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A Class Effect Network Meta-analysis of Lipid Modulation in Non-alcoholic Steatohepatitis for Dyslipidemia

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journal of Clinical and Translational Hepatology 2022年第6期10卷 1042-1049页

作者： jieling Xiao Cheng-Han Ng Yip-Han Chin darren jun Hao Tan Wen-Hui Lim Grace Lim jingxuan Quek Ansel Shao Pin Tang Kai-En Chan Rou-Yi Soong Nicholas Chew Benjamin Tay Daniel Q.Huang Nobuharu Tamaki Roger Foo Mark Y.Chan Mazen Noureddin Mohammad Shadab Siddiqui Arun j.Sanyaland Mark D.Muthiah Yong Loo Lin School of Medicine National University of SingaporeSingapore Lee Kong Chian School of Medicine Nan-yang Technological UniversitySingapore Department of Cardiology National University Heart CenterNational University HospitalSingapore Division of Gastroenterology and Hepatology Department of MedicineNational University HospitalSingaporeSingapore National University Center for Organ Transplantation National University Health SystemSingapore NAFLD Research Center Division of Gastroenterology and HepatologyDepartment of MedicineUniversity of California at San DiegoLa JollaCAUSA Department of Gastroenterology and Hepatology Musashino Red Cross HospitalTokyoJapan Cedars-Sinai Fatty Liver Program Division of Digestive and Liver DiseasesDepartment of MedicineComprehen-sive Transplant CenterCedars-Sinai Medical CenterLos AngelesCAUSA Division of Gastroenterology Hepatology and NutritionDepartment of Internal MedicineVirginia Commonwealth UniversityRichmondVAUSA

Background and Aims:Pharmaceutical therapy for NASH is associated with lipid modulation,but the consensus on drug treatment is limited and lacks comparative analysis of effectiveness.A network meta-analysis was conducted to compare NASH drug classes in lipid ***:Online databases were searched for randomized controlled trails(RCTs)evaluating NASH treatments in biopsy-proven NASH *** were classified into four groups:(1)inflammation,(2)energy,(3)bile acids,and(4)fibro-sis based on the mechanism of action.A Bayesian network analysis was conducted with outcome measured by mean difference(MD)with credible intervals(Crl)and surface un-der the cumulative ranking curve(SUCRA).Results:Forty-four RCTs were included in the *** acid modulat-ing treatments(MD:0.05,Crl:0.03-0.07)were the best treatment for improvement in high-density lipid(HDL)cho-lesterol,followed by treatments modulating energy(MD:0.03,Crl:0.02-0.04)and fibrosis(MD:0.01,Crl:−0.12 to 0.14)compared with *** top three treatments for reduction in triglycerides were treatments modulating energy(MD:−0.46,Crl:−0.49 to−0.43),bile acids(MD:−0.22,Crl:−0.35 to−0.09),and inflammation(MD:−0.08,Crl:−0.13 to−0.03)compared with *** found treatment modulating fibrosis(MD:−1.27,Crl:−1.76 to−0.79)was the best treatment for reduction in low-density lipid(LDL)cholesterol followed by treatment modulating in-flammation(MD:−1.03,Crl:−1.09 to−0.97)and energy(MD:−0.37,Crl:−0.39 to−0.34)compared with placebo,but LDL cholesterol was worsened by treatments modulat-ing bile ***:Network analysis comparing the class effects of dyslipidemia modulation in NASH found that treatment targets can include optimization of athero-genic *** studies are required to evaluate the cardiovascular outcomes.

关键词： Lipid modulation NASH Dyslipidemia

肿瘤领域生物仿制药有效性和安全性的临床研究分析

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中国临床药理学杂志 2018年第21期34卷 2557-2562页

作者：杨继春于树青 SENGWEE darren TOH 杨智荣颜钰松詹思延孙凤北京大学公共卫生学院流行病与卫生统计学系北京100191 哈佛大学医学院群体医学系美国波士顿02215 剑桥大学初级医疗中心

