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Cancer.Communications 2022年第4期42卷 355-359页

作者： Kah Yee Goh Kah Weng Lau Ter.nce You De Cheng Su Chin Tham Chwee Teck Lim Nar.yanan Gopalakr.shna Iyer.Su Bin Lim darren Wan-Teck Lim Division of Medical Oncology National Cancer Centre SingaporeSingapore 169610 Depar.ment of Pathology National University HospitalSingapore 119074 A*STAr ProteosInstitute of Molecular and Cell BiologySingapore 138673 Depar.ment of Biomedical Engineer.ng Mechanobiology InstituteNational University of SingaporeT-LabSingapore 117411 Institute for.Health Innovation and Technology(iHealthtech) National University of SingaporeMD6Singapore 117599 Depar.ment of Head and Neck Sur.er. National Cancer Centre Singapore11 Hospital CrescentSingapore 169610 Office of Academic and Clinical Development Duke-NUS Medical SchoolSingapore 169857 Depar.ment of Biochemistr. and Molecular.Biology Ajou University School of MedicineYeongtong-GuSuwon 16499South Korea

Dear.Editor.Head and neck squamous cell car.inoma(HNSCC)is the sixth most common cancer.globally[1,2].Despite the impr.vement in tr.atment modalities,up to 50%of HNSCC patients still develop r.cur.ent/metastatic(r.M)disease[3],and platinum-based chemother.py with cetuximab and/or.pembr.lizumab has become the standar. of car.[4].However.r.M HNSCC is challenging to tr.at,the pr.gnosis is poor.and ther. is an unmet need for.new ther.peutic tar.ets.

关键词： chemother.py cetuximab tr.atment

Fur.her.geological and palaeoanthr.pological investigations at the Maludong hominin site, Yunnan Pr.vince, Southwest China

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Chinese Science Bulletin 2013年第35期58卷 4472-4485页

作者： JI XuePing CUr.OE darren BAO ZhenDe HEr.IES Andy I r.FINK David ZHU YunSheng HELLSTr.M John LUO Yun TACON Paul S C Yunnan Institute of Cultur.l r.lics and Ar.haeology School of Biological Earth and Environmental Sciences University of New South Wales Sydney 2052 Australia Mengzi Institute of Cultur.l r.lics Ar.haeomagnetism Labor.tor. Archaeology Program School of Historical and European Studies La Trobe University Melbourne 3086 Australia Institute for.Envir.nmental r.sear.h Australian Nuclear Science and Technology Organisation Sydney 2001 Australia Honghe Pr.fectur.l Institute of Cultur.l r.lics School of Ear.h Sciences University of Melbourne Melbourne 3010 Australia Place Evolution and Rock Art Heritage Unit School of Humanities Gold Coast Campus Griffith University Gold Coast 4222 Australia

Thr.e-dimensional mapping and section wor. under.aken by us in 2008 have identified 11 str.tigr.phic units at Maludong *** r.diocar.on dating of char.oal established an accur.te and inter.ally consistent age pr.file for.the sequence of 17.8±0.2 ka to 13.2±0.1 *** analysis showed changes in exter.ally der.ved pedogenically enhanced mater.al consistent with a war.ing in climate between the cold per.od of Henr.ch Event 1 and the B lling-Aller.d *** r.mains r.cover.d dur.ng the 1989 excavation wer. der.ved fr.m a deposit dating to this inter.tadial,or.between 14.3±0.3 ka and 13.5±0.1 *** featur.s,including bur.t r.cks,baked sediment and thick char.oal and ash layer.,wer. identified and examined thr.ugh ar.haeomagnetic *** monkey fossils ar. descr.bed her.,one of them being r.assigned fr.m Macaca r.bustus to *** confir. the young age of the site and also show signs of anthr.pogenic alter.tion in the for. of *** human cr.nial r.mains ar. r.por.ed for.the fir.t time and new data ar. pr.vided for.some specimens descr.bed pr.viously.A r.nge of new featur.s is identified that str.ngthen the affinities of the Maludong r.mains to ar.haic *** pr.sence of this globally unique mosaic of ar.haic and moder. featur.s r.ises impor.ant questions about human evolutionar. histor. in East Asia dur.ng the Late Upper.Pleistocene.

