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Acetabular cup size trends in total hip arthroplasty

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World Journal of Orthopedics 2024年第1期15卷 39-44页

作者： Daniel Patrick McKenna Alex Price Timothy McAleese darren Dahly Paul McKenna May cleary Department of Trauma and Orthopaedics University Hospital WaterfordWaterford X91 ER8EIreland Department of Epidemiology and Public Health University College CorkCork T12 XF62Ireland

BAcKGROUND Total hip arthroplasty(THA)is a common procedure for end stage *** learning curve for THA is complex and *** of the most difficult skills to master is acetabular *** wish to identify if experience in arthroplasty leads to preservation of more bone *** To investigate if increasing surgeon experience will predict an ever decreasing acetabular cup *** A retrospective case series of four attending orthopaedic surgeons was *** uncemented elective total hip arthroplasties since appointment were selected for *** size of acetabular cup used was noted and logistic regression was used to identify if a trend to smaller cups *** A total of 1614 subjects were included with a mean age of 64 *** cups were on average 0.18mm smaller per year(95%confidence interval-0.25 to-0.11,Pcup sizes to decrease 0.27 mm/year for surgeon A,0.02 mm/year for surgeon B,0.15 mm/year for surgeon c and 0.29 mm/year for surgeon *** of the four surgeons had a more pronounced trend to smaller cups for male subjects than their female *** We found increasing surgeon experience to be associated with an ever-decreasing acetabular cup *** acetabular cup size may act as a surrogate marker of surgical proficiency by virtue of decreased acetabular reaming.

关键词： Hip Arthroplasty Acetabulum cup Learning

Statin, aspirin and metformin use and risk of hepatocellular carcinoma related outcomes following liver transplantation: A retrospective study

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World Journal of Transplantation 2024年第3期14卷 120-131页

作者： William chung Kevin Wong Noel Ravindranayagam Lauren Tang Josephine Grace darren Wong Danny con Marie Sinclair Avik Majumdar Numan Kutaiba Samuel Hui Paul Gow Vijayaragavan Muralidharan Alexander Dobrovic Adam Testro Department of Gastroenterology Austin HealthHeidelberg 3084VictoriaAustralia Victorian Liver Transplant Unit Austin HealthHeidelberg 3084VictoriaAustralia Department of Radiology Austin HealthHeidelberg 3084VictoriaAustralia Department of Gastroenterology Monash HealthClayton 3168VictoriaAustralia Department of Surgery University of MelbourneAustin HealthHeidelberg 3048VictoriaAustralia Department of Surgery Beacon LaboratoryAustin PrecinctThe University of MelbourneAustin HospitalHeidelberg 3048VictoriaAustralia

BAcKGROUND Liver transplantation(LT)is a potentially curative therapy for patients with hepatocellular carcinoma(Hcc).Hcc-recurrence following LT is associated with reduced *** is increasing interest in chemoprophylaxis to improve Hcc-related outcomes *** To investigate whether there is any benefit for the use of drugs with proposed chemoprophylactic properties against Hcc,and patient outcomes following *** This was a retrospective study of adult patients who received Deceased Donor LT for Hcc from 2005-2022,from a single Australian *** use was defined as statin,aspirin or metformin therapy for≥29 days,within 24 months post-LT.A cox proportional-hazards model with time-dependent covariates was used for survival *** measures were the composite-endpoint of Hcc-recurrence and all-cause mortality,Hcc-recurrence and Hcc-related *** analysis was performed to account for immortality time bias and statin *** Three hundred and five patients were included in this study,with 253(82.95%)males with a median age of 58.90 *** of liver disease were 150(49.18%)hepatitis c,73(23.93%)hepatitis B(HBV)and 33(10.82%)non-alcoholic fatty liver disease(NAFLD).56(18.36%)took statins,51(16.72%)aspirin and 50(16.39%)*** a median follow-up time of 59.90 months,34(11.15%)developed Hcc-recurrence,48(15.74%)died,17(5.57%)from Hcc-related ***,aspirin or metformin use was not associated with statistically significant differences in the composite endpoint of Hcc-recurrence or all-cause mortality[hazard ratio(HR):1.16,95%cI:0.58-2.30;HR:1.21,95%cI:0.28-5.27;HR:0.61,95%cI:0.27-1.36],Hcc-recurrence(HR:0.52,95%cI:0.20-1.35;HR:0.51,95%cI:0.14-1.93;HR 1.00,95%cI:0.37-2.72),or Hcc-related mortality(HR:0.32,95%cI:0.033-3.09;HR:0.71,95%cI:0.14-3.73;HR:1.57,95%cI:0.61-4.04)*** dosing was not associated with statist-ically significant differences in Hcc-related ***