目的分析肿瘤领域生物仿制药有效性和安全性的临床研究现状。方法系统检索Pub Med、EMbase、Clinicaltrials. org、Cochrane Library、Web of science、ASCO Meeting library、中国知网、万方、Sinomed等数据库,截至2017-12-21,关于肿瘤领域生物仿制药的相关研究。从生物仿制药的种类、研究类型、适应证等多个方面系统分析其临床研究。使用偏倚风险评价工具,对纳入研究进行偏倚风险评价。结果共纳入52篇英文文献,包括单抗类生物仿制药、促红细胞生成素(ESA)生物仿制药、粒细胞集落刺激因子(G-CSF)生物仿制药。临床研究进展特点表现为临床试验均为上市前研究,观察性研究既有回顾性研究也有前瞻性研究;发表年代范围从2009年至2017年;纳入研究样本量均较小,尤其对照研究的样本量更小;大部分随机对照试验(RCT)研究为会议摘要,提供的结局信息不全;纳入的研究偏倚风险较低。结论目前关于生物仿制药的临床研究以病例系列研究为主,高证据级别的RCT研究和队列研究较少,样本量较小,而且大部分研究为会议摘要,尚无法进行定量分析。

关键词：肿瘤领域生物仿制药有效性安全性临床研究系统综述

拓扑材料γ-PtBi_(2)的变温晶体结构研究

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核聚变与等离子体物理 2022年第S1期42卷 114-119页

作者：张世车刘威杨萌林宇冯娅石友国 Kenya Shimada 杨晓峰 darren C Peets 何少龙中北大学理学院太原030051 中国科学院宁波材料技术与工程研究所宁波315201 中国科学院物理研究所北京100190 福建省先进高场超导材料与工程协同创新中心福州350117 福建师范大学物理与能源学院福州350117 广岛同步辐射中心日本广岛739-0046 德累斯顿工业大学材料物理研究所德国德累斯顿01069 中国科学院大学材料科学与光电工程中心北京100049

利用X射线衍射(XRD)、角分辨光电子能谱(ARPES)和能带计算的方法研究了不同温度下γ-PtBi_(2)的晶体结构。利用单晶XRD确定了室温下晶体的结构为P31m。为了确定低温时样品的晶体结构,用ARPES测得了样品的电子结构并与计算结果进行了对比... 详细信息

利用X射线衍射(XRD)、角分辨光电子能谱(ARPES)和能带计算的方法研究了不同温度下γ-PtBi_(2)的晶体结构。利用单晶XRD确定了室温下晶体的结构为P31m。为了确定低温时样品的晶体结构,用ARPES测得了样品的电子结构并与计算结果进行了对比,结果显示样品的结构与P31m相吻合,这表明在低温时样品依然保持P31m结构。进一步的高温XRD研究表明,在高温时样品的晶体结构仍为P31m结构。

关键词：拓扑 X射线衍射晶体结构角分辨光电子能谱

The control of soil-transmitted helminthiases in the Philippines: the story continues

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Infectious Diseases of Poverty 2021年第3期10卷 98-98页

作者： Mary Lorraine S.Mationg Veronica L.Tallo Gail M.Williams Catherine A.Gordon Archie C.A.Clements Donald P.McManus darren j.Gray Department of Global Health Research School of Population HealthThe Australian National UniversityBuilding 62 Mills RdActon ACTCanberra 2601Australia 不详

Background:Soil-transmitted helminth(STH)infections have long been an important public health concern in the *** this review,we describe the current status of STH infections there and highlight the control efforts undertaken to reduce STH *** text:A nationwide STH mass drug administration(MDA)programme was started in 2006 but the overall STH prevalence remains stubbornly high across the Philippines,rangi ng from 24.9%to 97.4%.

关键词： Soil-transmitted helminths Epidemiology Control The Philippines

Foregut bypass *** bariatric procedures for nonalcoholic fatty liver disease:a meta-analysis of 3,355 individuals

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Hepatobiliary Surgery and Nutrition 2023年第5期12卷 658-670,I0001-I0003页