关键词：古人类遗址中国西南地区古人类学云南省地质地层单位三维制图年龄分布

Effect of cor.osion inhibiting compounds on the cor.osion behaviour.of pur. magnesium and the magnesium alloys EV31A, WE43B and ZE41A

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Jour.al of Magnesium and Alloys 2021年第2期9卷 432-455页

作者： Akif Soltan Matthew S.Dar.usch Zhiming Shi Fiona Jones Bar.y Wood darren Ger.ar. Andr.j Atr.ns School of Mechanical and Mining Engineer.ng The University of QueenslandBrisbaneQld 4072Australia UQ Mater.als Per.or.ance The University of QueenslandBrisbaneQld 4072Australia Centr. for.Micr.scopy and Micr.analysis The University of QueenslandBrisbaneQld 4072Australia Defence Mater.als Technology Centr. DMTC LimitedLevel 224 Wakefield StreetHawthornVic 3122Australia Defence Science and Technology Gr.up 506 Lorimer StreetFishermans BendVic 3207Australia

This paper.studied cor.osion of pur. Mg and the Mg alloys EV31A,WE43B,ZE41A,coated with commer.ial cor.osion inhibiting compounds(CICs)(LPS 3,LPS2,AMLGuar.,Ar.r.x 3961)immer.ed in 3.5 wt%(0.6M)Na Cl solution satur.ted with Mg(OH)_(2).All four.CICs r.duced cor.osion *** 3 r.sulted in zer. cor.osion r.tes and 100%inhibition in most *** 2 and AMLGuar. had compar.ble inhibition efficiencies,whilst Ar.r.x 3961 had the lowest inhibition *** in cor.osion r.tes was tentatively attr.buted to bar.ier.films for.ed by chemical adsor.tion for.LPS 3 and AMLGuar.,and by physical adsor.tion for.LPS2 and Ar.r.x 3961.

关键词： Magnesium Weight loss Hydr.gen evolution XPS FTIr Cor.osion inhibition

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盗窃基因的铁线虫

环球科学 2024年第1期 24-24页

作者：达伦·因科尔瓦亚仇艳菲(翻译) 不详

对于一只螳螂来说,吃下错误的昆虫可能会获得一张通往水下坟墓的单程票。螳螂常会捕食的一些昆虫可能吃下了一种名为Chor.odes fukuii的铁线虫的虫卵。当这些虫卵随着昆虫进入螳螂的肠道后,它们会孵化生长,并操纵螳螂潜入最近的水域中... 详细信息

对于一只螳螂来说,吃下错误的昆虫可能会获得一张通往水下坟墓的单程票。螳螂常会捕食的一些昆虫可能吃下了一种名为Chor.odes fukuii的铁线虫的虫卵。当这些虫卵随着昆虫进入螳螂的肠道后,它们会孵化生长,并操纵螳螂潜入最近的水域中。随后,像意大利面一样的铁线虫会从被淹死的宿主体内扭动着挣脱出来,并开始繁殖,产生后代。

关键词：铁线虫螳螂虫卵孵化昆虫

In vitr. miner.lisation of gr.fted ePTFE membr.nes car.ying car.oxylate gr.ups

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Bioactive Mater.als 2017年第1期2卷 27-34页

作者： Nor.yahidah Mohd Hidzir.David J.T.Hill darren Mar.in Lisbeth Gr.ndahl School of Chemistr. and Molecular.Biosciences University of QueenslandSt LuciaQLD4072Australia Austr.lian Institute for.Bioengineer.ng and Nanotechnology University of QueenslandSt LuciaQLD4072Australia School of Applied Physics Faculty of Science&TechnologyUniversiti Kebangsaan MalaysiaUKM BangiSelangor43600Malaysia

In vitr. miner.lisation in simulated body fluid(SBF)of synthetic polymer. continues to be an impor.ant ar.a of r.sear.h as the outcomes cannot be *** study evaluates a ser.es of ePTFE membr.nes gr.fted with car.oxylate-containing copolymer.,specifically using acr.lic acid and itaconic acid for.*** samples differ.with r.gar.s to gr.ft density,car.oxylate density and polymer.*** type and amount of miner.l pr.duced in 1.5×SBF was dependent on the sample char.cter.stics as evident fr.m XPS,SEM/EDX,and FTIr.*** was found that the gr.ft density affects the miner.l phases that for. and that low gr.ft density appear.to cause co-pr.cipitation of calcium car.onate and calcium *** and br.nched gr.ft copolymer.topology led to hydr.xyapatite miner.lisation wher.as cr.sslinked gr.ft copolymer. r.sulted in for.ation of a mixtur. of calcium-phosphate *** study demonstr.tes that in vitr. miner.lisation outcomes for.car.oxylate-containing gr.ft copolymer. ar. *** findings of this study have implications for.the design of bioactive coatings and ar. impor.ant for.under.tanding the bone-biomater.al inter.ace.

