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Management of hepatocellular carcinoma with portal vein tumor thrombosis: Review and update at 2016

World Journal of Gastroenterology 2016年第32期22卷 7289-7300页

作者： Stephen L Chan Charing CN Chong Anthony WH Chan darren mc poon Kenneth SH Chok State Key Laboratory in Oncology of South China Institute of Digestive Disease The Chinese University of Hong Kong Department of Clinical Oncology Sir YK Pao Center for Cancer Hong Kong Cancer Institute The Chinese University of Hong Kong Prince of Wales Hospital Department of Surgery Prince of Wales Hospital The Chinese University of Hong Kong State Key Laborator in Oncology of South China Department of Anatomical and Cellular Pathology The Chinese University of Hong Kong Department of Surgery Queen Mary Hospital The University of Hong Kong

Portal vein tumor thrombosis(PVTT) is a common phenomenon in hepatocellular carcinoma(HCC). Compared to HCC without PVTT, HCC with PVTT is characterized by an aggressive disease course, worse hepatic function, a higher chance of complications related to portal hypertension and poorer tolerance to treatment. Conventionally, HCC with PVTT is grouped together with metastatic HCC during the planning of its management, and most patients are offered palliative treatment with sorafenib or other systemic agents. As a result, most data on the management of HCC with PVTT comes from subgroup analyses or retrospective series. In the past few years, there have been several updates on management of HCC with PVTT. First, it is evident that HCC with PVTT consists of heterogeneous subgroups with different prognoses. Different classifications have been proposed to stage the degree of portal vein invasion/thrombosis, suggesting that different treatment modalities may be individualized to patients with different risks. Second, more studies indicate that more aggressive treatment, including surgical resection or locoregional treatment, may benefit select HCC patients with PVTT. In this review, we aim to discussthe recent conceptual changes and summarize the data on the management of HCC with PVTT.

关键词： Liver cancer Vascular invasion Targeted agent Surgery Radiotherapy

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Risk of cardiovascular thrombotic events after surgical castration versus gonadotropin-releasing hormone agonists in Chinese men with prostate cancer

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Asian Journal of Andrology 2015年第3期17卷 493-496页

作者： Jeremy YC Teoh Samson YS Chan Peter KF Chiu darren mc poon Ho-Yuen Cheung Simon SM Hou Chi-Fai Ng Department of Surgery Division of Urology Prince of Wales Hospital The Chinese University of Hong Kong Shatin Hong Kong China Department of Clinical Oncology Prince of Wales Hospital The Chinese University of Hong Kong Shatin Hong Kong China Department of Surgery Division of Urology North District Hospital Hong Kong China

We investigated the cardiovascular thrombotic risk after surgical castration （SC） versus genadotmpin-releasing hormone agonists （GnRHa） in Chinese men with prostate cancer. All Chinese prostate cancer patients who were treated with SC or GnRHa from year 2000 to 2009 were reviewed and compared. The primary outcome was any new-onset of cardiovascular thrombotic events after SC or GnRHa, which was defined as any event of acute myocardial infarction or ischemic stroke. The risk of new-onset cardiovascular thrombotic event was compared between the SC group and the GnRHa group using Kaplan-Meier method. Multivariate Cox regression analysis was performed to adjust for other potential confounding factors. A total of 684 Chinese patients was included in our study, including 387 patients in the SC group and 297 patients in the GnRHa group. The mean age in the SC group （75.3 ~ 7.5 years） was significantly higher than the GnRHa group （71.8 ~ 8.3 years）（P 〈 0.001）. There was increased risk of new cardiovascular thrombotic events in the SC group when compared to the GnRHa group upon Kaplan-Meier analysis （P= 0.014）. Upon multivariate Cox regression analysis, age （hazard ratio [HR] 1.072, 95% confidence interval [CI] 1.04-1.11, P 〈 0.001）, hyperlipidemia （HR 2.455, 95% Cl 1.53-3.93, P 〈 0.001）, and SC （HR 1.648, 95% CI 1.05-2.59, P = 0.031） were significant risk factors of cardiovascular thrombotic events. In conclusion, SC was associated with increased risk of cardiovascular thrombotic events when compared to GnRHa. This is an important aspect to consider while deciding on the method of androgen deprivation therapy, especially in elderly men with known history of hyperlipidemia.

关键词： androgen deprivation therapy Chinese population cardiovascular events myocardial infarction prostate cancer stroke

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Repair of traumatic plasmalemmal damage to neurons and other eukaryotic cells

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Neural Regeneration Research 2016年第7期11卷 1033-1042页

作者： George D.Bittner Christopher S.Spaeth Andrew D.poon Zachary S.Burgess Christopher H.mc Gill Department of Neuroscience The University of Texas at Austin