关键词： Liver transplantation Hepatocellular carcinoma Transplant oncology Statins HMG-co-A reductase Aspirin Metformin Mammalian target of rapamycin

Microenvironmental influences on T cell immunity in cancer and inflammation

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cellular & Molecular Immunology 2022年第3期19卷 316-326页

作者： darren R.Heintzman Emilie L.Fisher Jeffrey c.Rathmell Department of Pathology Microbiologyand ImmunologyVanderbilt University Medical CenterNashvilleTN37205USA Vanderbilt center for Immunobiology Vanderbilt University Medical CenterNashvilleTN37205USA

T cell metabolism is dynamic and highly *** the intrinsic metabolic programs of T cell subsets are integral to their distinct differentiation and functional patterns,the ability of cells to acquire nutrients and cope with hostile microenvironments can limit these pathways.T cells must function in a wide variety of tissue settings,and how T cells interpret these signals to maintain an appropriate metabolic program for their demands or if metabolic mechanisms of immune suppression restrain immunity is an area of growing *** in inflamed and cancer tissues,a wide range of changes in physical conditions and nutrient availability are now acknowledged to shape *** include fever and increased temperatures,depletion of critical micro and macro-nutrients,and accumulation of inhibitory waste *** we review several of these factors and how the tissue microenvironment both shapes and constrains immunity.

关键词： immunometabolism T cell microenvironment cancer inflammation

Graph neural network modeling of grain-scale anisotropic elastic behavior using simulated and measured microscale data

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npj computational Materials 2022年第1期8卷 2471-2482页

作者： darren c.Pagan calvin R.Pash Austin R.Benson Matthew P.Kasemer Pennsylvania State University University ParkPA16802USA cornell University IthacaNY14853USA University of Alabama TuscaloosaAL35487USA

Here we assess the applicability of graph neural networks(GNNs)for predicting the grain-scale elastic response of polycrystalline metallic *** GNN surrogate models,grain-averaged stresses during uniaxial elastic tension in low solvus high-refractory(LSHR)Ni Superalloy and Ti 7 wt%Al(Ti-7Al)are predicted as example face-centered cubic and hexagonal closed packed alloys,respectively.A transfer learning approach is taken in which GNN surrogate models are trained using crystal elasticity finite element method(cEFEM)simulations and then the trained surrogate models are used to predict the mechanical response of microstructures measured using high-energy X-ray diffraction microscopy(HEDM).The performance of using various microstructural and micromechanical descriptors for input nodal features to the GNNs is explored through comparisons to traditional mean-field theory predictions,reserved full-field cEFEM data,and measured far-field HEDM *** effects of elastic anisotropy on GNN model performance and outlooks for the extension of the framework are discussed.

关键词： grain neural behavior

Hypoxia Enhances the Therapeutic Potential of Superparamagnetic Iron Oxide-labeled Adipose-derived Stem cells for Myocardial Infarction

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Journal of Huazhong University of Science and Technology(Medical Sciences) 2017年第4期37卷 516-522页

作者：王剑向波邓继先林宏宇 darren H.Freed Rakesh c.Arora 田钢虹 Department of Vascular Surgery Union HospitalTongji Medical CollegeHuazhong University of Science and TechnologyWuhan 430022China National Research council of canada Winnipeg R3B 1Y6Canada Department of Physiology Faculty of MedicineUniversity of ManitobaWinnipeg R3E 3P5Canada Department of Pharmacology and Therapeutics Faculty of MedicineUniversity of ManitobaWinnipeg R3E OT6Canada Division of cardiac Surgery University of Alberta Hospital Edmonton T6G 2B7Canada cardiac Science Program Institute of Cardiovascular ScienceSt.Boniface General Hospital Winnipeg R2H 2A6Canada

