检索结果-南通市图书馆

The new antioxidant 1-benzoyl-6-hydroxy-2,2,4-trimethyl-1,2- dihydroquinoline has a protective effect against carbon tetrachloride-induced hepatic injury in rats

引用

The Journal of Biomedical Research 2022年第6期36卷 423-434页

作者： Evgenii Dmitrievich Kryl'skii darya andreevna sinitsyna Tatyana Nikolaevna Popova Khidmet Safarovich Shikhaliev Svetlana Mikhajlovna Medvedeva Larisa Vladimirovna Matasova Valentina Olegovna Mittova Department of Medical Biochemistry and Microbiology Voronezh State UniversityVoronezhVoronezh region 394018Russia Department of Organic Chemistry Voronezh State UniversityVoronezhVoronezh region 394018Russia Department of Clinical Laboratory Diagnostics Voronezh State Medical University named after N.N.BurdenkoVoronezhVoronezh region 394036Russia

Liver diseases with the central pathogenetic mechanism of oxidative stress are one of the main causes of mortality ***,dihydroquinoline derivatives,which are precursors of hepatoprotectors and have antioxidant activity,are of *** have previously found that some compounds in this class have the ability to normalize redox homeostasis under experimental ***,we initially analyzed the hepatoprotective potential of the dihydroquinoline derivative 1-benzoyl-6-hydroxy-2,2,4-trimethyl-1,2-dihydroquinoline(BHDQ)for carbon tetrachloride(CCl4)-induced liver injury in *** suggested that BHDQ normalized the alanine aminotransferase,aspartate aminotransferase,and gamma-glutamyl transpeptidase in *** also observed an improvement in liver tissue morphology related to *** with CCl4-induced liver injuries treated with BHDQ had less oxidative stress compared to animals with CCl4-induced liver *** promoted activation changes in superoxide dismutase,catalase,glutathione peroxidase,glutathione reductase,and glutathione transferase on control values in animals with CCl4-induced liver *** also activated gene transcription in Sod1 and Gpx1 via nuclear factor erythroid 2-related factor 2 and forkhead box protein O1 ***,the compound of concern has a hepatoprotective effect by inhibiting the development of necrotic processes in the liver tissue,through antioxidation.

关键词： CCl4-induced hepatic injury oxidative stress 1-benzoyl-6-hydroxy-2,2,4-trimethyl-1 2-dihydroquinoline antioxidants

来源：

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

欢迎您,

建议与咨询留下您的常用邮箱和电话号码，以便我们向您反馈解决方案和替代方法

时间限定

文献类型

馆藏选择

核心期刊

语言

文献类型

帮助

文字说明：

检索规则说明：

检索范例：

分类表

所选分类

限定检索结果

文献类型

馆藏范围

日期分布

学科分类号

主题

机构

作者

语言

在线全文

请选择保存的检索档案：

请选择收藏分类：

通借通还

欢迎您,

建议与咨询 留下您的常用邮箱和电话号码，以便我们向您反馈解决方案和替代方法

时间限定

文献类型

馆藏选择

核心期刊

语言

文献类型

帮助

文字说明：

检索规则说明：

检索范例：

分类表

所选分类

限定检索结果

文献类型

馆藏范围

日期分布

学科分类号

主题

机构

作者

语言

在线全文

请选择保存的检索档案： 新增检索档案 确定 取消

请选择收藏分类： 新增自定义分类 确定 取消

通借通还

建议与咨询留下您的常用邮箱和电话号码，以便我们向您反馈解决方案和替代方法

请选择保存的检索档案：

请选择收藏分类：