The repair（sealing） of plasmalemmal damage,consisting of small holes to complete transections,is critical for cell survival,especially for neurons that rarely regenerate cell *** first describe and evaluate different measures of cell *** measures,including morphological/ultra-structural observations,membrane potential,and input resistance,provide very ambiguous assessments of plasmalemmal *** contrast,measures of ionic current flow and dye barriers can,if appropriately used,provide more accurate *** describe the effects of various substances（calcium,calpains,cytoskeletal proteins,ESCRT proteins,m UNC-13,NSF,PEG） and biochemical pathways（PKA,PKC,PLC,Epac,cytosolic oxidation） on plasmalemmal sealing probability,and suggest that substances,pathways,and cellular events associated with plasmalemmal sealing have undergone a very conservative *** sealing,calcium ion influx mobilizes vesicles and other membranous structures（lysosomes,mitochondria,etc.） in a continuous fashion to form a vesicular plug that gradually restricts diffusion of increasingly smaller molecules and ions over a period of seconds to ***,we find no direct evidence that sealing occurs through the collapse and fusion of severed plasmalemmal leaflets,or in a single step involving the fusion of one large wound vesicle with the nearby,undamaged *** describe how increases in perikaryal calcium levels following axonal transection account for observations that cell body survival decreases the closer an axon is transected to the ***,we speculate on relationships between plasmalemmal sealing,Wallerian degeneration,and the ability of polyethylene glycol（PEG） to seal cell membranes and rejoin severed axonal ends – an important consideration for the future treatment of trauma to peripheral nerves.A better knowledge of biochemical pathways and cytoplasmic structures involved in plasmalemmal sealing might provide insights to develo

关键词： sealing traumatic eukaryotic vesicles axonal membranous closer biochemical vesicular muscular

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简化现代雷达测试分析

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国外电子测量技术 2014年第3期33卷 22-26页

作者： darren mc Carthy 罗德与施瓦茨公司

先进的的下一代雷达系统受益于数字技术和计算能力的进步.雷达基带部分越来越倾向于使用直接数字合成（direct digital synthesis,DDS）技术,从而具有强大的数字信号处理和宽基带波形生成能力,以便创建软件定义的雷达.DDS雷达优点突出.... 详细信息

先进的的下一代雷达系统受益于数字技术和计算能力的进步.雷达基带部分越来越倾向于使用直接数字合成（direct digital synthesis,DDS）技术,从而具有强大的数字信号处理和宽基带波形生成能力,以便创建软件定义的雷达.DDS雷达优点突出.在评估是否应该将这一技术与有源电子扫描天线（active electronically scanned antenna,AESA）技术相结合时,应该考虑下述潜在的系统优点：

关键词：现代雷达测试分析数字技术直接数字合成数字信号处理电子扫描天线计算能力雷达系统

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Effect of body mass index on functional outcome in primary total knee arthroplasty——a single institution analysis of 2180 primary total knee replacements

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World Journal of Orthopedics 2016年第10期7卷 664-669页

作者： Shane C O'Neill Joseph S Butler Adam Daly darren F Lui Patrick Kenny Department of Orthopaedics Cappagh National Orthopaedic Hospital

AIM To evaluate the effect of body mass index(BMI) on short-term functional outcome and complications in primary total knee arthroplasty. METHODS All patients undergoing primary total knee arthroplasty at a single institution between 2007 and 2013 were identified from a prospective arthroplasty database. 2180 patients were included in the study. Age, gender, BMI, pre- and post-operative functional scores [Western Ontario and mc Master University Arthritis Index(WOMAC) and SF-36], complications and revision rate were recorded. Patients were grouped according to the WHO BMI classification. The functional outcome of the normal weight cohort(BMI 0.05). Sub-group analysis revealed significantly worse WOMAC scores in class 2 obese 30.80 compared to overweight 25.80(P 25. Patients should not be denied total knee arthroplasty based solely on weight alone.

关键词： Total knee replacement Body mass index Total knee arthroplasty

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东南亚国家联盟放疗资源基本情况调查及对中国科技援外工作启示

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中华放射肿瘤学杂志 2023年第11期32卷 958-962页

作者：祝鸿程夏凡胡伟刚潘明骏易俊林高献书章真复旦大学附属肿瘤医院放射治疗中心上海200032 香港中文大学临床肿瘤学系中国香港999077 国家癌症中心/国家肿瘤临床医学研究中心/中国医学科学院北京协和医学院肿瘤医院放疗科北京100021 北京大学第一医院放疗科北京100034

目的调查了解东南亚国家联盟(简称东盟)放射治疗资源现状,分析其放射治疗需求,为中国放射治疗科技援外工作提出建议。方法使用开源数据创建了10个东盟国家的数据库,包括人口规模、人均国民总收入、肿瘤新发病例以及放射治疗设备(兆伏级... 详细信息

目的调查了解东南亚国家联盟(简称东盟)放射治疗资源现状,分析其放射治疗需求,为中国放射治疗科技援外工作提出建议。方法使用开源数据创建了10个东盟国家的数据库,包括人口规模、人均国民总收入、肿瘤新发病例以及放射治疗设备(兆伏级单位)的数据。同时估算了需要放射治疗的病例数和放射治疗设备需求。采用描述性统计呈现汇总数据和各国数据。结果2020年东盟国家新发肿瘤病例为109.92万例,需要接受放射治疗的肿瘤患者数估算总计为70.03万例,需要放射治疗设备数量为1406台。目前东盟国家实际放射治疗设备为564台,部分东盟国家现有的放射治疗资源与本国肿瘤患者实际需求均存在一定差距。2040年东盟国家新发肿瘤病例预估为180.03万例,东盟国家需要接受放射治疗的肿瘤患者数预估总计为114.12万例,需要放射治疗设备数量为2287台。到2040年,东盟国家放射治疗设备需求增长率为305%,所有东盟国家都需要配置更多的放射治疗资源以应对肿瘤患者数量和放射治疗需求的增加。结论东南亚国家联盟未来20年对放射治疗存在巨大需求,但不同国家之间差异较大。中国精准放疗科技在东盟国家有巨大空间潜力,根据各国需求有针对性地提出科技援外计划,有助于中国放疗事业持续发挥影响力,促进东盟国家人民健康事业发展。

关键词：东南亚国家联盟放疗资源配置科技援外

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