Adipose-derived stem cells（AScs） induce therapeutic angiogenesis due to pro-angiogenic cytokines secretion. Superparamagnetic iron oxide（SPIO） nanoparticles are critical for magnetic resonance（MR） tracking of implanted cells. Hypoxia is a powerful stimulus for angiogenic activity of AScs. In this study, we investigated whether therapeutic potency could be enhanced by implantation of hypoxia-preconditioned SPIO-labeled AScs（SPIOAScs） into the infarcted myocardium. AScs and SPIOAScs were cultured under 2% O_2（hypoxia） or 95% air（normoxia）. cells were intramyocardially injected into the infarcted myocardium after 48-h culture. We found that hypoxia culture increased the m RNA expression of hypoxia-inducible factor-1 alpha（HIF-1α） and vascular endothelial growth factor（VEGF） in AScs and SPIOAScs. The VEGF protein in the conditioned medium was significantly higher in hypoxic AScs and SPIOAScs than in normoxic AScs and SPIOAScs. The capillary density and left ventricular contractile function in the infarcted myocardium were significantly higher 4 weeks after implantation with hypoxic AScs and SPIOAScs than with normoxic AScs and SPIOAScs. Improvement in the capillary density and left ventricle function didn＇t differ between hypoxic AScs-transplanted rats and hypoxic SPIOAScs-transplanted rats. Hypoxic culture enhanced the angiogenic efficiency of AScs. It was concluded that implantation of hypoxic AScs or SPIOAScs promotes therapeutic angiogenesis and cardiac function recovery in the infarcted myocardium. SPIO labeling does not impact the beneficial effect of hypoxic AScs.

关键词： hypoxia adipose-derived stem cells superparamagnetic iron oxide myocardial infarction

Effect of body mass index on functional outcome in primary total knee arthroplasty——a single institution analysis of 2180 primary total knee replacements

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World Journal of Orthopedics 2016年第10期7卷 664-669页

作者： Shane c O'Neill Joseph S Butler Adam Daly darren F Lui Patrick Kenny Department of Orthopaedics Cappagh National Orthopaedic Hospital

AIM To evaluate the effect of body mass index(BMI) on short-term functional outcome and complications in primary total knee arthroplasty. METHODS All patients undergoing primary total knee arthroplasty at a single institution between 2007 and 2013 were identified from a prospective arthroplasty database. 2180 patients were included in the study. Age, gender, BMI, pre- and post-operative functional scores [Western Ontario and Mc Master University Arthritis Index(WOMAc) and SF-36], complications and revision rate were recorded. Patients were grouped according to the WHO BMI classification. The functional outcome of the normal weight cohort(BMI compared to the overweight and obese(BMI ≥ 25) cohort. A separate sub-group analysis was performed comparing all five WHO BMI groups; Normal weight, overweight, class 1 obese, class 2 obese and class 3 *** With a mean age of 67.89(28-92), 2180 primary total knee replacements were included. 64.36%(1403) were female. The mean BMI was 31.86(18-52). Ninty-three percent of patients were either overweight or obese. Mean follow-up 19.33 mo(6-60 mo). There was no significant difference in pre or post-operative WOMAc score in the normal weight(BMI cohort compared to patients with a BMI ≥ 25(P > 0.05). Sub-group analysis revealed significantly worse WOMAc scores in class 2 obese 30.80 compared to overweight 25.80(P class 1 obese 25.50(P cantly worse SF-36 scores in class 2 obese 58.16 compared to overweight 63.93(P class 1 obese 63.65(P cial infections, 9(0.41%) deep infections and 19(0.87%) revisions overall with no complications or revisions in the normal weight cohort(BMI cONcLUSION Post-operative functional outcome was not influenced by BMI comparing normal weight individuals with BMI > 25. Patients should not be denied total knee arthroplasty based solely on weight alone.

关键词： Total knee replacement Body mass index Total knee arthroplasty

Diversity,endemism and conservation of the freshwater crabs of china(Brachyura:Potamidae and Gecarcinucidae)

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Integrative Zoology 2011年第1期6卷 45-55页

作者： Neil cUMBERLIDGE Peter K.L.NG darren c.J.YEO Tohru NARUSE Kirstin S.MEYER Lara J.ESSER Department of Biology Northern Michigan UniversityMarquetteMichiganUSA Department of Biological Sciences National University of SingaporeSingapore University of the Ryukyus NishiharaOkinawaJapan Imperial college University of LondonLondonUK

china lies at the heart of the global center of freshwater crab diversity in tropical Asia,where the 2 most diverse families occur:Potamidae(505 species,95 genera)and Gecarcinucidae(344 species,59 genera).china stands out as the country with the highest species richness of freshwater crabs *** fauna comprises 243 species in 37 genera and in 2 families,and species discovery is still progressing at a rapid *** vast majority of the species are distributed in southwest,south central and eastern china in the Oriental zoogeographical *** also stands out as having a highly endemic freshwater crab fauna at the species level(96%)and at the genus level(78%).Although the recent International Union for the conservation of Nature(IUcN)red list conservation assessment found only 6 out of 228 species(2%)to be threatened(5 potamids and 1 gecarcinucid),the majority(more than 75%)of chinese species are regarded as data deficient,so the number of threatened species is likely to be a serious *** from increasing habitat destruction and pollution are a major concern due to the rapidly growing economy and massive developments taking place in *** is therefore an urgent need for increased species exploration and for the development of a conservation strategy for china’s threatened(and potentially threatened)endemic freshwater crab species.