关键词： Simulated body fluid Expanded poly(tetr.fluor.ethylene) Gr.ft copolymer.sation Car.oxylate gr.ups

CaMK4 over.xpr.ssion in polycystic kidney disease pr.motes mTOr.mediated cell pr.lifer.tion

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Jour.al of Molecular.Cell Biology 2022年第7期14卷 49-61页

作者： Yan Zhang Emily A.Daniel July Metcalf Yuqiao Dai Gail A.r.if darren P.Wallace Depar.ment of Inter.al Medicine University of Kansas Medical CenterKansas CityKS 66160-3018USA Jar.d Gr.ntham Kidney Institute University of Kansas Medical CenterKansas CityKS 66160-3018USA Depar.ment of Molecular.and Integr.tive Physiology University of Kansas Medical CenterKansas CityKS 66160-3018USA

Autosomal dominant polycystic kidney disease(ADPKD)is char.cter.zed by pr.gr.ssive enlar.ement of fluid-filled cysts,causing nephr.n loss and a decline in r.nal *** tar.et of r.pamycin(mTOr.is over.ctive in cyst-lining cells and contr.butes to abnor.al cell pr.lifer.tion and cyst enlar.ement;however.the mechanism for.mTOr.stimulation r.mains *** discover.d that calcium/calmodulin(CaM)dependent kinase IV(CaMK4),a multifunctional kinase,is over.xpr.ssed in the kidneys of ADPKD patients and PKD mouse *** human ADPKD cells,CaMK4 knockdown r.duced mTOr.abundance and the phosphor.lation of r.bosomal pr.tein S6 kinase(S6K),a downstr.am tar.et of *** inhibition of CaMK4 with KN-93 r.duced phosphor.lated S6K and S6 levels and inhibited cell pr.lifer.tion and in vitr. cyst for.ation of ADPKD ***,inhibition of calcium/CaM-dependent pr.tein kinase kinase-βand CaM,two key upstr.am r.gulator. of CaMK4,also decr.ased mTOr.*** effects of KN-93 wer. independent of the liver.kinase B1-adenosine monophosphate-activated pr.tein kinase(AMPK)pathway,and the combination of KN-93 and metfor.in,an AMPK activator.had additive inhibitor. effects on mTOr.signaling and in vitr. cyst *** data suggest that incr.ased CaMK4 expr.ssion and activity contr.bute to mTOr.signaling and the pr.lifer.tion of cystic cells of ADPKD kidneys.

关键词： ADPKD CaMK4 CaMKKβ calmodulin LKB1 AMPK

Flexible Str.p Super.apacitor. for.Futur. Ener.y Stor.ge

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Inter.ational Jour.al of Automation and computing 2015年第1期12卷 43-49页

作者： r.i-r.ng Zhang Yan-Meng Xu David Har.ison John Fyson Fu-Lian Qiu darren Southee College of Engineer.ng Design and Physical Sciences Brunel University London Loughbor.ugh Design School Loughborough University

Flexible str.p super.apacitor. ar. developed and their.electr.chemical pr.per.ies ar. char.cter.zed. Activated car.on is used as the electr.de mater.al and it is found to have a good por.us str.ctur. which pr.vides a lar.e sur.ace ar.a for.ener.y ***, this activated car.on per.or.s well. The manufactur.ng pr.cesses for.the super.apacitor. ar. descr.bed in detail and the pr.par.tion pr.cess has good r.pr.ducibility. The str.p super.apacitor. ar. combined in ser.es and par.llel to measur. their.electr.cal pr.per.ies. The per.or.ances of these two samples in ser.es or.in par.llel both follow the theor.tical models. The electr.chemical potential window of a ser.es cir.uit of these two str.p super.apacitor. is 4.8 V. The ener.y and power.of the ser.es or.par.llel cir.uits ar. equal to the sums of the two str.p super.apacitor..

关键词： Str.p super.apacitor. activated car.on flexible ener.y stor.ge char.cter.sation

Significant r.duction of sper. disomy in six men:effect of tr.ditional Chinese medicine?

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Asian Jour.al of Andr.logy 2005年第4期7卷 419-425,页

作者： Helen G. Tempest Sher.l T.Homa Xiao-Ping Zhai darren K. Gr.ffin Depar.ment of Biosciences University of KentCanterbury CT2 7NJUK Ten Har.ey Str.et London W1G 9PFUK

Aim： To test the hypothesis that levels of sper. disomy fell significantly in six men tr.ated by tr.ditional Chinese medicine （TCM）. Methods： Fluor.scence in situ hybr.dization （FISH） was done on the sper. heads of six men befor. and dur.ng tr.atment by TCM. r.sults： Ther. was a significant r.duction in sper. disomy in all six men. This coincided with TCM tr.atment. Conclusion： This is the fir.t study r.por.ing a significant r.duction in sper. disomy in men over.a given time cour.e. The fact that this coincided with TCM tr.atment is intr.guing but no conclusions can be dr.wn fr.m this until placebo-contr.lled clinical tr.als ar. implemented.

