaga-Lejarreta Jesús Sot darya Tsvirkun Sebastiaan Martijn van Liempd Felix M Goni Cristina Alonso María Luz Martínez-Chantar Felix Elortza Liat Hayardeny Shelly C Lu JoséM Mato Precision Medicine and Metabolism Laboratory Centro de Investigación Cooperativa en Biociencias(CIC bioGUNE)Derio 48160BizkaiaSpain CIBERehd-Centro de Investigación Biomédica en Red de enfermedades hepáticas y digestivas Madrid 28029Spain department of Precision Medicine University of Campania"Luigi Vanvitelli"Naples 80138Italy Liver disease Laboratory Centro de Investigación Cooperativa en Biociencias(CIC bioGUNE)Derio 48160Spain Proteomics Platform Centro de Investigación Cooperativa en Biociencias(CIC bioGUNE)Derio 48160Spain OWL Metabolomics Derio 48160Spain Instituto Biofisika(UPV/EHU CSIC)Leioa 48940SpainDepartamento de Bioquímica y Biología MolecularUniversidad del País VascoLeioa 48940Spain Pre-clinical and Chemistry Manufacturing and ControlsGalmed PharmaceuticalsTel Aviv 6578317Israel Metabolomics Platform Centro de Investigación Cooperativa en Biociencias(CIC bioGUNE)Derio 48160Spain division of digestive and Liver diseases Cedars-Sinai Medical CenterLos AngelesCA 90048United States

BACKGROUNd Arachidyl amido cholanoic acid(Aramchol)is a potent downregulator of hepatic stearoyl-CoA desaturase 1(SCd1)protein expression that reduces liver triglycerides and fibrosis in animal models of *** a phase IIb clinical trial in patients with nonalcoholic steatohepatitis(NASH),52 wk of treatment with Aramchol reduced blood levels of glycated hemoglobin A1c,an indicator of glycemic *** To assess lipid and glucose metabolism in mouse hepatocytes and in a NASH mouse model[induced with a 0.1%methionine and choline deficient diet(0.1MCd)]after treatment with *** Isolated primary mouse hepatocytes were incubated with 20μmol/L Aramchol or vehicle for 48 ***,analyses were performed including Western blot,proteomics by mass spectrometry,and fluxomic analysis with 13C-uniformly labeled *** the in vivo part of the study,male C57BL/6J mice were randomly fed a control or 0.1MCd for 4 wk and received 1 or 5 mg/kg/d Aramchol or vehicle by intragastric gavage for the last 2 *** metabolomics were assessed using ultra-high-performance liquid chromatography-time of flight-MS for the determination of glucose metabolism-related *** Combination of proteomics and Western blot analyses showed increased AMPK activity while the activity of nutrient sensor mTORC1 was decreased by Aramchol in *** translated into changes in the content of their downstream targets including proteins involved in fatty acid(FA)synthesis and oxidation[PACCα/β(S79),SCd1,CPT1A/B,HAdHA,and HAdHB],oxidative phosphorylation(NdUFA9,NdUFB11,NdUFS1,NdUFV1,ETFdH,and UQCRC2),tricarboxylic acid(TCA)cycle(MdH2,SUCLA2,and SUCLG2),and ribosome(P-p70S6K[T389]and P-S6[S235/S236]).Flux experiments with 13Cuniformely labeled glucose showed that TCA cycle cataplerosis was reduced by Aramchol in hepatocytes,as indicated by the increase in the number of rounds that malate remained in the TCA ***,liver metabolomic analysis showed

关键词： Nonalcoholic fatty liver disease Steatohepatitis Methionine and choline deficient diet Tricarboxylic acid cycle Hemoglobin A1c Stearoyl-CoA desaturase 1

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阿姆河上游的琐罗亚斯德教遗迹

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内蒙古艺术学院学报 2023年第1期20卷 54-61页

作者： [英]d.A.斯考特祁晓庆(译) 王毓琴(校) 剑桥大学亚洲和中东研究学系英国剑桥CB21TN 敦煌研究院人文研究部甘肃兰州730030 内蒙古自治区对外友好协会内蒙古呼和浩特010055

文献记载、考古证据都表明,中亚地区曾经流行琐罗亚斯德教信仰,近现代人类学家对阿姆河上游一带的琐罗亚斯德教遗迹进行了追溯考察,发现在这些地区保存了很多拜火教元素,如神灵与恶魔、丧葬习俗、火的用途、动物的特征和创始神话等,引... 详细信息

文献记载、考古证据都表明,中亚地区曾经流行琐罗亚斯德教信仰,近现代人类学家对阿姆河上游一带的琐罗亚斯德教遗迹进行了追溯考察,发现在这些地区保存了很多拜火教元素,如神灵与恶魔、丧葬习俗、火的用途、动物的特征和创始神话等,引证了文献记载和考古发现的历史事实。

关键词：阿姆河琐罗亚斯德教火坛丧葬礼仪

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Variability in precipitation,temperature and river runoff in West Central Asia during the past-2000 years

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地球环境学报 2011年第1期 320-320页

作者： Oberhnsli H Novotná K Písková A Chabrillat S Nourgaliev d K Kurbaniyazov A K Grygar T Helmholtz-Centre Potsdam German Geoscience Centre(GFZ)TelegraphenbergD-14473 PotsdamGermany Institute of Inorganic Chemistry of the ASCR v.v.i.250 68 RezCzech Republic Faculty of Science Charles University in PragueCzech Republic Faculty of Geology Kazan State UniversityKazanTatarstanRussia Federation420008Russia Ahmed Yasawi International Kazakh-Turkish University TurkestanKazakhstan

The tributary rivers Amu darya and Syr darya contribute major amounts of water to the hydrological budget of the endorheic Aral *** controlling the flow of water into rivers in the headwater systems in Tien Shan（Kyrgyzstan） and Pamir（Tajikistan） are therefore most *** water mineralization is strongly dependent on river discharge and has been inferred from spectrometrically determined gypsum *** of highresolution mineralization data with other proxies for tracing precipitation in NW China indicate that mineralization over the past;000 years in the Aral Sea reflects snow cover variability and glacier extent in Tien Shan and Pamir（at the NW and W edges of the Tibetan Plateau）.Snow cover in W Central Asia is preferentially a winter expression controlled by temperature patterns that impact the moisture-loading capacity over N Europe and NW *** observed that the runoff,resulting from warmer winter temperatures in W Central Asia and resulting in a reduction of snow cover,decreased between Ad 100-300,Ad 1150-1250,Ad 1380-1450,Ad 1580-1680 and during several low frequency events after Ad 1800.

关键词： Asia Variability in precipitation,temperature and river runoff in West Central Asia during the past-2000 years Ad

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