作者： Wen Hui Lim Snow Yunni Lin Cheng Han Ng darren jun Hao Tan jieling Xiao jie Ning Yong Phoebe Wen Lin Tay Nicholas Syn Yip Han Chin Kai En Chan Chin Meng Khoo Nicholas Chew Roger S.Y.Foo Asim Shabbir Eunice X.Tan Daniel Q.Huang Mazen Noureddin Arun j.Sanyal Mohammad Shadab Siddiqui Mark D.Muthiah Yong Loo Lin School of Medicine National University of SingaporeSingaporeSingapore Division of Endocrinology Department of MedicineNational University HospitalSingaporeSingapore Department of Cardiology National University Heart CentreNational University HospitalSingaporeSingapore Division of General Surgery(Upper Gastrointestinal Surgery) Department of SurgeryNational University HospitalSingaporeSingapore Division of Gastroenterology and Hepatology Department of MedicineNational University HospitalSingaporeSingapore National University Centre for Organ Transplantation National University Health SystemSingaporeSingapore Cedars-Sinai Fatty Liver Program Division of Digestive and Liver DiseasesDepartment of MedicineComprehensive Transplant CenterCedars-Sinai Medical CentreLos AngelesCAUSA Division of Gastroenterology Hepatology and NutritionDepartment of Internal MedicineVirginia Commonwealth UniversityRichmondVAUSA

Background:Bariatric surgery represents an important treatment option for severely obese patients with nonalcoholic fatty liver disease(NAFLD).However,there remains inadequate data regarding the effects of different bariatric procedures on various NAFLD parameters,especially for histological ***,this meta-analysis aimed to compare the effects of restrictive bariatric procedures and foregut bypass on the metabolic,biochemical,and histological parameters for patients with ***:Medline and Embase were searched for articles relating to bariatric procedures and *** meta-analysis was conducted to compare efficacy of bariatric procedures ***-procedure with subgroup analysis to further compare restrictive against foregut bypass ***:Thirty-one articles involving 3,355 patients who underwent restrictive bariatric procedures(n=1,460)and foregut bypass(n=1,895)were *** foregut bypass(P<0.01)and restrictive procedures(P=0.03)significantly increased odds of fibrosis *** to restrictive procedures,foregut bypass resulted in a borderline non-significant decrease in fibrosis score(P=0.06)and significantly lower steatosis score(P<0.001).For metabolic parameters,foregut bypass significantly lowered body mass index(P=0.003)and low-density lipoprotein(P=0.008)compared to restrictive *** significant differences were observed between both procedures for aspartate aminotransferase(P=0.17)and alkaline phosphatase(P=0.61).However,foregut bypass resulted in significantly lower gamma-glutamyl transferase than restrictive procedures(P=0.01)while restrictive procedures resulted in significantly lower alanine transaminase than foregut bypass(P=0.02).Conclusions:The significant histological and metabolic advantages and comparable improvements in biochemical outcomes support the choice of foregut bypass over restrictive bariatric procedures in NAFLD management.

关键词： Bariatric surgery non-alcoholic fatty liver disease(NAFLD) obesity fibrosis endoscopy

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物联网数据需求下,革命性提升存储器的性能

中国电子商情(基础电子) 2017年第8期 33-37页

作者： Mike Wissolik darren Zacher Anthony Torza Brandon Day 赛灵思公司

随着物联网的逐步扩张和完善,数据将变得越来越庞大,存储器的需求也将变得至关重要。数据中心、有线应用及其它带宽密集型应用所需的性能,远远高于传统的DRAM技术。和市场上已有的存储器相比,HBM存储器在性能、功耗和尺寸上,能为系统架... 详细信息

随着物联网的逐步扩张和完善,数据将变得越来越庞大,存储器的需求也将变得至关重要。数据中心、有线应用及其它带宽密集型应用所需的性能,远远高于传统的DRAM技术。和市场上已有的存储器相比,HBM存储器在性能、功耗和尺寸上,能为系统架构师和FPGA设计人员带来前所未有的优势。

关键词：存储器带宽堆栈接口 HBM AXI 物联网

教育全球化背景下南京“留学生街”的形成与演变

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现代城市研究 2022年第6期37卷 67-73页

作者：孙洁余思奇朱喜钢戴伦·史密斯南京大学建筑与城市规划学院南京林业大学风景园林学院英国拉夫堡大学地理系

随着教育全球化发展,来华留学生数量迅速增长,并在大学周边聚集从而形成独特的社会空间现象通过对南京市金银街的长期实地调研和深入访谈,获取丰富一手资料,揭示了在大学、政府以及市场的共同推动下,“留学生街”萌芽、形成以及演变的过... 详细信息