关键词： china conservation distribution endemism Potamoidea

Transition from a maternal to external nitrogen source in maize seedlings

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Journal of Integrative Plant Biology 2017年第4期59卷 261-274页

作者： Kasra Sabermanesh Luke R. Holtham Jessey George Ute Roessner Berin A. Boughton Sigrid Heuer Mark Tester darren c. Plett Trevor P. Garnett Australian centre for Plant Functional Genomics Waite Research Institute University of Adelaide Adelaide SA 5064 Australia School of Agriculture Food and Wine Waite Research Institute University of Adelaide Adelaide SA 5064 Australia Australian centre for Plant Functional Genomics School of BioSciences University of Melbourne Parkville Vic. 3010 Australia Metabolomics Australia School of BioSciences University of Melbourne Vic. 3010 Australia King Abdullah University of Science and Technology Center for Desert Agriculture Thuwal 23955-6900 Kingdom of Saudi Arabia6. The Australian Plant Phenomics Facility The Plant Accelerator Waite Campus The University of Adelaide Adelaide SA 5064 Australia The Australian Plant Phenomics Facility The Plant Accelerator Waite Campus The University of Adelaide Adelaide SA 5064 Australia

Maximizing NO3 uptake during seedling development is important as it has a major influence on plant growth and yield. However, little is known about the processes leading to, and involved in, the initiation of root NO3 uptake capacity in developing seedlings. This study examines the physiological processes involved in root NO3 uptake and metabolism, to gain an understanding of how the NO3 uptake system responds to meet demand as maize seedlings transition from seed N use to external N capture. The concentrations of seedderived free amino acids within root and shoot tissues are initially high, but decrease rapidly until stabilizing eight days after imbibition （DAI）. Similarly, shoot N% decreases, but does not stabilize until 12-13 DAI. Following the decrease in free amino acid concentrations, root NO3- uptake capacity increases until shoot N% stabilizes. The increase in root NO3 uptake capacity corresponds with a rapid rise in transcript levels of putative NO3 transporters, ZmNRT2.1 and ZmNRT2.2. The processes underlying the increase in root NO3- uptake capacity to meet N demand provide an insight into the processes controlling N uptake.

关键词： NRT Transition from a maternal to external nitrogen source in maize seedlings NO

Further geological and palaeoanthropological investigations at the Maludong hominin site, Yunnan Province, Southwest china

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chinese Science Bulletin 2013年第35期58卷 4472-4485页

作者： JI XuePing cURNOE darren BAO ZhenDe HERRIES Andy I R FINK David ZHU YunSheng HELLSTROM John LUO Yun TAcON Paul S c Yunnan Institute of cultural Relics and Archaeology School of Biological Earth and Environmental Sciences University of New South Wales Sydney 2052 Australia Mengzi Institute of cultural Relics Archaeomagnetism Laboratory Archaeology Program School of Historical and European Studies La Trobe University Melbourne 3086 Australia Institute for Environmental Research Australian Nuclear Science and Technology Organisation Sydney 2001 Australia Honghe Prefectural Institute of cultural Relics School of Earth Sciences University of Melbourne Melbourne 3010 Australia Place Evolution and Rock Art Heritage Unit School of Humanities Gold Coast Campus Griffith University Gold Coast 4222 Australia

Three-dimensional mapping and section work undertaken by us in 2008 have identified 11 stratigraphic units at Maludong *** radiocarbon dating of charcoal established an accurate and internally consistent age profile for the sequence of 17.8±0.2 ka to 13.2±0.1 *** analysis showed changes in externally derived pedogenically enhanced material consistent with a warming in climate between the cold period of Henrich Event 1 and the B lling-Aller d *** remains recovered during the 1989 excavation were derived from a deposit dating to this interstadial,or between 14.3±0.3 ka and 13.5±0.1 *** features,including burnt rocks,baked sediment and thick charcoal and ash layers,were identified and examined through archaeomagnetic *** monkey fossils are described here,one of them being reassigned from Macaca robustus to *** confirm the young age of the site and also show signs of anthropogenic alteration in the form of *** human cranial remains are reported for the first time and new data are provided for some specimens described previously.A range of new features is identified that strengthen the affinities of the Maludong remains to archaic *** presence of this globally unique mosaic of archaic and modern features raises important questions about human evolutionary history in East Asia during the Late Upper Pleistocene.

关键词：古人类遗址中国西南地区古人类学云南省地质地层单位三维制图年龄分布