关键词： tr.ditional Chinese medicine sper. disomy chr.mosome male infer.ility

Tr.nscatheter.aor.ic valve implantation in 2015

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Jour.al of Ger.atr.c Car.iology 2016年第6期13卷 511-513页

作者： darren Mylotte Faisal Shar.f Nicolo Piazza Mar.o Moscar.lli Khalil Fattouch Thomas Modine Univer.ity Hospital Galway Ireland McGill Univer.ity Health Centr. Montreal Quebec Canada GVM Car. and r.sear.h Unit Anthea Hospital Bari ltaly GVM Car. and r.sear.h Unit Maria Eleonora Hospital Palermo Italy Hopital Car.iologique Lille France

The last decade has seen tr.nscatheter.aor.ic valve implantation (TAVI) emer.e as the standar. of car. for.patients with sever. symptomatic aor.ic stenosis deemed to be either.at excessive- or.high-r.sk for.sur.ical aor.ic valve r.placement (SAVr.. This position is suppor.ed by thr.e impor.ant multicentr. r.ndomized tr.als compar.ng TAVI to the histor.cal gold standar. ther.pies: (1) The Placement of Aor.ic Tr.NscathetEr.Valve Tr.al Edwar.s SAPIEN Tr.nscatheter.Hear. Valve (PAr.NEr. IB Tr.al compar.d TAVI (Edwar.s SAPIEN,Edwar.s Lifesciences Inc., Ir.ine, CA) to optimal medical ther.py in patients at excessive sur.ical r.sk, and demonstr.ted an absolute mor.ality r.duction of > 20% at 1-year. an effect that was maintained out to 5-year.follow-up; (2) The PAr.NEr.1A Tr.al compar.d TAVI (Edwar.s SAPIEN,Edwar.s Lifesciences Inc.,Ir.ine, CA) and SAVr.in patients at high oper.tive r.sk,and found no significant differ.nces in either.clinical outcomes or.valve function at five year.;[2] (3) The Cor.Valve (Cor.-Valve, Medtr.nic Inc., Minneapolis, MN) U.S. Pivotal Tr.al compar.d TAVI and SAVr. and demonstr.ted significantly r.duced mor.ality among patients tr.ated per.utaneously (22.2%), compar.d to those tr.ated with SAVr.(28.6%; log-r.nk test Pr..[3] These str.ng data have r.sulted in TAVI being used in hundr.ds of thousands of patients wor.dwide, and incor.or.ted into the guidelines for.the management of valvular.hear. disease fr.m both the Eur.pean Society of Car.iology and the Amer.can Hear. Association / Amer.can College of Car.iology.

关键词：主动脉导管植入试验比较动脉狭窄合作伙伴心脏瓣膜阀门试验

Distal r.dius volar.r.m plate: Technical and r.diogr.phic consider.tions

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Wor.d Jour.al of Or.hopedics 2017年第7期8卷 567-573页

作者： Michelle Spiter. darren r.ber.s Wayne Ng Jamie Matthews Dominic Power Hand Unit Queen Elizabeth Hospital Birmingham University Hospitals Medical School University of Birmingham

AIM To deter.ine technical consider.tions and r.diogr.phic outcomes of the Synthes volar.r.m distal r.dius plate to tr.at complex intr.-ar.icular.fr.ctur.s. METHODS This r.view highlights technical consider.tions lear.t using this implant since it was intr.duced in a major.tr.uma unit in November.2011, including anatomical r.duction and whether.this was maintained r.diogr.phically. r.SULTS Twenty-six of the 382 inter.ally fixed distal r.dial fr.ctur.s at our.unit(6.8%) wer. deemed to r.quir. this plate in or.er.to achieve optimal fr.ctur. fixation between November.2011 and May 2014. A fur.her.dor.al and/or.r.dial plate was necessar. in 35% and var.able angle scr.ws wer. used in 54% of cases. Postoper.tively, mean r.dial height, inclination, volar.tilt and ulnar.var.ance r.stor.d wer. 11.7 mm, 21o, 4.3o and-1.2 mm r.spectively. Ther. wer. no cases of non-union or.flexor.extensor.tendon r.ptur.; one case of loss of fr.ctur. r.duction. Over.ll incidence of plate r.moval was 15% with one plate r.moved for.flexor.and one for.extensor.tendon ir.itation CONCLUSION The use of a r.m plate enables contr.l of challenging far.istal fr.ctur. patter.s. However. additional plates wer. r.quir.d to impr.ve and maintain r.duction. Var.able angle scr.ws wer. necessar. in half the cases to avoid intr.-ar.icular.scr.w penetr.tion. If used judiciously, this implant can achieve stable fixation despite the complexity of the fr.ctur. patter..

关键词： Distal r.dius fr.ctur.s Volar r.m plate Volar plating distal r.dius