随着教育全球化发展,来华留学生数量迅速增长,并在大学周边聚集从而形成独特的社会空间现象通过对南京市金银街的长期实地调研和深入访谈,获取丰富一手资料,揭示了在大学、政府以及市场的共同推动下,“留学生街”萌芽、形成以及演变的过程-金银街具有人口异质化、文化多元化以及季节性、高频率人口流动的社会特征。然而,不同于西方国家留学生聚居空间的日益扩张,我国留学生政策、大学管理制度以及城市更新等多重因素却导致了金银街逐渐“去留学生化”该演变折射了中国城市空间重构语境中全球化与地方化互动与角力的复杂机理.这致使留学生的日常生活受限,不利于其地方融入和文化适应.未来我国城市政府和大学需要重视留学生活动空间的规划与治理。

关键词：留学生全球化学生化城市更新社会空间金银街

Prevalence of Echinococcus granulosus and *** in domestic dogs in a Chinese community highly endemic for echinococcosis

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Prevalence of Echinococcus granulosus and *** in domestic do...

平版印刷法制作电致发光显示器的微型化电极布线

第五届全国人畜共患病学术研讨会

作者： Cong-Nuan Liu Yang-Yang Xu Angela M.Cadavid-Restrepo Zhong-Zi Lou Hong-Bin Yan Li Li Bao-Quan Fu darren j.Gray Archie A.Clements Tamsin S.Barnes Gail M.Williams Wan-Zhong jia Donald P.McManus Yu-Rong Yang State Key Laboratory of Veterinary Etiological Biology/Key Laboratory of Veterinary Parasitology of Gansu Province/Key Laboratory of Zoonoses of Agriculture Ministry/Lanzhou Veterinary Research Institute CAAS Neurosurgery Department Tianjin Xiqing Hospital Ningxia Medical Universities Molecular Parasitology Laboratory QIMR Berghofer Medical Research Institute Research School of Population Health Australian National University School of Population Health Infectious Disease Epidemiology UnitUniversity of Queensland Queensland Alliance for Agriculture and Food Innovation University of Queensland

Background:To undertake a survey to determine the infection prevalence of Echinococcus granulosus and *** in domestic dogs and to monitor the transmission dynamics of echinococcosis in Xiji County,Ningxia Hui Autonomous Region(NHAR),***,an area co-endemic for both human alveolar and cystic echinococcosis(AE and CE)where a control campaign,based on dog de-worming with praziquantel(PZQ),has been in operation over the past

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电子器件 2008年第1期31卷 12-16页

作者： jack Silver Robert Withnall George R. Fern Paul j. Marsh Terry G. Ireland Paul G. Harris Peter S.A. Evans darren. j. Southee Gareth I. Hay David. j. Harrison Kesar F. B. Breen 布鲁纳尔大学豪尔夫逊材料研究处理中心 UxbridgeMiddlesex UB8 3PH英国布鲁纳尔大学清洁电子学研究处理中心 UxbridgeMiddlesex UB8 3PH英国

平板印刷柔性的电致发光显示器的交错对插的电极。根据电致发光的荧光粉颗粒尺寸的大小采用的不同的方法将其沉积。小颗粒荧光粉分子可以很容易地与印刷油墨混合。使用这种交错对插电极的柔性显示器不需要透明的导电氧化物作为阳极,容... 详细信息

平板印刷柔性的电致发光显示器的交错对插的电极。根据电致发光的荧光粉颗粒尺寸的大小采用的不同的方法将其沉积。小颗粒荧光粉分子可以很容易地与印刷油墨混合。使用这种交错对插电极的柔性显示器不需要透明的导电氧化物作为阳极,容易实现大规模生产,造价低。这种显示器使用ACEL可以实现多色彩显示。ACEL可以发射出从绿光到使用ZnS:Cu,X(X = Cl , Br ,I)荧光粉的蓝光,或者是到使用ZnS:Cu,Mn荧光粉的橙光。此外,还可以使用颜色转换材料以产生其他颜色的光。

关键词：柔性显示交流电致发光粉平版印刷